Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

The Acute Respiratory Distress Syndrome

Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924 · see citing works

The Acute Respiratory Distress Syndrome

Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666 · see citing works

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works

A blast from the past: clearance of apoptotic cells regulates immune responses

Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works

Resolvins and protectins in inflammation resolution

Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works

Inflammatory Resolution: new opportunities for drug discovery

Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772 · see citing works

Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome

Gadek, J. E., DeMichele, S. J., Karlstad, M. D., Pacht, E. R., Donahoe, M., Albertson, T. E., Van Hoozen, C., Wennberg, A. K., Nelson, J. L., & Noursalehi, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00001 · Cited by 757 · see citing works

Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation

Arita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works

A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation

Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627 · see citing works

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

Rossi, A. G., Sawatzky, D. A., Walker, A., Ward, C., Sheldrake, T. A., Riley, N. A., Caldicott, A., Martínez‐Losa, M., Walker, T. R., Duffin, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1468 · Cited by 506 · see citing works

Resolvin E1 Regulates Inflammation at the Cellular and Tissue Level and Restores Tissue Homeostasis In Vivo

Hastürk, H., Kantarcı, A., Goguet, E., Blackwood, A., Andry, C., Serhan, C. N., & Dyke, T. E. V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7021 · Cited by 462 · see citing works

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008) · Nature Immunology · doi:10.1038/ni.1627 · Cited by 425 · see citing works

Effects of enteral feeding with eicosapentaenoic acid, γ-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock*

Pontes-Arruda, A., Aragão, A. M. A., & Albuquerque, J. D. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000234033.65657.b6 · Cited by 423 · see citing works

Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome

Matute‐Bello, G., Liles, W. C., Radella, F., Steinberg, K. P., RUZINSKI, J. T., Jonas, M., CHI, E. Y., Hudson, L. D., & MARTIN, T. R. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.6.96-12081 · Cited by 394 · see citing works

Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis

Mayanskiy, N. A., Geissler, J., Srinivasula, S. M., Alnemri, E. S., Roos, D., & Kuijpers, T. W. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401320 · Cited by 385 · see citing works

Synthetic chemerin-derived peptides suppress inflammation through ChemR23

Cash, J. L., Hart, R., Russ, A., Dixon, J. P. C., Colledge, W. H., Doran, J., Hendrick, A. G., Carlton, M. B. L., & Greaves, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071601 · Cited by 372 · see citing works

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

MOULDING, D. A., Quayle, J. A., Hart, C. A., & Edwards, S. W. (1998) · Blood · doi:10.1182/blood.v92.7.2495 · Cited by 356 · see citing works

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

Oh, S. F., Pillai, P. S., Recchiuti, A., Yang, R., & Serhan, C. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42545 · Cited by 292 · see citing works

Interleukin-10 Counterregulates Proinflammatory Cytokine-Induced Inhibition of Neutrophil Apoptosis During Severe Sepsis

Keel, M. J. B., Ungethüm, U., Steckholzer, U., Niederer, E. M., Härtung, T., Trentz, O., & Ertel, W. (1997) · Blood · doi:10.1182/blood.v90.9.3356 · Cited by 291 · see citing works

CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract.

Schwartz, D. A., Quinn, T. J., Thorne, P. S., Sayeed, S., Yi, A., & KRIEG, A. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119523 · Cited by 250 · see citing works

Elucidation of Molecular Events Leading to Neutrophil Apoptosis following Phagocytosis

Zhang, B., Hirahashi, J., Culleré, X., & Mayadas, T. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210727200 · Cited by 242 · see citing works

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works

15-Epi-lipoxin A4 Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

Kebir, D. E., József, L., Pan, W., Wang, L., Petasis, N. A., Serhan, C. N., & Filep, J. G. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1601oc · Cited by 206 · see citing works

Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution

Campbell, E. L., Louis, N. A., Tomassetti, S. E., Canny, G. O., Arita, M., Serhan, C. N., & Colgan, S. P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8473com · Cited by 205 · see citing works

Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation

Kebir, D. E., József, L., Pan, W., & Filep, J. G. (2008) · Circulation Research · doi:10.1161/01.res.0000326772.76822.7a · Cited by 191 · see citing works

Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome

Pacht, E. R., DeMichele, S. J., Nelson, J. L., Hart, J., Wennberg, A. K., & Gadek, J. E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000049952.96496.3e · Cited by 191 · see citing works

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

Koedel, U., Frankenberg, T., Kirschnek, S., Obermaier, B., Häcker, H., Paul, R. H., & Häcker, G. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000461 · Cited by 179 · see citing works

Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma

Aoki, H., Hisada, T., Ishizuka, T., Utsugi, M., Kawata, T., Shimizu, Y., Okajima, F., Dobashi, K., & Mori, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.012 · Cited by 172 · see citing works

Serum amyloid A opposes lipoxin A ₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

Bozinovski, S., Uddin, M., Vlahos, R., Thompson, M., McQualter, J. L., Merritt, A.-S., Wark, P. A. B., Hutchinson, A., Irving, L. B., Levy, B. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109382109 · Cited by 163 · see citing works

NK Cells Are Effectors for Resolvin E1 in the Timely Resolution of Allergic Airway Inflammation

Haworth, O., Cernadas, M., & Levy, B. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004007 · Cited by 144 · see citing works

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

McGrath, E. E., Marriott, H. M., Lawrie, A., Francis, S., Sabroe, I., Renshaw, S. A., Dockrell, D. H., & Whyte, M. K. B. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211062 · Cited by 138 · see citing works

Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation

Kebir, D. E., József, L., Khreiss, T., Pan, W., Petasis, N. A., Serhan, C. N., & Filep, J. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.616 · Cited by 136 · see citing works

Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils

McLeish, K. R., Klein, J. B., Coxon, P. Y., Head, K. Z., & Ward, R. A. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.6.835 · Cited by 110 · see citing works

Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution

Hong, S., Porter, T. F., Lu, Y., Oh, S. F., Pillai, P. S., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3512 · Cited by 107 · see citing works

CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes

József, L., Khreiss, T., & Filep, J. G. (2004) · The FASEB Journal · doi:10.1096/fj.04-2048fje · Cited by 95 · see citing works

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice

Brovkovych, V. M., Gao, X.-P., Ong, E., Brovkovych, S. D., Brennan, M., Su, X., Hazen, S. L., Malik, A. B., & Skidgel, R. A. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00450.2007 · Cited by 74 · see citing works

Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kγ, ROS, and actin

Xu, Y., Loison, F., & Luo, H. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912717107 · Cited by 72 · see citing works

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

MOULDING, D. A., Quayle, J. A., Hart, C. A., et al. (1998) · Blood · doi:10.1182/blood.v92.7.2495.2495_2495_2502 · Cited by 42 · see citing works

Pro-resolving lipid mediators are leads for resolution physiology

Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344 · see citing works

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

Apoptotic cell clearance: basic biology and therapeutic potential

Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,042 · see citing works

Resolution of inflammation: a new therapeutic frontier

Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works

Specialized pro-resolving mediators: endogenous regulators of infection and inflammation

Basil, M. C., & Levy, B. D. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.4 · Cited by 805 · see citing works

Neutrophils in chronic inflammatory diseases

Herrero-Cervera, A., Soehnlein, O., & Kenne, E. M. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00832-3 · Cited by 719 · see citing works

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works

Neutrophil chemoattractant receptors in health and disease: Double-edged swords

Metzemaekers, M., Gouwy, M., & Proost, P. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0412-0 · Cited by 570 · see citing works

Nutrition, immunity and COVID-19

Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

Serhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 553 · see citing works

Lipid Mediators in the Resolution of InflammationPreprint

Serhan, C. N., Chiang, N., Dalli, J., & Levy, B. D. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016311 · Cited by 545 · see citing works

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works

Natural resolution of inflammation

Freire, M., & Dyke, T. E. V. (2013) · Periodontology 2000 · doi:10.1111/prd.12034 · Cited by 391 · see citing works

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

Chiang, N., Dalli, J., Colas, R. A., & Serhan, C. N. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150225 · Cited by 388 · see citing works

