Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant H istone 3 Tail
Open accessAbstract
Primary brain tumors occur in 8 out of 100 000 people and are the leading cause of cancer-related death in children. Among brain tumors, high-grade astrocytomas (HGAs) including glioblastoma multiforme (GBM) are aggressive and are lethal human cancers. Despite decades of concerted therapeutic efforts, HGAs remain essentially incurable in adults and children. Recent discoveries have revolutionized our understanding of these tumors in children and young adults. Recurrent somatic driver mutations in the tail of histone 3 variant 3 (H3.3), leading to amino acid substitutions at key residues, namely lysine (K) 27 (K27M) and glycine 34 (G34R/G34V), were identified as a new molecular mechanism in pediatric GBM. These mutations represent the pediatric counterpart of the recurrent mutations in isocitrate dehydrogenases (IDH) identified in young adult gliomas and provide a much-needed new pathway that can be targeted for therapeutic development. This review will provide an overview of the potential role of these mutations in altering chromatin structure and affecting specific molecular pathways ultimately leading to gliomagenesis. The distinct changes in chromatin structure and the specific downstream events induced by each mutation need characterizing independently if progress is to be made in tackling this devastating cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More than 90% of pediatric high-grade gliomas arising in the brain midline, including diffuse intrinsic pontine gliomas, carry K27M mutations in an H3 variant.
“Indeed, more than 90% of pHGG in the brain midline, including the particularly deadly diffuse intrinsic pontine gliomas (DIPG), carry lysine 27 to methionine (K27M) mutations in an H3 variant (H3F3A/H3.3, HIST1H3B or HIST1H3C/H3.1 and rarely HIST2H3B/H3.2)”
From H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas (2017) · cites this paper as Fontebasso et al., 2013
G34R/V mutations in H3.3 occur in 36% of pediatric high-grade gliomas in the cerebral hemispheres.
“while mutations of glycine 34 to arginine or valine (G34R/V) in H3.3 occur in 36% of pHGG in the cerebral hemispheres”
From H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas (2017) · cites this paper as Fontebasso et al., 2013
Cites
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,422 · see citing works
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735 · see citing works
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575 · see citing works
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857 · see citing works
<i>IDH1</i> and <i>IDH2</i> Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847 · see citing works
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154 · see citing works
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337 · see citing works
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature · doi:10.1038/nature10860 · Cited by 1,985 · see citing works
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E., Campos, C., Fabius, A. W. M., Lu, C., Ward, P. S., et al. (2012) · Nature · doi:10.1038/nature10866 · Cited by 1,974 · see citing works
Sturm, D., Witt, H., Hovestadt, V., Khuong-Quang, D.-A., Jones, D. T. W., Konermann, C., Pfaff, E., Tönjes, M., Sill, M., Bender, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.024 · Cited by 1,828 · see citing works
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project (2012) · Nature Genetics · doi:10.1038/ng.1102 · Cited by 1,724 · see citing works
Morin, R. D., Johnson, N. A., Severson, T., Mungall, A. J. J., An, J., Goya, R., Paul, J. E., Boyle, M., Woolcock, B. W., Kuchenbauer, F. C., et al. (2010) · Nature Genetics · doi:10.1038/ng.518 · Cited by 1,670 · see citing works
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596 · cited 1× · see citing works
“Gain of function mutations in EZH2, the main K27 trimethyltransferase, has been identified in leukemias and lymphomas (44, 46, 70), and overexpression of this gene was also identified in many cancers including medulloblastoma (30, 47).”
BackgroundDistinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Goldberg, A. D., Banaszynski, L. A., Noh, K., Lewis, P. W., Elsässer, S. J., Stadler, S. C., Dewell, S. B., Law, M. J., Guo, X., Li, X., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.003 · Cited by 1,281 · see citing works
Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers
Chi, P., Allis, C. D., & Wang, G. G. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2876 · Cited by 1,099 · see citing works
Altered Telomeres in Tumors with <i>ATRX</i> and <i>DAXX</i> Mutations
Heaphy, C. M., de Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., et al. (2011) · Science · doi:10.1126/science.1207313 · Cited by 1,083 · see citing works
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Chowdhury, R., Yeoh, K. K., Tian, Y., Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K. H., Li, X. S., Woon, E. C. Y., Yang, M., et al. (2011) · The EMBO Reports · doi:10.1038/embor.2011.43 · Cited by 1,035 · see citing works
Khuong-Quang, D.-A., Buczkowicz, P., Rakopoulos, P., Liu, X.-Y., Fontebasso, A. M., Bouffet, E., Bartels, U., Albrecht, S., Schwartzentruber, J., Letourneau, L., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0998-0 · Cited by 1,028 · see citing works
Jones, D., Kocialkowski, S., Liu, L., Pearson, D. M., Bäcklund, L. M., Ichimura, K., & Collins, V. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2097 · Cited by 938 · see citing works
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Northcott, P. A., Shih, D. J. H., Peacock, J., Garzia, L., Morrissy, A. S., Zichner, T., Stütz, A. M., Korshunov, A., Reimand, J., Schumacher, S. E., et al. (2012) · Nature · doi:10.1038/nature11327 · Cited by 887 · see citing works
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Molenaar, J. J., Köster, J., Zwijnenburg, D. A., Sluis, P. V., Valentijn, L. J., van der Ploeg, I., Hamdi, M., van Nes, J., Westerman, B. A., van Arkel, J., et al. (2012) · Nature · doi:10.1038/nature10910 · Cited by 869 · see citing works
Histone variants — ancient wrap artists of the epigenome
Talbert, P. B., & Henikoff, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2861 · Cited by 844 · see citing works
Dissecting the genomic complexity underlying medulloblastoma
Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y.-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., et al. (2012) · Nature · doi:10.1038/nature11284 · Cited by 839 · see citing works
Self-citationLewis, P., Elsaesser, S. J., Noh, K., Stadler, S., & Allis, C. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1008850107 · Cited by 830 · see citing works
Paugh, B. S., Qu, C., Jones, C., Liu, Z., Adamowicz‐Brice, M., Zhang, J., Bax, D. A., Coyle, B., Barrow, J., Hargrave, D. R., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.7252 · Cited by 651 · see citing works
Weller, M., Felsberg, J., Hartmann, C. J., Berger, H., Steinbach, J. P., Schramm, J., Westphal, M., Schackert, G., Simon, M., Tonn, J. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.0805 · Cited by 615 · see citing works
Frequent ATRX , CIC , FUBP1 and IDH1 mutations refine the classification of malignant gliomas
Jiao, Y., Killela, P. J., Reitman, Z. J., Rasheed, B. A., Heaphy, C. M., de Wilde, R. F., Rodríguez, F. J., Rosemberg, S., Oba‐Shinjo, S. M., Marie, S. K. N., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.588 · Cited by 584 · see citing works
Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3
Cha, T., Zhou, B. P., Xia, W., Wu, Y., Yang, C., Chen, C., Ping, B., Otte, A. P., & Hung, M. (2005) · Science · doi:10.1126/science.1118947 · Cited by 552 · see citing works
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
Pfister, S. M., Janzarik, W. G., Remke, M., Ernst, A., Werft, W., Becker, N., Toedt, G., Wittmann, A., Kratz, C. P., Olbrich, H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33656 · Cited by 521 · see citing works
Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma
Cheung, N. V. (2012) · JAMA · doi:10.1001/jama.2012.228 · Cited by 467 · see citing works
Hake, S. B., & Allis, C. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600803103 · Cited by 435 · see citing works
Lai, A., Kharbanda, S., Pope, W. B., Tran, A. N., Solis, O. E., Peale, F. V., Jr., Forrest, W. F., Pujara, K., Carrillo, J., Pandita, A., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.8715 · Cited by 432 · see citing works
Liu, X.-Y., Gerges, N., Korshunov, A., Sabha, N., Khuong-Quang, D.-A., Fontebasso, A. M., Fleming, A. J., Hadjadj, D., Schwartzentruber, J., Majewski, J., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1031-3 · Cited by 428 · see citing works
