Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
Open accessAbstract
Primary cilia are microtubule‐based sensory organelles that coordinate signalling pathways in cell‐cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Designated class II and III RTKs, including PDGFRα, IR, and IGF1R, operate in primary cilia to control specific cellular and tissue processes.
“Designated subtypes of class II and class III RTKs, including platelet-derived growth factor alpha receptor (PDFGRα), the insulin receptor (IR) and insulin-like growth factor receptor (IGFIR) operate in primary cilia to control specific processes in cells and tissues 222, 223”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [223]
The RTK overview and the PDGFRα and IGF-1R signalling sections describe PDGFRα and IGF1R signalling through primary cilia in cell migration, cell-cycle control, and differentiation. The IGF-1R section mentions IR as a related receptor and a kinase that targets IRS-1, but does not say IR operates in primary cilia. The cited passages also do not specify the class II/III designations; page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works
Role of platelet-derived growth factors in physiology and medicinePreprint
Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,444 · see citing works
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824 · see citing works
Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. A., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,619 · see citing works
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U. F., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,460 · see citing works
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425 · see citing works
Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423 · see citing works
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384 · see citing works
Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331 · see citing works
When cilia go bad: cilia defects and ciliopathies
Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2278 · Cited by 1,257 · see citing works
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255 · see citing works
The Ciliopathies: An Emerging Class of Human Genetic Disorders
Badano, J. L., Mitsuma, N., Beales, P. L., & Katsanis, N. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115610 · Cited by 1,144 · see citing works
Overview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142 · cited 2× · see citing works
“The transition fibres and ciliary necklace appear to act as a selective filter or pore for cargo destined for the cilium [7,9–11].”
BackgroundSelf-citationPLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 952 · see citing works
HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890 · see citing works
Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium
Prætorius, H. A., & Spring, K. R. (2001) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0075-4 · Cited by 828 · see citing works
Shin, I., Yakes, F. M., Rojo, F., Shin, N.-Y., Bakin, A. V., Baselga, J. M., & Arteaga, C. L. (2002) · Nature Medicine · doi:10.1038/nm759 · Cited by 790 · see citing works
CENTRIOLES AND THE FORMATION OF RUDIMENTARY CILIA BY FIBROBLASTS AND SMOOTH MUSCLE CELLS
Sorokin, S. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.15.2.363 · Cited by 732 · see citing works
Mammalian target of rapamycin: a central node of complex signaling cascades.
Dobashi, Y., Watanabe, Y., Miwa, C., Suzuki, S., & Koyama, S. (2011) · PubMed Central · Cited by 721 · see citing works
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
Itoh, N., & Ornitz, D. M. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq121 · Cited by 708 · see citing works
The Vertebrate Primary Cilium in Development, Homeostasis, and Disease
Gerdes, J. M., Davis, E. E., & Katsanis, N. (2009) · Cell · doi:10.1016/j.cell.2009.03.023 · Cited by 700 · see citing works
Ciliopathies: an expanding disease spectrum
Waters, A. M., & Beales, P. L. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1731-7 · Cited by 676 · see citing works
PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts
Schneider, L., Clement, C. A., Teilmann, S. C., Pazour, G. J., Hoffmann, E. K., Satir, P., & Christensen, S. T. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.012 · Cited by 592 · see citing works
Self-citationNodal Flow and the Generation of Left-Right Asymmetry
Hirokawa, N., Tanaka, Y., Okada, Y., & Takeda, S. (2006) · Cell · doi:10.1016/j.cell.2006.03.002 · Cited by 576 · see citing works
Chapter Two Intraflagellar Transport (IFT)
Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521 · see citing works
Self-citationHu, Q., Milenković, L., Jin, H., Scott, M. P., Nachury, M. V., Spiliotis, E. T., & Nelson, W. J. (2010) · Science · doi:10.1126/science.1191054 · Cited by 513 · see citing works
The primary cilium at a glance
Satir, P., Pedersen, L. B., & Christensen, S. T. (2010) · Journal of Cell Science · doi:10.1242/jcs.050377 · Cited by 502 · see citing works
Self-citationp27 Kip1 modulates cell migration through the regulation of RhoA activationPreprint
Besson, A., Gurian-West, M., Schmidt, A., Hall, A., & Roberts, J. M. (2004) · Genes & Development · doi:10.1101/gad.1185504 · Cited by 487 · see citing works
Gilula, N. B., & Satir, P. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.53.2.494 · Cited by 484 · see citing works
Self-citationDavenport, J. R., Watts, A. J., Roper, V. C., Croyle, M. J., van Groen, T., Wyss, J. M., Nagy, T. R., Kesterson, R. A., & Yoder, B. K. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.034 · Cited by 482 · see citing works
Williams, C. L., Li, C., Kida, K., Inglis, P. N., Mohan, S., Semenec, L., Bialas, N. J., Stupay, R. M., Chen, N., Blacque, O. E., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201012116 · Cited by 453 · see citing works
Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?
