Cited by 197Dementia and Cognitive Impairment ResearchCOVID-19 and Mental HealthLong-Term Effects of COVID-19

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Neuropsychiatric symptoms and quality of life in Spanish patients with Alzheimer’s disease during the COVID‐19 lockdown

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Lara, B., Carnes, A., Dakterzada, F., Benitez, I., Piñol‐Ripoll, G.·2020·European Journal of Neurology

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Abstract

BACKGROUND AND PURPOSE: The COVID-19 epidemic is affecting almost all individuals worldwide, and patients with Alzheimer's disease (AD) and amnesic mild cognitive impairment (MCI) are particularly at risk due to their characteristics and age. We analysed the impact of the pandemic on these patients' neuropsychiatric symptoms and their quality of life after 5 weeks of lockdown in Spain. METHODS: A total of 40 patients with a diagnosis of MCI (n = 20) or mild AD (n = 20) from the Cognitive Stimulation Program of the Cognitive Disorders Unit were evaluated. All patients had undergone a previous evaluation during the month before the lockdown, and were re-evaluated after 5 weeks of lockdown. The Neuropsychiatric Inventory (NPI) and EuroQol-5D questionnaire (EQ-5D) were used to assess neuropsychiatric symptoms in patients and the quality of life in patients as well in caregivers. RESULTS: The mean (SD) total baseline NPI score was 33.75 (22.28), compared with 39.05 (27.96) after confinement (P = 0.028). The most frequently affected neuropsychiatric symptoms were apathy [4.15 (3.78) vs. 5.75 (4.02); P = 0.002] and anxiety [3.95 (3.73) vs. 5.30 (4.01); P = 0.006] in patients with MCI, and apathy [2.35 (2.70) vs. 3.75 (3.78); P = 0.036], agitation [0.45 (1.14) vs. 1.50 (2.66); P = 0.029] and aberrant motor behaviour [1.25 (2.86) vs. 2.00 (2.93); P = 0.044] in patients with AD. We did not observe differences in EQ-5D scores during the re-evaluation. The 30% of patients and 40% of caregivers reported a worsening of the patients' health status during confinement. CONCLUSIONS: The results of this study show the worsening of neuropsychiatric symptoms in patients with AD and MCI during 5 weeks of lockdown, with agitation, apathy and aberrant motor activity being the most affected symptoms.

