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Cited by 10Ovarian function and disordersCardiovascular and exercise physiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Serum testosterone predicts cardiorespiratory fitness impairment in normal‐weight women with polycystic ovary syndrome

Bacchi, Elisabetta, Negri, Carlo, Di Sarra, Daniela, Tosi, Flavia, Tarperi, Cantor, Moretta, Rossella, Schena, Federico, Bonora, Enzo +2 more·2015·Clinical Endocrinology
DOI 10.1111/cen.12855
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Abstract

Summary: Objective: Limited literature has shown that maximal oxygen consumption (V'O 2max), that is the maximal capacity of an individual to perform aerobic work, may be lowered in overweight/obese women with polycystic ovary syndrome (PCOS). However, it remains unclear whether this impairment is associated with PCOS per se or is entirely due to body fat excess. Our objective was to assess whether cardiorespiratory fitness is altered in normal‐weight PCOS women and to investigate which factors are associated with this phenomenon. Subjects: Fifteen normal‐weight PCOS women and 15 age‐ and BMI‐matched healthy controls. Fourteen subjects in each group completed the protocol. Measurements: V'O 2max and ventilatory thresholds (maximal incremental cycle ergometer test with breath‐by‐breath analysis of gas exchange), insulin sensitivity (hyperinsulinaemic euglycaemic clamp) and androgenaemia (serum total and free testosterone, measured by liquid chromatography mass spectrometry and equilibrium dialysis) were accurately assessed. Results: Maximal V'O 2 and power were strikingly impaired in normal‐weight PCOS individuals, as compared with healthy controls (29·4 ± 1·5 vs 35·8 ± 1·6 ml O 2/kg/min, P = 0·008; 138 ± 6 vs 170 ± 10 W, P = 0·011, respectively). Similarly, oxygen consumption and power at both the first and second ventilatory thresholds were significantly lower in PCOS subjects than in healthy women. In multiple regression analysis, V'O 2max was negatively predicted by serum‐free testosterone levels, but not by body fat mass and glucose disposal rate (R2 = 0·45 P = 0·013). Conclusions: Cardiorespiratory fitness is impaired in normal‐weight PCOS women. Androgen excess but not insulin sensitivity is associated with this alteration.

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Authors
Bacchi, E., Negri, C., Di Sarra, D., Tosi, F., Tarperi, C., Moretta, R., Schena, F., Bonora, E., Kaufman, J., & Moghetti, P.
Affiliations
  • Azienda Ospedaliera Universitaria Integrata Verona (IT)
  • Unit of Endocrinology, Diabetes and Metabolism University and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy
  • University of Verona (IT)
  • Ghent University Hospital (BE)
Corresponding author
Moghetti, Paolo
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2015-08-11
Volume
83
Issue
6
Pages
895-901
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/cen.12855
OpenAlex
W1911073603
Cited by
10
References
28
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
Università degli Studi di Verona
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, cardiorespiratory fitness, VO2max, free testosterone, hyperandrogenism, ventilatory threshold, insulin sensitivity, normal-weight women, fat mass
MeSH terms
Adolescent, Adult, Female, Humans, Insulin Resistance, Oxygen Consumption, Polycystic Ovary Syndrome, Testosterone, Body Mass Index, Case-Control Studies, Overweight, Young Adult

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