Nachury, M. V., Seeley, E. S., & Jin, H. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113337 · Cited by 423 · see citing works
Bielas, S. L., Silhavy, J. L., Brancati, F., Kisseleva, M. V., Al‐Gazali, L., Sztriha, L., Bayoumi, R., Zaki, M. S., Aleem, A. K. A., Rosti, R. Ö., et al. (2009) · Nature Genetics · doi:10.1038/ng.423 · Cited by 397 · see citing works
Primary cilia regulate mTORC1 activity and cell size through Lkb1
Boehlke, C. S., Kotsis, F., Patel, V., Braeg, S., Voelker, H., Bredt, S., Beyer, T., Janusch, H., Hamann, C., Gödel, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2117 · Cited by 387 · see citing works
Craige, B., Tsao, C.-C., Diener, D. R., Hou, Y., Lechtreck, K. F., Rosenbaum, J. L., & Witman, G. B. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006105 · Cited by 385 · see citing works
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
Zhang, H., Bajraszewski, N., Wu, E., Wang, H., Moseman, A. P., Dabora, S. L., Griffin, J. D., & Kwiatkowski, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28984 · Cited by 382 · see citing works
Conserved function for embryonic nodal cilia
Essner, J. J., Vogan, K. J., Wagner, M. K., Tabin, C. J., Yost, H. J., & Brueckner, M. K. (2002) · Nature · doi:10.1038/418037a · Cited by 375 · see citing works
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells
Tucker, R. W., Pardee, A. B., & Fujiwara, K. (1979) · Cell · doi:10.1016/0092-8674(79)90261-7 · Cited by 366 · see citing works
Nishimura, D. Y., Fath, M. A., Mullins, R. F., Searby, C. C., Andrews, M., Davis, R., Andorf, J. L., Mykytyn, K., Swiderski, R. E., Yang, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405496101 · Cited by 365 · see citing works
The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action
White, M. F., & Yenush, L. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80481-6_8 · Cited by 360 · see citing works
An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans
Tissenbaum, H. A., & Ruvkun, G. (1998) · Genetics · doi:10.1093/genetics/148.2.703 · Cited by 354 · see citing works
Berbari, N. F., Johnson, A. D., Lewis, J. S., Askwith, C. C., & Mykytyn, K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0942 · Cited by 352 · see citing works
Lechtreck, K.-F., Johnson, E. C., Sakai, T., Cochran, D., Ballif, B. A., Rush, J., Pazour, G. J., Ikebe, M., & Witman, G. B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200909183 · Cited by 347 · see citing works
Blacque, O. E., Reardon, M. J., Li, C., McCarthy, J., Mahjoub, M. R., Ansley, S. J., Badano, J. L., Mah, A. K., Beales, P. L., Davidson, W. S., et al. (2004) · Genes & Development · doi:10.1101/gad.1194004 · Cited by 347 · see citing works
FGF signalling: diverse roles during early vertebrate embryogenesis
Dorey, K., & Amaya, E. (2010) · Development · doi:10.1242/dev.037689 · Cited by 341 · see citing works
Jacoby, M., Cox, J. J., Gayral, S., Hampshire, D. J., Ayub, M., Blockmans, M., Pernot, E., Kisseleva, M. V., Compère, P., Schiffmann, S. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.427 · Cited by 339 · see citing works
Common corruption of the mTOR signaling network in human tumors
Menon, S., & Manning, B. D. (2008) · Oncogene · doi:10.1038/onc.2009.352 · Cited by 328 · see citing works
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
Seo, S., Guo, D., Bugge, K., Morgan, D. A., Rahmouni, K., & Sheffield, V. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp031 · Cited by 315 · see citing works
