Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in the livers of male mice
Open accessAbstract
Estrogens play pivotal roles in sexual development, growth, reproduction, and sex differentiation and have been implicated in a number of physiological processes in various tissues. Most of the effects of estrogens are mediated by the estrogen receptors alpha (ER α), beta (ER β), and G protein‐coupled receptor 30 (GPR 30). The liver is known to be a target tissue for estrogen signaling, but the physiological role of this signaling is not well characterized. Through analyses of an estradiol (E2)‐treated hepatocyte cell line and mice, we showed that E2 signaling controls hepatocyte proliferation. Importantly, our data showed that the E2 signaling that is mediated through ER α is crucial for efficient liver regeneration after partial hepatectomy (PH). PH rapidly induced marked increases in circulating E2 and ER α transcripts in periportal hepatocytes, well before the onset of hepatocyte proliferation. Taken together, our results indicate that increased E2 is one of the initiating signals that trigger liver regeneration. We suggest that E2 treatment could be beneficial for stimulating liver regeneration in humans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
General hepatocyte-specific eRegulons were found for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB, and zonation-associated eRegulons such as ESR1 and SOX9 periportally and PPARG and AR pericentrally.
“We found general hepatocyte-specific eRegulons for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB21–23, and zonation-associated eRegulons such as ESR1 and SOX9 periportally24,25 and PPARG and AR pericentrally26,27.”
From Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation (2024) · cites this paper as [24]
Cites
Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442 · see citing works
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057 · see citing works
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828 · see citing works
Higgins, G. (1931) · Cited by 2,444 · see citing works
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045 · see citing works
Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development · doi:10.1242/dev.127.19.4277 · Cited by 1,064 · see citing works
Ligand-activated site-specific recombination in mice.
Feil, R., Brocard, J., Mascrez, B., LeMeur, M., Metzger, D., & Chambon, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10887 · Cited by 907 · see citing works
The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
Dauvois, S., White, R., & Parker, M. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1377 · Cited by 522 · see citing works
The estrogen receptor: a model for molecular medicine.
Jensen, E. V., & Jordan, V. C. (2003) · PubMed · Cited by 470 · see citing works
Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J., Messaddeq, N., Wendling, O., Mark, M. P., Desvergne, B., Wahli, W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400356101 · Cited by 383 · see citing works
Self-citationIn vivo imaging of transcriptionally active estrogen receptors
Ciana, P., Raviscioni, M., Mussi, P., Vegeto, E., Que, I., Parker, M. G., Löwik, C. W. G. M., & Maggi, A. C. (2002) · Nature Medicine · doi:10.1038/nm809 · Cited by 286 · see citing works
Adlanmérini, M., Solinhac, R., Abot, A., Fabre, A., Raymond‐Letron, I., Guihot, A., Boudou, F., Sautier, L., Vessières, E., Kim, S. H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322057111 · Cited by 263 · see citing works
Estrogen Receptors in Human Nontarget Tissues: Biological and Clinical Implications*
Ciocca, D. R., & Vargas-Roig, L. M. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-35 · Cited by 259 · see citing works
Niederreither, K., Fraulob, V., Garnier, J.-M., Chambon, P., & Dollé, P. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00561-5 · Cited by 246 · see citing works
Engineering of a Mouse for the in Vivo Profiling of Estrogen Receptor Activity
Ciana, P., Luccio, G. D., Belcredito, S., Pollio, G., Vegeto, E., Tatangelo, L., Tiveron, C., & Maggi, A. C. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0658 · Cited by 181 · see citing works
Dollé, P., & Duboule, D. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03535.x · Cited by 175 · see citing works
Steer, C. J. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.14.7589980 · Cited by 163 · see citing works
The effect of estrogen and tamoxifen on hepatocyte proliferation in Vivo and in Vitro
Francavilla, A., Polimeno, L., Leo, A. D., Barone, M., Ove, P., Coetzee, M. L., Eagon, P. K., Makowka, L., Ambrosino, G., Mazzaferro, V., et al. (1989) · Hepatology · doi:10.1002/hep.1840090417 · Cited by 128 · see citing works
Imai, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011528898 · Cited by 119 · see citing works
Self-citationSex Hormone-Related Functions in Regenerating Male Rat Liver
Francavilla, A., Eagon, P. K., Leo, A. D., Polimeno, L., Panella, C., Aquilino, A., Ingrosso, M., Thiel, D. H. V., & Starzl, T. E. (1986) · Gastroenterology · doi:10.1016/s0016-5085(86)80026-9 · Cited by 100 · see citing works
Relation of estrogen and its receptor to rat liver growth and regeneration.
