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Cited by 17Dermatological diseases and infestationsDermatology and Skin DiseasesParasitic Diseases Research and Treatment

Clinical efficacy and safety of topical versus oral ivermectin in treatment of uncomplicated scabies

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Ahmad, Hesham M., Abdel-Azim, Eman S., Abdel-Aziz, Rasha T.·2016·Dermatologic Therapy
DOI 10.1111/dth.12310
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Abstract

Many medications are available for scabies treatment including oral and topical ivermectin. However, studies comparing these two forms as a scabies treatment are few. This study compares efficacy and safety of topical versus oral ivermectin as scabies treatment. The study included 62 confirmed uncomplicated scabies patients, divided into: Group I (32 patients, received topical ivermectin) and Group II (30 patients, received oral ivermectin). Patients were assessed, clinically and by KOH smear at 1, 2 and 4 weeks. Treatment was repeated after one week in patients with persistent infection. Adverse events were recorded. Most patients (87.5% and 73.5% in group I and group II respectively) were symptom free after a single treatment. A second treatment was required in 4 patients of group I and 8 patients of group II. However, 2 weeks after treatment symptoms and signs completely resolved in all cases with no recurrence at 4 weeks. This study suggests that both topical and oral ivermectin are safe and equally effective in treatment of uncomplicated scabies. Single treatment, whether topical or oral, is associated with high cure rate in a week post treatment. However, repeating treatment after one week may be required to achieve 100% cure.

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  • Topical permethrin and oral and topical ivermectin have similar efficacy for cure of scabies.

    “Topical permethrin and oral and topical ivermectin have similar efficacy for cure of scabies (1405–1410).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1410]

    The Discussion reports that topical and oral ivermectin were equally effective for uncomplicated scabies, with no statistically significant difference in cure rates after one treatment. The study did not compare either treatment with topical permethrin, so it does not establish similar efficacy across all three treatments. (LLM, conf=0.90)

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Research works printed but not linked: 2

  1. Monsel G, Chosidow O. Management of scabies. Skin Therapy Lett 2012: 17(3): 1-4.
  2. Chosidow O. Clinical practice. Scabies. N Engl J Med 2006: 354(16): 1718-1727.

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Authors
Ahmad, H. M., Abdel-Azim, E. S., & Abdel-Aziz, R. T.
Affiliations
  • Minia University (EG)
  • Department of Dermatology and Venereology, Faculty of Medicine; Minia University; Egypt
Corresponding author
Ahmad, Hesham M.
ORCID
Abdel-Aziz, Rasha T.
Venue
Dermatologic Therapy
Publisher
Hindawi Limited
Published
2015-11-11
Volume
29
Issue
1
Pages
58-63
ISSN
1396-0296 (ISSN-L)
DOI
10.1111/dth.12310
OpenAlex
W2110993585
Cited by
17
References
18
Citations by year
2026: 2 · 2025: 2 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 1
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations
  • Dermatologic Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
scabies, ivermectin, topical ivermectin, oral ivermectin, treatment efficacy, treatment safety, adverse events, cure rate, persistent infection, single-dose therapy
MeSH terms
Administration, Cutaneous, Administration, Oral, Adolescent, Adult, Aged, Antiparasitic Agents, Child, Child, Preschool, Drug Administration Schedule, Egypt, Female, Humans, Ivermectin, Male, Middle Aged, Remission Induction, Scabies, Skin, Time Factors, Treatment Outcome, Young Adult

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