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The impact of COVID-19 on the lives of community- dwelling people with dementia and informal carers in the context of using the social and medical services – a qualitative studyPreprint
Maćkowiak, M., Senczyszyn, A., Lion, K., Trypka, E., Małecka, M., Ciułkowicz, M., Mazurek, J., Świderska, R., Giebel, C. M., Gabbay, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-415217/v1
COVID-19 - O VÍRUS QUE MOVIMENTOU A CIÊNCIA - VOLUME 2
Duarte, F. B., Dutra, A. P. B. S., de Freitas, G. V., Fukuoka, V. M., Guimarães, L. F., Moeller, A. G., de Oliveira, F., Paz, A. A., Seroiska, G., da Silva, A. L., et al. (2021) · Editora Pasteur eBooks · doi:10.29327/535425
Soins virtuels pour les patients atteints de la maladie d’Alzheimer et de démences connexes à l’ère de la COVID-19 et au-delà
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Editorial_COVID-19 and Geriatric Mental Health: the biopsychosocial aspects
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Разработка технологии и оценка качества порошков из крупяных шротов
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Health-related quality of life following percutaneous coronary intervention during the COVID-19 pandemic
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“Other studies have been limited by small cohort sizes and often no comparative group, showing neutral (inflammatory bowel disease, cancer) [20, 21, 23], mixed (Alzheimer’s) [24], or negative (common variable immuno-deficiency, Parkinson’s disease) [25, 26] impacts of COVID-19 on HRQOL among various disease populations.”
Background
Direct and indirect neurological, cognitive and behavioral effects of COVID-19 on the normal elderly, Mild-Cognitive-Impairment and Alzheimer’s Disease populationsPreprint
Iodice, F., Cassano, V., & Rossini, P. M. (2020) · doi:10.21203/rs.3.rs-77758/v1
Neuro-Covid-19 et population gériatrique : quelles particularités ?
Khattab, H., Sikkal, A., Bellakhdar, S., Otmani, H. E., Moutawakil, B. E., & Rafai, M. A. (2022) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2022.01.005
How Can We Facilitate Psychological Recovery Following the COVID-19 Pandemic?
Datta, S. S., Mukherjee, A., & Maitra, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-8472-2_6
Minimal impact of COVID-19 on the mental health and well-being of people living with dementia: analysis on matched longitudinal data from the IDEAL studyPreprint
Sabatini, S. (2022) · doi:10.31219/osf.io/vc4jm
Cognitive impairment in patients with coronavirus infection
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Association between Anxiety and Disease Pathophysiology in Participants of Longitudinal Observational Studies in Aging during the COVID-19 LockdownPreprint
Servaes, S., Lussier, F. Z., Tissot, C., Therriault, J., Bezgin, G., Wang, Y.-T., Stevenson, J., Rahmouni, N., Pallen, V., Elgbeili, G., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1968616/v1
Coronavirus infection and cognitive disorders: possible approaches to treatment with Ginkgo biloba
Koberskaya, N. N., & Yakhno, N. N. (2021) · Hi+Med High Technologies in Medicine · doi:10.55947/2782-4748-2021-68-5-8-14
A Comparison of Occupational Balance, Fatigue, Depression, and Anxiety in Hospital-Discharged COVID-19 Survivors with Healthy Individuals: A Cross-sectional Study
Dehmiyani, A., Azizi, S., Kazemi-Galougahi, M. H., Dadarkhah, A., & Asgari, A. (2022) · Annals of Military and Health Sciences Research · doi:10.5812/amh-132868
“Another study reported that psychiatric symptoms in people with Alzheimer’s disease increased and significantly worsened five weeks after being infected with COVID-19 (37).”
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Dolgotrajni covid-19/postcovidni sindrom in kognitivne motnje
Lovrečić, B., Lovrečić, M., & Grkman, L. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_06
Uvodne strani / Front
(2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_00
Breme neformalnih oskrbovalcev oseb z demenco v času covida-19
Lovrečić, B., Lovrečić, M., & Mavrič, N. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_08
Research Progress on the Impact of Social Isolation on Alzheimer’s Disease
肖, 静. (2022) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2022.124035
Post-COVID-19 manifestations: A study of analyzing symptoms, complications following hospitalization
Kaur, D., Agrawal, K. C., Deep, A., Choudhary, H., Soni, L. K., Saran, R., & Sankhla, V. (2022) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_219_22
Dinamika nevropsihiatričnih simptomov pri osebah z demenco v povezavi s pandemijo in covidom-19
Lovrečić, B., Lovrečić, M., & Grkman, L. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_05
Duševno zdravje neformalnih družinskih oskrbovalcev oseb z demenco
Lovrečić, B., Lovrečić, M., & Cizl, M. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_07
Javnozdravstveni izzivi demence
Lovrečić, B., Lovrečić, M., Sambt, J., Grkman, L., Simon, M. R., Mavrič, N., Sedlak, S., Jelenc, M., Cizl, M., Kralj, M., et al. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966 · Cited by 2
Poznavanje demence med splošno javnostjo
Lovrečić, B., Lovrečić, M., & Mavrič, N. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_02
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Ekonomsko breme demence v Sloveniji glede na rutinske podatkovne zbirke zdravstvenega varstva
Lovrečić, B., Sambt, J., Sedlak, S., & Jelenc, M. (2022) · ZRC SAZU, Založba ZRC eBooks · doi:10.3986/9789610506966_04
The effects of lifestyle in Alzheimer's disease during the COVID-19 pandemic
Ray, S., Khan, S. Y., Khan, S., Ali, K., Gray, Z. C., Manna, P. R., & Reddy, P. H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00006-4
Impact of COVID-19 restrictions on newly occurring loneliness in older people – a prospective study in a memory clinic populationPreprint
Defrancesco, M., Hofer, A., & Schurr, T. A. (2023) · Research Square · doi:10.21203/rs.3.rs-3481270/v1
DEMÊNCIA DE ALZHEIMER: DESAFIOS, IMPACTO NOS CUIDADORES INFORMAIS E IMPLICAÇÕES PARA A PRÁTICA
Brito, L., Leite, Â. M. T., & Pereira, M. G. (2023) · Editora Artemis eBooks · doi:10.37572/edart_2911230938 · Cited by 1
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COVID-19 AS A TRIGGER FOR THE ONSET AND PROGRESSION OF NEURODEGENERATIVE PATHOLOGY PREDOMINANTLY IN ELDERLY AND SENILE POPULATION
Арьев, А. Л., & Лаптева, Е. С. (2024) · Успехи геронтологии · doi:10.34922/ae.2023.36.6.006
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Authors: Lara, B., Carnes, A., Dakterzada, F., Benitez, I., & Piñol‐Ripoll, G.
Affiliations: Hospital Universitari de Santa Maria (ES)
Hospital Universitari Arnau de Vilanova (ES)
Corresponding author: Piñol‐Ripoll, G.
ORCID: Lara, B.
Carnes, A.
Dakterzada, F.
Benitez, I.
Piñol‐Ripoll, G.
Venue: European Journal of Neurology
Publisher: Wiley
Published: 2020-06-24
Volume: 27
Issue: 9
Pages: 1744-1747
ISSN: 1351-5101 (ISSN-L)
1468-1331
DOI: 10.1111/ene.14339
PMC: PMC7283827
OpenAlex: W3026319603
Cited by: 197
References: 12
Citations by year: 2025: 10 · 2024: 18 · 2023: 19 · 2022: 68 · 2021: 60 · 2020: 21
FWCI: 30.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neurology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Repositori ObertUDL (University of Lleida) (acceptedVersion)
Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca (FI_B100153, SLT008/18)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords: Alzheimer's disease, amnestic mild cognitive impairment, neuropsychiatric symptoms, COVID-19 lockdown, quality of life, apathy, anxiety, agitation, caregiver burden, cognitive stimulation, Spain, EuroQol-5D, Neuropsychiatric Inventory, caregiver anxiety
MeSH terms: COVID-19, Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Female, Humans, Male, Neuropsychological Tests, Psychomotor Agitation, Quality of Life, Quarantine, Surveys and Questionnaires, Spain, Apathy, Pandemics

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Neuropsychiatric symptoms and quality of life in Spanish patients with Alzheimer’s disease during the COVID‐19 lockdown

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