Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis
Open accessAbstract
Context: The intake of macronutrients as components of a Western dietary pattern leads to oxidative stress and inflammation. Evidence Acquisition: Data were largely retrieved from our previous and most recent work. PubMed and Google Scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin resistance, obesity, and atherogenesis. The most relevant, high-quality articles were included in our review. Evidence Synthesis: Our previous work has demonstrated the molecular mechanisms of macronutrient-mediated oxidative stress and inflammation. With the induction of inflammation, proinflammatory molecules potentially interfere with insulin signal transduction, thus causing insulin resistance. In addition, other molecules promote atherogenic inflammation. More recently, our work has also shown that certain foods are noninflammatory or anti-inflammatory and thus, do not interfere with insulin signaling. Finally, as obesity is induced by chronic excessive caloric intake, it is characterized by an increase in the expression of proinflammatory molecules, which are induced acutely by a Western diet. Caloric restriction, including fasting, is associated with a reduction in oxidative and inflammatory stress. Conclusions: This review summarizes and attempts to provide an up-to-date profile of the molecular mechanisms involved in macronutrient-mediated oxidative/inflammatory stress and its potential consequences. An understanding of these underlying mechanisms is crucial for making appropriate dietary choices.
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High-protein and low-carbohydrate diets improve satiety, preserve muscle mass, and reduce insulin resistance and hyperandrogenism.
“High-protein and low-carbohydrate diets improve satiety, preserve muscle mass, and reduce insulin resistance and hyperandrogenism [15, 16].”
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- Authors
- Biobaku, F., Ghanim, H., Batra, M., & Dandona, P.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dandona, Paresh
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2019-06-20
- Volume
- 104
- Issue
- 12
- Pages
- 6118-6128
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2951964451
- Cited by
- 104
- References
- 90
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 10 · 2023: 21 · 2022: 25 · 2021: 12 · 2020: 12
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Eli Lilly and Company
- GlaxoSmithKline
- Sanofi
- Novo Nordisk
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- macronutrients, dietary inflammation, oxidative stress, insulin resistance, obesity, atherogenesis, Western diet, insulin signaling, caloric restriction, fasting, anti-inflammatory foods, proinflammatory molecules
- MeSH terms
- Nutrients, Animals, Diet, Humans, Inflammation, Insulin Resistance, Obesity, Risk Factors, Oxidative Stress, Inflammation Mediators, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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