Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works

Antioxidants and Atherosclerotic Heart Disease

Diaz, M. N., Frei, B. B., Vita, J. A., & Keaney, J. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370607 · Cited by 1,347 · see citing works

High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men

Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284 · see citing works

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,172 · see citing works

Oxidative Stress as a Regulator of Gene Expression in the Vasculature

KUNSCH, C. A., & Medford, R. M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.753 · Cited by 795 · see citing works

Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo

Williams, S. B., Goldfine, A. B., Timimi, F. K., Ting, H. H., Roddy, M.-A., Simonson, D. C., & Creager, M. A. (1998) · Circulation · doi:10.1161/01.cir.97.17.1695 · Cited by 793 · see citing works

Nitric oxide and iron proteins

Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510 · see citing works

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

Smith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B. (1992) · Biochemical Journal · doi:10.1042/bj2860901 · Cited by 455 · see citing works

Body Iron Stores and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study

Kiechl, S., Willeit, J., Egger, G., Poewe, W., & Oberhollenzer, F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3300 · Cited by 390 · see citing works

Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium

Zeiher, A. M., Drexler, H., Wollschlaeger, H., Saurbier, B., & Just, H. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90414-2 · Cited by 349 · see citing works

Dietary iron intake and risk of coronary disease among men.

Ascherio, A., Willett, W. C., Rimm, E. B., Giovannucci, E. L., & Stampfer, M. J. (1994) · Circulation · doi:10.1161/01.cir.89.3.969 · Cited by 286 · see citing works

Iron, Atherosclerosis, and Ischemic Heart Disease

de Valk, B., & Marx, J. J. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.14.1542 · Cited by 250 · see citing works

Heterozygosity for a Hereditary Hemochromatosis Gene Is Associated With Cardiovascular Death in Women

Roest, M., van der Schouw, Y. T., de Valk, B., Marx, J. J. M., Tempelman, M. J., de Groot, P. G., Sixma, J. J., & Banga, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.12.1268 · Cited by 245 · see citing works

Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies

Danesh, J., & Appleby, P. (1999) · Circulation · doi:10.1161/01.cir.99.7.852 · Cited by 226 · see citing works

Contribution of Vasodilator Prostanoids and Nitric Oxide to Resting Flow, Metabolic Vasodilation, and Flow-Mediated Dilation in Human Coronary Circulation

Duffy, S. J., Castle, S., Harper, R. W., & Meredith, I. T. (1999) · Circulation · doi:10.1161/01.cir.100.19.1951 · Cited by 198 · see citing works

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

Halliwell, B. B. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90129-7 · Cited by 184 · see citing works

Iron-Deficient Diet Reduces Atherosclerotic Lesions in ApoE-Deficient Mice

Lee, T.-S., Shiao, M.-S., Pan, C.-C., & Chau, L.-Y. (1999) · Circulation · doi:10.1161/01.cir.99.9.1222 · Cited by 179 · see citing works

Studies in Desferrioxamine and Ferrioxamine Metabolism in Normal and Iron‐Loaded Subjects

Summers, M. R., Jacobs, A., Tudway, D. C., Perera, P., & Ricketts, C. (1979) · British Journal of Haematology · doi:10.1111/j.1365-2141.1979.tb01167.x · Cited by 179 · see citing works

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation

Biemond, P., Swaak, A. J. G., Beindorff, C. M., & Koster, J. F. (1986) · Biochemical Journal · doi:10.1042/bj2390169 · Cited by 179 · see citing works

Evidence that desferrioxamine cannot enter cells by passive diffusion

Lloyd, J. B., Cable, H. C., & Rice-Evans, C. A. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90109-i · Cited by 163 · see citing works

Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension

Sherman, D. L., Keaney, J. F., Biegelsen, E. S., Duffy, S. J., Coffman, J. D., & Vita, J. A. (2000) · Hypertension · doi:10.1161/01.hyp.35.4.936 · Cited by 158 · see citing works

Coronary Artery Responses to Physiological Stimuli Are Improved by Deferoxamine but not by l -Arginine in Non–Insulin-Dependent Diabetic Patients With Angiographically Normal Coronary Arteries and No Other Risk Factors

Nitenberg, A., Paycha, F., Ledoux, S., Sachs, R. N., Attali, J. R., & Valensi, P. E. (1998) · Circulation · doi:10.1161/01.cir.97.8.736 · Cited by 130 · see citing works

Iron-Dependent Human Platelet Activation and Hydroxyl Radical Formation

Praticò, D., Pasin, M., Barry, Ó. P., Ghiselli, A., Sabatino, G., Iuliano, L., FitzGerald, G. A., & Violi, F. (1999) · Circulation · doi:10.1161/01.cir.99.24.3118 · Cited by 129 · see citing works

Heme coordination of NO in NO synthase.

