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Cited by 74HIV-related health complications and treatmentsHIV/AIDS Research and InterventionsDiabetes, Cardiovascular Risks, and Lipoproteins

Incidence of diabetes mellitus in a population‐based cohort of HIV‐infected and non‐HIV‐infected persons: the impact of clinical and therapeutic factors over time

Tripathi, A., Liese, A. D., Jerrell, J. M., Zhang, J., Rizvi, A. A., Albrecht, H., Duffus, W. A.·2014·Diabetic Medicine
DOI 10.1111/dme.12455
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Abstract

Aims: To examine incidence density rate and correlates of incident diabetes mellitus in a cohort of HIV‐infected individuals compared with matched non‐HIV‐infected persons. Methods: Data were obtained from the South Carolina Medicaid system and the enhanced HIV/AIDS Reporting System surveillance database for persons ≥ 18 years of age who had been attended to during the period 1994 to 2011. Time‐dependent proportional hazards analysis and marginal structural models were used to analyse the data. Results: A total of 13 632 individuals (6816, 1:1 matched HIV‐infected and non‐HIV‐infected persons; median age 39 years; 57% male) contributed 88 359 person‐years of follow‐up. Incidence rate of diabetes was higher in the non‐HIV‐infected group compared with the HIV‐infected group (13.60 vs. 11.35 per 1000 person‐years). Multivariable hazards analysis suggested a significantly lower risk of incident diabetes among HIV‐infected persons treated with combination antiretroviral therapy compared with the matched non‐HIV‐infected persons (adjusted hazards ratio 0.55; 95% CI 0.46–0.65). Among HIV‐infected persons, marginal structural modelling suggested a significantly higher risk of diabetes with cumulative exposure to protease inhibitors over the observation period (adjusted relative risk 1.35; 95% CI 1.03–1.78), but this association was not significant for exposure to non‐nucleoside reverse transcriptase inhibitors. Overall, female gender, older age, non‐white race/ethnicity, and pre‐existing hypertension, dyslipidaemia, obesity and hepatitis C infection were associated with higher risk of diabetes incidence. Conclusions: HIV infection may not be independently associated with increased risk of diabetes. Among HIV‐infected persons, exposure to protease inhibitor‐based regimens may increase the risk of diabetes. Healthcare providers should make every effort to use combination antiretroviral therapy regimens with a better cardiometabolic profile.

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  • Incidence of type II diabetes is increased in individuals with HIV compared to general population.

    “Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”

    From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Tripathi et al, 2014

  • Exposure to antiretroviral therapy drives the association between HIV and increased type II diabetes incidence, rather than HIV infection per se.

    “Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”

    From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Tripathi et al, 2014

  • The association between HIV and increased type II diabetes incidence is independent of age and obesity.

    “Results were also independent on age or whether patients were obese, suggesting traditional risk factors are not involved (Tripathi et al, 2014; Samad et al, 2017; Hernandez‐Romieu et al, 2017).”

    From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Tripathi et al, 2014

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Authors
Tripathi, A., Liese, A. D., Jerrell, J. M., Zhang, J., Rizvi, A. A., Albrecht, H., & Duffus, W. A.
Affiliations
  • University of Mississippi Medical Center (US)
  • University of South Carolina (US)
Corresponding author
Tripathi, A.
ORCID
Venue
Diabetic Medicine
Publisher
Wiley
Published
2014-04-28
Volume
31
Issue
10
Pages
1185-1193
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1111/dme.12455
OpenAlex
W1994885749
Cited by
74
References
24
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 3 · 2014: 1
FWCI
8.89
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
diabetes incidence, HIV infection, highly active antiretroviral therapy, protease inhibitors, non-nucleoside reverse transcriptase inhibitors, cardiometabolic risk, hepatitis C coinfection, hypertension, dyslipidemia, obesity, racial and ethnic disparities, South Carolina
MeSH terms
Adult, Aged, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Medicaid, Middle Aged, Retrospective Studies, Risk Factors, South Carolina, United States, Cohort Studies, HIV Infections, Incidence, Proportional Hazards Models, HIV Protease Inhibitors, Anti-HIV Agents, Young Adult, Epidemiological Monitoring

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