Vitamin B12 deficiency
Abstract
#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively.2 3 Methylmalonic acid is converted into succinyl-CoA, of which vitamin B12 is a cofactor for the reaction. Homocysteine is biosynthesised from methionine then resynthesised into methionine or converted into amino acid cysteine. Vitamin B12 (also referred to as cobalamin) deficiency is relatively common, with important and variable clinical consequences. This review presents a concise summary of the most up to date evidence on how to diagnose and manage vitamin B12 deficiency. #### Sources and selection criteria We searched PubMed and Google Scholar using the terms “vitamin B12 deficiency” and “cobalamin deficiency”, and hand selected the most relevant and appropriate articles. We also used evidence based guidelines from the British Committee for Standards in Haematology; however, evidence, especially in the form of randomised controlled trials, is lacking.4 Foods containing vitamin B12 are …
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Cobalamin deficiency induces neurological dysfunction, including myelopathy, neuropathy and neuropsychiatric abnormalities, and is associated with mental and cognitive impairment up to dementia.
“Cobalamin (vitamin B12) deficiency induces neurological dysfunction, including myelopathy, neuropathy and neuropsychiatric abnormalities. Such neurological damage has been reported in 20–30% of cases of vitamin B12 deficiency [147], and can even occur before serum vitamin B12 concentrations reach a level that would be considered deficient by standard criteria.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [148]
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- Authors
- Hunt, A., Harrington, D., & Robinson, S.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Hunt, A.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2014-09-04
- Volume
- 349
- Issue
- sep04 1
- Pages
- g5226-g5226
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W1986242571
- Cited by
- 406
- References
- 19
- Citations by year
- 2026: 25 · 2025: 43 · 2024: 55 · 2023: 50 · 2022: 41 · 2021: 47 · 2020: 51 · 2019: 41 · 2018: 15 · 2017: 10 · 2016: 20 · 2015: 6 · 2013: 1
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- vitamin B12 deficiency, vitamin B12, methylcobalamin, adenosylcobalamin, methylmalonic acid, homocysteine, methylation, diagnosis, food sources
- MeSH terms
- Homocysteine, Humans, Hydroxocobalamin, Methylmalonic Acid, Transcobalamins, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency
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