Cited by 104Adipokines, Inflammation, and Metabolic DiseasesNutritional Studies and DietDiet, Metabolism, and Disease

Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

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Biobaku, Fatimo, Ghanim, Husam, Batra, Manav, Dandona, Paresh·2019·The Journal of Clinical Endocrinology & Metabolism

Abstract

Context: The intake of macronutrients as components of a Western dietary pattern leads to oxidative stress and inflammation. Evidence Acquisition: Data were largely retrieved from our previous and most recent work. PubMed and Google Scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin resistance, obesity, and atherogenesis. The most relevant, high-quality articles were included in our review. Evidence Synthesis: Our previous work has demonstrated the molecular mechanisms of macronutrient-mediated oxidative stress and inflammation. With the induction of inflammation, proinflammatory molecules potentially interfere with insulin signal transduction, thus causing insulin resistance. In addition, other molecules promote atherogenic inflammation. More recently, our work has also shown that certain foods are noninflammatory or anti-inflammatory and thus, do not interfere with insulin signaling. Finally, as obesity is induced by chronic excessive caloric intake, it is characterized by an increase in the expression of proinflammatory molecules, which are induced acutely by a Western diet. Caloric restriction, including fasting, is associated with a reduction in oxidative and inflammatory stress. Conclusions: This review summarizes and attempts to provide an up-to-date profile of the molecular mechanisms involved in macronutrient-mediated oxidative/inflammatory stress and its potential consequences. An understanding of these underlying mechanisms is crucial for making appropriate dietary choices.

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Crossref · 10.1210/jc.2018-01833

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Authors
Biobaku, F., Ghanim, H., Batra, M., & Dandona, P.
Affiliations
University at Buffalo, State University of New York (US)
Corresponding author
Dandona, Paresh
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2019-06-20
Volume
104
Issue
12
Pages
6118-6128
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2951964451
Cited by
104
References
90
Citations by year
2026: 7 · 2025: 17 · 2024: 10 · 2023: 21 · 2022: 25 · 2021: 12 · 2020: 12
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • Eli Lilly and Company
  • GlaxoSmithKline
  • Sanofi
  • Novo Nordisk
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
macronutrients, dietary inflammation, oxidative stress, insulin resistance, obesity, atherogenesis, Western diet, insulin signaling, caloric restriction, fasting, anti-inflammatory foods, proinflammatory molecules
MeSH terms
Nutrients, Animals, Diet, Humans, Inflammation, Insulin Resistance, Obesity, Risk Factors, Oxidative Stress, Inflammation Mediators, Atherosclerosis

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