Microalgae for High-Value Compounds and Biofuels Production: A Review with Focus on Cultivation under Stress Conditions
Abstract
Microalgal biomass as feedstock for biofuel production is an attracting alternative to terrestrial plant utilization for biofuels production. However, today the microalgal cultivation systems for energy production purposes seem not yet to be economically feasible. Microalgae, though cultivated under stress conditions, such as nutrient starvation, high salinity, high temperature etc. accumulate considerable amounts (up to 60-65% of dry weight) of lipids or carbohydrates along with several secondary metabolites. Especially some of the latter are valuable compounds with an enormous range of industrial applications. The simultaneous production of lipids or carbohydrates for biofuel production and of secondary metabolites in a biorefinery concept might allow the microalgal production to be economically feasible. This paper aims to provide a review on the available literature about the cultivation of microalgae for the accumulation of high-value compounds along with lipids or carbohydrates focusing on stress cultivation conditions.
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Carotenoids (β-Carotene) derived from Chlorella sp. are sold at USD 300-700 per kg in the open market.
“carotenoids (β-Carotene) derived from Chlorella sp. are sold at USD 300–700 per kg in the open market [46].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [46]
Cites
Commercial Applications of Microalgae
Spolaore, P., Joannis-Cassan, C., Duran, E., & Isambert, A. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.87 · Cited by 4,285 · see citing works
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745 · see citing works
Rodolfi, L., Chini Zittelli, G., Bassi, N., Padovani, G., Biondi, N., Bonini, G., & Tredici, M. R. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22033 · Cited by 2,879 · see citing works
Techniques for extraction of bioactive compounds from plant materials: A review
Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., Jahurul, M. H. A., Ghafoor, K., Norulaini, N. A. N., & Omar, A. K. M. (2013) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2013.01.014 · Cited by 2,870 · see citing works
Micro-algae as a source of protein
Becker, E. W. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2006.11.002 · Cited by 2,311 · see citing works
Valuable Products from Biotechnology of Microalgae
Pulz, O., & Gross, W. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1647-x · Cited by 2,132 · see citing works
Heterotrophic cultures of microalgae: Metabolism and potential products
Perez‐Garcia, O., Escalante, F. M. E., de‐Bashan, L. E., & Yoav Bashan, A. (2010) · Water Research · doi:10.1016/j.watres.2010.08.037 · Cited by 1,766 · see citing works
From Glycerol to Value‐Added Products
Pagliaro, M., Ciriminna, R., Kimura, H., Rossi, M., & Pina, C. D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604694 · Cited by 1,653 · see citing works
High-value products from microalgae—their development and commercialisation
Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585 · see citing works
Cyanobacteria secondary metabolites—the cyanotoxins
Carmichael, W. W. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb01858.x · Cited by 1,457 · see citing works
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190 · see citing works
Frank, H. A., & Cogdell, R. J. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03022.x · Cited by 1,185 · see citing works
Environmental Life Cycle Comparison of Algae to Other Bioenergy Feedstocks
Clarens, A. F., Resurreccion, E. P., White, M. A., & Colosi, L. M. (2010) · Environmental Science & Technology · doi:10.1021/es902838n · Cited by 1,118 · see citing works
Extraction of oil from microalgae for biodiesel production: A review
Halim, R., Danquah, M. K., & Webley, P. A. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.01.001 · Cited by 1,043 · see citing works
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960 · see citing works
Handbook of microalgal culture: biotechnology and applied phycology.