Ezratty, E. J., Stokes, N., Chai, S., Shah, A. S., Williams, S. E., & Fuchs, E. V. (2011) · Cell · doi:10.1016/j.cell.2011.05.030 · Cited by 314 · see citing works
Wallingford, J. B., & Mitchell, B. J. (2011) · Genes & Development · doi:10.1101/gad.2008011 · Cited by 304 · see citing works
The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
Molla‐Herman, A., Ghossoub, R., Blisnick, T., Meunier, A., Serres, C., Silbermann, F., Emmerson, C., Romeo, K., Bourdoncle, P., Schmitt, A., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.059519 · Cited by 301 · see citing works
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Moritz, A., Yu, L., Guo, A., Villén, J., Wang, Y., MacNeill, J., Kornhauser, J. M., Sprott, K. M., Zhou, J., Possemato, A. P., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000998 · Cited by 293 · see citing works
Testis determination requires insulin receptor family function in mice
Nef, S., Verma‐Kurvari, S., Merenmies, J. M., Vassalli, J. D., Efstratiadis, A., Accili, D., & Parada, L. F. (2003) · Nature · doi:10.1038/nature02059 · Cited by 292 · see citing works
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
Chauvet, V., Tian, X., Husson, H., Grimm, D. H., Wang, T., Hieseberger, T., Igarashi, P., Bennett, A. M., Ibraghimov‐Beskrovnaya, O., Somlo, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21753 · Cited by 292 · see citing works
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP
Dishinger, J. F., Kee, H. L., Jenkins, P. M., Fan, S., Hurd, T. W., Hammond, J. W., Truong, Y. N., Margolis, B. L., Martens, J. R., & Verhey, K. J. (2010) · Nature Cell Biology · doi:10.1038/ncb2073 · Cited by 285 · see citing works
Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease
Veland, I. R., Awan, A., Pedersen, L. B., Yoder, B. K., & Christensen, S. T. (2009) · Nephron Physiology · doi:10.1159/000208212 · Cited by 276 · see citing works
Self-citationInsulin-like Growth Factor I Receptor β-Subunit Heterogeneity
Moxham, C., Duronio, V., & Jacobs, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51620-3 · Cited by 261 · see citing works
FGF signalling during embryo development regulates cilia length in diverse epithelia
Neugebauer, J. M., Amack, J. D., Peterson, A. G., Bisgrove, B. W., & Yost, H. J. (2009) · Nature · doi:10.1038/nature07753 · Cited by 260 · see citing works
Sensory Cilia and Integration of Signal Transduction in Human Health and Disease
Christensen, S. T., Pedersen, L. B., Schneider, L. H., & Satir, P. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00516.x · Cited by 256 · see citing works
Self-citationNde1-mediated inhibition of ciliogenesis affects cell cycle re-entry
Kim, S., Zaghloul, N. A., Bubenshchikova, E., Oh, E. C. T., Rankin, S., Katsanis, N., Obara, T., & Tsiokas, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2183 · Cited by 251 · see citing works
Schneider, L., Cammer, M., Lehman, J., Nielsen, S., Guerra, C., Veland, I., Stock, C., Hoffmann, E., Yoder, B., Schwab, A., et al. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000276562 · Cited by 250 · see citing works
Self-citationA comprehensive map of the mTOR signaling network
Caron, É., Ghosh, S., Matsuoka, Y., Ashton‐Beaucage, D., Therrien, M., Lemieux, S., Perreault, C., Roux, P. P., & Kitano, H. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.108 · Cited by 241 · see citing works
