Iron homeostasis in the metabolic syndrome
Abstract
The metabolic syndrome (MetS) affects iron homeostasis in a many‐faceted fashion. On the one side, hyperferritinaemia with normal or mildly elevated transferrin saturation is observed in approximately one‐third of patients with non‐alcoholic fatty liver disease (NAFLD) or the MetS. This constellation has been named the ‘dysmetabolic iron overload syndrome (DIOS)’. Current evidence suggests that elevated body iron stores exert a detrimental effect on the clinical course of obesity‐related conditions and that iron removal improves insulin sensitivity and delays the onset of T2 DM. On the other side, iron deficiency is a frequent finding in more progressed stages of obesity. The mechanisms underlying the DIOS and obesity‐related iron deficiency appear strikingly similar as elevated hepcidin concentrations, low expression of duodenal ferroportin (FPN) and impaired iron absorption are found in both conditions. This review summarizes the current knowledge about the dysregulation of iron homeostasis in the MetS and particularly in its hepatic manifestation NAFLD.
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Iron deficiency and obesity are molecularly linked and mutually affect each other.
“It has become clear that iron deficiency and obesity do not merely represent the coincidence of two frequent conditions but are molecularly linked and mutually affect each other [2].”
From Obesity as an emerging risk factor for iron deficiency (2014) · cites this paper as [2]
Cites
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Adams, L. A., Lymp, J. F., St. Sauver, J., Sanderson, S. O., Lindor, K. D., Feldstein, A., & Angulo, P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.014 · Cited by 2,890 · see citing works
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123 · see citing works
Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736 · see citing works
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267 · see citing works
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084 · see citing works
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974 · see citing works
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969 · see citing works
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydınok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.130 · Cited by 675 · see citing works
George, D. K., Goldwurm, S., Macdonald, G. A., Cowley, L. L., Walker, N. I., Ward, P. J., Jazwinska, E. C., & Powell, L. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70482-2 · Cited by 655 · see citing works
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H., Subramaniam, V. N., Powell, L. W., Anderson, G. J., & Ramm, G. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12602-5 · Cited by 620 · see citing works
Body Iron Stores in Relation to Risk of Type 2 Diabetes in Apparently Healthy Women
Jiang, R. (2004) · JAMA · doi:10.1001/jama.291.6.711 · Cited by 598 · see citing works
The serine protease TMPRSS6 is required to sense iron deficiency
Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., et al. (2008) · Science · doi:10.1126/science.1157121 · Cited by 578 · see citing works
Kowdley, K. V., Belt, P. H., Wilson, L., Yeh, M. M., Neuschwander‐Tetri, B. A., Chalasani, N., Sanyal, A. J., & Nelson, J. E. (2011) · Hepatology · doi:10.1002/hep.24706 · Cited by 541 · see citing works
Bekri, S., Gual, P., Anty, R., Luciani, N., Dahman, M., Ramesh, B., Iannelli, A., Staccini–Myx, A., Casanova, D., Ben Amor, I., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.007 · Cited by 496 · see citing works
Insulin resistance–associated hepatic iron overload
Mendler, M.-H., Turlin, B., Moirand, R., Jouanolle, A., Sapey, T., Guyader, D., Gall, J. L., Brissot, P., David, V., & Deugnier, Y. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70401-4 · Cited by 493 · see citing works
Bugianesi, E., Manzini, P. M., D’Antico, S., Vanni, E., Longo, F., Leone, N., Massarenti, P., Piga, A. G., Marchesini, G., & Rizzetto, M. (2004) · Hepatology · doi:10.1002/hep.20023 · Cited by 436 · see citing works
Diabetes and serum ferritin concentration among U.S. adults.
