Electrophysiological evidence of heterogeneity in visual statistical learning in young children with ASD
Open accessAbstract
Statistical learning is characterized by detection of regularities in one's environment without an awareness or intention to learn, and it may play a critical role in language and social behavior. Accordingly, in this study we investigated the electrophysiological correlates of visual statistical learning in young children with autism spectrum disorder (ASD) using an event‐related potential shape learning paradigm, and we examined the relation between visual statistical learning and cognitive function. Compared to typically developing (TD) controls, the ASD group as a whole showed reduced evidence of learning as defined by N1 (early visual discrimination) and P300 (attention to novelty) components. Upon further analysis, in the ASD group there was a positive correlation between N1 amplitude difference and non‐verbal IQ, and a positive correlation between P300 amplitude difference and adaptive social function. Children with ASD and a high non‐verbal IQ and high adaptive social function demonstrated a distinctive pattern of learning. This is the first study to identify electrophysiological markers of visual statistical learning in children with ASD. Through this work we have demonstrated heterogeneity in statistical learning in ASD that maps onto non‐verbal cognition and adaptive social function.
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This pattern resembles earlier electrophysiological findings of reduced mismatch negativity and smaller P300, and BOLD findings of reduced repetition suppression, but now in pupillometry.
“This pattern mirrors previous findings in the domains of electrophysiology (reduced mismatch negativity in ASD/smaller P300 36,37 and BOLD imaging (reduced fMRI repetition suppression in ASD 21,23) but now in the novel domain of pupillometry.”
From Adults with autism overestimate the volatility of the sensory environment (2017) · cites this paper as [37]
The citation is attached to the electrophysiological finding of a smaller P300 in ASD. In Results §3.2 (page unavailable), the paper reports no significant group effect for P300; its finding that the ASD group did not differentiate expected from unexpected conditions is not a finding of a smaller P300 than the TD group. The mismatch-negativity and BOLD findings are attached to other citations. (LLM, conf=0.85)
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Experimental — accuracy not yet measuredBehavioural and pupillometric results based on the experimental ground truth converge on a reduced distinction between unexpected and expected outcomes in ASD.
“In this study, behavioural (RT/error rates) and pupillometric results based on the experimental ground truth converge on the finding of reduced distinction between unexpected and expected outcomes in ASD (Figure 2, Figure 5a) which is consistent with many previous studies across a range of methods reporting reduced ‘surprise’ in ASD 21,23,36,37.”
From Adults with autism overestimate the volatility of the sensory environment (2017) · cites this paper as [37]
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Adults with autism overestimate the volatility of the sensory environment
Lawson, R. P., Mathys, C., & Rees, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4615 · Cited by 470 · see citing works
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- Authors
- Jeste, S. S., Kirkham, N., Senturk, D., Hasenstab, K., Sugar, C., Kupelian, C., Baker, E., Sanders, A. J., Shimizu, C., Norona, A., Paparella, T., Freeman, S. F. N., & Johnson, S. P.
- Affiliations
- University of California, Los Angeles (US)
- Birkbeck, University of London (GB)
- Department of Psychiatry UCLA Semel Institute of Biobehavioral Sciences USA
- Corresponding author
- Jeste, Shafali S.
- ORCID
- Venue
- Developmental Science
- Publisher
- Wiley
- Published
- 2014-05-13
- Volume
- 18
- Issue
- 1
- Pages
- 90-105
- ISSN
- 1363-755X (ISSN-L)
- 1467-7687
- PMC
- PMC4231013
- OpenAlex
- W1994998763
- Cited by
- 71
- References
- 63
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 10 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 3 · 2014: 1
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- BIROn (Birkbeck, University of London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (1K23MH094517-01)
- NICHD (2P50HD055784-06)
- NIMH (P30MH089901-01)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- visual statistical learning, autism spectrum disorder, children, event-related potentials, N1 component, P300, non-verbal IQ, electrophysiological markers
- MeSH terms
- Age Factors, Awareness, Child, Child Development Disorders, Pervasive, Child, Preschool, Discrimination, Psychological, Electroencephalography, Evoked Potentials, Female, Humans, Language, Learning Disabilities, Male, Neuropsychological Tests, Social Behavior, Visual Perception
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