The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction
Open accessAbstract
There are many misconceptions surrounding the roles of protein phosphatases in the regulation of signal transduction, perhaps the most damaging of which is the erroneous view that these enzymes exert their effects merely as constitutively active housekeeping enzymes. On the contrary, the phosphatases are critical, specific regulators of signalling in their own right and serve an essential function, in a coordinated manner with the kinases, to determine the response to a physiological stimulus. This review is a personal perspective on the development of our understanding of the protein tyrosine phosphatase family of enzymes. I have discussed various aspects of the structure, regulation and function of the protein tyrosine phosphatase family, which I hope will illustrate the fundamental importance of these enzymes in the control of signal transduction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Protein Tyrosine Phosphatases in the Human Genome
Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T. (2004) · Cell · doi:10.1016/j.cell.2004.05.018 · Cited by 1,886
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
Neel, B. G., Gu, H., & Pao, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00091-4 · Cited by 1,249
Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235
Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) · Cell · doi:10.1016/0092-8674(93)90383-2 · Cited by 1,156
Self-citationRedox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T.-C., Hinks, J. A., Tonks, N. K., & Barford, D. (2003) · Nature · doi:10.1038/nature01680 · Cited by 951
Self-citationRegulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843
Dual-specificity phosphatases: critical regulators with diverse cellular targets
Patterson, K. I., Brummer, T., O'brien, P. M., & Daly, R. J. (2009) · Biochemical Journal · doi:10.1042/bj20082234 · Cited by 744
Structural Basis for Endosomal Targeting by the Bro1 Domain
Kim, J., Sitaraman, S., Hierro, A., Beach, B. M., Odorizzi, G., & Hurley, J. H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.001 · Cited by 174
Hao, L., Tiganis, T., Tonks, N. K., & Charbonneau, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29322 · Cited by 78
Self-citationA PTEN-related 5-Phosphatidylinositol Phosphatase Localized in the Golgi
Merlot, S., Meili, R., Pagliarini, D. J., Maehama, T., Dixon, J. E., & Firtel, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306318200 · Cited by 32
Cited by
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C.-M., Page, R., Blackledge, M., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1528 · Cited by 372
Self-citationProtein tyrosine phosphatases as potential therapeutic targets
He, R.-J., Yu, Z.-H., Zhang, R.-Y., & Zhang, Z.-Y. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.80 · Cited by 327
Genomics and evolution of protein phosphatases
Chen, M. J., Dixon, J. E., & Manning, G. (2017) · Science Signaling · doi:10.1126/scisignal.aag1796 · Cited by 300
The JAK / STAT pathway in obesity and diabetes
Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · The FEBS Journal · doi:10.1111/febs.13709 · Cited by 249
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome
Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., Van Aelst, L., Shea, S. D., & Tonks, N. K. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80323 · Cited by 110
Self-citation
Metadata
- Authors
- Tonks, N. K.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 280
- Issue
- 2
- Pages
- 346-378
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2027446232
- Cited by
- 432
- References
- 10
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction. https://app.cochat.ai/papers/10.1111/febs.12077
- The paper
- Tonks, N. K. (2013). Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction. The FEBS Journal. https://doi.org/10.1111/febs.12077
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
