Carcinogenesis resistance in the longest‐lived rodent, the naked mole‐rat
Open accessAbstract
Certain mammalian species are resistant to cancer, and a better understanding of how this cancer resistance arises could provide valuable insights for basic cancer research. Recent technological innovations in molecular biology have allowed the study of cancer‐resistant mammals, despite the fact that they are not the classical model animals, which are easily studied using genetic approaches. Naked mole‐rats (NMRs; Heterocephalus glaber) are the longest‐lived rodent, with a maximum lifespan of more than 37 years, and almost never show spontaneous carcinogenesis. NMRs are currently attracting much attention from aging and cancer researchers, and published studies on NMR have continued to increase over the past decade. Cancer development occurs via multiple steps and involves many biological processes. Recent research on the NMR as a model for cancer resistance suggests that they possess various unique carcinogenesis‐resistance mechanisms, including efficient DNA repair pathways, cell‐autonomous resistance to transformation, and dampened inflammatory response. Here, we summarize the molecular mechanisms of carcinogenesis resistance in NMR, which have been uncovered over the past two decades, and discuss future perspectives.
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Naked mole rats achieve resistance to tumors through efficient DNA damage repair and synthesis of unique anti-inflammatory high molecular weight hyaluronan.
“As a successful aging specifications, nude mole also achieved resistance to tumor through a variety of methods, such as efficient DNA damage repair, synthesis of unique anti-inflammatory high molecular weight hyaluronan.311”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [311]
The 'Resistance to DNA Damage' section describes efficient DNA repair in naked mole-rats, and 'Cell-Autonomous Resistance to Transformation Induction' links their secretion of high-molecular-mass hyaluronan to tumor-suppressive contact inhibition. The paper does not describe that hyaluronan as anti-inflammatory; its 'Dampened Inflammatory Response' section instead links reduced inflammation to loss-of-function mutations in RIPK3 and MLKL. Page numbers were not available in our copy. (LLM, conf=0.88)
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Inflammation and aging: signaling pathways and intervention therapies
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“As a successful aging specifications, nude mole also achieved resistance to tumor through a variety of methods, such as efficient DNA damage repair, synthesis of unique anti-inflammatory high molecular weight hyaluronan.(311) The special longevity mechanism of naked mole makes it a good animal model for longevity rese…”
Background
- Authors
- Yamamura, Y., Kawamura, Y., Oka, K., & Miura, K.
- Affiliations
- Kumamoto University (JP)
- Center for Metabolic Regulation of Healthy Aging, Kumamoto University (JP)
- Corresponding author
- Miura, Kyoko
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2022-09-20
- Volume
- 113
- Issue
- 12
- Pages
- 4030-4036
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- PMC
- PMC9746031
- OpenAlex
- W4295049489
- Cited by
- 20
- References
- 58
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancer Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency (JPMJFR216C)
- Japan Society for the Promotion of Science (JP22K15024, JP22K06069, JP21H05143, JP21H02392, JP22K18355)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- naked mole-rat, tumor resistance, DNA repair, inflammation, aging, longevity, tumor suppression
- MeSH terms
- Aging, Animals, Biological Phenomena, Longevity, Neoplasms, Mole Rats
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