RICHMOND, A. E. (2004) · Cited by 861 · see citing works
Microalgal production — A close look at the economics
Norsker, N.-H., Barbosa, M. J., Vermuë, M. H., & Wijffels, R. H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.08.005 · Cited by 819 · see citing works
Carotenoids in Algae: Distributions, Biosyntheses and Functions
Takaichi, S. (2011) · Marine Drugs · doi:10.3390/md9061101 · Cited by 809 · see citing works
Outdoor cultivation of microalgae for carotenoid production: Current state and perspectives
Del Campo, J. A., García-González, M., & Guerrero, M. G. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0844-9 · Cited by 739 · see citing works
Constraints to Commercialization of Algal Fuels
Chisti, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.07.020 · Cited by 719 · see citing works
Production of phycocyanin—a pigment with applications in biology, biotechnology, foods and medicine
Eriksen, N. T. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1542-y · Cited by 714 · see citing works
Bioethanol production using carbohydrate-rich microalgae biomass as feedstock
Ho, S.-H., Huang, S.-W., Chen, C.-Y., Hasunuma, T., Kondo, A., & Chang, J.-S. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.015 · Cited by 683 · see citing works
Renewable fuels from algae: An answer to debatable land based fuels
Singh, A., Nigam, P. S. N., & Murphy, J. D. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.032 · Cited by 661 · see citing works
Exocellular polysaccharides from cyanobacteria and their possible applications
Philippis, R. D., & Vincenzini, M. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00365.x · Cited by 661 · see citing works
HANDBOOK OF MICROALGAL CULTURE: BIOTECHNOLOGY AND APPLIED PHYCOLOGY
Henry, E. C. (2004) · Journal of Phycology · doi:10.1111/j.1529-8817.2004.40502.x · Cited by 655 · see citing works
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae
Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000414 · Cited by 649 · see citing works
Microalgae as sources of carotenoids
Guedes, A. C., Amaro, H. M., & Malcata, F. X. (2011) · Marine Drugs · doi:10.3390/md9040625 · Cited by 639 · see citing works
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591 · see citing works
Phycobiliproteins as a commodity: Trends in applied research, patents and commercialization
Sekar, S., & Chandramohan, M. (2008) · Journal of Applied Phycology · doi:10.1007/s10811-007-9188-1 · Cited by 589 · see citing works
Markou, G., Angelidaki, I., & Georgakakis, D. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4398-0 · Cited by 549 · see citing works
Methods of downstream processing for the production of biodiesel from microalgae
Kim, J., Yoo, G., Lee, H., Lim, J., Kim, K., Kim, C. W., Park, M. S., & Yang, J.-W. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.04.006 · Cited by 519 · see citing works
Biorefineries: Current activities and future developments
Demirbaş, A. (2009) · Energy Conversion and Management · doi:10.1016/j.enconman.2009.06.035 · Cited by 514 · see citing works
Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis1
Boussiba, S., & Vonshak, A. (1991) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078171 · Cited by 502 · see citing works
Biorefinery of microalgae for food and fuel
Vanthoor-Koopmans, M., Wijffels, R. H., Barbosa, M. J., & Eppink, M. H. M. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.135 · Cited by 502 · see citing works
Second generation biofuels: Economics and policies
Carriquiry, M., Du, X., & Timilsina, G. R. (2011) · Energy Policy · doi:10.1016/j.enpol.2011.04.036 · Cited by 493 · see citing works
Microalgae—novel highly efficient starch producers
Brányiková, I., Maršálková, B., Doucha, J., Brányik, T., Bišová, K., Zachleder, V., & Vítová, M. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.23016 · Cited by 489 · see citing works
Mechanism and challenges in commercialisation of algal biofuels
Singh, A., Nigam, P. S., & Murphy, J. D. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.057 · Cited by 476 · see citing works
Phycobiliproteins — a family of valuable, widely used fluorophores
Glazer, A. N. (1994) · Journal of Applied Phycology · doi:10.1007/bf02186064 · Cited by 449 · see citing works
CHEMICAL PROFILE OF SELECTED SPECIES OF MICROALGAE WITH EMPHASIS ON LIPIDS1
Ben‐Amotz, A., Tornabene, T. G., & Thomas, W. H. (1985) · Journal of Phycology · doi:10.1111/j.0022-3646.1985.00072.x · Cited by 419 · see citing works
Biotechnological production of lutein and its applications
Fernández-Sevilla, J. M., Acién, F. G., & Grima, E. M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2420-y · Cited by 406 · see citing works
Nutrient limitation as a strategy for increasing starch accumulation in microalgae
Dragone, G., Fernandes, B. D., Abreu, A. P., Vicente, A. A., & Teixeira, J. A. (2011) · Applied Energy · doi:10.1016/j.apenergy.2011.03.012 · Cited by 403 · see citing works
Advanced Biofuels and Bioproducts
(2013) · doi:10.1007/978-1-4614-3348-4 · Cited by 392 · see citing works
Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress
Lemoine, Y., & Schoefs, B. (2010) · Photosynthesis Research · doi:10.1007/s11120-010-9583-3 · Cited by 384 · see citing works
Ben‐Amotz, A., & Avron, M. (1983) · PLANT PHYSIOLOGY · doi:10.1104/pp.72.3.593 · Cited by 365 · see citing works
Olaizola, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008159127672 · Cited by 359 · see citing works
Skjånes, K., Rebours, C., & Lindblad, P. (2013) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2012.681625 · Cited by 352 · see citing works
Mishra, A., & Jha, B. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.02.006 · Cited by 352 · see citing works
Biotechnological and industrial significance of cyanobacterial secondary metabolites.