Ford, E. S., & Cogswell, M. E. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1978 · Cited by 419 · see citing works
Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target
Dongiovanni, P., Fracanzani, A. L., Fargion, S. R., & Valenti, L. V. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.008 · Cited by 360 · see citing works
Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195503 · Cited by 352 · see citing works
De Domenico, I., Ward, D. M., di Patti, M. C. B., Jeong, S. Y., David, S., Musci, G., & Kaplan, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601735 · Cited by 350 · see citing works
Blood Letting in High-Ferritin Type 2 Diabetes
Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., Hernández‐Aguado, I., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1000 · Cited by 333 · see citing works
Zacharski, L. R., Chow, B. K., Howes, P. S., Shamayeva, G., Baron, J. A., Dalman, R. L., Malenka, D. J., Ozaki, C. K., & Lavori, P. W. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn209 · Cited by 304 · see citing works
Valenti, L. V. C., Fracanzani, A. L., Dongiovanni, P., Bugianesi, E., Marchesini, G., Manzini, P. M., Vanni, E., & Fargion, S. R. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01192.x · Cited by 289 · see citing works
Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease
Duffy, S. J., Biegelsen, E. S., Holbrook, M., Russell, J. D., Gokce, N., Keaney, J. F., & Vita, J. A. (2001) · Circulation · doi:10.1161/01.cir.103.23.2799 · Cited by 271 · see citing works
Chitturi, S., Weltman, M., Farrell, G. C., McDonald, D., Liddle, C., Samarasinghe, D., Lin, R., Abeygunasekera, S., & George, J. (2002) · Hepatology · doi:10.1053/jhep.2002.33892 · Cited by 246 · see citing works
Kawabata, H., Fleming, R. E., Gui, D., Moon, S. Y., Saitoh, T., O’Kelly, J., Umehara, Y., Wano, Y., SAID, J. W., & Koeffler, H. P. (2004) · Blood · doi:10.1182/blood-2004-04-1416 · Cited by 238 · see citing works
Fargion, S., Mattioli, M., Fracanzani, A. L., Sampietro, M., Tavazzi, D., Fociani, P., Taioli, E., Valenti, L. V. C., & Fiorelli, G. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04052.x · Cited by 233 · see citing works
Hemochromatosis: An endocrine liver disease
Pietrangelo, A. (2007) · Hepatology · doi:10.1002/hep.21886 · Cited by 212 · see citing works
Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
Aigner, E., Theurl, I., Theurl, M., Lederer, D., Haufe, H., Dietze, O., Strasser, M., Datz, C., & Weiss, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1374 · Cited by 190 · see citing works
Self-citationLeptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells
Chung, B., Matak, P., McKie, A. T., & Sharp, P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2366 · Cited by 186 · see citing works
Sorrentino, P., D’Angelo, S., Ferbo, U., Micheli, P., Bracigliano, A., & Vecchione, R. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.09.011 · Cited by 182 · see citing works
Serum Ferritin Is Associated With Visceral Fat Area and Subcutaneous Fat Area
Iwasaki, T., Nakajima, A., Yoneda, M., Yamada, Y., Mukasa, K., Fujita, K., Fujisawa, N., Wada, K., & Terauchi, Y. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2486 · Cited by 171 · see citing works
Dongiovanni, P., Valenti, L. V. C., Fracanzani, A. L., Gatti, S., Cairo, G., & Fargion, S. R. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070097 · Cited by 169 · see citing works
Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease
Aigner, E. S., Theurl, I., Haufe, H., Seifert, M., Hohla, F., Scharinger, L., Stickel, F., Mourlane, F., Weiß, G., & Datz, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.007 · Cited by 163 · see citing works
Self-citationWrede, C. E., Buettner, R., Bollheimer, L. C., Schölmerich, J., Palitzsch, K.-D., & Hellerbrand, C. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02083 · Cited by 161 · see citing works
The relationship between obesity and hypoferraemia in adults: A systematic review
Cheng, H. L., Bryant, C., Cook, R., O'Connor, H., Rooney, K., & Steinbeck, K. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00938.x · Cited by 159 · see citing works
Iron Stores, Blood Donation, and Insulin Sensitivity and Secretion
Fernández‐Real, J. M., López‐Bermejo, A., & Ricart, W. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.046847 · Cited by 154 · see citing works
Otogawa, K., Kinoshita, K., Fujii, H., Sakabe, M., Shiga, R., Nakatani, K., Ikeda, K., Nakajima, Y., Ikura, Y., Ueda, M., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060441 · Cited by 153 · see citing works
Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations
Dallalio, G. A., Law, E., & Means, R. T. (2005) · Blood · doi:10.1182/blood-2005-07-2854 · Cited by 147 · see citing works
Histologic Features of the Liver in Insulin Resistance–Associated Iron Overload
Turlin, B., Mendler, M. H., Moirand, R., Guyader, D., Guillygomarc’h, A., & Deugnier, Y. (2001) · American Journal of Clinical Pathology · doi:10.1309/wwne-kw2c-4ktw-ptj5 · Cited by 140 · see citing works
Gestational diabetes mellitus in the last trimester – a feature of maternal iron excess?