Wang, J., Rousseau, D. L., Abu‐Soud, H. M., & Stuehr, D. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10512 · Cited by 109 · see citing works

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2

Kim, S. W., & Ponka, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33035 · Cited by 91 · see citing works

Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease

Franco, Zago, Trip, M. D., Cate, T., van den Ende, C. H. M., Prins, M. H., Kastelein, & Reitsma (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00898.x · Cited by 77 · see citing works

Mannitol: kinetics of distribution, excretion, and utilization in human beings.

Domínguez, R., CORCORAN, A. C., & PAGE, I. H. (1947) · PubMed · Cited by 72 · see citing works

Neuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity

Mohanakumar, K. P., Hanbauer, I., & Chiueh, C. C. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00032-5 · Cited by 67 · see citing works

Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients.

Willerson, J. T., Curry, G. C., Atkins, J. M., Parkey, R. W., & Horwitz, L. D. (1975) · Circulation · doi:10.1161/01.cir.51.6.1095 · Cited by 50 · see citing works

Commentarv Mannitol: Molecule Magnifique or a Case of Radical Misinterpretation?

Gillbe, C. E., Sage, F. J., & Gutteridge, J. M. C. (1996) · Free Radical Research · doi:10.3109/10715769609087994 · Cited by 38 · see citing works

Mutation of the Five Conserved Histidines in the Endothelial Nitric-oxide Synthase Hemoprotein Domain

Rodríguez‐Crespo, I., Nishida, C. R., Knudsen, G. M., & de Montellano, P. R. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21617 · Cited by 22 · see citing works

The clinical implications of endothelial dysfunction

Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Yu, Y., Yan, Y., Niu, F., Wang, Y., Chen, X., Su, G., Liu, Y., Zhao, X., Lü, Q., Liu, P., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00579-w · Cited by 793 · see citing works

Absorption and metabolism of polyphenols in the gut and impact on health

Scalbert, A., Morand, C., Manach, C., & Rémésy, C. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00205-6 · Cited by 723 · see citing works

Cross-Talk Between Iron Metabolism and Diabetes

Fernández-Real, J. M., López-Bermejo, A., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2348 · Cited by 704 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Anemia as a risk factor for cardiovascular disease in the atherosclerosis risk in communities (aric) study

Sarnak, M. J., Tighiouart, H., Manjunath, G., MacLeod, B., Griffith, J. L., Salem, D. N., & Levey, A. S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01938-1 · Cited by 513 · see citing works

A Randomized, Placebo-Controlled, Double-Blind Trial of the Effect of Combined Therapy With Deferoxamine and Deferiprone on Myocardial Iron in Thalassemia Major Using Cardiovascular Magnetic Resonance

Tanner, M. A., Galanello, R., Dessì, C., Smith, G. C., Westwood, M. A., Agus, A., Roughton, M., Assomull, R., Nair, S. V., Walker, J. M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.648790 · Cited by 480 · see citing works

Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities

Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works

Iron Therapy, Advanced Oxidation Protein Products, and Carotid Artery Intima-Media Thickness in End-Stage Renal Disease

Drüeke, T. B., Witko‐Sarsat, V., Massy, Z. A., Descamps‐Latscha, B., Guérin, A. P., Marchais, S. J., Gausson, V., & London, G. M. (2002) · Circulation · doi:10.1161/01.cir.0000035250.66458.67 · Cited by 375 · see citing works

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

Blood Letting in High-Ferritin Type 2 Diabetes

Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., Hernández‐Aguado, I., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1000 · Cited by 333 · see citing works

Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications

Stankiewicz, J. M., Panter, S. S., Neema, M., Arora, A., Batt, C. E., & Bakshi, R. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.006 · Cited by 301 · see citing works

Transferrin Receptor-dependent Iron Uptake Is Responsible for Doxorubicin-mediated Apoptosis in Endothelial Cells

Kotamraju, S., Chitambar, C. R., Kalivendi, S. V., Joseph, J., & Kalyanaraman, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111604200 · Cited by 233 · see citing works