Rastogi, R. P., & Sinha, R. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.04.009 · Cited by 349 · see citing works
Functional properties of carotenoids originating from algae
Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346 · see citing works
<i>Dunaliella</i>biotechnology: methods and applications
Hosseini Tafreshi, A., & Shariati, M. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04153.x · Cited by 343 · see citing works
Enigmatic Microorganisms and Life in Extreme Environments
Seckbach, J. (1999) · Springer eBooks · doi:10.1007/978-94-011-4838-2 · Cited by 336 · see citing works
Nobre, B. P., Villalobos, F., Barragán, B. E., Oliveira, A. C., Batista, A. P., Marques, P. A. S. S., Mendes, R. L., Sovová, H., Palavra, A. F., & Gouveia, L. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.11.084 · Cited by 333 · see citing works
Carpi, A. (2011) · InTech eBooks · doi:10.5772/771 · Cited by 326 · see citing works
Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta)
Campo, J. A. D., Rodr�guez, H., Moreno, J., Vargas, M. A., Rivas, J., & Guerrero, M. G. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1510-5 · Cited by 324 · see citing works
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323 · see citing works
Stehfest, K., Toepel, J., & Wilhelm, C. (2005) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2005.07.001 · Cited by 316 · see citing works
Recovery of pure B-phycoerythrin from the microalga Porphyridium cruentum
Román, R. B., Álvarez‐Pez, J. M., Acién, F. G., & Grima, E. M. (2002) · Journal of Biotechnology · doi:10.1016/s0168-1656(01)00385-6 · Cited by 314 · see citing works
Lipid analysis in Haematococcus pluvialis to assess its potential use as a biodiesel feedstock
Damiani, M. C., Popovich, C. A., Constenla, D., & Leonardi, P. I. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.12.136 · Cited by 301 · see citing works
Fu, W., Guðmundsson, Ó., Paglia, G., Herjólfsson, G., Andrésson, Ó. S., Palsson, B. Ø., & Brynjólfsson, S. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4502-5 · Cited by 289 · see citing works
Exopolysaccharide-producing cyanobacteria and their possible exploitation: A review
Philippis, R. D., Sili, C., Paperi, R., & Vincenzini, M. (2001) · Journal of Applied Phycology · doi:10.1023/a:1017590425924 · Cited by 280 · see citing works
Razón, L. F., & Tan, R. R. (2011) · Applied Energy · doi:10.1016/j.apenergy.2010.12.052 · Cited by 280 · see citing works
Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M. G. J., de Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22725 · Cited by 277 · see citing works
Zhekisheva, M., Boussiba, S., Khozin‐Goldberg, I., Zarka, A., & Cohen, Z. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01107.x · Cited by 267 · see citing works
Antioxidant activity of the polysaccharide of the red microalga Porphyridium sp
Tannin-Spitz, T., Bergman, M., van Moppes, D., Grossman, S., & Arad, S. M. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-0679-7 · Cited by 265 · see citing works
Sánchez, J. F., Fernández, J. M., Acién, F. G., Rueda, A., Pérez-Parra, J., & Molina, E. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.01.004 · Cited by 264 · see citing works
Rabbani, S., Beyer, P., Lintig, J. V., Hugueney, P., & Kleinig, H. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.4.1239 · Cited by 263 · see citing works
Anaerobic digestion of microalgae residues resulting from the biodiesel production process
Ehimen, E. A., Sun, Z., Carrington, C. G., Birch, E. J., & Eaton‐Rye, J. J. (2010) · Applied Energy · doi:10.1016/j.apenergy.2010.10.020 · Cited by 261 · see citing works
Sarada, R., Tripathi, U., & Ravishankar, G. A. (2002) · Process Biochemistry · doi:10.1016/s0032-9592(01)00246-1 · Cited by 249 · see citing works