Lao, T. T., Chan, P. L., & Tam, K. F. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00453.x · Cited by 137 · see citing works
Effect of Phlebotomy on Plasma Glucose and Insulin Concentrations
Facchini, F. S. (1998) · Diabetes Care · doi:10.2337/diacare.21.12.2190a · Cited by 126 · see citing works
Transferrin and iron induce insulin resistance of glucose transport in adipocytes
Green, A., Basile, R., & Rumberger, J. M. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.015 · Cited by 111 · see citing works
Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload
Barisani, D., Pelucchi, S., Mariani, R., Galimberti, S., Trombini, P., Fumagalli, D., Meneveri, R., Nemeth, E., Ganz, T., & Piperno, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.03.011 · Cited by 106 · see citing works
Valenti, L. V. C., Dongiovanni, P., Fracanzani, A. L., Santorelli, G., Fatta, E., Bertelli, C., Taioli, E., Fiorelli, G., & Fargion, S. (2003) · Digestive and Liver Disease · doi:10.1016/s1590-8658(03)00025-2 · Cited by 98 · see citing works
Ruivard, M., Lainé, F., Ganz, T., Olbina, G., Westerman, M., Nemeth, E., Rambeau, M., Mazur, A., Gerbaud, L., Tournilhac, V., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.029 · Cited by 89 · see citing works
Venesection therapy of insulin resistance-associated hepatic iron overload
Guillygomarc’h, A., Mendler, M. H., Moirand, R., Lainé, F., Quentin, V., David, V., Brissot, P., & Deugnier, Y. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00147-7 · Cited by 89 · see citing works
Luque‐Ramírez, M., Álvarez‐Blasco, F., Botella-Carretero, J. I., Sánchón, R., Millán, J. L. S., & Escobar-Morreale, H. F. (2007) · Diabetes Care · doi:10.2337/dc07-0642 · Cited by 88 · see citing works
Body Iron Stores and Glucose Intolerance in Premenopausal Women
Martínez-García, M. Á., Luque‐Ramírez, M., San‐Millán, J. L., & Escobar-Morreale, H. F. (2009) · Diabetes Care · doi:10.2337/dc09-0420 · Cited by 83 · see citing works
Serum Ferritin Concentration Predicts Mortality in Patients Awaiting Liver Transplantation
Walker, N. M., Stuart, K. A., Ryan, R. J., Desai, S., Saab, S., Nicol, J. A., Fletcher, L. M., & Crawford, D. H. (2010) · Hepatology · doi:10.1002/hep.23537 · Cited by 79 · see citing works
Yokomori, N., Iwasa, Y., Aida, K., INOUE, M., Tawata, M., & Onaya, T. (1991) · Endocrinology · doi:10.1210/endo-128-3-1474 · Cited by 77 · see citing works
Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations
Aigner, E. S., Felder, T. K., Oberkofler, H., Hahne, P., Auer, S., Soyal, S. M., Stadlmayr, A., Schwenoha, K., Pirich, C., Hengster, P., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.02.017 · Cited by 75 · see citing works
Self-citationValenti, L. V. C., Canavesi, E., Galmozzi, E., Dongiovanni, P., Rametta, R., Maggioni, P., Maggioni, M., Fracanzani, A. L., & Fargion, S. R. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.023 · Cited by 64 · see citing works
Ramakrishnan, U., Kuklina, E. V., & Stein, A. D. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1256 · Cited by 63 · see citing works
Abraham, D., Rogers, J., Gault, P. M., Kushner, J. P., & McClain, D. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0445-7 · Cited by 63 · see citing works
Fernández‐Real, J. M., Moreno‐Navarrete, J. M., Chico, B., López‐Bermejo, A., & Ricart, W. (2007) · Diabetes Care · doi:10.2337/dc06-1581 · Cited by 55 · see citing works
Nelson, J. E., Brunt, E. M., & Kowdley, K. V. (2012) · Hepatology · doi:10.1002/hep.25856 · Cited by 54 · see citing works
Piperno, A., Vergani, A., Salvioni, A., Trombini, P., Viganò, M., Riva, A., Zoppo, A., Boari, G., & Mancia, G. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0988.x · Cited by 50 · see citing works
The iron-heart disease connection: is it dead or just hiding?
Wood, R. J. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.04.002 · Cited by 49 · see citing works
Treatment of hyperferritinemia
Beaton, M. D., & Adams, P. C. (2012) · Annals of Hepatology · doi:10.1016/s1665-2681(19)30923-8 · Cited by 47 · see citing works
Galan, P., Noisette, N., Estaquio, C., Czernichow, S., Mennen, L. I., Renversez, J., Briançon, S., Favier, A. E., & Herçberg, S. (2006) · Public Health Nutrition · doi:10.1079/phn2005826 · Cited by 46 · see citing works
Weismüller, T. J., Kirchner, G. I., Scherer, M. N., Negm, A. A., Schnitzbauer, A. A., Lehner, F., Klempnauer, J. L., Schlitt, H. J., Manns, M. P., & Strassburg, C. P. (2010) · Hepatology · doi:10.1002/hep.24635 · Cited by 45 · see citing works
Fernández‐Real, J. M., Moreno‐Navarrete, J. M., & Ricart, W. (2008) · Diabetes · doi:10.2337/db08-0041 · Cited by 44 · see citing works
Valenti, L. V. C., Fracanzani, A. L., & Fargion, S. R. (2003) · Gastroenterology · doi:10.1053/gast.2003.50130 · Cited by 42 · see citing works
Hemochromatosis gene and nonalcoholic fatty liver disease: A systematic review and meta-analysis
Hernáez, R., Yeung, E. H., Clark, J. M., Kowdley, K. V., Brancati, F. L., & Kao, W. H. L. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.013 · Cited by 36 · see citing works
Reduction of Macroalbuminuria With Pentoxifylline in Diabetic Nephropathy: Report of three cases
Gorson, D. M. (1998) · Diabetes Care · doi:10.2337/diacare.21.12.2190b · Cited by 36 · see citing works
Ku, B. J., Kim, S.-Y., Lee, T., & Park, K. S. (2009) · Disease Markers · doi:10.1155/2009/931082 · Cited by 35 · see citing works
Iron stores, liver transaminase levels and metabolic risk in healthy teenagers
Aigner, E. S., Hinz, C., Steiner, K., Rossmann, B., Pfleger, J., Hohla, F., Steger, B., Stadlmayr, A., Patsch, W., & Datz, C. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02238.x · Cited by 31 · see citing works
Self-citationKu, B.-J., Kim, S.-Y., Lee, T., et al. (2009) · PubMed · doi:10.3233/dma-2009-0676 · Cited by 31 · see citing works
The risk factors of fibrosis in nonalcoholic steatohepatitis.