Cell Death in the Lung: The Apoptosis–Necroptosis Axis

Sauler, M., Bazan, I. S., & Lee, P. J. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114320 · Cited by 325 · see citing works

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Chiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works

The role of neutrophils in inflammation resolution

Jones, H. R., Robb, C. T., Perretti, M., & Rossi, A. G. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.007 · Cited by 298 · see citing works

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

Bang, S., Xie, Y., Zhang, Z., Wang, Z., Xu, Z., & Ji, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99888 · Cited by 288 · see citing works

Neutrophils in innate and adaptive immunity

Jaillon, S., Galdiero, M. R., Prete, D. D., Cassatella, M. A., Garlanda, C., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0374-8 · Cited by 284 · see citing works

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

Dobrev, D., Heijman, J., Hiram, R., Li, N., & Nattel, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00759-w · Cited by 272 · see citing works

The role of non-resolving inflammation in atherosclerosis

Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97950 · Cited by 266 · see citing works

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.001 · Cited by 266 · see citing works

Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential

Potey, P. M., Rossi, A. G., Lucas, C. D., & Dorward, D. A. (2018) · The Journal of Pathology · doi:10.1002/path.5221 · Cited by 248 · see citing works

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

Serhan, C. N., Chiang, N., & Dalli, J. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.08.002 · Cited by 246 · see citing works

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H. H., Cheng, C.-Y. C., Chiang, N., Petasis, N. A., & Serhan, C. N. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.11.010 · Cited by 246 · see citing works

Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology

Sansbury, B. E., & Spite, M. R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307308 · Cited by 226 · see citing works

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Ishihara, T., Yoshida, M., & Arita, M. (2019) · International Immunology · doi:10.1093/intimm/dxz001 · Cited by 218 · see citing works

Resolution of inflammation: Mechanisms and opportunity for drug development

Alessandri, A. L., Sousa, L. P., Lucas, C. D., Rossi, A. G., Pinho, V., & Teixeira, M. M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.006 · Cited by 217 · see citing works

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212 · see citing works

Production of hydroxy fatty acids by microbial fatty acid-hydroxylation enzymes

Kim, K.-R., & Oh, D. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.004 · Cited by 187 · see citing works

Roles of neutrophil granule proteins in orchestrating inflammation and immunity

Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works

Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

Lee, C.-T., Teles, R. P., Kantarcı, A., Chen, T., McCafferty, J., Starr, J. R., Brito, L. C. N., Paster, B. J., & Dyke, T. E. V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600859 · Cited by 176 · see citing works

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease

Pirault, J., & Bäck, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01273 · Cited by 167 · see citing works

COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

Sorokin, A. V., Karathanasis, S. K., Yang, Z., Freeman, L. A., Kotani, K., & Remaley, A. T. (2020) · The FASEB Journal · doi:10.1096/fj.202001451 · Cited by 166 · see citing works

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

Satyanarayanan, S. K., Kebir, D. E., Soboh, S., Butenko, S., Sekheri, M., Saadi, J., Peled, N., Assi, S., Othman, A., Schif‐Zuck, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10903-9 · Cited by 160 · see citing works

Neutrophil and remnant clearance in immunity and inflammation

Singhal, A., & Kumar, S. (2021) · Immunology · doi:10.1111/imm.13423 · Cited by 158 · see citing works

Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity

Estaki, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15650 · Cited by 146 · see citing works

Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology

Dalli, J., & Serhan, C. N. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14336 · Cited by 138 · see citing works

Efferocytosis and Lung Disease

McCubbrey, A. L., & Curtis, J. L. (2013) · CHEST Journal · doi:10.1378/chest.12-2413 · Cited by 130 · see citing works

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

Li, Y., Dalli, J., Chiang, N., Baron, R. M., Quintana, C., & Serhan, C. N. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.011 · Cited by 126 · see citing works

Immune resolution mechanisms in inflammatory arthritis

Perretti, M., Cooper, D., Dalli, J., & Norling, L. V. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.193 · Cited by 126 · see citing works