Fisher, B., Gündüz, N., Saffer, E., & Zheng, S. (1984) · PubMed · Cited by 90 · see citing works
Imai, T., Jiang, M., Kastner, P., Chambon, P., & METZGER, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071056098 · Cited by 87 · see citing works
Self-citationVaucher, L., Funaro, M. G., Mehta, A., Mielnik, A., Bolyakov, A., Prossnitz, E. R., Schlegel, P. N., & Paduch, D. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092425 · Cited by 63 · see citing works
Movérare‐Skrtic, S., Börjesson, A., Farman, H. H., Sjögren, K., Windahl, S. H., Lagerquist, M. K., Andersson, A., Stubelius, A., Carlsten, H., Gustafsson, J.-Α., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322910111 · Cited by 56 · see citing works
Estradiol and testosterone levels in patients undergoing partial hepatectomy
Francavilla, A., Gavaler, J. S., Makowka, L., Barone, M., Mazzaferro, V., Ambrosino, G., Iwatsuki, S., Guglielmi, F., Leo, A. D., Balestrazzi, A., et al. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01540264 · Cited by 49 · see citing works
GPER signaling in spermatogenesis and testicular tumors
Chimento, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00030 · Cited by 41 · see citing works
Ferri, D., Moro, L., Mastrodonato, M., Capuano, F., Marra, E., Liquori, G. E., & Greco, M. (2005) · Biology of the Cell · doi:10.1042/bc20040154 · Cited by 38 · see citing works
Imai, T., Matsuda, K., Shimojima, T., Hashimoto, T., Masuhiro, Y., Kitamoto, T., Sugita, A., Suzuki, K., Matsumoto, H., Masushige, S., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6531 · Cited by 38 · see citing works
Self-citationVacca, M., D’Amore, S., Graziano, G., D’Orazio, A., Cariello, M., Massafra, V., Salvatore, L., Martelli, N., Murzilli, S., Sasso, G. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104449 · Cited by 31 · see citing works
Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females
Antal, M., Petit-Demoulière, B., Meziane, H., Chambon, P., & Krust, A. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1217668109 · Cited by 25 · see citing works
Niwa‐Kawakita, M., Abramowski, V., Kalamarides, M., Thomas, G. D., & Giovannini, M. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 22 · see citing works
Self-citationDoes hyperprolactinemia affect hepatic regeneration independent of sex steroids?
Kahn, D., Gavaler, J. S., Makowka, L., Chapchap, P., Mazzaferro, V., CASAVILLA, A., Smith, M. S., Eagon, P. K., Starzl, T. E., & Thiel, D. H. V. (1988) · PubMed · Cited by 9 · see citing works
Imai, T. (2003) · The Keio Journal of Medicine · doi:10.2302/kjm.52.198 · Cited by 7 · see citing works
Self-citationEffect of tamoxifen on hepatic regeneration in male rats
Kahn, D. R., Eagon, P. K., Porter, L. E., Elm, M. S., Makowka, L., Podestá, L. G., Starzl, T. E., & Thiel, D. H. V. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01536150 · Cited by 7 · see citing works
Prohibitins, novel vitamin K2 target factors in osteoblast
Uebi, T., Umeda, M., Maekawa, N., Karasawa, S., Handa, H., & Imai, T. (2013) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2013.13001 · Cited by 6 · see citing works
Self-citationEffective cofactor complex purification using nanobeads
Umeda, M., Uebi, T., Maekawa, N., Masaike, Y., Handa, H., & Imai, T. (2013) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2013.13002 · Cited by 5 · see citing works
Self-citationPGJIFs, new mitochondrial PGJ2 target factors, regulate cell proliferation
Umeda, M., Uebi, T., Maekawa, N., Handa, H., & Imai, T. (2013) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2013.13003 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
2 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cooke, P. S., Nanjappa, M. K., Ko, C. J., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 475 · see citing works
