The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
COVID‐19 is a Real Headache!
Open accessAbstract
After the emergence of a novel coronavirus named SARS‐CoV‐2, coronavirus disease 2019 (COVID‐19) was initially characterized by fever, sore throat, cough, and dyspnea, mainly manifestations of respiratory system. However, other manifestations such as headache, abdominal pain, diarrhea, loss of taste and smell were added to the clinical spectrum, during the course of the COVID‐19 pandemic. The reports on the neurological findings are increasing rapidly and headache seems to be the leader on the symptom list. Headache was reported in 11%‐34% of the hospitalized COVID‐19 patients, but clinical features of these headaches were totally missing in available publications. According to our initial experience, significant features of headache presentation in the symptomatic COVID‐19 patients were new‐onset, moderate‐severe, bilateral headache with pulsating or pressing quality in the temporoparietal, forehead or periorbital region. The most striking features of the headache were sudden to gradual onset and poor response to common analgesics, or high relapse rate, that was limited to the active phase of the COVID‐19. Symptomatic COVID‐19 patients, around 6%‐10%, also reported headache as a presenting symptom. The possible pathophysiological mechanisms of headache include activation of peripheral trigeminal nerve endings by the SARS‐CoV‐2 directly or through the vasculopathy and/or increased circulating pro‐inflammatory cytokines and hypoxia. We concluded that as a common non‐respiratory symptom of COVID‐19, headache should not be overlooked, and its characteristics should be recorded with scrutiny.
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Cites
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Cited by
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01283-z · Cited by 4,862
Pathophysiology and mechanism of long COVID: a comprehensive review
Castanares-Zapatero, D., Chalon, P., Kohn, L., Dauvrin, M., Detollenaere, J., Maertens de Noordhout, C., Primus-de Jong, C., Cleemput, I., & Van den Heede, K. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2076901 · Cited by 585
LaRovere, K. L., Riggs, B. J., Poussaint, T. Y., Young, C. C., Newhams, M. M., Maamari, M., Walker, T. C., Singh, A. R., Dapul, H., Hobbs, C. V., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.0504 · Cited by 396
Harapan, B. N., & Yoo, H. J. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10406-y · Cited by 359
Migraine and neuroinflammation: the inflammasome perspective
Kursun, O., Yemisci, M., van den Maagdenberg, A. M. J. M., & Karatas, H. (2021) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01271-1 · Cited by 266
Metadata
- Authors
- Bolay, H., Gül, A., & Baykan, B.
- Venue
- Headache: The Journal of Head and Face Pain
- Publisher
- Wiley
- Published
- 2020-05-27
- Volume
- 60
- Issue
- 7
- Pages
- 1415-1421
- ISSN
- 0017-8748 (ISSN-L)
- 1526-4610
- OpenAlex
- W3024635576
- Cited by
- 257
- References
- 37
- FWCI
- 21.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bolay, H., Gül, A., & Baykan, B. (2020). COVID‐19 is a Real Headache! Headache: The Journal of Head and Face Pain. https://doi.org/10.1111/head.13856
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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