Targeting Neutrophils for Promoting the Resolution of Inflammation

Filep, J. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866747 · Cited by 128 · see citing works

Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice

Sercundes, M. K., Ortolan, L. D. S., Debone, D., Pereira, P. V. S., Gomes, E., Aitken, E. H., Condino‐Neto, A., Russo, M., Lima, M. R. D., Álvarez, J. M., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006054 · Cited by 123 · see citing works

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

Kebir, D. E., & Filep, J. G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00060 · Cited by 121 · see citing works

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

Lee, H., & Surh, Y. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.002 · Cited by 119 · see citing works

Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator–Heme Oxygenase-1 Circuits

Chiang, N., Shinohara, M., Dalli, J., Mirakaj, V., Kibi, M., Choi, A. M. K., & Serhan, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202969 · Cited by 117 · see citing works

Human health benefits of very-long-chain polyunsaturated fatty acids from microalgae

Lupette, J., & Christoph Benning, A. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.022 · Cited by 117 · see citing works

15-Epi-LXA 4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

Sekheri, M., Kebir, D. E., Edner, N. M., & Filep, J. G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920193117 · Cited by 113 · see citing works

Novel proresolving and tissue‐regenerative resolvin and protectin sulfido‐conjugated pathways

Dalli, J., Ramon, S., Norris, P. C., Colas, R. A., & Serhan, C. N. (2015) · The FASEB Journal · doi:10.1096/fj.14-268441 · Cited by 111 · see citing works

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

Abdolmaleki, F., Kovanen, P. T., Mardani, R., Hayat, S. M. G., Bo, S., & Sahebkar, A. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08754-9 · Cited by 104 · see citing works

Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids

Husson, M.-O., Ley, D., Portal, C., Aumar, M., Hueso, T., Desseyn, J., & Gottrand, F. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.10.001 · Cited by 103 · see citing works

The role of pro‐resolution lipid mediators in infectious disease

Russell, C. D., & Schwarze, J. (2013) · Immunology · doi:10.1111/imm.12206 · Cited by 101 · see citing works

Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part III: Mechanisms: A 2016 Consensus Group Statement of the International Society for Heart and Lung Transplantation

Gelman, A. E., Fisher, A. J., Huang, H. J., Baz, M. A., Shaver, C. M., Egan, T. M., & Mulligan, M. S. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.07.014 · Cited by 100 · see citing works

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

Winkler, J. W., Orr, S. K., Dalli, J., Cheng, C.-Y. C., Sanger, J. M., Chiang, N., Petasis, N. A., & Serhan, C. N. (2016) · Scientific Reports · doi:10.1038/srep18972 · Cited by 99 · see citing works

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Dalli, J., Vlasakov, I., Riley, I. R., Rodrı́guez, A. R., Spur, B. W., Petasis, N. A., Chiang, N., & Serhan, C. N. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607003113 · Cited by 99 · see citing works

Resolvin D4 attenuates the severity of pathological thrombosis in mice

Cherpokova, D., Jouvene, C. C., Libreros, S., DeRoo, E., Chu, L., de la Rosa, X., Norris, P. C., Wagner, D. D., & Serhan, C. N. (2019) · Blood · doi:10.1182/blood.2018886317 · Cited by 97 · see citing works

Lipid mediators in immune dysfunction after severe inflammation

Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.008 · Cited by 87 · see citing works

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

Freire, M., Dalli, J., Serhan, C. N., & Dyke, T. E. V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601543 · Cited by 90 · see citing works

Targeting Neutrophil Apoptosis for Enhancing the Resolution of Inflammation

Kebir, D. E., & Filep, J. G. (2013) · Cells · doi:10.3390/cells2020330 · Cited by 89 · see citing works

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases

Krishnamoorthy, N., Abdulnour, R.-E. E., Walker, K. H., Engstrom, B. D., & Levy, B. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00026.2017 · Cited by 84 · see citing works

Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury

Hong, S., & Lü, Y. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00013 · Cited by 85 · see citing works

Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

Sagini, K., Costanzi, E., Emiliani, C., Buratta, S., & Urbanelli, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041227 · Cited by 85 · see citing works

