Functional connectivity of hippocampal networks in temporal lobe epilepsy
Open accessAbstract
Summary: Objective: Temporal lobe epilepsy (TLE) affects brain areas beyond the temporal lobes due to connections of the hippocampi and other temporal lobe structures. Using functional connectivity magnetic resonance imaging (MRI), we determined the changes of hippocampal networks in TLE to assess for a more complete distribution of abnormality. Methods: Regions of interest (ROI s) were defined in the right and left hippocampi in three groups of participants: left TLE (n = 13), right TLE (n = 11), and healthy controls (n = 16). Brain regions functionally connected to these ROI s were identified by correlating resting‐state low‐frequency functional MRI (f MRI) blood oxygenation level–dependent (BOLD) signal fluctuations. The grouped results were compared using independent sample t‐test. Results: TLE was associated with increased hippocampal connectivity involving several key areas of the limbic network (temporal lobe, insula, thalamus), frontal lobes, angular gyrus, basal ganglia, brainstem, and cerebellum, along with reduced connectivity involving areas of the sensorimotor cortex (visual, somatosensory, auditory, primary motor) and the default mode network (precuneus). Left TLE had more marked connectivity changes than right TLE. Significance: The observed connectivity changes in TLE indicate dysfunctional networks that underlie widespread brain involvement in TLE. There are identifiable differences in the connectivity of the hippocampi between left and right TLE.
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In disease states, electrophysiological source imaging has revealed epileptic network characteristics in patients, even in the absence of epileptic activity.
“In disease states, ESI has revealed epileptic network characteristics in patients (89, 90), even in the absence of epileptic activity.”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [90]
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Electrophysiological source imaging: A noninvasive window to brain dynamics
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- Authors
- Haneef, Z., Lenartowicz, A., Yeh, H. J., Levin, H. S., Engel, J., & Stern, J. M.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Corresponding author
- Haneef, Zulfi
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2013-12-06
- Volume
- 55
- Issue
- 1
- Pages
- 137-145
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- PMC
- PMC3946924
- OpenAlex
- W1973720103
- Cited by
- 235
- References
- 61
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 14 · 2023: 10 · 2022: 19 · 2021: 27 · 2020: 24 · 2019: 21 · 2018: 17 · 2017: 14 · 2016: 26 · 2015: 19 · 2014: 16
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- The Epilepsy Foundation of America (ZH)
- NIH-NINDS K23 (NS044936)
- The Leff Family Foundation (JMS)
- National Institutes of Health (NIH
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- temporal lobe epilepsy, hippocampal network, functional connectivity, resting-state fMRI, limbic network, hemispheric lateralization, default mode network, thalamus, insula, sensorimotor cortex, cerebellum, basal ganglia
- MeSH terms
- Adult, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Young Adult, Functional Neuroimaging
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