Boussiba, S., Bing, W., Yuan, J.-P., Zarka, A., & Chen, F. (1999) · Biotechnology Letters · doi:10.1023/a:1005507514694 · Cited by 247 · see citing works
Adams, C., Godfrey, V., Wahlen, B., Seefeldt, L., & Bugbee, B. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.12.143 · Cited by 242 · see citing works
Neochloris oleabundans UTEX #1185: a suitable renewable lipid source for biofuel production
Gouveia, L., Marques, A. E., da Silva, T. L., & dos Reis, A. J. D. (2009) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-009-0559-2 · Cited by 236 · see citing works
Environmental Effects on Cell Composition
Hu, Q. (2013) · Handbook of Microalgal Culture · doi:10.1002/9781118567166.ch7 · Cited by 232 · see citing works
Metabolite Profiling of Chlamydomonas reinhardtii under Nutrient Deprivation
Bölling, C., & Fiehn, O. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.071589 · Cited by 225 · see citing works
Borowitzka, M. A., Huisman, J. M., & Osborn, A. (1991) · Journal of Applied Phycology · doi:10.1007/bf02392882 · Cited by 224 · see citing works
Aflalo, C., Meshulam, Y., Zarka, A., & Boussiba, S. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21391 · Cited by 220 · see citing works
Lamers, P. P., Janssen, M., De Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.04.018 · Cited by 216 · see citing works
Bioethanol Production by Carbohydrate-Enriched Biomass of Arthrospira (Spirulina) platensis
Μάρκου, Γ., Angelidaki, İ., Nerantzis, E. T., & Georgakakis, D. (2013) · Energies · doi:10.3390/en6083937 · Cited by 207 · see citing works
Self-citationFactors responsible for astaxanthin formation in the Chlorophyte Haematococcus pluvialis
Harker, M., Tsavalos, A. J., & Young, A. J. (1996) · Bioresource Technology · doi:10.1016/0960-8524(95)00002-x · Cited by 195 · see citing works
Dominguez-Bocanegra, A. R., Legarreta, I. G., Martı́nez-Jerónimo, F., & Tomasini-Campocosio, A. (2003) · Bioresource Technology · doi:10.1016/j.biortech.2003.04.001 · Cited by 184 · see citing works
Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90261-r · Cited by 178 · see citing works
Carballo-Cárdenas, E. C., Tuan, P. M., Janssen, M., & Wijffels, R. H. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00040-6 · Cited by 177 · see citing works
Effects of salinity increase on carotenoid accumulation in the green alga Dunaliella salina
Borowitzka, M. A., Borowitzka, L. J., & Kessly, D. (1990) · Journal of Applied Phycology · doi:10.1007/bf00023372 · Cited by 176 · see citing works
Young, G., Nippgen, F., Titterbrandt, S., & Cooney, M. J. (2010) · Separation and Purification Technology · doi:10.1016/j.seppur.2010.01.009 · Cited by 175 · see citing works
Biotechnological Applications of Microalgae
Chu, W.-L. (2012) · International e-Journal of Science, Medicine & Education · doi:10.56026/imu.6.suppl1.s24 · Cited by 174 · see citing works
You, T., & Barnett, S. M. (2004) · Biochemical Engineering Journal · doi:10.1016/j.bej.2004.02.004 · Cited by 169 · see citing works
Panda, B., Jain, P. K., Sharma, L., & Mallick, N. (2005) · Bioresource Technology · doi:10.1016/j.biortech.2005.05.013 · Cited by 165 · see citing works
Feng, P., Deng, Z., Fan, L., & Hu, Z. (2012) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.05.007 · Cited by 165 · see citing works
Durmaz, Y. (2007) · Aquaculture · doi:10.1016/j.aquaculture.2007.07.213 · Cited by 160 · see citing works
Iwamoto, H. (2003) · doi:10.1002/9780470995280.ch11 · Cited by 157 · see citing works
Hyper-accumulation of astaxanthin in a green algaHaematococcus pluvialis at elevated temperatures
Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., & Nagai, S. (1994) · Biotechnology Letters · doi:10.1007/bf01021659 · Cited by 151 · see citing works
