Skin manifestations of mitochondrial dysfunction: More important than previously thought
Open accessAbstract
Mitochondrial DNA (mtDNA) research is emerging within the dermatological field as a unique biomarker for diagnostic, prognostic and even therapeutic exploration. Since the first review of the role of mtDNA in skin disease was authored by our group some 14 years ago (1), there have been many exciting observations linking mitochondria to the defective structural, cell signaling, and oxidative damage pathways that promote skin disease manifestation
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Alterations in mitochondrial function can adversely impact skin health and lead to skin disease.
“This is of particular importance as there is increasing evidence that alterations in mitochondrial function can adversely impact skin health and lead to skin disease [26].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [26]
Cites
Quinlan, C. L., Orr, A. L., Perevoshchikova, I. V., Treberg, J. R., Ackrell, B. A., & Brand, M. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374629 · Cited by 670 · see citing works
Greaves, L. C., Reeve, A. K., Taylor, R. W., & Turnbull, D. M. (2011) · The Journal of Pathology · doi:10.1002/path.3028 · Cited by 301 · see citing works
Birch-Machin, M. A., & Swalwell, H. (2010) · Mutagenesis · doi:10.1093/mutage/gep061 · Cited by 159 · see citing works
Self-citationMitochondrial dysfunction: a neglected component of skin diseases
Feichtinger, R. G., Sperl, W., Bauer, J. W., & Kofler, B. (2014) · Experimental Dermatology · doi:10.1111/exd.12484 · Cited by 90 · see citing works
Oyewole, A. O., Wilmot, M., Fowler, M., & Birch‐Machin, M. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-237008 · Cited by 90 · see citing works
Tulah, A. S., & Birch‐Machin, M. A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.11.007 · Cited by 72 · see citing works
Self-citationBirch‐Machin, M. A. (2000) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2000.00605.x · Cited by 63 · see citing works
Self-citationBowman, A., Martinez‐Levasseur, L. M., Acevedo‐Whitehouse, K. A., Gendron, D., & Birch‐Machin, M. A. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.04.003 · Cited by 16 · see citing works
Self-citationBoulton, S. J., Keane, P. C., Morris, C. M., et al. (2012) · Redox Report · doi:10.1179/1351000212y.0000000011 · Cited by 9 · see citing works
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Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin
Naidoo, K., & Birch-Machin, M. (2017) · Cosmetics · doi:10.3390/cosmetics4010004 · Cited by 83 · see citing works
Self-citationMitochondrial damage and ageing using skin as a model organ
Hudson, L., Bowman, A., Rashdan, E., & Birch-Machin, M. A. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.04.021 · Cited by 25 · see citing works
Determination of the Action Spectrum of UVR-Induced Mitochondrial DNA Damage in Human Skin Cells
Latimer, J. A., Lloyd, J. J., Diffey, B. L., Matts, P. J., & Birch-Machin, M. A. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.194 · Cited by 15 · see citing works
Self-citation
- Authors
- Boulton, S. J., Bowman, A., Koohgoli, R., & Birch‐Machin, M. A.
- Affiliations
- Dermatological Sciences Institute of Cellular Medicine Newcastle University Newcastle UK
- Newcastle University (GB)
- University of Guelph (CA)
- Corresponding author
- Birch‐Machin, Mark A.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 24
- Issue
- 1
- Pages
- 12-13
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2043759663
- Cited by
- 19
- References
- 9
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc)
- Funders
- National Institute for Health Research Newcastle Biomedical Research Centre (RES/0211/7699)
- Newcastle University (C0241N3010)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- mitochondrial dysfunction, mitochondrial DNA mutations, skin diseases, heteroplasmy, mitochondrial electron transport chain, succinate dehydrogenase, epidermolysis bullosa simplex, oxidative phosphorylation, ATP production, mitochondrial markers, skin blistering, TCA cycle
- MeSH terms
- Humans, Mitochondria, Skin Diseases, Mitochondrial Diseases
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