Fierbinteanu-Braticevici, C. G., Benguș, A., Neamţu, M., & Usvat, R. (2002) · PubMed · Cited by 22 · see citing works
Dubern, B., GIRARDET, J. P., & Tounian, P. (2006) · International Journal of Pediatric Obesity · doi:10.1080/17477160600569594 · Cited by 20 · see citing works
Grace, N. D. (1973) · Postgraduate Medicine · doi:10.1080/00325481.1973.11713342 · Cited by 15 · see citing works
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Ponikowski, P. P., van Veldhuisen, D. J., Colet, J. C., Ertl, G., Michel Komajda, N., VIu, M., McDonagh, T. A., Parkhomenko, A. N., Tavazzi, L., Levesque, V., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu385 · Cited by 1,240 · see citing works
The multifaceted role of ferroptosis in liver disease
Chen, J., Li, X., Ge, C., Min, J., & Wang, F. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00941-0 · Cited by 679 · see citing works
Kell, D. B., & Pretorius, E. (2014) · Metallomics · doi:10.1039/c3mt00347g · Cited by 667 · see citing works
Obesity as an emerging risk factor for iron deficiency
Aigner, E., Feldman, A., & Datz, C. (2014) · Nutrients · doi:10.3390/nu6093587 · Cited by 328 · see citing works
Self-citationEid, R., Arab, N. T. T., & Greenwood, M. T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.12.002 · Cited by 286 · see citing works
Li, X., Wang, T., Huang, X., Li, Y., Sun, T., Zang, S., Guan, K., Xiong, Y., Liu, J., & Yuan, H. (2020) · Liver International · doi:10.1111/liv.14428 · Cited by 279 · see citing works
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Milić, S., Mikolašević, I., Orlić, L., Devcic, E., Čizmarević, N. S., Štimac, D., Kapović, M., & Ristič, S. (2016) · Medical Science Monitor · doi:10.12659/msm.896494 · Cited by 244 · see citing works
Jankowska, E. A., Kasztura, M., Sokolski, M., Bronisz, M., Nawrocka, S., kowska-Florek, W. O., ski, R. Z., Biegus, J., owski, P. S., Banasiak, W., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu235 · Cited by 242 · see citing works
Piper, J. D., & Piper, P. W. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12284 · Cited by 202 · see citing works
Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders
Steinbicker, A. U., & Muckenthaler, M. U. (2013) · Nutrients · doi:10.3390/nu5083034 · Cited by 196 · see citing works
Hsu, C. C.-S., Senussi, N. H., Fertrin, K. Y., & Kowdley, K. V. (2022) · Hepatology Communications · doi:10.1002/hep4.2012 · Cited by 155 · see citing works
Iron overload: Effects on cellular biochemistry
Nogueira, L. S., Oliveira, M. M., Pessoa, M. T., & Barbosa, L. A. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.029 · Cited by 144 · see citing works
Hyperferritinemia—A Clinical Overview
Sandnes, M., Ulvik, R. J., Vorland, M., & Reikvam, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10092008 · Cited by 139 · see citing works
Epidemiological associations between iron and cardiovascular disease and diabetes
Basuli, D., Stevens, R. G., Torti, F. M., & Torti, S. V. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00117 · Cited by 119 · see citing works
Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress
Backe, M. B., Moen, I. W., Ellervik, C., Hansen, J. B., & Mandrup-Poulsen, T. R. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050939 · Cited by 116 · see citing works
Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver
Aigner, E. S. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v7.i2.177 · Cited by 113 · see citing works
Self-citationIron Deficiency in Obesity and after Bariatric Surgery
Bjørklund, G., Peana, M., Pivina, L., Dosa, A., Aaseth, J., Semenova, Y., Chirumbolo, S., Medici, S., Dadar, M., & Costea, D.-O. (2021) · Biomolecules · doi:10.3390/biom11050613 · Cited by 99 · see citing works
Iron overload inhibits late stage autophagic flux leading to insulin resistance
Jahng, J. W. S., Alsaadi, R. M., Palanivel, R., Song, E., Hipolito, V. E. B., Sung, H. K., Botelho, R. J., Russell, R. C., & Sweeney, G. (2019) · EMBO Reports · doi:10.15252/embr.201947911 · Cited by 95 · see citing works