The Pediatric Cancer Genome Project
Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C., Ding, L., Ley, T. J., & Evans, W. E. (2012) · Nature Genetics · doi:10.1038/ng.2287 · Cited by 375 · see citing works
Paugh, B. S., Broniscer, A., Qu, C., Miller, C. P., Zhang, J., Tatevossian, R., Olson, J. M., Geyer, J. R., Chi, S. N., da Silva, N. S., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.5677 · Cited by 318 · see citing works
Jones, D., Kocialkowski, S., Liu, L., Pearson, D. M., Ichimura, K., & Collins, V. P. (2009) · Oncogene · doi:10.1038/onc.2009.73 · Cited by 316 · see citing works
Zarghooni, M., Bartels, U. K., Lee, E., Buczkowicz, P., Morrison, A., Huang, A., Bouffet, É., & Hawkins, C. E. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.5463 · Cited by 313 · see citing works
Pathogenesis of follicular lymphoma
Kridel, R., Sehn, L. H., & Gascoyne, R. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63186 · Cited by 310 · see citing works
Expression of p53 and Prognosis in Children with Malignant Gliomas
Pollack, I. F., Finkelstein, S. D., Woods, J., Burnham, J. A., Holmes, E. J., Hamilton, R. L., Yates, A. J., Boyett, J. M., Finlay, J. L., & Sposto, R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012224 · Cited by 278 · see citing works
Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
Kannan, K. S., Inagaki, A., Silber, J., Gorovets, D. J., Zhang, J., Kastenhuber, E. R., Heguy, A., Petrini, J. H. J., Chan, T. A.-T., & Huse, J. T. (2012) · Oncotarget · doi:10.18632/oncotarget.689 · Cited by 277 · see citing works
BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma
Hawkins, C. E., Walker, E. J., Mohamed, N. S., Zhang, C., Jacob, K., Shirinian, M., Alon, N., Kahn, D., Fried, I., Scheinemann, K., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0034 · Cited by 249 · see citing works
Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition
Eyler, C. E., Foo, W., LaFiura, K. M., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1073 · Cited by 242 · see citing works
Cin, H., Meyer, C., Herr, R., Janzarik, W. G., Lambert, S. R., Jones, D., Jacob, K., Benner, A., Witt, H., Remke, M., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0817-z · Cited by 233 · see citing works
Faury, D., Nantel, A., Dunn, S. E., Guiot, M.-C., Haque, T., Hauser, P., Garami, M., Bognár, L., Hanzély, Z., Liberski, P. P., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.8626 · Cited by 224 · see citing works
Marking histone H3 variants: How, when and why?
Loyola, A., & Almouzni, G. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.08.004 · Cited by 192 · see citing works
A Network Model of a Cooperative Genetic Landscape in Brain Tumors
Bredel, M., Scholtens, D. M., Harsh, G. R., Bredel, C., Chandler, J. P., Renfrow, J. J., Yadav, A. K., Vogel, H. S., Scheck, A. C., Tibshirani, R. J., et al. (2009) · JAMA · doi:10.1001/jama.2009.997 · Cited by 190 · see citing works
Jacob, K., Albrecht, S., Sollier, C., Faury, D., Sader, E., Montpetit, A., Serre, D., Hauser, P., Garami, M., Bognár, L., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605179 · Cited by 185 · see citing works
for the Children’s Oncology Group, Pollack, I. F., Hamilton, R. L., Sobol, R. W., Nikiforova, M. N., Lyons‐Weiler, M. A., LaFramboise, W. A., Burger, P. C., Brat, D. J., Rosenblum, M. K., et al. (2010) · Child s Nervous System · doi:10.1007/s00381-010-1264-1 · Cited by 185 · see citing works
DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs
So, A.-Y., Jung, J., Lee, S., Kim, H., & Kang, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019503 · Cited by 180 · see citing works
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9
Dhayalan, A., Tamas, R., Bock, I., Tattermusch, A., Dimitrova, E., Kudithipudi, S., Ragozin, S., & Jeltsch, A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr107 · Cited by 170 · see citing works
Jacob, K., Khuong-Quang, D.-A., Jones, D., Witt, H., Lambert, S. R., Albrecht, S., Witt, O., Vézina, C., Shirinian, M., Faury, D., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0127 · Cited by 168 · see citing works
Genetic profile of astrocytic and oligodendroglial gliomas
Ohgaki, H., & Kleihues, P. (2011) · Brain Tumor Pathology · doi:10.1007/s10014-011-0029-1 · Cited by 167 · see citing works
Chen, Y., Lin, M. C.-M., Yao, H., Wang, H., Zhang, A., Yu, J. Q., Hui, C., Lau, G. K. K., He, M., Sung, J. J. �., et al. (2007) · Hepatology · doi:10.1002/hep.21668 · Cited by 162 · see citing works