Quarmby, L. M., & Parker, J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503053 · Cited by 239 · see citing works
Li, A., Saito, M., Chuang, J.-Z., Tseng, Y. Y., Dedesma, C., Tomizawa, K., Kaitsuka, T., & Sung, C.-H. (2011) · Nature Cell Biology · doi:10.1038/ncb2218 · Cited by 231 · see citing works
Phosphoinositide 3-Kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis
Brader, S., & Eccles, S. A. (2004) · Tumori Journal · doi:10.1177/030089160409000102 · Cited by 216 · see citing works
Pedersen, L. B., Veland, I. R., Schrøder, J. M., & Christensen, S. T. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21521 · Cited by 205 · see citing works
Self-citationWalczak‐Sztulpa, J., Eggenschwiler, J. T., Osborn, D. P. S., Brown, D. A., Emma, F., Klingenberg, C., Hennekam, R. C. M., Torre, G., Garshasbi, M., Tzschach, A., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.04.012 · Cited by 203 · see citing works
Localization of Extracellular Matrix Receptors on the Chondrocyte Primary Cilium
McGlashan, S. R., Jensen, C. G., & Poole, C. A. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6866.2006 · Cited by 191 · see citing works
Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors
Insinna, C., & Besharse, J. C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21554 · Cited by 190 · see citing works
Cilia in the nervous system: linking cilia function and neurodevelopmental disorders
Lee, J. E., & Gleeson, J. G. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283444d05 · Cited by 185 · see citing works
PKD2 Functions as an Epidermal Growth Factor-Activated Plasma Membrane Channel
Ma, R., Li, W.-P., Rundle, D., Kong, J., Akbarali, H. I., & Tsiokas, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8285-8298.2005 · Cited by 177 · see citing works
Rohatgi, R., & Snell, W. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.03.010 · Cited by 173 · see citing works
Cell Cycle–Dependent Ciliogenesis and Cancer
Plotnikova, O. V., Golemis, E. A., & Pugacheva, E. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5838 · Cited by 172 · see citing works
Centriole Age Underlies Asynchronous Primary Cilium Growth in Mammalian Cells
Anderson, C. T., & Stearns, T. (2009) · Current Biology · doi:10.1016/j.cub.2009.07.034 · Cited by 169 · see citing works
Albrecht‐Buehler, G. (1977) · Cell · doi:10.1016/0092-8674(77)90109-x · Cited by 161 · see citing works
Christensen, S. T., Pedersen, S. F., Satir, P., Veland, I. R., & Schneider, L. H. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00810-7 · Cited by 156 · see citing works
Self-citationZhu, D., Shi, S., Wang, H., & Liao, K. (2009) · Journal of Cell Science · doi:10.1242/jcs.046276 · Cited by 156 · see citing works
Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ
Jensen, C. G., Poole, C. A., McGlashan, S. R., Marko, M., Issa, Z. I., Vujcich, K. V., & Bowser, S. S. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.11.007 · Cited by 155 · see citing works
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery
Kiprilov, E. N., Awan, A., Desprat, R., Velho, M., Clement, C. A., Byskov, A. G., Andersen, C. Y., Satir, P., Bouhassira, E. E., Christensen, S. T., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706028 · Cited by 153 · see citing works
Self-citationKim, S., & Tsiokas, L. (2011) · Cell Cycle · doi:10.4161/cc.10.16.17009 · Cited by 150 · see citing works
p57KIP2: “Kip”ing the Cell under Control