Age Decreases Endothelial Progenitor Cell Recruitment Through Decreases in Hypoxia-Inducible Factor 1α Stabilization During Ischemia

Chang, E. I., Loh, S. A., Ceradini, D. J., Chang, E. I., Lin, S.-E., Bastidas, N., Aarabi, S., Chan, D. A., Freedman, M. L., Giaccia, A. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.715847 · Cited by 206 · see citing works

Haptoglobin Genotype– and Diabetes-Dependent Differences in Iron-Mediated Oxidative Stress In Vitro and In Vivo

Asleh, R., Guetta, J., Kalet-Litman, S., Miller‐Lotan, R., & Levy, A. P. (2005) · Circulation Research · doi:10.1161/01.res.0000156653.05853.b9 · Cited by 202 · see citing works

Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis

Day, S. M., Duquaine, D., Mundada, L. V., Menon, R. G., Khan, B. V., Rajagopalan, S., & Fay, W. P. (2003) · Circulation · doi:10.1161/01.cir.0000066910.02844.d0 · Cited by 192 · see citing works

Iron homeostasis in the metabolic syndrome

Datz, C., Felder, T. K., Niederseer, D., & Aigner, E. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12032 · Cited by 181 · see citing works

Pathological Roles of Iron in Cardiovascular Disease

Kobayashi, M., Suhara, T., Baba, Y., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2018) · Current Drug Targets · doi:10.2174/1389450119666180605112235 · Cited by 179 · see citing works

Reduction of Iron Stores and Cardiovascular Outcomes in Patients With Peripheral Arterial Disease

Zacharski, L. R., Chow, B. K., Howes, P. S., Shamayeva, G., Baron, J. A., Dalman, R. L., Malenka, D. J., Ozaki, C. K., & Lavori, P. W. (2007) · JAMA · doi:10.1001/jama.297.6.603 · Cited by 180 · see citing works

The molecular mechanisms of ferroptosis and its role in cardiovascular disease

Zhang, Y., Xin, L., Xiang, M., Shang, C., Wang, Y., Wang, Y., Cui, X., & Lu, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112423 · Cited by 174 · see citing works

Atherogenesis and iron: from epidemiology to cellular level

Vinchi, F., Muckenthaler, M. U., da Silva, M. C., Balla, G. J., Balla, J., & Jeney, V. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00094 · Cited by 173 · see citing works

Cold ischemic injury of transplanted kidneys: new insights from experimental studies

Salahudeen, A. K. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00098.2004 · Cited by 166 · see citing works

The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

Ravíngerová, T., Kindernay, L., Barteková, M., Ferko, M., Adameová, A., Zohdi, V., Bernátová, I., Ferenczyová, K., & Lazou, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217889 · Cited by 165 · see citing works

Oxidative Stress–Induced Iron Signaling Is Responsible for Peroxide-Dependent Oxidation of Dichlorodihydrofluorescein in Endothelial Cells

Tampo, Y., Kotamraju, S., Chitambar, C. R., Kalivendi, S. V., Keszler, Á., Joseph, J., & Kalyanaraman, B. (2003) · Circulation Research · doi:10.1161/01.res.0000048195.15637.ac · Cited by 164 · see citing works

Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets

Sawicki, K. T., Jesus, A. D., & Ardehali, H. (2023) · Circulation Research · doi:10.1161/circresaha.122.321667 · Cited by 165 · see citing works

The role of iron neurotoxicity in ischemic stroke

Selim, M. H., & Ratan, R. R. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.04.001 · Cited by 158 · see citing works

Arterial Stiffness and Endothelial Function in Patients With β-Thalassemia Major

Cheung, Y., Chan, G., & Ha, S. (2002) · Circulation · doi:10.1161/01.cir.0000037225.92759.a7 · Cited by 150 · see citing works

Molecular, physiological and clinical aspects of the iron storage protein ferritin

Orino, K., & Watanabe, K. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.07.006 · Cited by 148 · see citing works

Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis

Gaenzer, H., Marschang, P., Sturm, W., Neumayr, G., Vogel, W., Patsch, J. R., & Weiß, G. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02611-6 · Cited by 147 · see citing works

The Role of Oxidative Stress in the Metabolic Syndrome

Whaley‐Connell, A. T., McCullough, P. A., & Sowers, J. R. (2011) · Reviews in Cardiovascular Medicine · doi:10.3909/ricm0555 · Cited by 143 · see citing works

Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability

Sullivan, J. L. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-54 · Cited by 143 · see citing works

Iron and thrombosis

Franchini, M., Targher, G., Montagnana, M., & Lippi, G. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0416-1 · Cited by 142 · see citing works

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice

Zhang, W., Hao, W., & Frei, B. B. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2009.009229 · Cited by 117 · see citing works

A Diffusible Substance(s) Mediates Endothelium-Dependent Contractions in the Aorta of SHR

Yang, D., Félétou, M., Levens, N. R., Zhang, J. N., & Vanhoutte, P. M. (2003) · Hypertension · doi:10.1161/01.hyp.0000047651.45322.16 · Cited by 117 · see citing works

Iron Stores and Vascular Function in Voluntary Blood Donors

Zheng, H., Cable, R. G., Spencer, B. R., Votto, N., & Katz, S. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000174126.28201.61 · Cited by 112 · see citing works

Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver

Aigner, E. S. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v7.i2.177 · Cited by 113 · see citing works

Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in the Study of Health in Pomerania (SHIP)

Wolff, B., Völzke, H., Lüdemann, J., Robinson, D., Vogelgesang, D., Staudt, A., Kessler, C., Dahm, J. B., John, U., & Felix, S. B. (2004) · Stroke · doi:10.1161/01.str.0000114875.31599.1c · Cited by 108 · see citing works

The role of labile iron pool in cardiovascular diseases.

Kruszewski, M. K. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3585 · Cited by 104 · see citing works

The role of hepcidin and iron homeostasis in atherosclerosis

Wunderer, F., Traeger, L., Sigurslid, H. H., Meybohm, P., Bloch, D. B., & Malhotra, R. K. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104664 · Cited by 107 · see citing works

Iron overload and cardiovascular complications in dialysis patients

Kletzmayr, J., & Hörl, W. H. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.suppl_2.25 · Cited by 104 · see citing works

The iron chelator desferrioxamine inhibits atherosclerotic lesion development and decreases lesion iron concentrations in the cholesterol-fed rabbit

Minqin, R., Rajendran, R., Pan, N., Kwong-Huat Tan, B., Ong, W.-Y., Watt, F., & Halliwell, B. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.008 · Cited by 100 · see citing works

Anemia as a risk factor for cardiovascular disease

Pereira, A. A., & Sarnak, M. J. (2003) · Kidney International · doi:10.1046/j.1523-1755.64.s87.6.x · Cited by 102 · see citing works

Effect of Iron Chelation on Myocardial Infarct Size and Oxidative Stress in ST-Elevation–Myocardial Infarction

Chan, W., Taylor, A. J., Ellims, A., Lefkovits, L., Wong, C. Y., Kingwell, B. A., Natoli, A., Croft, K. D., Mori, T. A., Kaye, D. M., et al. (2012) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.111.966226 · Cited by 100 · see citing works

Iron overload in myelodysplastic syndromes (MDS)

Gattermann, N. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2367-1 · Cited by 96 · see citing works

Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease

Valenti, L. V. C., Swinkels, D. W., Burdick, L., Dongiovanni, P., Tjalsma, H., Motta, B. M., Bertelli, C., Fatta, E., Bignamini, D., Rametta, R., et al. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.01.003 · Cited by 93 · see citing works

Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2

Dreger, H., Westphal, K., Wilck, N., Baumann, G., Stangl, V., Stangl, K., & Meiners, S. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp279 · Cited by 90 · see citing works

The relationship between trace elements and cardiac markers in acute coronary syndromes

Altekin, E., Çöker, C., Şişman, A. R., Önvural, B., Kuralay, F., & Kırımlı, Ö. (2005) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2004.12.002 · Cited by 88 · see citing works

Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and Vascular Damage in Patients With Metabolic Syndrome Alterations

Valenti, L. V. C., Dongiovanni, P., Motta, B. M., Swinkels, D. W., Bonara, P., Rametta, R., Burdick, L., Frugoni, C., Fracanzani, A. L., & Fargion, S. R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214858 · Cited by 88 · see citing works

Tumor Necrosis Factor-α–Induced Iron Sequestration and Oxidative Stress in Human Endothelial Cells