The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice
Ingvorsen, C., Karp, N. A., & Lelliott, C. J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.6 · Cited by 88 · see citing works
Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Ponikowska, B., Suchocki, T., Paleczny, B., Olesińska‐Mader, M., Powierza, S., Borodulin-Nadzieja, L., Reczuch, K. W., von Haehling, S., Doehner, W., Anker, S. D., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0528 · Cited by 81 · see citing works
Sahay, M., Kalra, S., Badani, R. S., Bantwal, G., Bhoraskar, A., Das, A. K., Dhorepatil, B., Ghosh, S. K., Jeloka, T. K., Khandelwal, D., et al. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.04.026 · Cited by 77 · see citing works
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease
Magdaleno, F., Blajszczak, C. C., & Nieto, N. (2017) · Biomolecules · doi:10.3390/biom7010009 · Cited by 75 · see citing works
Mutual interaction between iron homeostasis and obesity pathogenesis
Nikonorov, A. А., Геннадиевна, С. М., Tinkov, A. A., & Skalny, A. V. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.05.005 · Cited by 72 · see citing works
Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease
Arndt, S., Wacker, E., Dorn, C., Koch, A., Saugspier, M., Thasler, W. E., Hartmann, A., Bosserhoff, A., & Hellerbrand, C. (2014) · Gut · doi:10.1136/gutjnl-2014-306968 · Cited by 66 · see citing works
Body mass index, iron absorption and iron status in childbearing age women
Mujica-Coopman, M. F., Brito, A., López de Romaña, D., Pizarro, F., & Olivares, M. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.03.008 · Cited by 61 · see citing works
Risk of Iron Overload in Obesity and Implications in Metabolic Health
Heslin, A. M., O’Donnell, A., Buffini, M., Nugent, A. P., Walton, J., Flynn, A., & McNulty, B. A. (2021) · Nutrients · doi:10.3390/nu13051539 · Cited by 58 · see citing works
Puri, N., Arefiev, Y., Chao, R., Sacerdoti, D., Chaudry, H., Nichols, A., Srikanthan, K., Nawab, A., Sharma, D. L., Lakhani, V., et al. (2017) · Journal of Nutrition and Metabolism · doi:10.1155/2017/4964571 · Cited by 56 · see citing works
Lower intake of magnesium and dietary fiber increases the incidence of type 2 diabetes in Taiwanese
Weng, L.-C. C., Lee, N.-J., Yeh, W., Ho, L.-T., & Pan, W. (2012) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2012.07.038 · Cited by 55 · see citing works
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
Folgueras, A. R., Freitas‐Rodríguez, S., Ramsay, A. J., Garabaya, C., Rodríguez, F. J., Velasco, G., & López-Otı́n, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03853-1 · Cited by 50 · see citing works
He, H., Liao, S., Zeng, Y., Liang, L., Chen, J., & Tao, C. (2022) · Liver International · doi:10.1111/liv.15455 · Cited by 46 · see citing works
Bone marrow iron depletion is common in patients with coronary artery disease
Jankowska, E. A., Wojtas, K., Kasztura, M., Mazur, G. J., Butrym, A. K., Kalicińska, E., Rybińska, I., Skiba, J., von Haehling, S., Doehner, W., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.10.006 · Cited by 46 · see citing works
The role of iron homeostasis in adipocyte metabolism
Wan, M., Jia, L., Xiong, Q., Feng, Y., & Du, H. (2021) · Food & Function · doi:10.1039/d0fo03442h · Cited by 45 · see citing works
The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease
Feldman, A., Aigner, E. S., Weghuber, D., & Paulmichl, K. (2015) · BioMed Research International · doi:10.1155/2015/287401 · Cited by 45 · see citing works
Self-citationStechemesser, L., Eder, S. K., Wagner, A., Patsch, W., Feldman, A., Straßer, M., Auer, S., Niederseer, D., Huber-Schönauer, U., Paulweber, B., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.006 · Cited by 45 · see citing works
Self-citationIs Correction of Iron Deficiency a New Addition to the Treatment of the Heart Failure?