Pateras, I. S., Apostolopoulou, K., Niforou, K., Kotsinas, A., & Gorgoulis, V. G. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0317 · Cited by 150 · see citing works
Cell biology of embryonic migration
Kurosaka, S., & Kashina, A. S. (2008) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20125 · Cited by 148 · see citing works
Chapter 5 Targeting Proteins to the Ciliary Membrane
Pazour, G. J., & Bloodgood, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00805-3 · Cited by 145 · see citing works
Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry
Kinzel, D., Boldt, K., Davis, E. E., Burtscher, I., Trümbach, D., Diplas, B. H., Attié‐Bitach, T., Wurst, W., Katsanis, N., Ueffing, M., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.005 · Cited by 145 · see citing works
C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome
Arts, H. H., Bongers, E. M. H. F., Mans, D. A., van Beersum, S. E. C., Oud, M. M., Bolat, E., Spruijt, L., Cornelissen, E. A. M., Schuurs-Hoeijmakers, J. H. M., de Leeuw, N., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2011.088864 · Cited by 144 · see citing works
EGF receptor activation by GPCRs: An universal pathway reveals different versions
Liebmann, C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.008 · Cited by 143 · see citing works
Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters
McGlashan, S. R., Cluett, E. C., Jensen, C. G., & Poole, C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21501 · Cited by 142 · see citing works
Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis
Miraoui, H., & Marie, P. J. (2010) · Science Signaling · doi:10.1126/scisignal.3146re9 · Cited by 141 · see citing works
Pathological Society of Great Britain and Ireland
McCance, D. J. (1984) · Journal of Medical Microbiology · doi:10.1099/00222615-18-3-438 · Cited by 139 · see citing works
Mechanical loading modulates chondrocyte primary cilia incidence and length
McGlashan, S. R., Knight, M. M., Chowdhury, T. T., Joshi, P., Jensen, C. G., Kennedy, S., & Poole, C. (2010) · Cell Biology International · doi:10.1042/cbi20090094 · Cited by 135 · see citing works
Knight, M. M., McGlashan, S. R., Garcia, M., Jensen, C. G., & Poole, C. A. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01021.x · Cited by 134 · see citing works
van Veelen, W., Korsse, S. E., van de Laar, L., & Peppelenbosch, M. P. (2011) · Oncogene · doi:10.1038/onc.2010.630 · Cited by 131 · see citing works
PLATELET-DERIVED GROWTH FACTOR
Ross, R. J. M. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.000443 · Cited by 126 · see citing works
IFT20 is required for opsin trafficking and photoreceptor outer segment development
Keady, B. T., Le, Y. Z., & Pazour, G. J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-09-0792 · Cited by 122 · see citing works
Protein Networks and Complexes in Photoreceptor Cilia
Roepman, R., & Wolfrum, U. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5943-8_10 · Cited by 122 · see citing works
p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility
Larrea, M. D., Wander, S. A., & Slingerland, J. M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9789 · Cited by 121 · see citing works
The ciliary pocket: a once-forgotten membrane domain at the base of cilia
Ghossoub, R., Molla‐Herman, A., Bastin, P., & Benmerah, A. (2011) · Biology of the Cell · doi:10.1042/bc20100128 · Cited by 118 · see citing works
Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?
