Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology
Open accessAbstract
Inflammatory diseases are a major socio‐economic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the primary treatment paradigm for many of these conditions was to develop drugs that inhibit or antagonize the production and biological actions of molecules that were thought to be the culprits in propagating disease; these include cytokines and eicosanoids. This approach is effective in controlling disease propagation; however, long‐term exposure to these anti‐inflammatories is also associated with many side effects, some of which are severe, including immune‐suppression. The discovery that termination of self‐limited acute inflammation is an active process orchestrated by endogenous mediators, including the essential fatty acid‐derived resolvins, protectins and maresins, has provided novel opportunities for the design of therapeutics that control inflammation with a lower burden of side effects. This is because at variance to anti‐inflammatories, pro‐resolving mediators do not completely inhibit inflammatory responses; instead, these mediators reprogramme the immune response to accelerate the termination of inflammation, facilitating the regain of function. The scope of this review is to highlight the biological actions of these autacoids and their potential utility as lead compounds in developing resolution pharmacology‐based therapeutics. Linked Articles: This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc
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SPMs suppress inflammation but, unlike anti-inflammatory drugs, promote both repair and continued pathogen clearance.
“From a translational perspective, SPMs suppress inflammation but, unlike anti-inflammatory drugs, these pro-resolving mediators promote both repair and continued pathogen clearance33,213–215.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [213]
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Self-citationCan Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil?
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Self-citationStereoselective synthesis of MaR2n-3 DPA
Sønderskov, J., Tungen, J. E., Palmas, F., Dalli, J., Serhan, C. N., Stenstrøm, Y., & Hansen, T. V. (2019) · Tetrahedron Letters · doi:10.1016/j.tetlet.2019.151510 · Cited by 14 · see citing works
Self-citationRodrigues‐Díez, R., Ballesteros‐Martínez, C., Moreno-Carriles, R. M., Nistal, F. J., del Campo, L. S. D., Cachofeiro, V., Dalli, J., García‐Redondo, A. B., Redondo, J. M., Salaíces, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116564 · Cited by 13 · see citing works
Self-citationExploiting oxidized lipids and the lipid‐binding GPCRs against cardiometabolic diseases
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Li, J., Xiang, Q., Xia, T., Meng, H., & Liu, X. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101978 · Cited by 12 · see citing works
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Dalli, J., Pistorius, K., & Walker, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_7 · Cited by 12 · see citing works
Self-citationBeyond cardiovascular medicine: potential future uses of icosapent ethyl
Bhatt, D. L., Hull, M. A., Song, M., Hulle, C. V., Carlsson, C. M., Chapman, M. J., & Toth, P. P. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa119 · Cited by 12 · see citing works
Sex Hormone–Dependent Lipid Mediator Formation in Male and Female Mice During Peritonitis
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Self-citationThe biosynthetic pathways of the protectins
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The First Total Synthesis of the Lipid Mediator PD2n-3 DPA
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Maresin1: A multifunctional regulator in inflammatory bone diseases
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Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse
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Maresin1 can be a potential therapeutic target for nerve injury
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Biology and Total Synthesis of n-3 Docosapentaenoic Acid-Derived Specialized Pro-Resolving Mediators
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Self-citationResolvins resolve to heal mucosal wounds
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Enzymatic studies with 3-oxa n-3 DPA
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Self-citationFerreira, M. V., Jesus, C. H. A., da Costa, J. P. B., Oliveira, G., Liebl, B., Verri, W. A., Jr., Zanoveli, J. M., & da Cunha, J. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177254 · Cited by 6 · see citing works
Maresins: The Mainstay in Periodontal Resolution
Gireddy, H., Rajaram, H., Koduganti, R. R., Ambati, M., Anilkumar, R., & Harika, T. S. L. (2022) · Cureus · doi:10.7759/cureus.21742 · Cited by 6 · see citing works
- Authors
- Dalli, J., & Serhan, C. N.
- Affiliations
- Queen Mary University of London (GB)
- Brigham and Women's Hospital (US)
- Corresponding author
- Dalli, Jesmond
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2018-06-03
- Volume
- 176
- Issue
- 8
- Pages
- 1024-1037
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC6451074
- OpenAlex
- W2801066468
- Cited by
- 138
- References
- 106
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 7 · 2023: 16 · 2022: 23 · 2021: 20 · 2020: 27 · 2019: 15 · 2018: 5
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- British Journal of Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- H2020 European Research Council (677542)
- National Institutes of Health (P01GM095467, R01GM38765)
- Wellcome Trust (107613/Z/15/Z)
- Royal Society
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- specialized pro-resolving mediators, resolvins, protectins, maresins, eicosanoids, essential fatty acids, immune reprogramming, autacoids, inflammatory diseases, lead compounds
- MeSH terms
- Drug Development, Animals, Anti-Inflammatory Agents, Humans, Eicosanoids, Inflammation Mediators, Metabolome
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