New functions for an old variant: no substitute for histone H3.3
Elsässer, S. J., Goldberg, A. D., & Allis, C. D. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.01.003 · Cited by 157 · see citing works
A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas
Bax, D. A., Mackay, A. G., Little, S. E., Carvalho, D. M., Viana‐Pereira, M., Tamber, N., Grigoriadis, A. E., Ashworth, A., Reis, R. M., Ellison, D. W., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0438 · Cited by 155 · see citing works
Pollack, I. F., Hamilton, R. L., James, C. D., Finkelstein, S. D., Burnham, J. A., Yates, A. J., Holmes, E. J., Zhou, T., & Finlay, J. L. (2006) · Journal of Neurosurgery Pediatrics · doi:10.3171/ped.2006.105.5.418 · Cited by 142 · see citing works
Update on molecular findings, management and outcome in low-grade gliomas
Bourne, T. D., & Schiff, D. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.159 · Cited by 141 · see citing works
Deregulation of H3K27 methylation in cancer
Martínez-García, E., & Licht, J. D. (2010) · Nature Genetics · doi:10.1038/ng0210-100 · Cited by 106 · see citing works
Qu, H., Jacob, K., Fattet, S., Ge, B., Barnett, D., Delattre, O., Faury, D., Montpetit, A., Solomon, L. A., Hauser, P., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/nop001 · Cited by 95 · see citing works
Brain Tumors: From Childhood Through Adolescence Into Adulthood
Kieran, M. W., Walker, D. A., Frappaz, D., & Prados, M. D. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.3481 · Cited by 90 · see citing works
Bower, K., Napier, C. E., Cole, S. L., Dagg, R. A., Lau, L. M. S., Duncan, E. L., Moy, E. L., & Reddel, R. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050062 · Cited by 81 · see citing works
Gene Expression Profiling from Formalin-Fixed Paraffin-Embedded Tumors of Pediatric Glioblastoma
Haque, T., Faury, D., Albrecht, S., López‐Aguilar, E., Hauser, P., Garami, M., Hanzély, Z., Bognár, L., Maestro, R. F. D., Atkinson, J. D., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0525 · Cited by 76 · see citing works
Compromised genomic integrity impedes muscle growth after Atrx inactivation
Huh, M. S., O’Dea, T. P., Ouazia, D., McKay, B. C., Parise, G., Parks, R. J., Rudnicki, M. A., & Picketts, D. J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63765 · Cited by 69 · see citing works
Bosch, A., & Suau, P. (1995) · PubMed · Cited by 51 · see citing works
Pediatric High-grade Glioma: Molecular Genetic Clues for Innovative Therapeutic Approaches
Rood, B. R., & MacDonald, T. J. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-6749-5 · Cited by 44 · see citing works
New Strategies in the Molecular Targeting of Glioblastoma: How Do You Hit a Moving Target?
Cloughesy, T. F., & Mischel, P. S. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2268 · Cited by 25 · see citing works
Epigenetic memory: H3.3 steps in the groove
Lacoste, N., & Almouzni, G. (2008) · Nature Cell Biology · doi:10.1038/ncb0108-7 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Primary brain tumours in adults
Lapointe, S., Perry, A., & Butowski, N. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30990-5 · Cited by 1,377 · see citing works
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
Sturm, D., Bender, S., Jones, D. T. W., Lichter, P., Grill, J., Becher, O., Hawkins, C., Majewski, J., Jones, C., Costello, J. F., et al. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3655 · Cited by 555 · see citing works
Identification of recurrent SMO and BRAF mutations in ameloblastomas
Sweeney, R. T., McClary, A. C., Myers, B. R., Biscocho, J., Neahring, L., Kwei, K. A., Qu, K., Gong, X., Ng, T., Jones, C. D., et al. (2014) · Nature Genetics · doi:10.1038/ng.2986 · Cited by 366 · see citing works
Harutyunyan, A. S., Krug, B., Chen, H., Papillon‐Cavanagh, S., Zeinieh, M. P., Jay, N. D., Deshmukh, S., Chen, C. C. L., Belle, J. I., Mikael, L. G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09140-x · Cited by 348 · see citing works
Karremann, M., Gielen, G. H., Hoffmann, M., Wiese, M., Colditz, N., Warmuth‐Metz, M., Bison, B., Claviez, A., van Vuurden, D. G., von Bueren, A. O., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox149 · Cited by 293 · see citing works
Pathania, M., De Jay, N., Maestro, N., Harutyunyan, A. S., Nitarska, J., Pahlavan, P., Henderson, S., Mikael, L. G., Richard-Londt, A., Zhang, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.014 · Cited by 264 · see citing works