Liver Regeneration: Analysis of the Main Relevant Signaling Molecules
Tao, Y.-C., Wang, M.-L., Chen, E., & Tang, H. (2017) · Mediators of Inflammation · doi:10.1155/2017/4256352 · Cited by 191 · see citing works
The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis
Phelps, T., Snyder, E., Rodriguez, E., Child, H., & Harvey, P. A. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0265-3 · Cited by 141 · see citing works
Lee, C., Kim, J., & Jung, Y. (2019) · Cells · doi:10.3390/cells8101259 · Cited by 123 · see citing works
Torre, S. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572490 · Cited by 118 · see citing works
The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones
Xu, L., Yuan, Y., Che, Z., Tan, X., Wu, B., Wang, C., Xu, C., & Xiao, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.939631 · Cited by 94 · see citing works
Bravo González-Blas, C., Matetovici, I., Hillen, H., Taskiran, I. I., Vandepoel, R., Christiaens, V., Sansores-García, L., Verboven, E., Hulselmans, G., Poovathingal, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-023-01316-4 · Cited by 85 · see citing works
“We found general hepatocyte-specific eRegulons for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB 21–23 , and zonation-associated eRegulons such as ESR1 and SOX9 peripor-tally 24,25 and PPARG and AR pericentrally 26,27 .”
Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology
Torre, S. D. (2021) · Cells · doi:10.3390/cells10092502 · Cited by 89 · see citing works
Lee, C., Kim, J., Han, J., Oh, D., Kim, M., Jeong, H., Kim, T., Kim, S., Kim, J. N., Seo, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28138-6 · Cited by 81 · see citing works
Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats
Yu, Y., Zhou, B.-H., Yang, Y.-L., Guo, C., Zhao, J., & Wang, H. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02857-1 · Cited by 42 · see citing works
Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration
Kao, T.-L., Kuan, Y.-P., Cheng, W., Chang, W.-C., Jeng, L., Yeh, S., & Ma, W. (2018) · Theranostics · doi:10.7150/thno.23624 · Cited by 37 · see citing works
Estradiol accelerates liver regeneration through estrogen receptor α
Tsugawa, Y., Natori, M., Handa, H., & Imai, T. (2019) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s214196 · Cited by 31 · see citing works
Self-citationArginine-induced insulin secretion in endoplasmic reticulum
Umeda, M., Hiramoto, M., Watanabe, A., Tsunoda, N., & Imai, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.006 · Cited by 30 · see citing works
Self-citationSoria-Jasso, L. E., Cariño‐Cortés, R., Muñoz‐Pérez, V. M., Pérez‐Hernández, E., Pérez‐Hernández, N., & Fernández‐Martínez, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194694 · Cited by 28 · see citing works
Ahmed, A. M. A., Rahman, M. A., Hossen, M. A., Reza, A. S. M. A., Islam, M. S., Rashid, M. M., Rafi, M. K. J., Siddique, T. A., Al-Noman, A., & Uddin, M. N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112215 · Cited by 26 · see citing works
Choi, E., Kim, W. K., Joo, S. K., Park, S.-Y., Park, J. H., Kang, Y. K., Jin, S.-Y., & Chang, M. S. (2018) · Diagnostic Pathology · doi:10.1186/s13000-018-0698-8 · Cited by 26 · see citing works
Wang, F., Tipoe, G. L., Yang, C., Nanji, A. A., Hao, X., So, K., & Xiao, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800144 · Cited by 25 · see citing works
Piotrowska, K., Tarnowski, M., Zgutka, K., & Pawlik, A. (2016) · Nutrients · doi:10.3390/nu8030176 · Cited by 23 · see citing works
Sex Disparities in Outcomes Following Major Liver Surgery
Birrer, D. L., Linecker, M., López‐López, V., Brusadín, R., Navarro‐Barrios, Á., Reese, T., Arbabzadah, S., Balcı, D., Malagó, M., Machado, M. A. C., et al. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005635 · Cited by 22 · see citing works