Xie, Y., Ho, S.-H., Chen, C.-N. N., Chen, C.-Y., Ng, I.-S., Jing, K.-J., Chang, J.-S., & Lu, Y. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.06.064 · Cited by 151 · see citing works
Polysaccharides from cyanobacteria
Bertocchi, C., Navarini, L., Cesàro, A., & Anastasio, M. (1990) · Carbohydrate Polymers · doi:10.1016/0144-8617(90)90015-k · Cited by 149 · see citing works
Polyhydroxyalkanoate (PHA) synthesis by Spirulina subsalsa from Gujarat coast of India
Shrivastav, A., Mishra, S. K., & Mishra, S. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.01.001 · Cited by 142 · see citing works
Campenni’, L., Nobre, B. P., Santos, C. A., Oliveira, A. C., Aires-Barros, M. R., Palavra, A. M. F., & Gouveia, L. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4570-6 · Cited by 141 · see citing works
Sharma, L., & Mallick, N. (2004) · Bioresource Technology · doi:10.1016/j.biortech.2004.10.009 · Cited by 140 · see citing works
Panda, B., & Mallick, N. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02048.x · Cited by 138 · see citing works
Exopolysaccharide production by a unicellular cyanobacterium isolated from a hypersaline habitat
Philippis, R. D., Margheri, M. C., Pelosi, E., & Ventura, S. (1993) · Journal of Applied Phycology · doi:10.1007/bf02182731 · Cited by 134 · see citing works
Coesel, S., Baumgartner, A., Teles, L. M., Ramos, A., Henriques, N., Cancela, M. L., & Varela, J. C. S. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9100-2 · Cited by 134 · see citing works
Cerón, M. C., García‐Malea, M. C., Rivas, J., Acién, F. G., Fernández-Sevilla, J. M., Río, E. D., Guerrero, M. G., & Molina, E. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0743-5 · Cited by 134 · see citing works
Hemlata, H., & Fatma, T. (2009) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-009-9837-y · Cited by 134 · see citing works
Production of astaxanthin from Haematococcus in open pond by two-stage growth one-step process
Zhang, B. Y., Geng, Y., Li, Z. K., Hu, H. J., & Li, Y. G. (2009) · Aquaculture · doi:10.1016/j.aquaculture.2009.06.043 · Cited by 123 · see citing works
Biochemical methane potential of microalgae biomass after lipid extraction
Alzate, M. E., Muñoz, R., Rogalla, F., Fdz-Polanco, F., & Pérez-Elvira, S. I. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.07.076 · Cited by 122 · see citing works
Saha, S. K., McHugh, E., Hayes, J., Moane, S., Walsh, D., & Murray, P. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.049 · Cited by 121 · see citing works
PHA Bioplastics, Biochemicals, and Energy from Crops
Somleva, M. N., Peoples, O. P., & Snell, K. D. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12039 · Cited by 121 · see citing works
Accumulation of poly-β-hydroxybutyrate in cyanobacterium Synechocystis sp. PCC6803
Wu, G., Wu, Q., & Shen, Z. Y. (2001) · Bioresource Technology · doi:10.1016/s0960-8524(00)00099-7 · Cited by 119 · see citing works
Chakraborty, M., Miao, C., McDonald, A. G., & Chen, S. (2011) · Fuel · doi:10.1016/j.fuel.2011.10.055 · Cited by 118 · see citing works
Evaluating industrial symbiosis and algae cultivation from a life cycle perspective
Soratana, K., & Landis, A. E. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.04.018 · Cited by 116 · see citing works
Evolution of pigment composition in Chlorella vulgaris
Gouveia, L. (1996) · Bioresource Technology · doi:10.1016/0960-8524(96)00058-2 · Cited by 115 · see citing works
Μάρκου, Γ., Chatzipavlidis, I., & Georgakakis, D. (2012) · BioEnergy Research · doi:10.1007/s12155-012-9205-3 · Cited by 114 · see citing works
Subhadra, B. G. (2010) · Energy Policy · doi:10.1016/j.enpol.2010.05.043 · Cited by 114 · see citing works
Heterotrophic cultivation of Euglena gracilis Z for efficient production of α-tocopherol
Ogbonna, J. C., Tomiyama, S., & Tanaka, H. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008011201437 · Cited by 113 · see citing works