Silverberg, D. S., Wexler, D., & Schwartz, D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160614056 · Cited by 42 · see citing works
Marmur, J., Beshara, S., Eggertsen, G., Onelöv, L., Albiin, N., Danielsson, O., Hultcrantz, R. W., & Stal, P. I. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0804-0 · Cited by 41 · see citing works
Iron Reshapes the Gut Microbiome and Host Metabolism
Botta, A. M., Barra, N. G., Lam, N. H., Chow, S., Pantopoulos, K., Schertzer, J. D., & Sweeney, G. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.2.160 · Cited by 39 · see citing works
Molecular pathogenesis and clinical consequences of iron overload in liver cirrhosis
Sikorska, K., Bernat, A., & Wróblewska, A. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60135-2 · Cited by 40 · see citing works
Kitamura, N., Yokoyama, Y., Taoka, H., Nagano, U., Hosoda, S., Taworntawat, T., Nakamura, A., Ogawa, Y., Tsubota, K., & 渡辺, 光. (2021) · Scientific Reports · doi:10.1038/s41598-021-89673-8 · Cited by 41 · see citing works
Taubert, R., Hardtke‐Wolenski, M., Noyan, F., Lalanne, C., Jonigk, D. D., Schlué, J., Krech, T., Lichtinghagen, R., Falk, C. S., Schlaphoff, V., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179074 · Cited by 38 · see citing works
Iron as a therapeutic target in chronic liver disease
Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i4.616 · Cited by 40 · see citing works
Kim, J. W., Kang, K. M., Yoon, T. K., Shim, S. H., & Lee, W. S. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.04.031 · Cited by 37 · see citing works
Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice
Li, Y., Jiang, W., Feng, Y. M., Wu, L., Jia, Y., & Zhao, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116263 · Cited by 37 · see citing works
Inflammation and iron status in bariatric surgery candidates
Careaga, M., Moizé, V., Flores, L., Deulofeu, R., Andreu, A., & Vidal, J. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.09.028 · Cited by 36 · see citing works
Potaczek, D. P., Jankowska, E. A., Wypasek, E., & Undas, A. (2016) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.3311 · Cited by 32 · see citing works
Hepatic iron content is independently associated with serum hepcidin levels in subjects with obesity
Moreno‐Navarrete, J. M., Moreno, M., Puig, J., Blasco, G., Ortega, F. J., Xifra, G., Ricart, W., & Fernández‐Real, J. M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.022 · Cited by 32 · see citing works
Chen, Q., Gao, M., Yang, H., Mei, L., Zhong, R., Han, P., Liu, P., Zhao, L., Wang, J., & Li, J. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02098-z · Cited by 32 · see citing works
Herter‐Aeberli, I., Thankachan, P., Bose, B., & Kurpad, A. V. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1048-1 · Cited by 32 · see citing works
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
Liao, W., Yang, W., Shen, Z., Ai, W., Pan, Q., Sun, Y., & Guo, S. (2021) · Diabetes · doi:10.2337/db20-0954 · Cited by 31 · see citing works
Mechanisms and Regulation of Intestinal Iron Transport
Collins, J. F., Flores, S. R., Wang, X., & Anderson, G. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00060-8 · Cited by 30 · see citing works
Yang, H., Kong, B., Shuai, W., Zhang, J., & Huang, H. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154086 · Cited by 29 · see citing works
Kanagasabai, T., Alkhalaqi, K., Churilla, J. R., & Ardern, C. I. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0080 · Cited by 28 · see citing works
Yan, Y., Zhang, W., Wang, Y., Yi, C., Yu, B., Pang, X., Li, K., Li, H., & Dai, Y. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127667 · Cited by 27 · see citing works
Do Dairy Minerals Have a Positive Effect on Bone Health?
Burrow, K., Young, W., McConnell, M. A., Carne, A., & Bekhit, A. E. A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12364 · Cited by 26 · see citing works
Prevalence of iron deficiency in different subtypes of pulmonary hypertension
Yu, X. F., Luo, Q., Liu, Z., Zhao, Z., Zhao, Q., An, C., Huang, Z., Jin, Q., Gao, L., & Yan, L. (2018) · Heart & Lung · doi:10.1016/j.hrtlng.2018.05.002 · Cited by 26 · see citing works
Iron metabolism in non-alcoholic fatty liver disease: A promising therapeutic target
Chen, H. (2022) · Liver Research · doi:10.1016/j.livres.2022.09.003 · Cited by 24 · see citing works
Wang, J., Jin, C., Ke, J.-F., Ma, Y.-L., Wang, Y., Lu, J., Li, M., & Li, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.942412 · Cited by 22 · see citing works
Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease
Jorgačević, B. Z., Mladenović, D. R., Ninković, M., Vesković, M. N., Dragutinović, V. V., Vatazević, A., Vučević, D. B., Ješić-Vukićević, R., & Radosavljević, T. S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/842108 · Cited by 22 · see citing works
Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study
