The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Prevalence and odds of S taphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis
Abstract
BACKGROUND: Staphylococcus aureus is increasingly implicated as a possible causal factor in the pathogenesis of atopic dermatitis (AD). However, the reported prevalence rates of skin and nasal colonization in the literature vary widely. OBJECTIVES: This study evaluates the prevalence and odds of skin and nasal colonization with S. aureus in patients with AD. METHODS: A systematic literature search was conducted. Odds ratios (ORs) for colonization in patients vs. controls and the prevalence of colonization in patients were pooled using the random-effects model. RESULTS: Overall, 95 observational studies were included, of which 30 had a control group. The Newcastle-Ottawa Scale was used to assess study quality, with the majority of studies being of fair to poor quality. Patients with AD were more likely to be colonized with S. aureus than healthy controls [OR 19·74, 95% confidence interval (CI) 10·88-35·81]. Differences were smaller in nonlesional skin (OR 7·77, 95% CI 3·82-15·82) and in the nose (OR 4·50, 95% CI 3·00-6·75). The pooled prevalence of S. aureus colonization among patients was 70% for lesional skin, 39% for nonlesional skin and 62% for the nose. In lesional skin, meta-regression showed that the prevalence of colonization increased with disease severity. Study heterogeneity should be taken into consideration when interpreting the results. CONCLUSIONS: These results demonstrate the importance of colonization with S. aureus in AD. Further evaluation of the mechanisms by which S. aureus influences inflammation is required in addition to the development of targeted strategies to decrease skin and nasal S. aureus load.
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Bias in meta-analysis detected by a simple, graphical test
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Cited by
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549
Skin microbiota–host interactions
Chen, Y. E., Fischbach, M. A., & Belkaid, Y. (2018) · Nature · doi:10.1038/nature25177 · Cited by 786
The microbiome in patients with atopic dermatitis
Paller, A. S., Kong, H. H., Seed, P., Naik, S., Scharschmidt, T. C., Gallo, R. L., Luger, T., & Irvine, A. D. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.015 · Cited by 525
Comorbidities and the impact of atopic dermatitis
Silverberg, J. I. (2019) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2019.04.020 · Cited by 431
Brough, H. A., Nadeau, K. C., Sindher, S. B., Alkotob, S. S., Chan, S., Bahnson, H. T., Leung, D. Y. M., & Lack, G. (2020) · Allergy · doi:10.1111/all.14304 · Cited by 275
Metadata
- Authors
- Totté, J. E. E., van der Feltz, W. T., Hennekam, M., van Belkum, A., van Zuuren, E. J., & Pasmans, S. G. M. A.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-05
- Volume
- 175
- Issue
- 4
- Pages
- 687-695
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2298124544
- Cited by
- 438
- References
- 60
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Totté, J. E. E., van der Feltz, W. T., Hennekam, M., van Belkum, A., van Zuuren, E. J., & Pasmans, S. G. M. A. (2016). Prevalence and odds of S taphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis. British Journal of Dermatology. https://doi.org/10.1111/bjd.14566
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