Self-citationAn integrative view on sex differences in brain tumors
Sun, T., Plutynski, A., Ward, S., & Rubin, J. B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1930-2 · Cited by 218 · see citing works
Chung, C., Sweha, S. R., Pratt, D. W., Tamrazi, B., Panwalkar, P., Banda, A., Bayliss, J. M., Hawes, D., Yang, F., Lee, H., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.008 · Cited by 198 · see citing works
H3F3A K27M mutations in thalamic gliomas from young adult patients
Aihara, K., Mukasa, A., Gotoh, K., Saito, K., Nagae, G., Tsuji, S., Tatsuno, K., Yamamoto, S., Takayanagi, S., Narita, Y., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not144 · Cited by 199 · see citing works
Anastas, J. N., Zee, B. M., Kalin, J. H., Kim, M., Guo, R., Alexandrescu, S., Blanco, M. A., Giera, S., Gillespie, S. M., Das, J., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.09.005 · Cited by 188 · see citing works
Majzner, R. G., Simon, J. S., Grosso, J. F., Martinez, D., Pawel, B. R., Santi, M., Merchant, M. S., Geoerger, B., Hezam, I., Marty, V., et al. (2017) · Cancer · doi:10.1002/cncr.30724 · Cited by 179 · see citing works
Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation
Aboian, M., Solomon, D. A., Felton, E., Mabray, M. C., Villanueva-Meyer, J. E., Mueller, S., & Cha, S. (2017) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5076 · Cited by 185 · see citing works
Venneti, S., Santi, M., Felicella, M. M., Yarilin, D. A., Phillips, J. J., Sullivan, L. M., Martínez, D., Perry, A., Lewis, P. W., Thompson, C. B., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1338-3 · Cited by 149 · see citing works
Developmental roles of histone H3 variants and their chaperones
Filipescu, D., Szenker‐Ravi, E., & Almouzni, G. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.06.002 · Cited by 141 · see citing works
Béchet, D., Gielen, G. H., Korshunov, A., Pfister, S. M., Rousso, C., Faury, D., Fiset, P., Benlimame, N., Lewis, P. W., Lü, C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1337-4 · Cited by 137 · see citing works
Histone H3.3 Mutations: A Variant Path to Cancer
Yuen, B. T. K., & Knoepfler, P. S. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.09.015 · Cited by 134 · see citing works
Feng, J., Hao, S., Pan, C., Wang, Y., Wu, Z., Zhang, J., Yan, H., Zhang, L., & Wan, H. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.07.002 · Cited by 121 · see citing works
Filipescu, D., Müller, S., & Almouzni, G. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013311 · Cited by 116 · see citing works
Cohen, A. R. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2116344 · Cited by 112 · see citing works
Yoshimoto, K., Hatae, R., Sangatsuda, Y., Suzuki, S. O., Hata, N., Akagi, Y., Kuga, D., Murata, H., Yamashita, K., Togao, O., et al. (2017) · Brain Tumor Pathology · doi:10.1007/s10014-017-0287-7 · Cited by 96 · see citing works
Reshaping Chromatin after DNA Damage: The Choreography of Histone Proteins
Polo, S. E. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.05.025 · Cited by 75 · see citing works
Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults
Picart, T., Barritault, M., Poncet, D., Berner, L.-P., Izquierdo, C., Tabouret, É., Figarella-Branger, D. F., Idbaïh, A., Bielle, F., Bourg, V., et al. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab061 · Cited by 73 · see citing works
Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and Beyond
Skucha, A., Ebner, J., & Grebien, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051029 · Cited by 70 · see citing works
Recent advances and future of immunotherapy for glioblastoma
Kamran, N., Calinescu, A., Candolfi, M., Chandran, M., Mineharu, Y., Asad, A. S., Koschmann, C. J., Núñez, F. J., Lowenstein, P. R., & Castro, M. G. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1212012 · Cited by 64 · see citing works
Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma
Williams, M. J., Singleton, W., Lowis, S. P., Malik, K. T. A., & Kurian, K. M. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00045 · Cited by 61 · see citing works
Actionable Molecular Biomarkers in Primary Brain Tumors
Staedtke, V., Dzaye, O. D. A., & Holdhoff, M. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.06.003 · Cited by 59 · see citing works
Stępniak, K., Machnicka, M. A., Mieczkowski, J., Macioszek, A., Wojtaś, B., Gielniewski, B., Poleszak, K., Perycz, M., Król, S. K., Guzik, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23922-2 · Cited by 54 · see citing works
Is Glioblastoma an Epigenetic Malignancy?
