Topological organization of CA 3‐to‐CA 1 excitation
Abstract
The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA1 network). Using functional multi-neuron calcium imaging of rat hippocampal slices, we monitored the spatiotemporal patterns of spontaneous CA3 and CA1 burst activity under pharmacological GABAergic blockade. We found that spatially clustered CA3 activity patterns were transformed into layered CA1 activity sequences. Specifically, synchronized bursts initiated from multiple hot spots in CA3 ensembles, and CA1 neurons located deeper in the pyramidal cell layer were recruited during earlier phases of the burst events. The order of these sequential activations was maintained across the bursts, but the sequence velocity varied depending on the inter-burst intervals. Thus, CA3 axons innervate CA1 neurons in a highly topographical fashion.
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The afferent divergence and convergence onto the cells were anatomically patterned, maintaining the topographical arrangement seen experimentally.
“The afferent divergence and convergence onto the cells were also anatomically patterned, maintaining the topographical arrangement seen experimentally (Hongo et al., 2015), for a total of 5.19 billion synaptic connections in the model network.”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Hongo et al., 2015
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- Authors
- Hongo, Y., Ogawa, K., Takahara, Y., Takasu, K., Royer, S., Hasegawa, M., Sakaguchi, G., & Ikegaya, Y.
- Affiliations
- Shionogi (Japan) (JP)
- Center for Functional Connectomics Korea Institute of Science and Technology Seoul South Korea
- Center for Information and Neural Networks (JP)
- Corresponding author
- Ikegaya, Yuji
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2015-07-02
- Volume
- 42
- Issue
- 5
- Pages
- 2135-2143
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2153440713
- Cited by
- 12
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kakenhi (25119004)
- Health and Labour Sciences Research Grants for Research on Regulatory Science of Pharmaceuticals and Medical Devices from MHLW (iNCENS)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- Schaffer collaterals, topographic mapping, functional connectivity, hippocampus, pyramidal neurons, spontaneous bursting, calcium imaging, interburst interval, neuronal ensembles
- MeSH terms
- Action Potentials, Animals, Calcium, Neural Pathways, Neurons, Rats, Wistar, Patch-Clamp Techniques, Tissue Culture Techniques, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Voltage-Sensitive Dye Imaging
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