Cited by 279Memory and Neural MechanismsSleep and Wakefulness ResearchNeurogenesis and neuroplasticity mechanisms

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

de Lavilléon, Gaetan, Lacroix, Marie Masako, Rondi-Reig, Laure, Benchenane, Karim·2015·Nature Neuroscience

Abstract

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

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Crossref · 10.1038/nn.3970

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  • Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.

    “These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”

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Authors
de Lavilléon, G., Lacroix, M. M., Rondi-Reig, L., & Benchenane, K.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Benchenane, Karim
Venue
Nature Neuroscience
Published
2015-03-09
Volume
18
Issue
4
Pages
493-495
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2092922261
Cited by
279
References
30
Citations by year
2026: 7 · 2025: 14 · 2024: 24 · 2023: 20 · 2022: 20 · 2021: 17 · 2020: 23 · 2019: 51 · 2018: 44 · 2017: 26 · 2016: 16 · 2015: 15
FWCI
20.22
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
Agence Nationale de la Recherche (ANR-10-LABX-0054, ANR-11-IDEX-0001)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
place cells, sleep, declarative memory, spatial memory consolidation, place preference, spatial navigation, hippocampus, place fields, goal-directed behavior, cognitive maps
MeSH terms
Animals, Behavior, Animal, Electric Stimulation, Electrodes, Implanted, Goals, Humans, Male, Medial Forebrain Bundle, Mice, Inbred C57BL, Reward, Sleep, Patch-Clamp Techniques, Mice, CA1 Region, Hippocampal, Spatial Memory, Spatial Navigation

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