Maleszewska, M., & Kaminska, B. (2013) · Cancers · doi:10.3390/cancers5031120 · Cited by 58 · see citing works
Management of high-grade gliomas in the pediatric patient: Past, present, and future
Vanan, M., & Eisenstat, D. D. (2014) · Neuro-Oncology Practice · doi:10.1093/nop/npu022 · Cited by 56 · see citing works
Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM
Pathak, P., Jha, P., Purkait, S., Sharma, V., Suri, V. S., Sharma, M. C., Faruq, M., Suri, A., & Sarkar, C. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1675-z · Cited by 49 · see citing works
Biomarker-based prognostic stratification of young adult glioblastoma
Zhang, R.-Q., Shi, Z., Chen, H., Chung, N. Y., Yin, Z., Li, K. K., Chan, D. T. M., Poon, W. S., Wu, J., Zhou, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5456 · Cited by 49 · see citing works
Prognostic and Predictive Biomarkers in Adult and Pediatric Gliomas: Toward Personalized Treatment
Haynes, H. R., Camelo-Piragua, S. I., & Kurian, K. M. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00047 · Cited by 45 · see citing works
Liu, Y., Zhang, Y., Xue, H., Mi, C., Bai, G., Mu, Z., Yao, Y., Sun, S., Fang, D., & Huang, J. (2021) · Cell Discovery · doi:10.1038/s41421-021-00261-6 · Cited by 44 · see citing works
Therapeutic Targets in Diffuse Midline Gliomas—An Emerging Landscape
Hayden, E., Holliday, H., Lehmann, R. J., Khan, A., Tsoli, M., Rayner, B. S., & Ziegler, D. S. (2021) · Cancers · doi:10.3390/cancers13246251 · Cited by 42 · see citing works
Remaining Challenges in Childhood Cancer and Newer Targeted Therapeutics
Smith, M. A., & Reaman, G. H. (2014) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2014.09.018 · Cited by 41 · see citing works
Venkatesh, I., Mehra, V., Wang, Z., Callif, B. L., & Blackmore, M. G. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22605 · Cited by 40 · see citing works
Primary Glial and Neuronal Tumors of the Ovary or Peritoneum
Li, L., Olar, A., Niu, N., Jiang, Y., Cheng, W., Bian, X., Yang, W., Zhang, J., Yemelyanova, A. V., Malpica, A. L., et al. (2016) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000635 · Cited by 39 · see citing works
Palmisciano, P., Ahmadieh, T. Y. E., Haider, A. S., Bin-Alamer, O., Robertson, F. C., Plitt, A. R., Aoun, S. G., Yu, K. K. H., Cohen‐Gadol, A., Moss, N. S., et al. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03898-1 · Cited by 36 · see citing works
Sewing, A. C. P., Lagerweij, T., van Vuurden, D. G., Meel, M. H., Veringa, S. J. E., Carcaboso, A. M., Gaillard, P. J., Vandertop, W. P., Wesseling, P., Noske, D. P., et al. (2017) · Journal of Neurosurgery Pediatrics · doi:10.3171/2016.9.peds16152 · Cited by 33 · see citing works
Pediatric high-grade astrocytomas: a distinct neuro-oncological paradigm
Gerges, N., Fontebasso, A. M., Albrecht, S., Faury, D., & Jabado, N. (2013) · Genome Medicine · doi:10.1186/gm470 · Cited by 33 · see citing works
The Role of MacroH2A Histone Variants in Cancer
Hsu, C.-J., Meers, O., Buschbeck, M., & Heidel, F. H. (2021) · Cancers · doi:10.3390/cancers13123003 · Cited by 31 · see citing works
Chakraborty, C., Nissen, I., Vincent, C. A., Hägglund, A., Hörnblad, A., & Remeseiro, S. (2023) · Nature Communications · doi:10.1038/s41467-023-41919-x · Cited by 30 · see citing works
Paediatric Gliomas: BRAF and Histone H3 as Biomarkers, Therapy and Perspective of Liquid Biopsies
Tan, J. Y., Wijesinghe, I. V. S., Kamarudin, M. N. A., & Parhar, I. S. (2021) · Cancers · doi:10.3390/cancers13040607 · Cited by 29 · see citing works
Mechanism of cancer: Oncohistones in action
Qiu, L., Hu, X., Jing, Q., Zeng, X., Chan, K. M., & Han, J. (2018) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2018.04.004 · Cited by 27 · see citing works
Histone Variants in Development and Diseases
Chen, P., Zhao, J., & Li, G. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.05.001 · Cited by 26 · see citing works
Single vs. combination immunotherapeutic strategies for glioma
Chandran, M., Candolfi, M., Shah, D., Mineharu, Y., Yadav, V. N., Koschmann, C. J., Asad, A. S., Lowenstein, P. R., & Castro, M. G. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1305353 · Cited by 23 · see citing works
Molecular alterations in pediatric brainstem gliomas
Porkholm, M., Raunio, A., Vainionpää, R., Salonen, T., Hernesniemi, J. A., Valanne, L. K., Satopää, J., Karppinen, A., Oinas, M., Tynninen, O., et al. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26751 · Cited by 22 · see citing works