Pyne, N. J., & Pyne, S. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.04.002 · Cited by 112 · see citing works
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms
Schrøder, J. M., Larsen, J., Komarova, Y. A., Akhmanova, A. S., Thorsteinsson, R. I., Grigoriev, I., Manguso, R. T., Christensen, S. T., Pedersen, S. F., Geimer, S., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.085852 · Cited by 112 · see citing works
Self-citationTakeuchi, K., & Ito, F. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07450.x · Cited by 109 · see citing works
Apical Oxidative Hyaluronan Degradation Stimulates Airway Ciliary Beating via RHAMM and RON
Manzanares, D., Monzon, M. E., Savani, R. C., & Salathe, M. A. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0413oc · Cited by 105 · see citing works
mTOR: A placental growth signaling sensor
Wen, H. Y., Abbasi, S., Kellems, R. E., & Xia, Y. (2005) · Placenta · doi:10.1016/j.placenta.2005.02.004 · Cited by 102 · see citing works
Rhodopsin Trafficking and its Role in Retinal Dystrophies
Sung, C.-H., & Tai, A. W. (1999) · International review of cytology · doi:10.1016/s0074-7696(08)62706-0 · Cited by 97 · see citing works
Evolution of the Insulin Receptor Family and Receptor Isoform Expression in Vertebrates
Hernández‐Sánchez, C., Mansilla, A., de Pablo, F., & Zardoya, R. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn036 · Cited by 97 · see citing works
Schneider, L., Stock, C.-M., Dieterich, P., Jensen, B. H., Pedersen, L. B., Satir, P., Schwab, A., Christensen, S. T., & Pedersen, S. F. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200806019 · Cited by 94 · see citing works
Self-citationFGF-dependent left–right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1
Hong, S., & Dawid, I. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812880106 · Cited by 93 · see citing works
Danilov, A. I., Gomes‐Leal, W., Ahlenius, H., Kokaia, Z., Carlemalm, E., & Lindvall, O. (2009) · Glia · doi:10.1002/glia.20741 · Cited by 89 · see citing works
Zhang, Q., Davenport, J. R., Croyle, M. J., Haycraft, C. J., & Yoder, B. K. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700207 · Cited by 87 · see citing works
TOR kinase complexes and cell migration
Liu, L., & Parent, C. A. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102090 · Cited by 87 · see citing works
Loss of Primary Cilia Upregulates Renal Hypertrophic Signaling and Promotes Cystogenesis
Bell, P. D., Fitzgibbon, W. R., Sas, K. M., Stenbit, A. E., Amria, M. Y., Houston, A., Reichert, R. J., Gilley, S. K., Siegal, G. P., Bissler, J. J., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010050526 · Cited by 86 · see citing works
de Andrea, C. E., Wiweger, M. I. K. N., Prins, F. A., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.81 · Cited by 81 · see citing works
Non-Random Distribution and Sensory Functions of Primary Cilia in Vascular Smooth Muscle Cells
Lu, C. J., Du, H., Wu, J., Jansen, D. A., Jordan, K. L., Xu, N., Sieck, G. C., & Qian, Q. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000132462 · Cited by 79 · see citing works
The solitary (primary) cilium–A mechanosensory toggle switch in bone and cartilage cells
Whitfield, J. F. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.001 · Cited by 78 · see citing works
Neuronal ciliary signaling in homeostasis and disease
Green, J. A., & Mykytyn, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0425-4 · Cited by 75 · see citing works
Polycystins, focal adhesions and extracellular matrix interactions
Drummond, I. A. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.003 · Cited by 75 · see citing works
Annenkov, A. E. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8081-0 · Cited by 73 · see citing works
Raychowdhury, M. K., Ramos, A. J., Zhang, P., McLaughin, M., Dai, X.-Q., Chen, X.-Z., Montalbetti, N., del Rocío Cantero, M., Ausiello, D. A., & Cantiello, H. F. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90509.2008 · Cited by 73 · see citing works
p21WAF1/CIP1 and cancer: A shifting paradigm?
Gartel, A. L. (2009) · BioFactors · doi:10.1002/biof.26 · Cited by 71 · see citing works
Intraflagellar transport proteins in ciliogenesis of photoreceptor cells
Sedmak, T., & Wolfrum, U. (2011) · Biology of the Cell · doi:10.1042/bc20110034 · Cited by 68 · see citing works
Cuello, F., Snabaitis, A. K., Cohen, M. S., et al. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029900 · Cited by 63 · see citing works
Pedersen, L. B., Schrøder, J. M., Satir, P., & Christensen, S. T. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110043 · Cited by 62 · see citing works
Self-citationFocal adhesion kinase as potential target for cancer therapy (Review)
Naomoto (2009) · Oncology Reports · doi:10.3892/or_00000524 · Cited by 62 · see citing works
Matsui, T., Thitamadee, S., Murata, T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017248108 · Cited by 61 · see citing works
Teilmann, S. C., & Christensen, S. T. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.03.006 · Cited by 59 · see citing works
Self-citationThe platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.
