Cited by 106Antimicrobial Resistance in StaphylococcusAutophagy in Disease and TherapyBacteriophages and microbial interactions

In or out: Phagosomal escape of Staphylococcus aureus

Open access
Moldovan, Adriana, Fraunholz, Martin J.·2019·Cellular Microbiology

Abstract

Staphylococcus aureus is internalised by host cells in vivo, and recent research results suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for recurrent infections. However, in different cells types, the pathogen resorts to alternative strategies to survive phagocytosis and the antimicrobial mechanisms of host cells. In non-professional phagocytes, S. aureus either escapes the endosome followed by cytoplasmic replication or replicates within autophagosomes. Professional phagocytes possess a limited capacity to kill S. aureus and hence the bacteria, well equipped with immune evasive mechanisms, replicate within the cells, eventually lyse out of the cells and thus persist in a continuous cycle of phagocytosis, host cell death, and bacterial release.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/cmi.12997

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The role of Nox2 during infection with Staphylococcus aureus is controversial.

    “In contrast to the clear role of Nox2-dervied ROS in antilisterial activity of macrophages, the role of Nox2 during infection with another Gram-positive pathogen, Staphylococcus aureus (S.a.), is controversial.”

    From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [247]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. NEJM199808203390806 · DOI
  2. M609784200 · DOI

Cited by

Sorted by citations

Authors
Moldovan, A., & Fraunholz, M. J.
Affiliations
University of Würzburg (DE)
Corresponding author
Fraunholz, Martin J.
Venue
Cellular Microbiology
Publisher
Wiley
Published
2019-01-18
Volume
21
Issue
3
Pages
e12997
ISSN
1462-5814 (ISSN-L)
OpenAlex
W2906195039
Cited by
106
References
119
Citations by year
2026: 12 · 2025: 16 · 2024: 18 · 2023: 12 · 2022: 18 · 2021: 20 · 2020: 7 · 2019: 3
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Cellular Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft (TRR34 (Project C11))
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Keywords
Staphylococcus aureus, phagosome escape, phagocytosis, intracellular bacterial replication, endosomal escape, autophagosomes, professional phagocytes, immune evasion, bacterial persistence, recurrent infections, host cell death, bacterial release
MeSH terms
Animals, Cytoplasm, Humans, Phagocytosis, Phagosomes, Staphylococcal Infections, Staphylococcus aureus, Host-Pathogen Interactions, Immune Evasion

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review