Using optical coherence tomography to evaluate skin sun damage and precancer
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Background and Objectives: Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods: OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results: Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P<0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P<0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion: OCT has the potential to guide biopsies and provide non‐invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Lesers Surg. Med. 39:687–695, 2007. © 2007 Wiley‐Liss, Inc.
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The majority of studies on OCT imaging of AK do not mention skin color, likely due to the perception that AK only affects people with light skin.
“the majority of studies do not mention skin color and this is likely due to the perception that AK only affects people with light skin.99–104”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [101]
OCT has been shown to accurately image the development of actinic keratosis (AK) in patients of FST I-III.
“Although OCT has been shown to accurately image the development of actinic keratosis (AK), a precursor to squamous cell carcinoma (SCC), in patients of FST I–III”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [101]
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- Authors
- Korde, V. R., Bonnema, G. T., Xu, W., Krishnamurthy, C., Ranger‐Moore, J., Saboda, K., Slayton, L. D., Salasche, S. J., Warneke, J. A., Alberts, D. S., & Barton, J. K.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Barton, Jennifer K.
- Venue
- Lasers in Surgery and Medicine
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 39
- Issue
- 9
- Pages
- 687-695
- ISSN
- 0196-8092 (ISSN-L)
- 1096-9101
- PMC
- PMC2397550
- OpenAlex
- W2069538592
- Cited by
- 145
- References
- 15
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 17 · 2012: 15
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lasers in Surgery and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01-CA27502, P01CA027502)
- National Institute of Biomedical Imaging and Bioengineering (T32EB000809)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- optical coherence tomography, actinic keratosis, sun damage, solar elastosis, precancerous skin lesions, non-invasive skin imaging, attenuation, chemoprevention
- MeSH terms
- Adult, Aged, Aged, 80 and over, Biopsy, Diagnosis, Differential, Humans, Keratosis, Middle Aged, Precancerous Conditions, Sensitivity and Specificity, Skin, Sunlight, Ultraviolet Rays, Tomography, Optical Coherence
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