Pathways mediating resolution of inflammation: when enough is too much

Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. (2013) · The Journal of Pathology · doi:10.1002/path.4232 · Cited by 81 · see citing works

Inflammatory processes during acute respiratory distress syndrome: a complex system

Reiss, L. K., Schuppert, A., & Uhlig, S. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000472 · Cited by 81 · see citing works

Role of Resolvins in the Inflammatory Resolution of Neurological Diseases

Li, C., Wu, X., Liu, S., Shen, D., Zhu, J., & Liu, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00612 · Cited by 80 · see citing works

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

Orr, S. K., Colas, R. A., Dalli, J., Chiang, N., & Serhan, C. N. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00370.2014 · Cited by 80 · see citing works

Resolution of inflammation in inflammatory bowel disease

Rogler, G. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(17)30031-6 · Cited by 79 · see citing works

Pneumonia-Induced Inflammation, Resolution and Cardiovascular Disease: Causes, Consequences and Clinical Opportunities

Stotts, C., Corrales‐Medina, V., & Rayner, K. J. (2023) · Circulation Research · doi:10.1161/circresaha.122.321636 · Cited by 86 · see citing works

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C., & Soong, L. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12674 · Cited by 78 · see citing works

Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation

Filep, J. G., & Ariel, A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00181.2020 · Cited by 75 · see citing works

Ghrelin Protects Alveolar Macrophages Against Lipopolysaccharide-Induced Apoptosis Through Growth Hormone Secretagogue Receptor 1a-Dependent c-Jun N-Terminal Kinase and Wnt/β-Catenin Signaling and Suppresses Lung Inflammation

Ли, Б., Zeng, M., He, W., Huang, X., Luo, L., Zhang, H., & Deng, D. Y. B. (2014) · Endocrinology · doi:10.1210/en.2014-1539 · Cited by 76 · see citing works

Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1

Balta, M. G., Loos, B. G., & Nicu, E. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01682 · Cited by 76 · see citing works

Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli–driven acute inflammation

Motwani, M. P., Colas, R. A., George, M. J., Flint, J., Dalli, J., Richard-Loendt, A., Maeyer, R. P. H. D., Serhan, C. N., & Gilroy, D. W. (2018) · JCI Insight · doi:10.1172/jci.insight.94463 · Cited by 74 · see citing works

Extracellular vesicles regulate immune responses and cellular function in intestinal inflammation and repair

Bui, T. M., Mascarenhas, L., & Sumagin, R. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1431038 · Cited by 73 · see citing works

Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution

Trilleaud, C., Gauttier, V., Biteau, K., Girault, I., Belarif, L., Mary, C., Pengam, S., Teppaz, G., Thépenier, V., Danger, R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd1453 · Cited by 73 · see citing works

Impaired Production and Diurnal Regulation of Vascular RvD n-3 DPA Increase Systemic Inflammation and Cardiovascular Disease

Colas, R. A., Souza, P. R., Walker, M. E., Burton, M., Zasłona, Z., Curtis, A. M., Marques, R. M., & Dalli, J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312472 · Cited by 71 · see citing works

Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma

Flesher, R. P., Herbert, C. A., & Kumar, R. K. (2013) · Clinical Science · doi:10.1042/cs20130623 · Cited by 70 · see citing works

Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections

Jordan, P. M., & Werz, O. (2021) · FEBS Journal · doi:10.1111/febs.16266 · Cited by 69 · see citing works

Types of necroinflammation, the effect of cell death modalities on sterile inflammation

Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 65 · see citing works

Omega 3 Fatty Acid and Skin Diseases

Sawada, Y., Saito‐Sasaki, N., & Nakamura, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.623052 · Cited by 68 · see citing works

Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils

Braunstein, I., Motohashi, H., Dallenga, T. K., Schaible, U. E., & Benhar, M. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.006 · Cited by 72 · see citing works

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Dalli, J., Sanger, J. M., Rodrı́guez, A. R., Chiang, N., Spur, B. W., & Serhan, C. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149319 · Cited by 67 · see citing works

