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Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis
Open accessAbstract
Primary cilia influence cell activity, and thus have a unique role in maintaining cell proliferation and differentiation. In atopic dermatitis (AD) and psoriasis, areas of skin inflammation exhibit dysregulated keratinocyte homeostasis. The role of primary cilia in these conditions remains unclear. The objectives of this study is to elucidate the incidence of primary cilia in skin inflammation and the potential mechanism underlying the dysregulation of keratinocytes. Primary cilia were observed using immunofluorescence staining. Normal skin samples were compared with skin samples from patients with AD or psoriasis in terms of cilia numbers and length. The effect of cytokine stimulation on ciliogenesis in keratinocytes was analysed using a primary keratinocyte culture. IFT88, an important ciliary intraflagellar protein, was blocked in Th2 and Th17 cytokines‐stimulated keratinocytes. These effects were analysed with quantitative polymerase chain reaction and Western blot. Significant increases in ciliated cells were observed in AD and psoriasis skin samples compared with normal skin samples. The stimulation of keratinocytes using Th2 and Th17 cytokines modulated the formation of primary cilia. The amount of IFT88 in the primary cilia associated with the phosphorylation of JNK, but not p38, in keratinocytes stimulated with interleukin‐13, 17A and 22. An increase of ciliated cells in the epidermis may impair keratinocyte differentiation under stress conditions caused by inflammation in both AD and psoriasis patients.
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The primary cilium can regulate immune responses.
“These reports suggest that the primary cilium can regulate immune responses, although the role of the primary cilium in neuroinflammation remains largely unexplored.”
From Astrocyte-specific inhibition of the primary cilium suppresses C3 expression in reactive astrocyte (2024) · cites this paper as Rizaldy et al. 2021
The Discussion (page unavailable) reports a relationship between primary cilia and pro-inflammatory NFκB signaling in chondrocytes. The paper also finds that a cilia-related protein affects JNK phosphorylation in cytokine-stimulated keratinocytes, but it does not establish that primary cilia regulate immune responses broadly. (LLM, conf=0.78)
Experimental — accuracy not yet measuredRecent evidence suggests a link between primary cilium defects and autoimmune and allergic diseases.
“Furthermore, recent evidence suggests a link between primary cilium defects and autoimmune and allergic diseases (Tsyklauri et al. 2021; Rizaldy et al. 2021; Toriyama et al. 2023; Toriyama and Ishii 2021).”
From Astrocyte-specific inhibition of the primary cilium suppresses C3 expression in reactive astrocyte (2024) · cites this paper as Rizaldy et al. 2021
The Results and Discussion report increased primary cilia in the epidermis of patients with atopic dermatitis and psoriasis, supporting a link between altered ciliation and these two inflammatory skin diseases. The paper does not establish primary-cilium defects across autoimmune and allergic diseases more broadly; it reports increased cilia rather than demonstrating a general defect. (LLM, conf=0.85)
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Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation
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Astrocyte-specific inhibition of the primary cilium suppresses C3 expression in reactive astrocyte
Muhamad, N. A., Masutani, K., Furukawa, S., Yuri, S., Toriyama, M., Matsumoto, C., Itoh, S., Shinagawa, Y., Isotani, A., Toriyama, M., et al. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01482-5 · Cited by 9
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Metadata
- Authors
- Rizaldy, D., Toriyama, M., Kato, H., Fukui, R., Fujita, F., Nakamura, M., Okada, F., Morita, A., & Ishii, K. J.
- Affiliations
- Bandung Institute of Technology (ID)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Nagoya City University (JP)
- Mandom Corp. (Japan) (JP)
- Corresponding author
- Morita, Akimichi
- Ishii, Ken J.
- ORCID
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2021-02-12
- Volume
- 30
- Issue
- 6
- Pages
- 792-803
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W3124185010
- Cited by
- 17
- References
- 4
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- NAIST Digital Library (Nara Institute of Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan International Cooperation Agency
- Nagoya City University
- National Institutes of Biomedical Innovation, Health and Nutrition
- Japan Society for the Promotion of Science (21K15087, 19K17797)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- primary cilia, atopic dermatitis, psoriasis, keratinocytes, epidermis, ciliogenesis, IFT88, Th2 cytokines, Th17 cytokines, IL-13, IL-17A, IL-22, JNK phosphorylation, keratinocyte differentiation, skin inflammation
- MeSH terms
- Cells, Cultured, Cilia, Dermatitis, Atopic, Epidermis, Humans, Psoriasis, Keratinocytes, Cytokines
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