Nanami, M., Ookawara, T., Otaki, Y., Ito, K., Moriguchi, R., Miyagawa, K., Hasuike, Y., Izumi, M., Eguchi, H., Suzuki, K., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000190610.63878.20 · Cited by 87 · see citing works

Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing

Duscher, D., Januszyk, M., Maan, Z. N., Whittam, A. J., Hu, M. S.-M., Walmsley, G. G., Dong, Y., Khong, S. M. L., Longaker, M. T., & Gurtner, G. C. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000003072 · Cited by 85 · see citing works

Blood Letting in High-Ferritin Type 2 Diabetes

Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., López‐Bermejo, A., & Ricart, W. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2249 · Cited by 85 · see citing works

Iron, oxidative stress, and redox signaling in the cardiovascular system

Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., Vergely, C., & Rochette, L. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400036 · Cited by 84 · see citing works

Iron and Heart Failure

Ghafourian, K., Shapiro, J. S., Goodman, L., & Ardehali, H. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.08.009 · Cited by 82 · see citing works

Mechanism of dilation to reactive oxygen species in human coronary arterioles

Sato, A., Sakuma, I., & Gutterman, D. D. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00458.2003 · Cited by 81 · see citing works

Micronutrient (Zn, Cu, Fe)–gene interactions in ageing and inflammatory age-related diseases: Implications for treatments

Mocchegiani, E., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A., & Malavolta, M. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.004 · Cited by 81 · see citing works

The effects of iron dextran on the oxidative stress in cardiovascular tissues of rats with chronic renal failure

Lim, C. S., & Vaziri, N. D. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00580.x · Cited by 80 · see citing works

The Role of Iron in the Pathogenesis of Atherosclerosis

Kraml, P. (2017) · Physiological Research · doi:10.33549/physiolres.933589 · Cited by 79 · see citing works

Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease

Maiocchi, S. L., Ku, J., Thai, T., Chan, E., Rees, M. D., & Thomas, S. R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107711 · Cited by 75 · see citing works

Are menstruating women protected from heart disease because of, or in spite of, estrogen? Relevance to the iron hypothesis

Sullivan, J. L. (2003) · American Heart Journal · doi:10.1067/mhj.2003.142 · Cited by 72 · see citing works

Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress

Issitt, T., Bosseboeuf, E., de Winter, N., Dufton, N., Gestri, G., Senatore, V., Chikh, A., RANDI, A. M., & Raimondi, C. (2018) · iScience · doi:10.1016/j.isci.2018.12.005 · Cited by 72 · see citing works

Role of iron in atherosclerosis

Shah, S. V., & Alam, M. G. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50091 · Cited by 72 · see citing works

Endothelial activation and induction of monocyte adhesion by nontransferrin‐bound iron present in human sera

Kartikasari, A. E. R., Georgiou, N., Visseren, F. L. J., Kats-Renaud, H. J. V., van Asbeck, B. S., & Marx, J. J. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4700fje · Cited by 69 · see citing works

Intracellular metal ion chelators inhibit TNFα-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells

Zhang, W. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01375-8 · Cited by 70 · see citing works

Ferroptosis in cardiovascular disease

Liu, G., Xie, X., Liao, W., Chen, S., Zhong, R., Qin, J., He, P., & Xie, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116057 · Cited by 69 · see citing works

Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls

Kazi, T. G., Afridi, H. I., Kazi, N. G., Jamali, M. K., Arain, M. B., Sarfraz, R. A., Jalbani, N. B., Ansari, R., Shah, A. Q., Memon, A. R., et al. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.12.004 · Cited by 68 · see citing works

Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A

Visseren, F. L. J., Verkerk, M. S. A., Van Der Bruggen, T., Marx, J. J. M., Van Asbeck, B. S., & Diepersloot, R. J. A. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1084.x · Cited by 64 · see citing works

Secretion of Ferritin by Iron-laden Macrophages and Influence of Lipoproteins

Yuan, X., Li, W., Baird, S. K., Carlsson, M., & Melefors, Ö. (2004) · Free Radical Research · doi:10.1080/10715760400011692 · Cited by 64 · see citing works

Iron-Induced Fibrin in Cardiovascular Disease

Lipiński, B., & Pretorius, E. (2013) · Current Neurovascular Research · doi:10.2174/15672026113109990016 · Cited by 63 · see citing works

Serum ferritin and risk for new-onset heart failure and cardiovascular events in the community

