Inflammation and Race and Gender Differences in Computerized Tomography‐measured Adipose Depots
Open accessAbstract
A growing body of evidence has consistently shown a correlation between obesity and chronic subclinical inflammation. It is unclear whether the size of specific adipose depots is more closely associated with concentrations of inflammatory markers than overall adiposity. This study investigated the relationship between inflammatory markers and computerized tomography-derived abdominal visceral and subcutaneous fat and thigh intermuscular and subcutaneous fat in older white and black adults. Data were from 2,651 black and white men and women aged 70-79 years participating in the Health, Aging, and Body Composition (Health ABC) study. Inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) were obtained from serum samples. Abdominal visceral and subcutaneous fat and thigh intermuscular and subcutaneous fat were quantified on computerized tomography images. Linear regression analysis was used to evaluate the cross-sectional relationship between specific adipose depots and inflammatory markers in four race/gender groups. As expected, blacks have less visceral fat than whites and women less visceral fat than men. However, abdominal visceral adiposity was most consistently associated with significantly higher IL-6 and CRP concentrations in all race/gender groups (P < 0.05), even after controlling for general adiposity. Thigh intermuscular fat had an inconsistent but significant association with inflammation, and there was a trend toward lower inflammatory marker concentration with increasing thigh subcutaneous fat in white and black women. Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined.
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Greater IMAT is associated with elevation in markers of inflammation.
“Furthermore, greater IMAT has been associated with elevation in markers of inflammation (46).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [46]
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- Authors
- Beasley, L. E., Koster, A., Newman, A. B., Javaid, M. K., Ferrucci, L., Kritchevsky, S. B., Kuller, L. H., Pahor, M., Schaap, L. A., Visser, M., Rubin, S. M., Goodpaster, B. H., Harris, T. B., & study, T. H. A.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 17
- Issue
- 5
- Pages
- 1062-1069
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC3268118
- OpenAlex
- W2010124801
- Cited by
- 234
- References
- 30
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 17 · 2022: 16 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 22 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 19 · 2013: 17 · 2012: 17
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health (n01ag062101-007, n01ag062103-006, n01ag062106-007)
- National Institute on Aging (N01‐AG‐6–2101, N01 AG062106, N01AG62106, N01-AG-62103, N01 AG062103, P30AG028740, P30AG021332, N01 AG062101)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- body fat distribution, visceral fat, subcutaneous adipose tissue, intermuscular fat, inflammation, interleukin-6, C-reactive protein, TNF-α, racial differences, gender differences, older adults, Health ABC Study
- MeSH terms
- Adipose Tissue, Aged, Body Composition, C-Reactive Protein, Female, Humans, Inflammation, Longitudinal Studies, Male, Sex Characteristics, Tomography, X-Ray Computed, Tumor Necrosis Factor-alpha, Cohort Studies, Biomarkers, Interleukin-6, Black People, White People, Racial Groups
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