Cited by 181Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

Iron homeostasis in the metabolic syndrome

Datz, Christian, Felder, Thomas K., Niederseer, David, Aigner, Elmar·2013·European Journal of Clinical Investigation

Abstract

The metabolic syndrome (MetS) affects iron homeostasis in a many‐faceted fashion. On the one side, hyperferritinaemia with normal or mildly elevated transferrin saturation is observed in approximately one‐third of patients with non‐alcoholic fatty liver disease (NAFLD) or the MetS. This constellation has been named the ‘dysmetabolic iron overload syndrome (DIOS)’. Current evidence suggests that elevated body iron stores exert a detrimental effect on the clinical course of obesity‐related conditions and that iron removal improves insulin sensitivity and delays the onset of T2 DM. On the other side, iron deficiency is a frequent finding in more progressed stages of obesity. The mechanisms underlying the DIOS and obesity‐related iron deficiency appear strikingly similar as elevated hepcidin concentrations, low expression of duodenal ferroportin (FPN) and impaired iron absorption are found in both conditions. This review summarizes the current knowledge about the dysregulation of iron homeostasis in the MetS and particularly in its hepatic manifestation NAFLD.

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Crossref · 10.1111/eci.12032

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  • Iron deficiency and obesity are molecularly linked and mutually affect each other.

    “It has become clear that iron deficiency and obesity do not merely represent the coincidence of two frequent conditions but are molecularly linked and mutually affect each other [2].”

    From Obesity as an emerging risk factor for iron deficiency (2014) · cites this paper as [2]

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Authors
Datz, C., Felder, T. K., Niederseer, D., & Aigner, E.
Affiliations
  • Krankenhaus Oberndorf (AT)
  • Paracelsus Medical University (AT)
Corresponding author
  • Datz, Christian
  • Aigner, Elmar
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
2013-01-07
Volume
43
Issue
2
Pages
215-224
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
OpenAlex
W2030921687
Cited by
181
References
76
Citations by year
2026: 8 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 22 · 2021: 14 · 2020: 15 · 2019: 8 · 2018: 14 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 22 · 2013: 5 · 2012: 1
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
iron homeostasis, metabolic syndrome, hyperferritinemia, transferrin saturation, non-alcoholic fatty liver disease, obesity, iron deficiency, hepcidin, ferroportin, iron absorption, insulin sensitivity, type 2 diabetes
MeSH terms
Ferroportin, Fatty Liver, Homeostasis, Humans, Iron, Obesity, Biomarkers, Anemia, Iron-Deficiency, Iron Overload, Antimicrobial Cationic Peptides, Metabolic Syndrome, Cation Transport Proteins, Hepcidins, Non-alcoholic Fatty Liver Disease

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