Identification and Functional Characterization of Brainstem Cannabinoid CB2Receptors
Open accessAbstract
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.
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CB2 receptor protein has been reported in the dorsal root ganglia, brainstem, thalamus, periaqueductal gray, and cerebellum of naive rats.
“CB2 receptor protein has been reported in the DRG,13 brainstem,14 thalamus,15 PAG,15 and cerebellum15, 16 of naive rats.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [14]
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Self-citation
- Authors
- Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., Marnett, L. J., Di Marzo, V., Pittman, Q. J., Patel, K. D., & Sharkey, K. A.
- Affiliations
- Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1.
- University of Calgary (CA)
- Corresponding author
- Duncan, Marnie
- Sharkey, Keith A.
- ORCID
- Venue
- Science
- Published
- 2005-10-14
- Volume
- 310
- Issue
- 5746
- Pages
- 329-332
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2124248227
- Cited by
- 1,470
- References
- 26
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 35 · 2023: 43 · 2022: 60 · 2021: 66 · 2020: 60 · 2019: 54 · 2018: 50 · 2017: 66 · 2016: 65 · 2015: 79 · 2014: 91 · 2013: 87 · 2012: 66
- FWCI
- 66.99
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- cc-by
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute of General Medical Sciences (GM 15431)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- CB2 receptor, brainstem neurons, endocannabinoids, 2-arachidonoylglycerol, CB1 receptor, receptor mRNA expression, receptor localization, central nervous system
- MeSH terms
- Animals, Arachidonic Acids, Brain Stem, Cannabinoids, Cerebellum, Cerebral Cortex, Ferrets, Immunohistochemistry, RNA, Messenger, Vomiting, Blotting, Western, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Cannabinoid, CB2, Mice, Rats, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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