A new exopolysaccharide produced by marine Cyanothece sp. 113
Chi, Z., Su, C., & Lu, W. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2006.05.001 · Cited by 112 · see citing works
Miao, C., Chakraborty, M., & Chen, S. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.01.047 · Cited by 108 · see citing works
Mishra, A., Mandoli, A., & Jha, B. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-008-0387-9 · Cited by 105 · see citing works
EFFECT OF TEMPERATURE AND IRRADIANCE ON GROWTH OF HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE)1
Fan, L., Vonshak, A., & Boussiba, S. (1994) · Journal of Phycology · doi:10.1111/j.0022-3646.1994.00829.x · Cited by 104 · see citing works
Enhancement of antioxidant production in Spirulina platensis under oxidative stress
El‐Baky, H. H. A., El-Baz, F. K., & El‐Baroty, G. S. (2009) · Acta Physiologiae Plantarum · doi:10.1007/s11738-009-0273-8 · Cited by 103 · see citing works
Extraction of proteins with ionic liquid aqueous two-phase system based on guanidine ionic liquid
Zeng, Q., Wang, Y., Li, N., Huang, X. F., Ding, X., Lin, X., Huang, S., & Liu, X. (2013) · Talanta · doi:10.1016/j.talanta.2013.06.011 · Cited by 103 · see citing works
Glycogen and poly- -hydroxybutyrate synthesis in Spirulina maxima
Philippis, R. D., Sili, C., & VINCENZINI, M. T. (1992) · Journal of General Microbiology · doi:10.1099/00221287-138-8-1623 · Cited by 98 · see citing works
Cerón-García, M. C., Sánchez, M. D. M., Sánchez‐Mirón, A., García-Camacho, F., & Grima, E. M. (2012) · Applied Energy · doi:10.1016/j.apenergy.2012.09.054 · Cited by 97 · see citing works
Fábregas, J., Domı́nguez, A., Maseda, A., & Otero, A. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1204-4 · Cited by 92 · see citing works
Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress
Wei, D., Chen, F., Chen, G., Zhang, X., Liu, L., & Zhang, H. (2008) · Science in China Series C: Life Sciences · doi:10.1007/s11427-008-0145-2 · Cited by 91 · see citing works
Yao, C., Ai, J.-N., Cao, X., & Xue, S. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4983-x · Cited by 91 · see citing works
İmamoğlu, E., Dalay, M. C., & Sukan, F. V. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.08.007 · Cited by 88 · see citing works
Enrichment of vitamin E from Spirulina platensis microalga by SFE
Mendiola, J. A., García-Martínez, D. L., Rupérez, F. J., Martín‐Álvarez, P. J., Reglero, G., Cifuentes, A., Barbas, C., Ibáñez, E., & Señoráns, F. J. (2007) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2007.07.021 · Cited by 85 · see citing works
Lupi, F. M., Fernandes, H. M. L., Tomé, M., Sá‐Correia, I., & Novais, J. M. (1994) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(94)90116-3 · Cited by 84 · see citing works
Gómez, P. I., & GONZÁLEZ, M. A. (2005) · Biological Research · doi:10.4067/s0716-97602005000200005 · Cited by 84 · see citing works
Oleic acid is the main fatty acid related with carotenogenesis in Dunaliella salina
Mendoza, H. M., Martel, A., del Río, M. J., & Reina, G. G. (1999) · Springer eBooks · doi:10.1007/978-94-011-4449-0_65 · Cited by 82 · see citing works
Hadi, M. R., Shariati, M., & Afsharzadeh, S. (2008) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-007-0185-7 · Cited by 80 · see citing works
Mogedas, B., Casal, C., Forján, E., & Vı́lchez, C. (2009) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2009.02.022 · Cited by 80 · see citing works
The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae)
Qin, S., Liu, G., & Hu, Z. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.03.010 · Cited by 80 · see citing works
Kobayashi, M. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949275 · Cited by 79 · see citing works
Microalgal biotechnology: Carotenoid production by the green algaeDunaliella salina