Bucurica, S., Lupanciuc, M., Radu, F. I., Ștefan, I., Munteanu, A. E., Anghel, D. N., Jinga, M., & Gaman, L. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216034 · Cited by 20 · see citing works
Imai, T., Umeda, M., & Hiramoto, M. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s80212 · Cited by 19 · see citing works
Self-citationNuclear ErbB2 expression in hepatocytes in liver disease
Döring, P., Calvisi, D. F., & Dombrowski, F. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02871-z · Cited by 16 · see citing works
Pregnancy facilitates maternal liver regeneration after partial hepatectomy
Lee, J., Garcia, V., Nambiar, S. M., Jiang, H., & Dai, G. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00125.2019 · Cited by 12 · see citing works
Zhao, Y., Klionsky, D. J., Wang, X., Huang, Q., Deng, Z., & Xiang, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312576 · Cited by 10 · see citing works
Liu, S., Zhao, J., Tian, W., Wang, J.-C., Wang, H., & Zhou, B.-H. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.04.005 · Cited by 11 · see citing works
Estrogen induces estrogen receptor α expression and hepatocyte proliferation in late pregnancy
Tsugawa, Y., Hiramoto, M., & Imai, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.119 · Cited by 11 · see citing works
Self-citationSigma 1 Receptor is Overexpressed in Hepatocellular Adenoma: Involvement of ERα and HNF1α
Villemain, L., Prigent, S., Abou-Lovergne, A., Pelletier, L., Chiral, M., Pontoglio, M., Foufelle, F., Caruso, S., Pineau, R., Rebouissou, S., et al. (2020) · Cancers · doi:10.3390/cancers12082213 · Cited by 10 · see citing works
Krawczyńska, A., Herman, A. P., Antushevich, H., Bochenek, J., Dziendzikowska, K., Gajewska, A., & Gromadzka-Ostrowska, J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.012 · Cited by 10 · see citing works
UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
Cho, J., Miyagawa, A., Yamaguchi, K., Abe, W., Tsugawa, Y., Yamamura, H., & Imai, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169094 · Cited by 10 · see citing works
Self-citationKucera, H., Puschner, B., Conley, A. J., & Berger, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215390 · Cited by 9 · see citing works
Signaling Pathways and Genes Associated with Hexavalent Chromium-Induced Hepatotoxicity
Li, X., Abdel‐Moneim, A. E., & Yang, B. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03291-7 · Cited by 9 · see citing works
Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase
Machado, D. E., Alessandra-Perini, J., de Mendonça, E. M., Claudino, M. C., Nasciutti, L. E., Sola‐Penna, M., Zancan, P., & Perini, J. A. (2020) · Reproduction · doi:10.1530/rep-19-0502 · Cited by 8 · see citing works
Zhu, M., Li, Y., Shen, Q., Gong, Z., & Liu, D. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050900 · Cited by 7 · see citing works
UDP-glucose, cereblon-dependent proinsulin degrader
Cho, J., Miyagawa, A., Yamaguchi, K., Abe, W., Tsugawa, Y., Yamamura, H., & Imai, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-18902-5 · Cited by 7 · see citing works
Self-citationDanoy, M., Tauran, Y., Poulain, S., Arakawa, H., Mori, D., Araya, K., Kato, S., Kido, T., Kusuhara, H., Kato, Y., et al. (2020) · Differentiation · doi:10.1016/j.diff.2020.05.006 · Cited by 7 · see citing works
Wang, Y., Fahy, C., & Lü, H. (2024) · Liver Research · doi:10.1016/j.livres.2024.06.001 · Cited by 6 · see citing works
Enhancer grammar of liver cell types and hepatocyte zonation states
González-Blas, C. B., Matetovici, I., Hillen, H., Taskiran, I. I., Vandepoel, R., Christiaens, V., Sansores-García, L., Verboven, E., Hulselmans, G., Poovathingal, S., et al. (2022) · doi:10.1101/2022.12.08.519575 · Cited by 5 · see citing works
Possible Estrogen Dependency in the Pathogenesis of Branchial Cleft Cysts
