Decreases in neprilysin and vasoconstrictors and increases in vasodilators following bariatric surgery
Abstract
The aim of this study was to determine if weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of the renin angiotensin system (RAS), catecholamines and endothelin-1, and also with an increase in the concentrations of vasodilators. Fasting blood samples were obtained from 15 patients with morbid obesity and diabetes prior to and 6 months after RYGB surgery. Circulating levels of neprilysin, vasoconstrictors, vasodilators, and the mRNA expression of related genes in circulating mononuclear cells (MNC) were measured. Six months after RYGB surgery the concentrations of neprilysin, angiotensinogen, angiotensin II, renin and endothelin-1 fell significantly by 27 ±16%, 22 ±10%, 22 ±8%, 35 ±13% and 17 ±6% (P < .05 for all), respectively, while ANP concentrations increased significantly by 24 ±13%. There was no significant change in aldosterone, BNP, cAMP or cGMP concentrations, or angiotensin converting enzyme (ACE) expression. These changes may contribute to the reduction of congestive cardiac failure and blood pressure risks after RYGB surgery.
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Bariatric surgery significantly increases atrial natriuretic peptide.
“We have shown that the levels of vasoconstrictors such as angiotensinogen, angiotensin II, renin, and endothelin-1 fall with bariatric surgery-induced weight loss while vasodilators such as atrial natriuretic peptide significantly increase after the surgery procedure [59].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [59]
Bariatric surgery-induced weight loss markedly lowers neprilysin.
“A marked fall in neprilysin, which is known to catalyze the degradation of natriuretic peptides, was also seen in our study [59], while no changes were seen in brain natriuretic peptide (BNP), cyclic guanosine monophosphate, and angiotensin-converting enzyme (ACE) levels.”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [59]
Bariatric surgery produces no changes in BNP, cyclic GMP, and ACE levels.
“A marked fall in neprilysin, which is known to catalyze the degradation of natriuretic peptides, was also seen in our study [59], while no changes were seen in brain natriuretic peptide (BNP), cyclic guanosine monophosphate, and angiotensin-converting enzyme (ACE) levels.”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [59]
Bariatric surgery-induced weight loss lowers levels of vasoconstrictors angiotensinogen, angiotensin II, renin, and endothelin-1.
“We have shown that the levels of vasoconstrictors such as angiotensinogen, angiotensin II, renin, and endothelin-1 fall with bariatric surgery-induced weight loss while vasodilators such as atrial natriuretic peptide significantly increase after the surgery procedure [59].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [59]
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- Authors
- Ghanim, H., Monte, S., Caruana, J., Green, K., Abuaysheh, S., & Dandona, P.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dandona, Paresh
- Venue
- Diabetes Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2018-05-02
- Volume
- 20
- Issue
- 8
- Pages
- 2029-2033
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2797258738
- Cited by
- 36
- References
- 17
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 4
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- neprilysin, Roux-en-Y gastric bypass, bariatric surgery, morbid obesity, weight loss, renin-angiotensin system, angiotensin II, endothelin-1, catecholamines, vasodilators, atrial natriuretic peptide, angiotensinogen, circulating mononuclear cells, diabetes mellitus, congestive heart failure, blood pressure
- MeSH terms
- Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Heart Failure, Glycated Hemoglobin, Humans, Hypertension, Insulin Resistance, Male, Middle Aged, Obesity, Morbid, Postoperative Period, Prospective Studies, Renin-Angiotensin System, Risk, Neprilysin, Weight Loss, Body Mass Index, Endothelin-1, Bariatric Surgery, Diabetic Cardiomyopathies
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