Applications and future directions for optical coherence tomography in dermatology*
Open accessAbstract
Optical coherence tomography (OCT) is a noninvasive optical imaging method that can generate high-resolution en face and cross-sectional images of the skin in vivo to a maximum depth of 2 mm. While OCT holds considerable potential for noninvasive diagnosis and disease monitoring, it is poorly understood by many dermatologists. Here we aim to equip the practising dermatologist with an understanding of the principles of skin OCT and the potential clinical indications. We begin with an introduction to the technology and discuss the different modalities of OCT including angiographic (dynamic) OCT, which can image cutaneous blood vessels at high resolution. Next we review clinical applications. OCT has been most extensively investigated in the diagnosis of keratinocyte carcinomas, particularly basal cell carcinoma. To date, OCT has not proven sufficiently accurate for the robust diagnosis of malignant melanoma; however, the evaluation of abnormal vasculature with angiographic OCT is an area of active investigation. OCT, and in particular angiographic OCT, also shows promise in monitoring the response to therapy of inflammatory dermatoses, such as psoriasis and connective tissues disease. We additionally discuss a potential role for artificial intelligence in improving the accuracy of interpretation of OCT imaging data.
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OCT currently does not have the accuracy to diagnose malignant melanomas.
“however, it currently does not have the accuracy to diagnose malignant melanomas.96”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [96]
OCT has potential for monitoring therapy for skin disorders such as scleroderma, psoriasis, eczema, and wound healing.
“It has also been shown to have potential for monitoring therapy for skin disorders such as scleroderma, psoriasis, eczema, and wound healing.96–98”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [96]
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- Authors
- Wan, B., Ganier, C., Du‐Harpur, X., Harun, N., Watt, F. M., Patalay, R., & Lynch, M. D.
- Affiliations
- King's College London (GB)
- Centre for Stem Cells and Regenerative Medicine King’s College LondonGuy’s Hospital Great Maze Pond London UK
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-08
- Volume
- 184
- Issue
- 6
- Pages
- 1014-1022
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W3088595766
- Cited by
- 148
- References
- 96
- Citations by year
- 2026: 31 · 2025: 28 · 2024: 43 · 2023: 24 · 2022: 15 · 2021: 7
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Dermatology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- The Wellcome Trust DBT India Alliance (211276/E/18/Z)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- optical coherence tomography, skin imaging, basal cell carcinoma, melanoma, cutaneous blood vessels, psoriasis, connective tissue diseases, inflammatory skin diseases, treatment response monitoring, artificial intelligence, non-invasive diagnosis
- MeSH terms
- Artificial Intelligence, Cross-Sectional Studies, Dermatology, Humans, Skin Neoplasms, Tomography, Optical Coherence
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