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Association between restless legs syndrome and migraine: a population‐based study
Abstract
Background and purpose: A higher prevalence of restless legs syndrome (RLS) in migraineurs has been reported in clinical samples and in two large‐scale clinical trials performed on healthcare workers but general population‐based studies on this topic are lacking. The aim of this study was to assess the association between migraine and RLS in an Italian rural adult population‐based setting. Methods: The presence of migraine and RLS was assessed via a computer‐assisted personal interview and self‐administered questionnaires according to current diagnostic criteria in 1567 participants of a preliminary phase of an adult population‐based study performed in S outh T yrol, I taly. Results: Migraineurs had an increased risk of having RLS also after adjustment for confounding factors such as age, sex, major depression, anxiety and sleep quality (odds ratio 1.79; confidence interval 1.00–3.19; P = 0.049). This association was not modified by aura status and possible causes of secondary RLS. RLS was not significantly associated with tension‐type headache. Conclusions: R estless legs syndrome and migraine were associated in our rural adult population. This association could be explained by a possible shared pathogenic pathway which would implicate new management strategies of these two disorders.
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Metadata
- Authors
- Zanigni, S., Giannini, G., Melotti, R., Pattaro, C., Provini, F., Cevoli, S., Facheris, M. F., Cortelli, P., & Pramstaller, P. P.
- Affiliations
- Eurac Research (IT)
- University of Bologna (IT)
- IRCCS Institute of Neurological Sciences of Bologna Bologna Italy
- Corresponding author
- Zanigni, Stefano
- ORCID
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2014-05-20
- Volume
- 21
- Issue
- 9
- Pages
- 1205-1210
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2159383166
- Cited by
- 32
- References
- 36
- Citations by year
- 2026: 1 · 2024: 7 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- restless legs syndrome, migraine, comorbidities, tension-type headache, migraine aura, sleep quality, depression, anxiety, rural population
- MeSH terms
- Adult, Aged, Cross-Sectional Studies, Europe, Female, Humans, Male, Middle Aged, Migraine Disorders, Regression Analysis, Restless Legs Syndrome, Comorbidity, Prevalence, Chi-Square Distribution, Community Health Planning
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