Poor outcome associated with symptomatic deterioration among help‐seeking individuals at risk for psychosis: a naturalistic follow‐up study
Abstract
Aims: It remains debatable whether early intervention for psychosis is capable of meeting the needs of at‐risk subjects. The aims of this study were to describe the actual impact of interventions on subjective difficulties and to explore the factors that may be associated with a poor outcome. Methods: Participants were help‐seeking outpatients at a university hospital who met the C riteria of P rodromal S yndromes. Changes in the symptoms, subjective experience and current insight were assessed using the S cales of P rodromal S ymptoms, the S ubjective W ell‐being under N euroleptics, and the S cale to A ssess U nawareness of M ental D isorder, respectively. Global functioning, social functioning and subjective quality of life were evaluated using the G lobal A ssessment of F unctioning S cale, the S ocial F unctioning S cale, and the WHO‐Q uality of L ife 26, respectively. These measures were assessed both at baseline and after 1 year. Results: Forty‐six patients agreed to participate. Of the 27 patients who completed the reassessment at the follow‐up point, 13 patients (48%) showed little improvement in their positive/negative symptoms, subjective well‐being or awareness of their symptoms. Additionally, less severe negative symptoms, more severe general symptoms and lower subjective well‐being at baseline significantly predicted a deterioration of positive/negative symptoms after 1 year. Conclusion: Our findings suggest that the current strategy for reducing psychosis risk based on positive symptoms should be reappraised.
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Recent evidence shows that positive symptoms are weaker predictors of transition to psychosis and poor functional outcome than subjective cognitive difficulties.
“and subjective cognitive difficulties 73,74”
From Clinical, socio‐demographic and psychological characteristics in individuals with persistent psychotic experiences with and without a “need for care” (2016) · cites this paper as [73]
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- Authors
- Morita, K., Kobayashi, H., Takeshi, K., Tsujino, N., Nemoto, T., & Mizuno, M.
- Affiliations
- Toho University (JP)
- University of Cambridge (GB)
- Corresponding author
- Kobayashi, Hiroyuki
- Venue
- Early Intervention in Psychiatry
- Publisher
- Wiley
- Published
- 2013-01-24
- Volume
- 8
- Issue
- 1
- Pages
- 24-31
- ISSN
- 1751-7885 (ISSN-L)
- 1751-7893
- OpenAlex
- W1483856166
- Cited by
- 16
- References
- 29
- Citations by year
- 2024: 1 · 2023: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Early Intervention in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- psychosis risk, early intervention in psychosis, symptom deterioration, negative symptoms, positive symptoms, subjective well-being, awareness of mental disorder, quality of life, social functioning, global functioning, predictors of poor outcome
- MeSH terms
- Adolescent, Adult, Disease Susceptibility, Female, Follow-Up Studies, Humans, Male, Patient Acceptance of Health Care, Psychotherapy, Psychotic Disorders, Psychotropic Drugs, Treatment Outcome, Young Adult, Early Medical Intervention, Prodromal Symptoms
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