Lih, C., Cohen, S. N., Wang, C., & Lin‐Chao, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4617 · Cited by 57 · see citing works
Orientation of Primary Cilia of Articular Chondrocytes in Three‐Dimensional Space
Farnum, C. E., & Wilsman, N. J. (2011) · The Anatomical Record · doi:10.1002/ar.21330 · Cited by 57 · see citing works
Targeting p27Kip1protein: its relevance in the therapy of human cancer
Borriello, A., Bencivenga, D., Criscuolo, M., Caldarelli, I., Cucciolla, V., Tramontano, A., Borgia, A., Spina, A., Oliva, A., Naviglio, S., et al. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.561318 · Cited by 56 · see citing works
Cilium-generated signaling: a cellular GPS?
Benzing, T. R., & Walz, G. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000222690.53970.ca · Cited by 55 · see citing works
Characterization of Primary Cilia in Human Airway Smooth Muscle Cells
Wu, J., Du, H., Wang, X., Mei, C., Sieck, G. C., & Qian, Q. (2009) · CHEST Journal · doi:10.1378/chest.08-1549 · Cited by 54 · see citing works
p57: A multifunctional protein in cancer (Review)
Nan, N. (2010) · International Journal of Oncology · doi:10.3892/ijo_00000617 · Cited by 53 · see citing works
Xu, P., Zhu, K.-Y., Jin, Y., Chen, Y., Sun, X., Deng, M., Chen, S., Chen, Z., & Liu, T. X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914396107 · Cited by 52 · see citing works
ERK1/2-p90RSK-mediated Phosphorylation of Na+/H+ Exchanger Isoform 1
Luo, J., Kintner, D. B., Shull, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702373200 · Cited by 49 · see citing works
Christensen, S. T., & Ott, C. M. (2007) · Science · doi:10.1126/science.1146180 · Cited by 46 · see citing works
Self-citationFibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone
Evans, M. J., Fanucchi, M. V., Winkle, L. S. V., Baker, G. L., Murphy, A. E., Nishio, S. J., Sannes, P. L., & Plopper, C. G. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00180.2002 · Cited by 44 · see citing works
Pedersen, O. F., & Butler, J. P. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100025 · Cited by 42 · see citing works
RPGR: Role in the photoreceptor cilium, human retinal disease, and gene therapy
Hosch, J. U., Lorenz, B., & Stieger, K. (2010) · Ophthalmic Genetics · doi:10.3109/13816810.2010.535889 · Cited by 42 · see citing works
Fgf4 is required for left–right patterning of visceral organs in zebrafish
Yamauchi, H., Miyakawa, N., Miyake, A., et al. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.568 · Cited by 41 · see citing works
Sápi, Z., Füle, T., Hajdu, M., et al. (2011) · Diagnostic Molecular Pathology · doi:10.1097/pdm.0b013e3181eb931b · Cited by 31 · see citing works
A Variant of Fibroblast Growth Factor Receptor 2 (Fgfr2) Regulates Left-Right Asymmetry in Zebrafish
Liu, D.-W., Hsu, C.-H., Tsai, S.-M., Hsiao, C., & Wang, W.-P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021793 · Cited by 26 · see citing works
The orientation of primary cilia during the wound response in 3Y1 cells
Katsumoto, T., Higaki, K., Ohno, K., et al. (1994) · Biology of the Cell · doi:10.1016/0248-4900(94)90050-7 · Cited by 22 · see citing works
Awan, A., Oliveri, R. S., Jensen, P. L., Christensen, S. T., & Andersen, C. Y. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-369-5_11 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845 · see citing works
Self-citationIns and outs of GPCR signaling in primary cilia
Schou, K. B., Pedersen, L. B., & Christensen, S. T. (2015) · The EMBO Reports · doi:10.15252/embr.201540530 · Cited by 221 · see citing works
Self-citationPrimary cilium-dependent signaling mechanisms
Pala, R., Alomari, N., & Nauli, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112272 · Cited by 205 · see citing works
The roles of evolutionarily conserved functional modules in cilia-related trafficking
Sung, C.-H., & Leroux, M. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2888 · Cited by 186 · see citing works
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
Badgandi, H. B., Hwang, S.-H., Shimada, I. S., Loriot, E., & Mukhopadhyay, S. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201607095 · Cited by 182 · see citing works
Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
Wingfield, J. L., Lechtreck, K.-F., & Lorentzen, E. (2018) · Essays in Biochemistry · doi:10.1042/ebc20180030 · Cited by 157 · see citing works
How do cilia organize signalling cascades?