Epigenetics Components of Aging in the Central Nervous System
Zhao, Y., Jordan, I. K., & Lunyak, V. V. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0229-y · Cited by 21 · see citing works
Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Youngblood, M. W., Erson-Omay, Z., Li, C., Najem, H., Coşkun, S., Tyrtova, E., Montejo, J. D., Miyagishima, D. F., Barak, T., Nishimura, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41926-y · Cited by 21 · see citing works
Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis)
Saade, E., Pirozhkova, I., Aimbetov, R., Lipinski, M., & Ogryzko, V. V. (2015) · Aging Cell · doi:10.1111/acel.12332 · Cited by 18 · see citing works
Hohm, A., Karremann, M., Gielen, G. H., Pietsch, T., Warmuth‐Metz, M., Vandergrift, L. A., Bison, B., Stock, A., Hoffmann, M., Pham, M., et al. (2021) · Clinical Neuroradiology · doi:10.1007/s00062-021-01120-3 · Cited by 18 · see citing works
Molecular biomarkers in pediatric glial tumors
Fontebasso, A. M., Béchet, D., & Jabado, N. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000007 · Cited by 17 · see citing works
Molecular Basis of Pediatric Brain Tumors
Κλώνου, Α., Piperi, C., Gargalionis, A. N., & Papavassiliou, A. G. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8455-9 · Cited by 17 · see citing works
Unravelling the mosaic: Epigenetic diversity in glioblastoma
Lucchini, S., Constantinou, M., & Marino, S. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13706 · Cited by 17 · see citing works
Principe, D. R., Kamath, S. D., Munshi, H. G., & Mohindra, N. A. (2019) · The Oncologist · doi:10.1634/theoncologist.2019-0393 · Cited by 15 · see citing works
H3K27M, IDH1, and ATRX expression in pediatric GBM and their clinical and prognostic significance
Uppar, A. M., Sugur, H. S., Prabhuraj, A. R., Rao, M. B., Devi, B. I., Sampath, S., Arivazhagan, A., & Santosh, V. (2019) · Child s Nervous System · doi:10.1007/s00381-019-04222-z · Cited by 14 · see citing works
Molecular Neuro-oncology and the Challenge of the Blood-Brain Barrier
Aiken, R. D. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.06.005 · Cited by 14 · see citing works
Byrne, E. M., Pascoe, M., Cooper, D., Armstrong, T. S., & Gilbert, M. R. (2023) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdad159 · Cited by 11 · see citing works
Updates in Pediatric Malignant Gliomas
Gonçalves, F. G., Alves, C., & Vossough, A. (2020) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000235 · Cited by 10 · see citing works
Kibe, Y., Chalise, L., Ohka, F., Motomura, K., Nakahara, N., Aoki, K., Deguchi, S., Shiba, Y., Takeuchi, K., Iwami, K., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01945-w · Cited by 7 · see citing works
Genetic signature and treatment of pediatric high‑grade glioma
Guidi, M., Giunti, L., Buccoliero, A. M., Caporalini, C., Censullo, M. L., Galli, L., Genitori, L., & Sardi, I. (2021) · Molecular and Clinical Oncology · doi:10.3892/mco.2021.2232 · Cited by 6 · see citing works
Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman
Low, J., Wang, S. J., & Peters, K. B. (2021) · CNS Oncology · doi:10.2217/cns-2020-0030 · Cited by 6 · see citing works
Unreported intrinsic disorder in proteins: Disorder emergency room
Uversky, V. N. (2015) · Intrinsically Disordered Proteins · doi:10.1080/21690707.2015.1010999 · Cited by 6 · see citing works
Emerging multi-omics biomarkers in glioblastoma: Integrative insights from genomics to metabolomics
Kakde, G. S., Dakal, T. C., & Maurya, P. K. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189540 · Cited by 5 · see citing works
Circulating miRNAs as potential liquid biomarkers for pediatric gliomas
Rogachevsky, D., Yalon, M., Toren, A., & Mehrian‐Shai, R. (2025) · Pediatric Research · doi:10.1038/s41390-025-04320-6 · Cited by 4 · see citing works
Roach, J. T., Riviere-Cazaux, C., Wells, B., Boop, F. A., & Daniels, D. J. (2024) · Child s Nervous System · doi:10.1007/s00381-024-06395-8 · Cited by 4 · see citing works
Diversity of metabolic features and relevance to clinical subtypes of gliomas
Dasgupta, P., & Puduvalli, V. K. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.008 · Cited by 3 · see citing works
What Epigenetics Teaches Us About Neuron–Glioma Interactions
Chakraborty, C., Nissen, I., & Remeseiro, S. (2025) · BioEssays · doi:10.1002/bies.70043 · Cited by 3 · see citing works
Médulloblastome. Anatomie pathologique
Siegfried, A., & Delisle, M. (2018) · Neurochirurgie · doi:10.1016/j.neuchi.2017.12.006 · Cited by 4 · see citing works
