Electrophysiological measures of resting state functional connectivity and their relationship with working memory capacity in childhood
Open accessAbstract
Functional connectivity is the statistical association of neuronal activity time courses across distinct brain regions, supporting specific cognitive processes. This coordination of activity is likely to be highly important for complex aspects of cognition, such as the communication of fluctuating task goals from higher-order control regions to lower-order, functionally specific regions. Some of these functional connections are identifiable even when relevant cognitive tasks are not being performed (i.e. at rest). We used magnetoencephalographic recordings projected into source space to demonstrate that resting state networks in childhood have electrophysiological underpinnings that are evident in the spontaneous fluctuations of oscillatory brain activity. Using the temporal structure of these oscillatory patterns we were able to identify a number of functional resting state networks analogous to those reported in the adult literature. In a second analysis we fused this dynamic temporal information with the spatial information from a functional magnetic resonance imaging analysis of functional connectivity, to demonstrate that inter-subject variability in these electrophysiological measures of functional connectivity is correlated with individual differences in cognitive ability: the strength of connectivity between a fronto-parietal network and lower-level processing areas in inferior temporal cortex was associated with spatial working memory capacity, as measured outside the scanner with educationally relevant standardized assessments. This study represents the first exploration of the electrophysiological mechanisms underpinning resting state functional connectivity in source space in childhood, and the extent to which the strength of particular connections is associated with cognitive ability.
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Enhancements in cognitive performance following training are mirrored by changes in neural activity and connectivity of the brain networks serving working memory.
“Enhancements in cognitive performance following training are mirrored by changes in the neural activity and connectivity of the brain networks serving WM (Astle et al., 2015; Barnes et al., 2016; Caeyenberghs et al., 2016; Constantinidis & Klingberg, 2016; Dahlin, Neely, Larsson, Backman, & Nyberg, 2008; Kundu, Sutterer, Emrich, & Postle, 2013; Olesen, Westerberg, & Klingberg, 2004; Takeuchi & Kaw”
From Working memory training involves learning new skills (2019) · cites this paper as Barnes et al., 2016
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Working memory training involves learning new skills
Gathercole, S. E., Dunning, D. L., Holmes, J., & Norris, D. (2019) · Journal of Memory and Language · doi:10.1016/j.jml.2018.10.003 · Cited by 225 · see citing works
“Enhancements in cognitive performance following training are mirrored by changes in the neural activity and connectivity of the brain networks serving WM (Astle et al., 2015; Barnes et al., 2016; Caeyenberghs et al., 2016; Constantinidis & Klingberg, 2016; Dahlin, Neely, Larsson, Backman, & Nyberg, 2008; Kundu, Sutter…”
BackgroundCognitive training enhances intrinsic brain connectivity in childhood
Astle, D. E., Barnes, J. J., Baker, K., Colclough, G. L., & Woolrich, M. W. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4517-14.2015 · Cited by 123 · see citing works
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- Authors
- Barnes, J. J., Woolrich, M. W., Baker, K., Colclough, G. L., & Astle, D. E.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- University of Oxford (GB)
- University of Cambridge (GB)
- Corresponding author
- Astle, Duncan E.
- Venue
- Developmental Science
- Publisher
- Wiley
- Published
- 2015-03-17
- Volume
- 19
- Issue
- 1
- Pages
- 19-31
- ISSN
- 1363-755X (ISSN-L)
- 1467-7687
- PMC
- PMC4832342
- OpenAlex
- W2081785818
- Cited by
- 32
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Developmental Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- British Academy
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- resting-state functional connectivity, working memory capacity, childhood, frontoparietal network, inferior temporal cortex, individual differences in cognitive ability, interindividual variability, functional MRI
- MeSH terms
- Brain, Brain Mapping, Child, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neural Pathways, Neuropsychological Tests, Magnetoencephalography, Electrophysiological Phenomena
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