Fungal sensing of host environment

Braunsdorf, C., Mailänder‐Sánchez, D., & Schaller, M. (2016) · Cellular Microbiology · doi:10.1111/cmi.12610 · Cited by 66 · see citing works

Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response

Chen, F., Fan, X., Wu, Y., Zhu, J., Wang, F., Bo, L., Li, J. B., Bao, R., & Deng, X. M. (2013) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-1978-6 · Cited by 64 · see citing works

Dietary -3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

Kalish, B. T., Mattè, A., Andolfo, I., Iolascon, A., Weinberg, O. K., Ghigo, A., Cimino, J., Siciliano, A., Hirsch, E., Federti, E., et al. (2015) · Haematologica · doi:10.3324/haematol.2015.124586 · Cited by 63 · see citing works

Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation

Serhan, C. N., de la Rosa, X., & Jouvene, C. C. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12871 · Cited by 63 · see citing works

Host modulation therapy using anti-inflammatory and antioxidant agents in periodontitis: A review to a clinical translation

Sulijaya, B., Takahashi, N., & Yamazaki, K. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.07.002 · Cited by 65 · see citing works

Enteral Immunomodulatory Diet (Omega-3 Fatty Acid, γ-Linolenic Acid and Antioxidant Supplementation) for Acute Lung Injury and Acute Respiratory Distress Syndrome: An Updated Systematic Review and Meta-Analysis

Li, C., Bo, L., Liu, W., Lü, X., & Jin, F. (2015) · Nutrients · doi:10.3390/nu7075239 · Cited by 63 · see citing works

Pharmacological strategies to resolve acute inflammation

Sousa, L. P., Alessandri, A. L., Pinho, V., & Teixeira, M. M. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.03.007 · Cited by 63 · see citing works

Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair

Rizo-Téllez, S. A., & Filep, J. G. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00652.2023 · Cited by 62 · see citing works

Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways

Levy, B. D. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00390 · Cited by 60 · see citing works

PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function

Pistorius, K., Souza, P. R., Matteis, R. D., Austin‐Williams, S., Primdahl, K. G., Vik, A., Mazzacuva, F., Colas, R. A., Marques, R. M., Hansen, T. V., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.04.017 · Cited by 60 · see citing works

Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary Disease

Kotlyarov, S. N., & Котлярова, А. А. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312803 · Cited by 58 · see citing works

Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair

Quirós, M., & Nusrat, A. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114504 · Cited by 47 · see citing works

Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation

Duvall, M. G., Brüggemann, T. R., & Levy, B. D. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.04.003 · Cited by 57 · see citing works

Regression of human coronary artery plaque is associated with a high ratio of (18‐hydroxy‐eicosapentaenoic acid + resolvin E1) to leukotriene B 4

Welty, F. K., Schulte, F., Alfaddagh, A., Elajami, T. K., Bistrian, B. R., & Hardt, M. (2021) · The FASEB Journal · doi:10.1096/fj.202002471r · Cited by 57 · see citing works

Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development

Yang, A., Wu, Y., Yu, G., & Wang, H. (2021) · Respiratory Research · doi:10.1186/s12931-021-01792-y · Cited by 56 · see citing works

Roles of resolvins in the resolution of acute inflammation

Qu, Q., Xuan, W., & Fan, G.-H. (2014) · Cell Biology International · doi:10.1002/cbin.10345 · Cited by 57 · see citing works

Resolvin E1 promotes neutrophil apoptosis and accelerates resolution of acute pulmonary inflammation

Filep, J. G., Gjorstrup, P., & Kebir, D. E. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.254.4

Resolvin E1 modulates Mac-1 signaling and promotes neutrophil apoptosis and the resolution of acute inflammation (P5064)

Filep, J. G., Gjorstrup, P., & Kebir, D. E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.180.15

Resolvin E1 enhances phagocytosis‐induced neutrophil apoptosis

Kebir, D. E., Gjorstrup, P., & Filep, J. G. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.137.10

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works

Science review: apoptosis in acute lung injury.

Matute‐Bello, G., & Martin, T. R. (2003) · Critical Care · doi:10.1186/cc1861 · Cited by 158 · see citing works