Vitamin B12Deficiency
Abstract
Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both. Current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis. Parenteral or high-dose oral vitamin B12 is effective therapy.
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The functional markers tHcy and MMA have been established as useful indicators of vitamin B-12 status and may be more sensitive indicators of mild vitamin B-12 deficiency.
“However, the functional markers total homocysteine (tHcy) 13 and methylmalonic acid (MMA) have been established as useful indicators of vitamin B-12 status (13) and may be more sensitive indicators of mild vitamin B-12 deficiency (14,15).”
From Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children (2017) · cites this paper as [14]
Elevated tHcy values in these children could not be caused by folate deficiency but rather poor cobalamin status.
“the elevated tHcy values in these children could not be caused by folate deficiency but rather poor cobalamin status (14,15).”
From Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children (2017) · cites this paper as [14]
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- Authors
- Stabler, S. P.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Stabler, Sally P.
- ORCID
- Stabler, Sally P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2013-01-10
- Volume
- 368
- Issue
- 2
- Pages
- 149-160
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3215299411
- Cited by
- 1,224
- References
- 47
- Citations by year
- 2026: 104 · 2025: 90 · 2024: 104 · 2023: 98 · 2022: 105 · 2021: 95 · 2020: 121 · 2019: 112 · 2018: 76 · 2017: 80 · 2016: 69 · 2015: 73 · 2014: 60 · 2013: 35
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- vitamin B12 deficiency, megaloblastic anemia, demyelinating disease, methylmalonic acid, sensitivity and specificity, treatment
- MeSH terms
- Administration, Oral, Anemia, Pernicious, Child, Diagnostic Errors, Female, Homocysteine, Humans, Infant, Infant Nutrition Disorders, Injections, Intestinal Absorption, Methylmalonic Acid, Middle Aged, Paresthesia, Vitamin B 12, Vitamin B 12 Deficiency, Child Nutrition Disorders, Practice Guidelines as Topic
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