Cited by 1,224Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersHematological disorders and diagnostics

Vitamin B12Deficiency

Stabler, Sally P.·2013·New England Journal of Medicine

Abstract

Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both. Current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis. Parenteral or high-dose oral vitamin B12 is effective therapy.

Integrity signals

Registry

Crossref · 10.1056/nejmcp1113996

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47 of 47 references verified0 citation errors · 0 not checkable

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Authors
Stabler, S. P.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Stabler, Sally P.
Venue
New England Journal of Medicine
Published
2013-01-10
Volume
368
Issue
2
Pages
149-160
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W3215299411
Cited by
1,224
References
47
Citations by year
2026: 104 · 2025: 90 · 2024: 104 · 2023: 98 · 2022: 105 · 2021: 95 · 2020: 121 · 2019: 112 · 2018: 76 · 2017: 80 · 2016: 69 · 2015: 73 · 2014: 60 · 2013: 35
FWCI
12.54
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
Keywords
vitamin B12 deficiency, megaloblastic anemia, demyelinating disease, methylmalonic acid, sensitivity and specificity, treatment
MeSH terms
Administration, Oral, Anemia, Pernicious, Child, Diagnostic Errors, Female, Homocysteine, Humans, Infant, Infant Nutrition Disorders, Injections, Intestinal Absorption, Methylmalonic Acid, Middle Aged, Paresthesia, Vitamin B 12, Vitamin B 12 Deficiency, Child Nutrition Disorders, Practice Guidelines as Topic

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