Mitochondrial damage and ageing using skin as a model organ
Open accessAbstract
Ageing describes the progressive functional decline of an organism over time, leading to an increase in susceptibility to age-related diseases and eventually to death, and it is a phenomenon observed across a wide range of organisms. Despite a vast repertoire of ageing studies performed over the past century, the exact causes of ageing remain unknown. For over 50 years it has been speculated that mitochondria play a key role in the ageing process, due mainly to correlative data showing an increase in mitochondrial dysfunction, mitochondrial DNA (mtDNA) damage, and reactive oxygen species (ROS) with age. However, the exact role of the mitochondria in the ageing process remains unknown. The skin is often used to study human ageing, due to its easy accessibility, and the observation that the ageing process is able to be accelerated in this organ via environmental insults, such as ultra violet radiation (UVR). This provides a useful tool to investigate the mechanisms regulating ageing and, in particular, the role of the mitochondria. Observations from dermatological and photoageing studies can provide useful insights into chronological ageing of the skin and other organs such as the brain and liver. Moreover, a wide range of diseases are associated with ageing; therefore, understanding the cause of the ageing process as well as regulatory mechanisms involved could provide potentially advantageous therapeutic targets for the prevention or treatment of such diseases.
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More recently the process of mitohormesis has been proposed based on observations that low concentrations of ROS can induce a positive response whilst higher concentrations of ROS promotes damage; different levels of oxidative stress may have opposite biological outcomes.
“More recently the process of mitohormesis has been proposed based on observations that low concentrations of ROS can induce a positive response whilst higher concentrations of ROS promotes damage; an interesting concept that different levels of oxidative stress may have opposite biological outcomes [Hudson et al., 2016].”
From Oxidative stress and ageing (2016) · cites this paper as Hudson et al., 2016
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Hanna, R., Crowther, J. M., Bulsara, P. A., Wang, X., Moore, D. J., & Birch‐Machin, M. A. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.04.009 · Cited by 11 · see citing works
Beyond skin deep: Revealing the essence of iPS cell-generated skin organoids in regeneration
Zhang, Y.-X., Zhou, Y., Xiong, Y., & Li, Y. (2024) · Burns · doi:10.1016/j.burns.2024.06.011 · Cited by 7 · see citing works
Adaptogen Technology for Skin Resilience Benefits
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Johzuka, J., Ona, T., & Nomura, M. (2018) · Analytical Sciences · doi:10.2116/analsci.18p013 · Cited by 5 · see citing works
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Tanakol, A., Uzunçakmak, T. K., & Kutlubay, Z. (2021) · Dermatoz · doi:10.4274/dermatoz.galenos.2021.68077 · Cited by 3 · see citing works
Oxidative Stress, Metabolism and Photoaging – The Role of Mitochondria
Jackson, M. J., Naidoo, K., & Birch‐Machin, M. A. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015981-00105 · Cited by 2 · see citing works
Shaping Up Mitochondrion in Motion
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Effect of menopausal hormone therapy on the skin as a component of healthy aging
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“Все закономерные возрастные процессы на клеточном уровне происходят в коже, поэтому ее часто используют в качестве удобной модели для изучения биологических механизмов старения человека в целом [1].”
Ruddy, E., Zhu, G., Idowu, O. C., & Birch‐Machin, M. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85666-9.00008-5
Mitochondrial DNA Biomarkers in Skin Disease Featuring Skin Aging
Moor, J., Ruddy, E., Idowu, O. C., & Birch‐Machin, M. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-66513-4_1
- Authors
- Hudson, L., Bowman, A., Rashdan, E., & Birch-Machin, M. A.
- Affiliations
- Newcastle University (GB)
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 93
- Pages
- 34-40
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W2345614571
- Cited by
- 25
- References
- 60
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- Medical Research Council (MC_PC_14101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- mitochondrial damage, aging, skin aging, photoaging, mitochondrial dysfunction, mitochondrial DNA damage, reactive oxygen species, ultraviolet radiation, chronological aging, age-related diseases
- MeSH terms
- Aging, Animals, DNA, Mitochondrial, Humans, Mitochondria, Skin, Reactive Oxygen Species
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