Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review
Open accessAbstract
In this paper we critically review the literature on the use of event related potentials (ERPs) to elucidate the neural sources of the core deficits in autism. We review auditory and visual ERP studies, and then review the use of ERPs in the investigation of executive function. We conclude that, in autism, impairments likely exist in both low and higher level auditory and visual processing, with prominent impairments in the processing of social stimuli. We also discuss the putative neural circuitry underlying these deficits. As we look to the future, we posit that tremendous insight can be gained by applying ERPs to the definition of endophenotypes, which, in turn, can facilitate early diagnosis and the creation of informed interventions for children with autism.
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Reduced amplitude of the frontal novelty P3 or P3a component in ASD is a largely consistent finding across multiple studies.
“A largely consistent finding across multiple studies has been reduced amplitude of the frontal (novelty) P3 or P3a component in ASD (Jeste and Nelson, 2009).”
From Atypical attentional networks and the emergence of autism (2013) · cites this paper as Jeste and Nelson, 2009
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- Authors
- Jeste, S. S., & Nelson, C. A.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Jeste, Shafali S.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2008-10-11
- Volume
- 39
- Issue
- 3
- Pages
- 495-510
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4422389
- OpenAlex
- W1987602273
- Cited by
- 179
- References
- 11
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 16 · 2018: 12 · 2017: 13 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 11 · 2012: 12
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Autism Speaks (AS1609)
- Child Neurology Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- autism spectrum disorder, event-related potentials, auditory processing deficits, visual processing deficits, social processing, executive function, neural circuits, endophenotypes, early diagnosis, children
- MeSH terms
- Auditory Perception, Autistic Disorder, Brain, Electroencephalography, Evoked Potentials, Evoked Potentials, Auditory, Evoked Potentials, Visual, Humans, Social Perception, Visual Perception
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