Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children
Open accessAbstract
Introduction: Myeloperoxidase (MPO), an enzyme linking obesity and cardiovascular (CV) risk in adults, has rarely been studied in young children and no studies assessed its association with renal function. We sought to explore a possible association between serum MPO levels, obesity, CV risk factors and renal function in prepubertal children. Materials/Methods: Cross‐sectional evaluation of 309 children aged 8–9 years (161 normal weight, 148 overweight/obese), members of the birth cohort Generation I (Portugal). Anthropometrics (body mass index (BMI), waist‐to‐height ratio (WH tR) and % body fat mass (%BFM) by bioelectrical impedance analysis), 24‐h ambulatory blood pressure monitoring and pulse wave velocity (PWV) were measured. Insulin resistance was estimated by the HOMA index (considering serum fasting glucose and insulin determinations). Serum MPO levels were assessed by immunoenzymatic assay. Results: MPO levels were positively associated with obesity indices (BMI z‐score, WH tR and %BFM). Higher MPO levels were associated with higher 24‐h and night‐time mean arterial pressure, with nondipping and with higher values of insulin resistance. In normal weight children, the endothelial function, as evaluated indirectly by PWV, was an independent predictor of MPO levels. In overweight/obese children, estimated glomerular filtration rate increased significantly across tertiles of MPO (Ptrend = 0·031) and this association held after adjustment for age, sex, neutrophil and monocyte counts and CV risk factors. Conclusions: Our results reinforce the role of MPO as a risk marker in obesity and related CV morbidities in young children. MPO levels associate with the dipping pattern and PWV and, among overweight/obese children, an association exists between MPO and renal function.
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HOCl is responsible for renal dysfunction among obese children, who show positive correlation between 8-iso-PGF2α and blood lipids, serum MPO, and insulin resistance.
“HOCl has been found to be responsible for renal dysfunction among obese children. These children have shown a positive correlation between an isoprostane 8-iso-prostaglandin F2α (8-iso-PGF2α) and blood lipids, serum levels of MPO, and insulin resistance (Yu et al. 2013; Correia-Costa et al. 2016).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Correia-Costa et al. 2016
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- Authors
- Correia‐Costa, L., Sousa, T., Morato, M., Cosme, D., Afonso, J., Moura, C., Mota, C., Areias, J. C., Guerra, A., Schaefer, F., Caldas Afonso, A., Barros, H., Albino‐Teixeira, A., & Azevedo, A.
- Affiliations
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Heidelberg University (DE)
- EPIUnit ‐ Institute of Public Health University of Porto Porto Portugal
- Corresponding author
- Correia‐Costa, Liane
- ORCID
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2015-12
- Volume
- 46
- Issue
- 1
- Pages
- 50-59
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W1919466827
- Cited by
- 19
- References
- 42
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 3
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- Federación Española de Enfermedades Raras
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- myeloperoxidase, childhood obesity, prepubertal children, cardiometabolic risk, renal function, estimated glomerular filtration rate, endothelial function, pulse wave velocity, insulin resistance, nocturnal blood pressure dipping, ambulatory blood pressure, cardiovascular risk markers
- MeSH terms
- Adipose Tissue, Blood Glucose, Blood Pressure, Body Composition, Cardiovascular Diseases, Child, Cross-Sectional Studies, Endothelium, Vascular, Female, Glomerular Filtration Rate, Humans, Insulin, Insulin Resistance, Male, Peroxidase, Obesity, Portugal, Risk Factors, Cohort Studies, Electric Impedance, Blood Pressure Monitoring, Ambulatory, Overweight, Pulse Wave Analysis
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