Evolution of ecological dominance of yeast species in high-sugar environments
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Abstract
In budding yeasts, fermentation in the presence of oxygen evolved around the time of a whole genome duplication (WGD) and is thought to confer dominance in high-sugar environments because ethanol is toxic to many species. Although there are many fermentative yeast species, only Saccharomyces cerevisiae consistently dominates wine fermentations. In this study, we use coculture experiments and intrinsic growth rate assays to examine the relative fitness of non-WGD and WGD yeast species across environments to assess when S. cerevisiae's ability to dominate high-sugar environments arose. We show that S. cerevisiae dominates nearly all other non-WGD and WGD species except for its sibling species S. paradoxus in both grape juice and a high-sugar rich medium. Of the species we tested, S. cerevisiae and S. paradoxus have evolved the highest ethanol tolerance and intrinsic growth rate in grape juice. However, the ability of S. cerevisiae and S. paradoxus to dominate certain species depends on the temperature and the type of high-sugar environment. Our results indicate that dominance of high-sugar environments evolved much more recently than the WGD, most likely just prior to or during the differentiation of Saccharomyces species, and that evolution of multiple traits contributes to S. cerevisiae's ability to dominate wine fermentations.
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Many aspects of S. cerevisiae energy metabolism are relatively recent evolutionary adaptations to the predominantly fermentative lifestyle and are not typical of other yeast lineages.
“many aspects of its energy metabolism are relatively recent evolutionary adaptations to the predominantly fermentative lifestyle and are not typical of other yeast lineages”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Williams et al. 2015
The passage on the evolution of fermentation (section labelled Abstract; page unavailable) describes changes in energy metabolism in S. cerevisiae’s lineage and says most yeast species instead use respiration in the presence of oxygen. But the Discussion calls the metabolic change ancient and says that ecological dominance—not the fermentative lifestyle—evolved much more recently. The source therefore does not support characterizing the metabolic adaptations themselves as relatively recent. (LLM, conf=0.83)
Experimental — accuracy not yet measuredS. cerevisiae belongs to yeasts exhibiting the Crabtree effect, a preference for fermentative energy production in high glucose concentration even in the presence of oxygen.
“S. cerevisiae belongs to yeasts exhibiting the Crabtree effect—preference for fermentative energy production in high glucose concentration even in the presence of oxygen (Hagman et al. 2013; Pfeiffer and Morley 2014; Williams et al. 2015; Nespolo et al. 2020).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Williams et al. 2015
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- Authors
- Williams, K. M., Liu, P., & Fay, J. C.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-07-14
- Volume
- 69
- Issue
- 8
- Pages
- 2079-2093
- ISSN
- 0014-3820 (ISSN-L)
- 1558-5646
- PMC
- PMC4751874
- OpenAlex
- W1901476197
- Cited by
- 59
- References
- 99
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 11 · 2016: 6
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evolution (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Open Scholarship Institutional Repository (Washington University in St. Louis) (submittedVersion)
- Washington University in St. Louis Libraries
- Funders
- National Institutes of Health (HG000045, GM080669)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Saccharomyces cerevisiae, Saccharomyces paradoxus, whole-genome duplication, ecological dominance, ethanol tolerance, intrinsic rate of increase, wine fermentation, grape juice, interspecific competition, temperature effects
- MeSH terms
- Ethanol, Fermentation, Genes, Fungal, Saccharomyces, Wine, Coculture Techniques, Gene Duplication, Vitis, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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