The DOI matches its Crossref record; 277 of the 277 references it cites were found in a registry or an index.
Modulating the endocannabinoid system in human health and disease – successes and failures
Open accessAbstract
The discovery of the endocannabinoid system, comprising the G‐protein coupled cannabinoid 1 and 2 receptors (CB1/2), their endogenous lipid ligands or endocannabinoids, and synthetic and metabolizing enzymes, has triggered an avalanche of experimental studies implicating the endocannabinoid system in a growing number of physiological/pathological functions. These studies have also suggested that modulating the activity of the endocannabinoid system holds therapeutic promise for a broad range of diseases, including neurodegenerative, cardiovascular and inflammatory disorders; obesity/metabolic syndrome; cachexia; chemotherapy‐induced nausea and vomiting; and tissue injury and pain, amongst others. However, clinical trials with globally acting CB1 antagonists in obesity/metabolic syndrome, and other studies with peripherally‐restricted CB1/2 agonists and inhibitors of the endocannabinoid metabolizing enzyme in pain, have introduced unexpected complexities, suggesting that a better understanding of the pathophysiological role of the endocannabinoid system is required to devise clinically successful treatment strategies.
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Self-citationCommensal bacteria make GPCR ligands that mimic human signalling molecules
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Early phytocannabinoid chemistry to endocannabinoids and beyond
Mechoulam, R., Hanuš, L. O., Pertwee, R., & Howlett, A. C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3811 · Cited by 393
Metadata
- Authors
- Pacher, P., & Kunos, G.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2013-04-22
- Volume
- 280
- Issue
- 9
- Pages
- 1918-1943
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2171530795
- Cited by
- 405
- References
- 277
- FWCI
- 31.49
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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