Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

DNA methylation and its basic function

Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906 · see citing works

DNA Methylation in MammalsPreprint

Li, E., & Zhang, Y. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019133 · Cited by 952 · see citing works

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

Cheng, J. B., Levine, M. A., Bell, N. H., Mangelsdorf, D. J., & Russell, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402490101 · Cited by 760 · see citing works

DNA methylation: An epigenetic mark of cellular memory

Kim, M., & Costello, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.10 · Cited by 450 · see citing works

Structure, function, and post–translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Franklin, C. C., Backos, D. S., Mohar, I., White, C. C., Forman, H. J., & Kavanagh, T. J. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.009 · Cited by 438 · see citing works

DNA Methylation and Demethylation in Mammals

Chen, Z., & Riggs, A. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.205286 · Cited by 395 · see citing works

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

Heydemann, A. (2016) · Journal of Diabetes Research · doi:10.1155/2016/2902351 · Cited by 376 · see citing works

Vitamin D and the epigenome

Fetahu, I. S., Höbaus, J., & Kállay, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00164 · Cited by 313 · see citing works

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

Cyr, A. R., & Domann, F. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3492 · Cited by 294 · see citing works

Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation

Roth, C. L., Elfers, C., Figlewicz, D. P., Melhorn, S. J., Morton, G. J., Hoofnagle, A. N., Yeh, M. M., Nelson, J. E., & Kowdley, K. V. (2011) · Hepatology · doi:10.1002/hep.24737 · Cited by 289 · see citing works

25(OH)D2 Half-Life Is Shorter Than 25(OH)D3 Half-Life and Is Influenced by DBP Concentration and Genotype

Jones, K. S., Assar, S. H., Harnpanich, D., Bouillon, R., Lambrechts, D., Prentice, A., & Schoenmakers, I. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1714 · Cited by 276 · see citing works

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

Novakovic, B., Sibson, M., Ng, H. K., Manuelpillai, U., Rakyan, V. K., Down, T. A., Beck, S., Fournier, T., Evain-Brion, D., Dimitriadis, E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809542200 · Cited by 238 · see citing works

New Insights into 5hmC DNA Modification: Generation, Distribution and Function

Shi, D., Ali, I., Tang, J., & Yang, W. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00100 · Cited by 225 · see citing works

1alpha-Hydroxylase and the action of vitamin D

Hewison, M., Zehnder, D., Bland, R., & Stewart, P. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250141 · Cited by 222 · see citing works

Glutathione Is Recruited into the Nucleus in Early Phases of Cell Proliferation

Marković, J., Borrás, C., Ortega, Á., Sastre, J., Viña, J., & Pallardó, F. V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609582200 · Cited by 195 · see citing works

Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

Manna, P., Achari, A. E., & Jain, S. K. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.01.002 · Cited by 181 · see citing works

Global DNA Methylation Is Associated With Insulin Resistance

Zhao, J., Goldberg, J. H., Bremner, J. D., & Vaccarino, V. (2011) · Diabetes · doi:10.2337/db11-1048 · Cited by 175 · see citing works

Vitamin D And Nonalcoholic Fatty Liver Disease (Nafld): Is It More Than Just An Association?

Kwok, R. M., Torres, D. M., & Harrison, S. A. (2013) · Hepatology · doi:10.1002/hep.26390 · Cited by 170 · see citing works

Glutathione Therapy: From Prodrugs to Genes

Anderson, M. E., & Luo, J. (1998) · Seminars in Liver Disease · doi:10.1055/s-2007-1007174 · Cited by 140 · see citing works

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation

Kadayıfçı, F. Z., Zheng, S., & Pan, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124055 · Cited by 139 · see citing works

Role of glutathione in the regulation of epigenetic mechanisms in disease

García-Giménez, J. L., Romá-Mateo, C., Pérez-Machado, G., Peiró-Chova, L., & Pallardó, F. V. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.008 · Cited by 116 · see citing works

Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure

García‐Giménez, J. L., González, G. O., Hake, S. B., Bönisch, C., Wiedemann, S. M., Marković, J., Dası́, F., Gimeno, A., Pérez-Quilis, C., Palacios, Ò., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5021 · Cited by 115 · see citing works

DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications

Kawai, K., Li, Y., Song, M.-F., & Kasai, H. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.10.124 · Cited by 110 · see citing works

A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American Adolescents

Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H., & Dong, Y. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.10.059 · Cited by 105 · see citing works

Nutritional factors and gender influence age‐related DNA methylation in the human rectal mucosa

Tapp, H. S., Commane, D. M., Bradburn, D. M., Arasaradnam, R. P., Mathers, J. C., Johnson, I. T., & Belshaw, N. J. (2012) · Aging Cell · doi:10.1111/acel.12030 · Cited by 101 · see citing works

l-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-κB activation in the livers of Zucker diabetic rats

Jain, S. K., Velusamy, T., Croad, J. L., Rains, J., & Bull, R. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.014 · Cited by 96 · see citing works

Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency

Jain, S. K., Parsanathan, R., Achari, A. E., Kanikarla-Marie, P., & Bocchini, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7462 · Cited by 87 · see citing works

Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future

Barchetta, I., Cimini, F. A., & Cavallo, M. G. (2017) · Nutrients · doi:10.3390/nu9091015 · Cited by 86 · see citing works

Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients

Jain, S. K., Micinski, D., Huning, L., Kahlon, G., Bass, P. F., & Levine, S. N. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.114 · Cited by 84 · see citing works

Changes in circulating 25-hydroxyvitamin D according to vitamin D binding protein genotypes after vitamin D3 or D2supplementation

Nimitphong, H., Saetung, S., Chanprasertyotin, S., Chailurkit, L., & Ongphiphadhanakul, B. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-39 · Cited by 79 · see citing works

Genetic disorders of Vitamin D biosynthesis and degradation

Miller, W. L. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.001 · Cited by 79 · see citing works

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

Alvarez, J. A., Chowdhury, R., Jones, D. P., Martin, G. S., Brigham, K. L., Binongo, J. N., Ziegler, T. R., & Tangpricha, V. (2014) · Clinical Endocrinology · doi:10.1111/cen.12449 · Cited by 74 · see citing works

Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C 2 C 12 mouse myotubes

Parsanathan, R., & Jain, S. K. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1431626 · Cited by 73 · see citing works

Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3–fortified bread and milk during winter in Denmark

Nissen, J., Vogel, U. B., Ravn‐Haren, G., Andersen, E. W., Madsen, K. H., Nexø, B. A., Andersen, R., Mejborn, H., Bjerrum, P. J., Rasmussen, L. B., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092148 · Cited by 67 · see citing works

Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

Wang, M., Kong, W., He, B., Li, Z., Song, H., Shi, P., & Wang, J. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0552-6 · Cited by 63 · see citing works

Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis

Wang, N., Chen, C., Zhao, L., Chen, Y., Han, B., Xia, F., Cheng, J., Li, Q., & Lu, Y. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.027 · Cited by 60 · see citing works

DNA methylation patterns associated with oxidative stress in an ageing population

Hedman, Å. K., Zilmer, M., Sundström, J., Lind, L., & Ingelsson, E. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0235-0 · Cited by 50 · see citing works

L‐cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25‐hydroxy‐vitamin D in Zucker diabetic fatty rats

Jain, S. K., Marie, P. K., Warden, C., & Micinski, D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500667 · Cited by 49 · see citing works

Dynamic regulation of epigenetic demethylation by oxygen availability and cellular redox

Lamadema, N., Burr, S., & Brewer, A. C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.009 · Cited by 48 · see citing works

Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry

Beckett, E., Duesing, K., Martin, C., Jones, P. R., Furst, J. E., King, K., Niblett, S. H., Yates, Z. R., Veysey, M. J., & Lucock, M. D. (2016) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2016.04.010 · Cited by 47 · see citing works

Maintenance of glutathione levels and its importance in epigenetic regulation

García-Giménez, J. L., & Pallardó, F. V. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00088 · Cited by 46 · see citing works

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine

Parsanathan, R., & Jain, S. K. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.12.023 · Cited by 42 · see citing works

A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice

Kaufmann, M., Lee, S. M., Pike, J. W., & Jones, G. (2015) · Endocrinology · doi:10.1210/en.2015-1664 · Cited by 38 · see citing works

l-Cysteine in vitro can restore cellular glutathione and inhibits the expression of cell adhesion molecules in G6PD-deficient monocytes

Parsanathan, R., & Jain, S. K. (2018) · Amino Acids · doi:10.1007/s00726-018-2559-x · Cited by 37 · see citing works

Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice

Parsanathan, R., & Jain, S. K. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.017 · Cited by 36 · see citing works

Can l -Cysteine and Vitamin D Rescue Vitamin D and Vitamin D Binding Protein Levels in Blood Plasma of African American Type 2 Diabetic Patients?

Jain, S. K., Kahlon, G., Bass, P. F., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6320 · Cited by 34 · see citing works

Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults

Niedzwiecki, M. M., Hall, M. N., Liu, X., Oka, J., Harper, K. N., Slavkovich, V. N., Ilievski, V., Levy, D., van Geen, A., Mey, J. L., et al. (2013) · Epigenetics · doi:10.4161/epi.25012 · Cited by 28 · see citing works

A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro

Jia, Z., Liang, Y., Ma, B., et al. (2017) · Journal of Visualized Experiments · doi:10.3791/55565 · Cited by 19 · see citing works

Unraveling the Complex Epigenetic Mechanisms that Regulate Gene Activity

Bemer, M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7318-7_13 · Cited by 16 · see citing works

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works

Effect of Thiamine Deficiency on Glutathione Contents of Erythrocytes and Tissues in the Rat

Hsu, J. M., & Chow, B. F. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-104-25771 · Cited by 19 · see citing works

Modulation of Glutathione Levels and Metabolism

Meister, A. (1987) · Springer eBooks · doi:10.1007/978-1-4615-6462-1_55 · Cited by 4 · see citing works

The multiple roles of glutathione in drug metabolism

Orrenius, S., & Moldéus, P. (1984) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(84)90495-4 · Cited by 132 · see citing works

S-35-glutathione preparation from yeast and tracer studies in cancerous and non-cancerous rats

Woodward, G. E. (1951) · Journal of the Franklin Institute · doi:10.1016/0016-0032(51)90600-x · Cited by 2 · see citing works

Glutathione Metabolism in Liver, Kidney and Testis of Rats Exposed to Cadmium

Shukla, G. S., Srivastava, R. S., & Chandra, S. (1987) · Industrial Health · doi:10.2486/indhealth.25.139 · Cited by 14 · see citing works