Nachury, M. V. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0465 · Cited by 150 · see citing works
Christensen, S. T., Morthorst, S. K., Mogensen, J. B., & Pedersen, L. B. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028167 · Cited by 125 · see citing works
Self-citationGuo, J., Otis, J. M., Suciu, S. K., Catalano, C., Xing, L., Constable, S., Wachten, D., Gupton, S., Lee, J., Lee, A., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.11.005 · Cited by 100 · see citing works
Clement, D. L., Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, S. F., & Christensen, S. T. (2012) · Journal of Cell Science · doi:10.1242/jcs.116426 · Cited by 94 · see citing works
Self-citationCilia and coordination of signaling networks during heart development
Koefoed, K., Veland, I. R., Pedersen, L. B., Larsen, L. A., & Christensen, S. T. (2014) · Organogenesis · doi:10.4161/org.27483 · Cited by 84 · see citing works
Self-citationThe intraflagellar transport machinery in ciliary signaling
Mourão, A., Christensen, S. T., & Lorentzen, E. (2016) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.06.009 · Cited by 83 · see citing works
Self-citationInversin/Nephrocystin-2 Is Required for Fibroblast Polarity and Directional Cell Migration
Veland, I. R., Montjean, R., Eley, L., Pedersen, L. B., Schwab, A., Goodship, J., Kristiansen, K., Pedersen, S. F., Saunier, S., & Christensen, S. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060193 · Cited by 67 · see citing works
Self-citationRegulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49 · see citing works
Self-citationWang, L., Guo, Q., Acharya, S., Zheng, X., Huynh, V., Whitmore, B., Yimit, A., Malhotra, M., Chatterji, S., Rosin, N., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01726-z · Cited by 33 · see citing works
Wang, H., Zou, X., Wei, Z., Wu, Y., Li, R., Zeng, R., Chen, Z., & Liao, K. (2014) · Journal of Cell Science · doi:10.1242/jcs.155101 · Cited by 21 · see citing works
- Authors
- Christensen, S. T., Clement, C. A., Satir, P., & Pedersen, L. B.
- Affiliations
- University of Copenhagen (DK)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Christensen, Søren T
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2011-11-21
- Volume
- 226
- Issue
- 2
- Pages
- 172-184
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- PMC
- PMC4294548
- OpenAlex
- W2074542365
- Cited by
- 181
- References
- 143
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 15 · 2017: 15 · 2016: 14 · 2015: 16 · 2014: 11 · 2013: 17 · 2012: 12
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- primary cilia, receptor tyrosine kinase signaling, ciliopathies, signaling crosstalk, developmental disorders, tissue homeostasis
- MeSH terms
- Cell Communication, Cell Cycle, Cell Differentiation, Cell Movement, Cilia, Humans, Signal Transduction, Receptors, Fibroblast Growth Factor, Receptor, IGF Type 1, Receptor Protein-Tyrosine Kinases, Receptor, Platelet-Derived Growth Factor alpha, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review