Rashidi, B. H., Shams, S., Shariat, M., Jaliseh, H. K., Mohebi, M., & Haghollahi, F. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0632-z · Cited by 23 · see citing works
Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms
Macchi, C., Steffani, L., Oleari, R., Lettieri, A., Valenti, L. V. C., Dongiovanni, P., Romero‐Ruíz, A., Tena‐Sempere, M., Cariboni, A. M., Magni, P., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.019 · Cited by 22 · see citing works
Kim, H. Y., Kwon, W. Y., Park, J. B., Lee, M., Oh, Y. J., Suh, S., Baek, Y. H., Jeong, J. S., & Yoo, Y. H. (2020) · The FASEB Journal · doi:10.1096/fj.202000790r · Cited by 22 · see citing works
Obesity and iron-deficiency anemia in women of reproductive age in northern Iran
Rad, H. A., Sefidgar, S., Tamadoni, A., Sedaghat, S., Bakouei, F., Bijani, A., & Omidvar, S. (2019) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_371_18 · Cited by 21 · see citing works
Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors
Bouglé, D. L., & Brouard, J. (2013) · Nutrients · doi:10.3390/nu5062222 · Cited by 21 · see citing works
Branisso, P. P. F. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-23102018-125025 · Cited by 26 · see citing works
Iron deficiency anemia and megaloblastic anemia in obese patients
Arshad, M., Jaberian, S., Pazouki, A., Riazi, S., Rangraz, M. A., & Mokhber, S. (2016) · Romanian Journal of Internal Medicine · doi:10.1515/rjim-2016-0046 · Cited by 20 · see citing works
Diestelhorst, J., Junge, N., Jonigk, D. D., Schlué, J., Falk, C. S., Manns, M. P., Baumann, U., Jaeckel, E., & Taubert, R. (2018) · Scientific Reports · doi:10.1038/s41598-017-18818-5 · Cited by 20 · see citing works
An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload
Ameka, M., Beavers, W. N., Shaver, C. M., Ware, L. B., Kerchberger, V. E., Schoenfelt, K. Q., Sun, L., Koyama, T., Skaar, E. P., Becker, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137417 · Cited by 19 · see citing works
Recent advances in the application of ionomics in metabolic diseases
Zhang, Y., Huang, B., Jin, J., Xiao, Y., & Ying, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1111933 · Cited by 19 · see citing works
Elli̇dağ, H. Y., Eren, E., & Akdağ, M. Z. (2016) · The Ukrainian Biochemical Journal · doi:10.15407/ubj88.06.076 · Cited by 19 · see citing works
Association between central obesity indices and iron status indicators among Qatari adults
Kerkadi, A., Ali, R. M., Shehada, A. A. H., AbouHassanein, E. A., Moawad, J., Bawadi, H. A., & Shi, Z. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250759 · Cited by 19 · see citing works
Calderón, B., Gómez‐Martín, J. M., Ayuso, M. C., Cobeta, P., Vega‐Piñero, B., Mateo, R. C., Galindo, J., & Botella-Carretero, J. I. (2020) · Nutrients · doi:10.3390/nu12113354 · Cited by 18 · see citing works
Cempaka, A. R., Tseng, S., Yuan, K.-C., Bai, C., Tinkov, A. A., Skalny, A. V., & Chang, J. (2019) · Nutrients · doi:10.3390/nu11112733 · Cited by 17 · see citing works
Stankowiak-Kulpa, H., Kargulewicz, A., Styszyński, A., Swora-Cwynar, E., & Grzymislawski, M. B. (2017) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1232092 · Cited by 17 · see citing works
Yan, J.-X., Pan, B.-J., Zhao, P.-P., Wang, L.-T., Liu, J.-F., & Fu, S.-B. (2021) · Endocrine Connections · doi:10.1530/ec-21-0367 · Cited by 16 · see citing works
Hepcidin and its potential clinical utility
Miseta, A., Nagy, J., Nagy, T., Poór, V. S., Fekete, Z., & Sipos, K. (2015) · Cell Biology International · doi:10.1002/cbin.10505 · Cited by 16 · see citing works
Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response
Chirumbolo, S., Rossi, A. P., Rizzatti, V., Zoico, E., Franceschetti, G., Girelli, D., & Zamboni, M. M. (2015) · Nutrition · doi:10.1016/j.nut.2015.04.007 · Cited by 16 · see citing works
Donation intensity and metabolic syndrome in active whole‐blood donors
Peffer, K., Verbeek, A. L. M., Swinkels, D. W., Geurts-Moespot, A. J., den Heijer, M., & Atsma, F. (2015) · Vox Sanguinis · doi:10.1111/vox.12258 · Cited by 15 · see citing works
Schindler, C., Birkenfeld, A. L., Markolf Hanefeld, E., Schatz, U., Köhler, C., Grüneberg, M., Tschöpe, D., Blüher, M., Hasslacher, C., & Bornstein, S. R. (2017) · Diabetes Therapy · doi:10.1007/s13300-017-0330-z · Cited by 15 · see citing works
Disturbances of Copper and Iron Metabolism
Lefkowitch, J. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-7584-1.00014-0 · Cited by 15 · see citing works
Marković, K., Čemažar, M., Serša, G., Milačić, R., & Ščančar, J. (2022) · Journal of Analytical Atomic Spectrometry · doi:10.1039/d2ja00161f · Cited by 14 · see citing works
Yu, G., Liu, L., Qin, T., Luo, Y., Song, C., Chen, X., Duan, H., Jiang, Y., Zeng, H., Wan, H., et al. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03666-4 · Cited by 14 · see citing works
Biological autoluminescence as a perturbance-free method for monitoring oxidation in biosystems