Diffuse Midline Glioma H3 K27M-Mutant Manifested as Progressive Paraplegia
Goldstein, E. D., Kyper, C. M., & Siegel, J. L. (2019) · The Neurohospitalist · doi:10.1177/1941874419847347 · Cited by 3 · see citing works
Developmental Roles of Histone H3 Variants and Their Chaperones
Müller, S., Filipescu, D., & Almouzni, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-38882-3_17 · Cited by 3 · see citing works
Histone H3G34 Mutation in Brain and Bone Tumors
Qiu, L., & Han, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-8104-5_5 · Cited by 3 · see citing works
Vanan, M., Mehta, V., & Eisenstat, D. D. (2015) · Springer eBooks · doi:10.1007/978-1-4939-1541-5_10 · Cited by 2 · see citing works
Campit, S., Bhowmick, R., Lu, T., Saoji, A. V., Jin, R., Shay, M. R., Robida, A. M., & Chandrasekaran, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.27.530260 · Cited by 2 · see citing works
Chen, Z., Gao, Q., Shang, Y., Ahmadabadi, B. N., Hu, Y., Zhang, W., & Liu, P. (2024) · hLife · doi:10.1016/j.hlife.2024.07.004 · Cited by 1 · see citing works
Hu, W. M., Shao, H., Yang, X., Zheng, L., Li, S., Tan, Q., Chen, N., Yue, Q., & Su, X. (2024) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-24-485 · Cited by 1 · see citing works
Park, I., Hashizume, R., & Phillips, J. J. (2025) · Molecules · doi:10.3390/molecules30214175 · Cited by 1 · see citing works
Analytical Insights into the Epidemiology of Glioma and Treatment Modalities
Ji, M., Tian, D., Qi, Q., Zhao, L., Tan, P., Lin, P., Li, Q., Wu, J., Lai, Y., Cheng, Y., et al. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.124757 · Cited by 1 · see citing works
The significance of histone H3 K27M mutation in brain tumors
Mukasa, A. (2017) · Progress in Neuro-Oncology · doi:10.11452/neurooncology.24.1_7 · Cited by 1 · see citing works
Tumor-Specific Mutations in Gliomas and Their Implications for Immunotherapy
Pirozzi, C. J., Carpenter, A. B., Hennika, T., Becher, O. J., & Yan, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802420-1.00005-3 · Cited by 1 · see citing works
Juvenile high-grade astrocytoma mimicking a cerebral abscess: A case report
Riefma, D., Adhimarta, W., Islam, A. A., Widodo, D., Nasrullah, N., Ihwan, A., & Faruk, M. (2021) · Medicina Clínica Práctica · doi:10.1016/j.mcpsp.2021.100230 · Cited by 1 · see citing works
Glioma di alto grado: astrocitoma anaplastico e glioblastoma
Benouaich‐Amiel, A., Catalaa, I., Lubrano, V., Moyal, E. C., & Uro‐Coste, E. (2014) · EMC - Neurologia · doi:10.1016/s1634-7072(14)67978-2
Physiologic and pathologic profiling of clonal variations
Wong, W. (2020) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/scfg-zs49
(2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54806-9.50111-7
Ashley, D. M., & Low Justin, T. (2024) · Cambridge University Press eBooks · doi:10.1017/9781108917339.012
Evaluation Of Surrogate Markers to Define H3 G34R/V-Mutant Gliomas
Thammachantha, S., & Teerapakpinyo, C. (2024) · SVOA Neurology · doi:10.58624/svoane.2024.05.0126
Analysis of Trends in the Epidemiology and Treatment Patterns of GliomasPreprint
qing, H., Ji, M., Qi, Q., Zhao, L., Tan, P., Lin, P., Li, Q., Wu, K., Lai, Y., & Yang, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4834285
Promising efficacy of teniposide in H3K27M mutant diffuse midline gliomas: a case report
Wang, X., Niu, T., Xia, J., Liu, J., & Sun, M. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1784250
Rogachevsky, D., Yalon, M., Mehrian‐Shai, R., & Toren, A. (2026) · Pediatric Research · doi:10.1038/s41390-026-05518-y
- Authors
- Fontebasso, A. M., Liu, X., Sturm, D., & Jabado, N.
- Affiliations
- McGill University Health Centre (CA)
- German Cancer Research Center (DE)
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2013-02-25
- Volume
- 23
- Issue
- 2
- Pages
- 210-216
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8029102
- OpenAlex
- W1754241820
- Cited by
- 89
- References
- 69
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 1 · 2021: 11 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 12 · 2013: 8
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- Genome Canada
- Deutsche Krebshilfe
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- glioblastoma, H3K27M mutation, chromatin remodeling, pediatric glioma, gliomagenesis, IDH mutation, therapeutic target
- MeSH terms
- Adolescent, Brain Neoplasms, Child, Glioblastoma, Histones, Humans, Mutation, Chromatin Assembly and Disassembly, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
