The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Guidelines for the diagnosis and treatment of cobalamin and folate disorders
Open accessAbstract
Summary of key recommendations: The clinical picture is the most important factor in assessing the significance of test results assessing cobalamin status because there is no ‘gold standard’ test to define deficiency. Serum cobalamin currently remains the first‐line test, with additional second‐line plasma methylmalonic acid to help clarify uncertainties of underlying biochemical/functional deficiencies. Serum holotranscobalamin has the potential as a first‐line test, but an indeterminate ‘grey area’ may still exist. Plasma homocysteine may be helpful as a second‐line test, but is less specific than methylmalonic acid. The availability of these second‐line tests is currently limited. Definitive cut‐off points to define clinical and subclinical deficiency states are not possible, given the variety of methodologies used and technical issues, and local reference ranges should be established. In the presence of discordance between the test result and strong clinical features of deficiency, treatment should not be delayed to avoid neurological impairment. Treatment of cobalamin deficiency is recommended in line with the British National Formulary. Oral therapy may be suitable and acceptable provided appropriate doses are taken and compliance is not an issue. Serum folate offers equivalent diagnostic capability to red cell folate and is the first‐line test of choice to assess folate status.
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Cites
Stabler, S. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcp1113996 · Cited by 1,224
Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · cited 1×
“…the elderly have a high incidence of food malabsorption, with some early studies suggesting possible cognitive improvement after cobalamin supplements with or without Folate/B vitamins (van Asselt et al, 2001; Nilsson et al, 2001; Smith & Refsum, 2009; Smith et al, 2010; de Jager et al, 2012).”
Backgroundde Jager, J., Kooy, A., Lehert, P., Wulffele, M. G., van der Kolk, J., Bets, D., Verburg, J., Donker, A. J. M., & Stehouwer, C. D. A. (2010) · BMJ · doi:10.1136/bmj.c2181 · Cited by 702
Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin
Bauman, W. A., Shaw, S., Jayatilleke, E., Spungen, A. M., & Herbert, V (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1227 · Cited by 412
Risk Factors of Vitamin B12 Deficiency in Patients Receiving Metformin
Ting, R. Z.-W. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.18.1975 · Cited by 333
Wile, D. J., & Toth, C. (2010) · Diabetes Care · doi:10.2337/dc09-0606 · Cited by 283
Torsvik, I., Ueland, P. M., Markestad, T., & Bjørke-Monsen, A.-L. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.061549 · Cited by 74
Oral cobalamin (vitamin B12) treatment. An update
ANDRÈS, E., DALI‐YOUCEF, N., VOGEL, T., SERRAJ, K., & ZIMMER, J. (2009) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2008.01115.x · Cited by 52 · cited 1×
“Dose finding studies using 2 5–1000 lg of oral cyanocobalamin have shown good response in terms of serum cobalamin using lower doses but lesser response in terms of tHcy and MMA (Rajan et al, 2002; Seal et al, 2002; Eussen et al, 2005; Andres et al, 2009).”
Background
Cited by
Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Self-citationBerger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615
Hunt, A., Harrington, D., & Robinson, S. (2014) · BMJ · doi:10.1136/bmj.g5226 · Cited by 406
Saravanan, P., Sukumar, N., Adaikalakoteswari, A., Goljan, I., Venkataraman, H., Gopinath, A., Bagias, C., Yajnik, C. S., Stallard, N., Ghebremichael-Weldeselassie, Y., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05510-7 · Cited by 91
Metadata
- Authors
- Devalia, V., Hamilton, M. S., Molloy, A. M., & the British Committee for Standards in Haematology
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2014-06-18
- Volume
- 166
- Issue
- 4
- Pages
- 496-513
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2118076374
- Cited by
- 511
- References
- 8
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Devalia, V., Hamilton, M. S., Molloy, A. M., & the British Committee for Standards in Haematology. (2014). Guidelines for the diagnosis and treatment of cobalamin and folate disorders. British Journal of Haematology. https://doi.org/10.1111/bjh.12959
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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