Raguse, J.-D., Anagnostopoulos, I., Doll, C., Heiland, M., & Jöhrens, K. (2017) · BioMed Research International · doi:10.1155/2017/1807056 · Cited by 5 · see citing works
Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice
Kozuki, S., Kabata, M., Sakurai, S., Iwaisako, K., Nishimura, T., Toi, M., Yamamoto, T., & Toyoshima, F. (2023) · Communications Biology · doi:10.1038/s42003-023-05614-3 · Cited by 5 · see citing works
Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver InjuryPreprint
Everton, E., del Río-Moreno, M., Villacorta-Martín, C., Bawa, P., Lindstrom-Vautrin, J., Muramatsu, H., Rizvi, F., Smith, A. R., Tam, Y. K., Pardi, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.17.537197 · Cited by 5 · see citing works
Ahmed, A. M. A., Rahman, M. A., Sharmen, F., Reza, A. S. M. A., Islam, M. S., Rashid, M. M., Rafi, M. K. J., Siddique, T. A., Ezaj, M. M. A., Saha, S., et al. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12452 · Cited by 4 · see citing works
Dong, C., Zhang, B., Ying, Y., Hou, L., Wu, W., Wei, H., & Luo, X. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16888 · Cited by 4 · see citing works
Kolasa, A., Kur, P., Rzeszotek, S., Grabowska, M., Blatkiewicz, M., Freus, M., & Wilk, A. (2025) · Reproductive Biology · doi:10.1016/j.repbio.2025.101044 · Cited by 3 · see citing works
Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
Cho, J., Tsugawa, Y., Imai, Y., & Imai, T. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.09.039 · Cited by 3 · see citing works
Self-citationSchade, M., Sanabria, J. A., Modarresi, M., Gillon, B., Hunter, Z., Fannin, J. C., Mallick, A., Brunengraber, H., & Sanabria, J. R. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.71659 · Cited by 3 · see citing works
Nukleäre HER2/neu-Expression in Hepatozyten bei Lebererkrankungen
Döring, P., Pilo, G., Calvisi, D. F., & Dombrowski, F. (2017) · Der Pathologe · doi:10.1007/s00292-017-0351-4 · Cited by 2 · see citing works
Zhu, M., Li, Y., Liu, D., & Gong, Z. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150937 · Cited by 1 · see citing works
Sugiritama, I. W., Wahyuniari, I. A. I., Ratnayanti, I. G. A. D., Linawati, N. M., Wiryawan, I. G. N. S., Komalasari, N. L. G. Y., & Arijana, I. G. K. N. (2020) · Bali Medical Journal · doi:10.15562/bmj.v9i3.1784 · Cited by 1 · see citing works
Farrag, A. A. M., Aatia, A. E. M., & Zaher, W. F. M. (2021) · Medico-Legal Update · doi:10.37506/mlu.v21i2.2656
Imai, T., Cho, J., Tsugawa, Y., Miyajima, A., Yamaguchi, K., Abe, W., & Yamamura, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1316195/v1
Self-citationMikail, M., Raji, A. A., Moses, M. M., Paarthiban, N. N., Danmaigoro, A., Hisham, N. E. B., Juha, M. F., Kamaruzaman, I. N. A., Reduan, M. F. H., Noor, M. H. M., et al. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70084
Le récepteur Sigma 1 : implication dans la prolifération et la stéatose des hépatocytes
Villemain, L. (2019) · theses.fr (ABES) · doi:10.70675/aed32a10z7bd9z4de2z8a3az71fb3976c7c5
- Authors
- Uebi, T., Umeda, M., & Imai, T.
- Affiliations
- National Center for Geriatrics and Gerontology (JP)
- Corresponding author
- Imai, Takeshi
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2014-12-12
- Volume
- 20
- Issue
- 3
- Pages
- 217-223
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W1999430059
- Cited by
- 52
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes to Cells (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Geriatrics and Gerontology
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- estrogen receptor alpha, estradiol signaling, hepatocyte proliferation, liver regeneration, partial hepatectomy, periportal hepatocytes
- MeSH terms
- Animals, Estradiol, Estrogens, Hepatectomy, Humans, Liver, Liver Regeneration, Male, Hepatocytes, Estrogen Receptor alpha, Cell Proliferation, Mice, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
