Explicit memory creation during sleep demonstrates a causal role of place cells in navigation
Abstract
Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.
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Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.
“These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [6]
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Influential
- Authors
- de Lavilléon, G., Lacroix, M. M., Rondi-Reig, L., & Benchenane, K.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Benchenane, Karim
- Venue
- Nature Neuroscience
- Published
- 2015-03-09
- Volume
- 18
- Issue
- 4
- Pages
- 493-495
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2092922261
- Cited by
- 279
- References
- 30
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 24 · 2023: 20 · 2022: 20 · 2021: 17 · 2020: 23 · 2019: 51 · 2018: 44 · 2017: 26 · 2016: 16 · 2015: 15
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-LABX-0054, ANR-11-IDEX-0001)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- place cells, sleep, declarative memory, spatial memory consolidation, place preference, spatial navigation, hippocampus, place fields, goal-directed behavior, cognitive maps
- MeSH terms
- Animals, Behavior, Animal, Electric Stimulation, Electrodes, Implanted, Goals, Humans, Male, Medial Forebrain Bundle, Mice, Inbred C57BL, Reward, Sleep, Patch-Clamp Techniques, Mice, CA1 Region, Hippocampal, Spatial Memory, Spatial Navigation
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