Increased expression of PD 1 and CD 39 on CD 3+CD 4+ skin T cells in the elderly
Abstract
Normal ageing is associated with an impaired systemic immune response contributing to an increased susceptibility to infectious diseases. The aim of this study was to compare the lymphocyte phenotype in human skin from old and young healthy subjects. Skin samples from donors were used for explant cultures before flow cytometric analysis. Our results depicted a higher proportion of CD 4+ and a lower proportion of CD 8+ among CD 3+ T cells, a decreased proportion of CD 45 RA+ naive T cells (3.5 ± 1.9% vs 22.9 ± 11.1%, P ≤ 0.007) and an upregulation of the expression of CD 39 and PD 1 on CD 3+CD 4+ T cells (25.1 ± 8.5% vs 12.5 ± 8.5%, P ≤ 0.003, 68.8 ± 11.6% vs 50.0 ± 11.3%, P ≤ 0.01, respectively) in the skin of old subjects. These findings could explain a reduced generation of long‐lived memory T cells and an impaired antitumoral response in the skin of the elderly.
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Aged skin exhibits increased numbers of regulatory T cells and elevated expression of the immunosuppressive receptor PD-1, which may contribute to weakened adaptive immunity.
“Moreover, aged skin exhibits increased numbers of regulatory T cells (Tregs)166 and elevated expression of the immunosuppressive receptor PD-1,165,167 which may contribute to weakened adaptive immunity.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [165]
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Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
- Authors
- Zuelgaray, E., Boccara, D., Ly Ka So, S., Boismal, F., Mimoun, M., Bagot, M., Bensussan, A., Bouaziz, J., & Michel, L.
- Affiliations
- Inserm (FR)
- INSERM UMRS‐976 Saint‐Louis Hospital Paris France
- Corresponding author
- Michel, Laurence
- ORCID
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2019-01
- Volume
- 28
- Issue
- 1
- Pages
- 80-82
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2901832992
- Cited by
- 23
- References
- 16
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Société Française de Dermatologie et de Pathologie Sexuellement Transmissible
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- PD-1, CD39, CD4+ T cells, aging, older adults, naive T cells, CD45RA, CD8+ T cells, memory T cells, antitumor immunity, immunosenescence, skin explant culture
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aging, Apyrase, Female, Humans, Male, Middle Aged, Phenotype, Skin, CD4-Positive T-Lymphocytes, CD4-CD8 Ratio, CD3 Complex, Leukocyte Common Antigens, CD8-Positive T-Lymphocytes, Young Adult, Programmed Cell Death 1 Receptor, Healthy Volunteers
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