Cited by 181Genetic and Kidney Cyst DiseasesCystic Fibrosis Research AdvancesHedgehog Signaling Pathway Studies

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

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Christensen, Søren T, Clement, Christian A, Satir, Peter, Pedersen, Lotte B·2012·The Journal of Pathology

Abstract

Primary cilia are microtubule‐based sensory organelles that coordinate signalling pathways in cell‐cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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  • Designated class II and III RTKs, including PDGFRα, IR, and IGF1R, operate in primary cilia to control specific cellular and tissue processes.

    “Designated subtypes of class II and class III RTKs, including platelet-derived growth factor alpha receptor (PDFGRα), the insulin receptor (IR) and insulin-like growth factor receptor (IGFIR) operate in primary cilia to control specific processes in cells and tissues 222, 223”

    From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [223]

    The RTK overview and the PDGFRα and IGF-1R signalling sections describe PDGFRα and IGF1R signalling through primary cilia in cell migration, cell-cycle control, and differentiation. The IGF-1R section mentions IR as a related receptor and a kinase that targets IRS-1, but does not say IR operates in primary cilia. The cited passages also do not specify the class II/III designations; page numbers are unavailable in our copy. (LLM, conf=0.85)

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Authors
Christensen, S. T., Clement, C. A., Satir, P., & Pedersen, L. B.
Affiliations
  • University of Copenhagen (DK)
  • Albert Einstein College of Medicine (US)
Corresponding author
Christensen, Søren T
Venue
The Journal of Pathology
Publisher
Wiley
Published
2011-11-21
Volume
226
Issue
2
Pages
172-184
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
OpenAlex
W2074542365
Cited by
181
References
143
Citations by year
2026: 6 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 15 · 2017: 15 · 2016: 14 · 2015: 16 · 2014: 11 · 2013: 17 · 2012: 12
FWCI
1.39
Type
journal article
Language
en
Open access
Locations
  • The Journal of Pathology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords
primary cilia, receptor tyrosine kinase signaling, ciliopathies, signaling crosstalk, developmental disorders, tissue homeostasis
MeSH terms
Cell Communication, Cell Cycle, Cell Differentiation, Cell Movement, Cilia, Humans, Signal Transduction, Receptors, Fibroblast Growth Factor, Receptor, IGF Type 1, Receptor Protein-Tyrosine Kinases, Receptor, Platelet-Derived Growth Factor alpha, ErbB Receptors

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