In or out: Phagosomal escape of Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is internalised by host cells in vivo, and recent research results suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for recurrent infections. However, in different cells types, the pathogen resorts to alternative strategies to survive phagocytosis and the antimicrobial mechanisms of host cells. In non-professional phagocytes, S. aureus either escapes the endosome followed by cytoplasmic replication or replicates within autophagosomes. Professional phagocytes possess a limited capacity to kill S. aureus and hence the bacteria, well equipped with immune evasive mechanisms, replicate within the cells, eventually lyse out of the cells and thus persist in a continuous cycle of phagocytosis, host cell death, and bacterial release.
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The role of Nox2 during infection with Staphylococcus aureus is controversial.
“In contrast to the clear role of Nox2-dervied ROS in antilisterial activity of macrophages, the role of Nox2 during infection with another Gram-positive pathogen, Staphylococcus aureus (S.a.), is controversial.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [247]
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Functions of ROS in Macrophages and Antimicrobial Immunity
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- Authors
- Moldovan, A., & Fraunholz, M. J.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Fraunholz, Martin J.
- Venue
- Cellular Microbiology
- Publisher
- Wiley
- Published
- 2019-01-18
- Volume
- 21
- Issue
- 3
- Pages
- e12997
- ISSN
- 1462-5814 (ISSN-L)
- OpenAlex
- W2906195039
- Cited by
- 106
- References
- 119
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 18 · 2023: 12 · 2022: 18 · 2021: 20 · 2020: 7 · 2019: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (TRR34 (Project C11))
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- Staphylococcus aureus, phagosome escape, phagocytosis, intracellular bacterial replication, endosomal escape, autophagosomes, professional phagocytes, immune evasion, bacterial persistence, recurrent infections, host cell death, bacterial release
- MeSH terms
- Animals, Cytoplasm, Humans, Phagocytosis, Phagosomes, Staphylococcal Infections, Staphylococcus aureus, Host-Pathogen Interactions, Immune Evasion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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