Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties
Abstract
Summary: Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)‐inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE‐inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.
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Algal peptides attenuate vascular inflammation by downregulating pro-inflammatory cytokines and inhibiting key inflammatory signaling pathways.
“They help attenuate vascular inflammation by downregulating pro-inflammatory cytokines and inhibiting key inflammatory signaling pathways [71].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [71]
The Ministry of Health, Labour and Welfare of Japan has approved enzymatic digests of Neopyropia yezoensis and Undaria pinnatifida as Foods for Specified Health Uses (FOSHU), based on their demonstrated antihypertensive effects.
“Notably, the Ministry of Health, Labour and Welfare of Japan has approved enzymatic digests of Neopyropia yezoensis (formerly Pyropia yezoensis) (Rhodophyta) and Undaria pinnatifida (Phaeophyceae) (commonly known as wakame) as Foods for Specified Health Uses (FOSHU), based on their demonstrated antihypertensive effects [71] along with reported IC50 values that demonstrate their potent enzyme-inhib”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [71]
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“…Pyropia yezoensis ) (Rhodophyta) and Undaria pinnatifida (Phaeophyceae) (commonly known as wakame) as Foods for Specified Health Uses (FOSHU), based on their demonstrated antihypertensive effects [71] along with reported IC 50 values that demonstrate their potent enzyme-inhibitory activity.”
- Authors
- Barkia, I., Al‐Haj, L., Abdul Hamid, A., Zakaria, M., Saari, N., & Zadjali, F.
- Affiliations
- Universiti Putra Malaysia (MY)
- Sultan Qaboos University (OM)
- Department of Food Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia
- Department of Aquaculture Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia
- Corresponding author
- Saari, Nazamid
- Zadjali, Fahad
- Venue
- International Journal of Food Science & Technology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-11-04
- Volume
- 54
- Issue
- 5
- Pages
- 1514-1522
- ISSN
- 0950-5423 (ISSN-L)
- 1365-2621
- OpenAlex
- W2899797213
- Cited by
- 76
- References
- 48
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Science & Technology (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Funders
- Sultan Qaboos University (SR/MED/BIOC/13/01)
- Kementerian Sains, Teknologi dan Inovasi (02‐01‐04‐SF2309)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Materials Science › Biomaterials › Diatoms and Algae Research
- Keywords
- marine diatoms, bioactive peptides, antihypertensive peptides, ACE inhibitory activity, antioxidant activity, enzymatic hydrolysis, microalgae, functional foods, nutraceuticals
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