Vahalová, P., & Cifra, M. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.10.009 · Cited by 14 · see citing works
The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders
Yeğin, Z. A., İyidir, Ö. T., Demirtaş, C., Suyanı, E., Yetkin, İ., Paşaoğlu, H., İlhan, Ç., & Sucak, G. T. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0174-6 · Cited by 13 · see citing works
Red Blood Cell Aggregation-Associated Dietary Pattern Predicts Hyperlipidemia and Metabolic Syndrome
Lin, P., Chang, C., Yuan, K.-C., Yeh, H., Fang, S.-U., Tiong, C., Teng, K.-T., Chao, K., Tang, J., Kao, W., et al. (2018) · Nutrients · doi:10.3390/nu10081127 · Cited by 13 · see citing works
Co‐regulation of hepatic steatosis by ferritinophagy and unsaturated fatty acid supply
Li, N., Liao, Y., Huang, H., & Fu, S. (2022) · Hepatology Communications · doi:10.1002/hep4.2040 · Cited by 12 · see citing works
QIN, Y., Huang, Y.-T., Li, Y., Qin, L., Wei, Q., Chen, X., Yang, C., & Zhang, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1143919 · Cited by 13 · see citing works
Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis
Visscher, C., Middendorf, L., Günther, R., Engels, A., Leibfacher, C., Möhle, H., Düngelhoef, K., Weier, S., Haider, W., & Radko, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0484-8 · Cited by 13 · see citing works
Kosteria, I., Tsangaris, G. T., Gkourogianni, A., Anagnostopoulos, A. K., Papadopoulou, A., Papassotiriou, I., Loutradis, D., Chrousos, G. P., & Kanaka‐Gantenbein, C. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2016-1052 · Cited by 13 · see citing works
Qu, H., Zhou, L., Wang, J., Tang, D., Zhang, Q., & Shi, J. (2025) · Obesity · doi:10.1002/oby.24236 · Cited by 12 · see citing works
Papalamprakopoulou, Z., Dey, P., Frascati, R., & Fountzilas, C. K. (2025) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000832 · Cited by 12 · see citing works
Yu, J., Xu, Z., Zhuo, Y., Wei, H., Ye, Y., Xu, Q., Li, Y., Yu, L., Feng, W., Hong, P., et al. (2021) · Hematology · doi:10.1080/16078454.2021.2003066 · Cited by 12 · see citing works
Iron depletion with a novel apheresis system in patients with hemochromatosis
Grabmer, C., Schmid, D., Mayer, G., Aigner, E. S., Wagner, A., Streif, D., Schallmoser, K., & Rohde, E. (2014) · Transfusion · doi:10.1111/trf.12949 · Cited by 12 · see citing works
Self-citationEl-Maleky, N. F., & Ebrahim, R. H. (2018) · Electromagnetic Biology and Medicine · doi:10.1080/15368378.2018.1531423 · Cited by 13 · see citing works
Bereta, M., Teplan, M., Chafai, D. E., Radil, R., & Cifra, M. (2021) · Scientific Reports · doi:10.1038/s41598-020-79668-2 · Cited by 11 · see citing works
Iron Fortification and Supplementation: Fighting Anemia of Chronic Diseases or Fueling Obesity?
El-Mallah, C. A., Beyh, Y. S., & Obeid, O. (2021) · Current Developments in Nutrition · doi:10.1093/cdn/nzab032 · Cited by 12 · see citing works
Maternal micronutrient disturbance as risks of offspring metabolic syndrome
Shi, Y., Zhong, H., & Pang, L. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127097 · Cited by 10 · see citing works
Radushkevitz-Frishman, T., Charni‐Natan, M., & Goldstein, I. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109407 · Cited by 9 · see citing works
Akinbami, A., Gbadegesin, A., John‐Olabode, S., Adediran, A., Dosunmu, A. O., Sobande, A. A., & Uche, E. I. (2015) · HIV/AIDS - Research and Palliative Care · doi:10.2147/hiv.s80137 · Cited by 9 · see citing works
Rashidi, B. H., Shams, S., Shariat, M., Bagheri, M., Mohebi, M., & Haghollahi, F. (2018) · PubMed Central · Cited by 9 · see citing works
Deregulation of Hepatic Mek1/2–Erk1/2 Signaling Module in Iron Overload Conditions
Tangudu, N. K., Buth, N., Strnad, P., Cirstea, I. C., & Spasić, M. V. (2019) · Pharmaceuticals · doi:10.3390/ph12020070 · Cited by 9 · see citing works
- Authors
- Datz, C., Felder, T. K., Niederseer, D., & Aigner, E.
- Affiliations
- Krankenhaus Oberndorf (AT)
- Paracelsus Medical University (AT)
- Corresponding author
- Datz, Christian
- Aigner, Elmar
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2013-01-07
- Volume
- 43
- Issue
- 2
- Pages
- 215-224
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2030921687
- Cited by
- 181
- References
- 76
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 22 · 2021: 14 · 2020: 15 · 2019: 8 · 2018: 14 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 22 · 2013: 5 · 2012: 1
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron homeostasis, metabolic syndrome, hyperferritinemia, transferrin saturation, non-alcoholic fatty liver disease, obesity, iron deficiency, hepcidin, ferroportin, iron absorption, insulin sensitivity, type 2 diabetes
- MeSH terms
- Ferroportin, Fatty Liver, Homeostasis, Humans, Iron, Obesity, Biomarkers, Anemia, Iron-Deficiency, Iron Overload, Antimicrobial Cationic Peptides, Metabolic Syndrome, Cation Transport Proteins, Hepcidins, Non-alcoholic Fatty Liver Disease
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