Klip, I. T., Voors, A. A., Swinkels, D. W., Bakker, S. J. L., Kootstra‐Ros, J. E., Lam, C. S. P., van der Harst, P., van Veldhuisen, D. J., & van der Meer, P. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.622 · Cited by 63 · see citing works

Lipocalin 2 regulation by thermal stresses: Protective role of Lcn2/NGAL against cold and heat stresses

Roudkenar, M. H., Halabian, R., Roushandeh, A. M., Nourani, M. R., Masroori, N., Ebrahimi, M., Nikogoftar, M., Rouhbakhsh, M., Bahmani, P., Jahanian‐Najafabadi, A., et al. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.08.019 · Cited by 62 · see citing works

Iron Sucrose Promotes Endothelial Injury and Dysfunction and Monocyte Adhesion/Infiltration

Kamanna, V. S., Ganji, S. H., Shelkovnikov, S., Norris, K. C., & Vaziri, N. D. (2011) · American Journal of Nephrology · doi:10.1159/000334939 · Cited by 62 · see citing works

Low-Renin Hypertension With Relative Aldosterone Excess Is Associated With Impaired NO-Mediated Vasodilation

Duffy, S. J., Biegelsen, E. S., Eberhardt, R. T., Kahn, D. F., Kingwell, B. A., & Vita, J. A. (2005) · Hypertension · doi:10.1161/01.hyp.0000184231.84465.62 · Cited by 60 · see citing works

Iron Chelation Suppresses Ferritin Upregulation and Attenuates Vascular Dysfunction in the Aorta of Angiotensin II–Infused Rats

Ishizaka, N., Saito, K., Mori, I., Matsuzaki, G., Ohno, M., & Nagai, R. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000181763.57495.2b · Cited by 55 · see citing works

Cardiovascular benefits of phlebotomy: relationship to changes in hemorheological variables

Holsworth, R., Cho, Y. I., Weidman, J. J., Sloop, G. D., & Cyr, J. A. S. (2013) · Perfusion · doi:10.1177/0267659113505637 · Cited by 57 · see citing works

Iron in Cardiovascular Disease: Challenges and Potentials

Li, S., & Zhang, X. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.707138 · Cited by 57 · see citing works

Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light

Ramakrishna, G., Rooke, T. W., & Cooper, L. T. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm493ra · Cited by 54 · see citing works

Dysregulation of iron metabolism in cardiovascular diseases: From iron deficiency to iron overload

Bi, Y., Ajoolabady, A., Demillard, L. J., Yu, W., Hilaire, M. L., Zhang, Y., & Ren, J. T. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114661 · Cited by 54 · see citing works

Calciphylaxis in the current era: emerging 'ironic' features?

Farah, M., Crawford, R. I., Levin, A., & Yan, C. C. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq407 · Cited by 53 · see citing works

Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability

Marques, V. B., Botelho, T., Júnior, R. F. R., Broseghini-Filho, G. B., Rossi, E. M., Graceli, J. B., & dos SANTOS, L. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.10.034 · Cited by 52 · see citing works

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia

Sutherland, B. A., Papadakis, M., Chen, R., & Buchan, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.209601 · Cited by 50 · see citing works

Iron overload in nonalcoholic steatohepatitis

Fujita, N., & Takei, Y. (2011) · Advances in clinical chemistry · doi:10.1016/b978-0-12-387042-1.00006-x · Cited by 49 · see citing works

Age-associated Iron Accumulation in Bone: Implications for Postmenopausal Osteoporosis and a New Target for Prevention and Treatment by Chelation

Liu, G., Men, P., KENNER, G. H., & Miller, S. C. (2006) · BioMetals · doi:10.1007/s10534-005-6666-2 · Cited by 50 · see citing works

Impairment of Transendothelial Leukocyte Migration by Iron Complexes

Sengoelge, G., Kletzmayr, J., Ferrara, I., Perschl, A. M., Hörl, W. H., & Sunder–Plassmann, G. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000087087.61306.4a · Cited by 50 · see citing works

Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation

Alul, R. H., Wood, M., Longo, J., Marcotte, A., Campione, A. L., Moore, M. K., & Lynch, S. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00028-5 · Cited by 47 · see citing works

Protective effects of an aqueous extract of Welsh onion green leaves on oxidative damage of reactive oxygen and nitrogen species

Wang, B., LIN, S., Hsiao, W.-C., FAN, J., FUH, L., & Duh, P. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.05.057 · Cited by 47 · see citing works

Nitric oxide-dependent vasodilation in human subjects

Vita, J. A. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)59183-7 · Cited by 44 · see citing works

Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models

dos SANTOS, L., Bertoli, S. R., Ávila, R. A., & Marques, V. B. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130172 · Cited by 44 · see citing works

Do Hemochromatosis Mutations Protect Against Iron-Mediated Atherogenesis?

