Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults
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Summary: Objective: Redox status and inflammation are important in the pathophysiology of numerous chronic diseases. Epidemiological studies have linked vitamin D status to a number of chronic diseases. We aimed to examine the relationships between serum 25‐hydroxyvitamin D [25(OH)D] and circulating thiol/disulphide redox status and biomarkers of inflammation. Design: This was a cross‐sectional study of N = 693 adults (449 females, 244 males) in an apparently healthy, working cohort in Atlanta, GA. Plasma glutathione (GSH), cysteine (Cys) and their associated disulphides were determined with high‐performance liquid chromatography, and their redox potentials (E h GSSG and E h Cy SS) were calculated using the Nernst equation. Serum inflammatory markers included interleukin‐6 (IL‐6), interleukin‐8 (IL‐8) and tumour necrosis factor‐α, assayed on a multiplex platform, and C‐reactive protein (CRP), assayed commercially. Relationships were assessed with multiple linear regression analyses. Results: Serum 25(OH)D was positively associated with plasma GSH (β ± SE: 0·002 ± 0·0004) and negatively associated with plasma E h GSSG (β ± SE: −0·06 ± 0·01) and Cys (β ± SE: −0·01 ± 0·003) (P < 0·001 for all); statistical significance remained after adjusting for age, gender, race, percentage body fat and traditional cardiovascular risk factors (P = 0·01–0·02). The inverse relationship between serum 25(OH)D and CRP was confounded by percentage body fat, and full adjustment for covariates attenuated serum 25(OH)D relationships with other inflammatory markers to nonstatistical significance. Conclusions: Serum 25(OH)D concentrations were independently associated with major plasma thiol/disulphide redox systems, suggesting that vitamin D status may be involved in redox‐mediated pathophysiology.
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25(OH)D concentrations correlate significantly positively with glutathione levels in healthy adult populations.
“Evidence shows that 25(OH)D concentrations correlate significantly positively with glutathione levels in healthy adult populations [154], and low vitamin D status is associated with increased inflammatory, oxidative and endothelial activation biomarkers in obese individuals [155].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [154]
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Vitamin D and Autism Spectrum Disorder: A Literature Review
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- Authors
- Alvarez, J. A., Chowdhury, R., Jones, D. P., Martin, G. S., Brigham, K. L., Binongo, J. N., Ziegler, T. R., & Tangpricha, V.
- Affiliations
- Emory University (US)
- Corresponding author
- Alvarez, Jessica A.
- ORCID
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2014-04-15
- Volume
- 81
- Issue
- 3
- Pages
- 458-466
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- PMC
- PMC4115025
- OpenAlex
- W2054306914
- Cited by
- 74
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 2
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Best Practice & Research Clinical Endocrinology & Metabolism
- Funders
- National Center for Advancing Translational Sciences of the National Institutes of Health (UL1 TR000454)
- National Institutes of Health (K23 AR054334, T32 DK007298-32S1, P20 HL113451, K24 DK096574)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- vitamin D status, 25-hydroxyvitamin D, glutathione, cysteine, glutathione disulfide, inflammation, C-reactive protein, interleukin-6, interleukin-8, TNF-α, fat mass, adults
- MeSH terms
- Cysteine, Female, Glutathione, Humans, Male, Middle Aged, Oxidation-Reduction, Vitamin D, Glutathione Disulfide
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