Sullivan, J. L. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.906230 · Cited by 43 · see citing works

Iron overdose: a contributor to adverse outcomes in randomized trials of anemia correction in CKD

Buren, P. N. V., Velez, R. L., Vaziri, N. D., & Zhou, X. J. (2011) · International Urology and Nephrology · doi:10.1007/s11255-011-0028-5 · Cited by 42 · see citing works

Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron

Vinchi, F. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8167 · Cited by 43 · see citing works

The Emerging Role of Ferroptosis in Cardiovascular Diseases

Hong, M., Rong, J., Tao, X., & Xu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.822083 · Cited by 42 · see citing works

Stored Iron and Vascular Reactivity

Sullivan, J. L. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000174124.20147.22 · Cited by 41 · see citing works

Foam cell death induced by 7β-hydroxycholesterol is mediated by labile iron-driven oxidative injury: Mechanisms underlying induction of ferritin in human atheroma

Li, W., Hellsten, A., Xu, L.-H., Zhuang, D., Jansson, K., Brunk, U. T., & Yuan, X. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.05.006 · Cited by 40 · see citing works

Management of the no-reflow phenomenon

Butler, M. J., Chan, W., Taylor, A. J., Dart, A. M., & Duffy, S. J. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.010 · Cited by 38 · see citing works

ENDOPLASMIC RETICULUM STRESS INVOLVED IN HEART AND LIVER INJURY IN IRON‐LOADED RATS

Lou, L., Geng, B., Chen, Y., Yu, F., Zhao, J., & Tang, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05114.x · Cited by 38 · see citing works

Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy

Anderson, T. J., Hubacek, J., Wyse, D. G., & Knudtson, M. L. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02770-5 · Cited by 38 · see citing works

Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity—Role for iron-dependent oxidative stress

Thomas, S. R., Schulz, E., & Keaney, J. F. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.012 · Cited by 37 · see citing works

The Statin–Iron Nexus: Anti-Inflammatory Intervention for Arterial Disease Prevention

Zacharski, L. R., DePalma, R. G., Shamayeva, G., & Chow, B. K. (2013) · American Journal of Public Health · doi:10.2105/ajph.2012.301163 · Cited by 37 · see citing works

Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis

Jin, S., Wang, H., Zhang, X., Song, M., Liu, B., & Sun, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116457 · Cited by 35 · see citing works

Effect of Dexrazoxane on Homocysteine-Induced Endothelial Dysfunction in Normal Subjects

Zheng, H., Dimayuga, C., Hudaihed, A., & Katz, S. D. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000023187.25914.5b · Cited by 33 · see citing works

Iron Contributes to Endothelial Dysfunction in Acute Ischemic Syndromes

Chekanov, V. S., & Nikolaychik, V. V. (2002) · Circulation · doi:10.1161/circ.105.4.e35 · Cited by 7 · see citing works

Iron as a Novel Risk Factor for Endothelial Dysfunction in Humans

Fukami, K., Matsuoka, H., Iida, S., Satoh, A., Okuda, S., & Imaizumi, T. (2000) · Hypertension · doi:10.1161/hyp.36.suppl_1.716-d

Iron chelation with deferoxamine improves endothelial function in patients with atherosclerosis

Duffy, S. J., Biegelsen, E. S., HOLBROOK, M. M., Keaney, J. F., & Vita, J. A. (2000) · Heart Lung and Circulation · doi:10.1046/j.1443-9506.2000.07637.x

Involvement of Iron-Evoked Oxidative Stress in Smoking-Related Endothelial Dysfunction in Healthy Young Men

Fukami, K., Yamagishi, S., Iida, S., Matsuoka, H., & Okuda, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089433 · Cited by 10 · see citing works

Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo

Oyama, J., Satoh, S., Suematsu, N., Kadokami, T., Maeda, T., Sugano, M., & Makino, N. (2010) · Heart and Vessels · doi:10.1007/s00380-009-1221-7 · Cited by 13 · see citing works