Jin, E., & Melis, A. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949276 · Cited by 78 · see citing works
Río, E. D., Acién, F. G., García‐Malea, M. C., Rivas, J., Grima, E. M., & Guerrero, M. G. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21770 · Cited by 78 · see citing works
He, P., Duncan, J. A., & Barber, J. P. (2007) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2007.00468.x · Cited by 77 · see citing works
Ben‐Amotz, A. (1996) · Journal of Phycology · doi:10.1111/j.0022-3646.1996.00272.x · Cited by 76 · see citing works
Yin-Nin, R., & Chen, F. (2001) · Process Biochemistry · doi:10.1016/s0032-9592(01)00157-1 · Cited by 73 · see citing works
Kinetic modeling of lutein production by heterotrophic Chlorella at various pH and temperatures
Shi, X., Wu, Z., & Chen, F. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600037 · Cited by 73 · see citing works
A matter of detail: Assessing the true potential of microalgal biofuels
Klein‐Marcuschamer, D., Yusuf Chisti, B., Benemann, J. R., & Lewis, D. M. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24967 · Cited by 71 · see citing works
Effect of nitrate and sulfate starvation on polysaccharide formation in rhodella reticulata
Arad, S. M., Lerental, Y., & Dubinsky, O. (1992) · Bioresource Technology · doi:10.1016/0960-8524(92)90073-7 · Cited by 69 · see citing works
Bhati, R., & Mallick, N. (2012) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.2737 · Cited by 68 · see citing works
Cysewski, G. R., & Lorenz, R. T. (2003) · doi:10.1002/9780470995280.ch14 · Cited by 66 · see citing works
Abalde, J., Fábregas, J., & Herrero, C. (1991) · Bioresource Technology · doi:10.1016/0960-8524(91)90142-7 · Cited by 65 · see citing works
Effects of growth conditions on exopolysaccharide production by Cyanospira capsulata
Philippis, R. D., Sili, C., Tassinato, G., VINCENZINI, M. T., & Materassi, R. (1991) · Bioresource Technology · doi:10.1016/0960-8524(91)90138-a · Cited by 64 · see citing works
Bergeron, C., Carrier, D. J., & Ramaswamy, S. (2012) · Wiley eBooks · doi:10.1002/9780470976692 · Cited by 62 · see citing works
Phadwal, K., & Singh, P. K. (2003) · Bioresource Technology · doi:10.1016/s0960-8524(03)00090-7 · Cited by 62 · see citing works
Effect of abiotic stress on the production of lutein and β-carotene by Chlamydomonas acidophila
Garbayo, I., Cuaresma, M., Vı́lchez, C., & Vega, J. M. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.06.012 · Cited by 60 · see citing works
Philippis, R. D., Ena, A., Guastiini, M., Sili, C., & Vincenzini, M. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05837.x · Cited by 60 · see citing works
Selection and optimisation of a method for efficient metabolites extraction from microalgae
Serive, B., Kaas, R., Bérard, J., Pasquet, V., Picot, L., & Cadoret, J. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.07.105 · Cited by 59 · see citing works
Ben‐Amotz, A. (1987) · Journal of Plant Physiology · doi:10.1016/s0176-1617(87)80290-0 · Cited by 59 · see citing works
Astaxanthin: A Comparative Case of Synthetic VS. Natural Production
Nguyen, K. D. (2013) · Cited by 58 · see citing works
Tripathi, U., Sarada, R., & Ravishankar, G. A. (2002) · Acta Physiologiae Plantarum · doi:10.1007/s11738-002-0058-9 · Cited by 56 · see citing works
Li, Z., Sun, M., Li, Q., Li, A., & Zhang, C. (2012) · Biotechnology Letters · doi:10.1007/s10529-012-0996-2 · Cited by 54 · see citing works
Exposure to Low Irradiances Favors the Synthesis of 9-cis β,β-Carotene in Dunaliella salina (Teod.)
Orset, S., & Young, A. J. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.2.609 · Cited by 52 · see citing works
Isolation of Dunaliella spp. from a hypersaline lake and their ability to accumulate glycerol
Kaçka, A., & Dönmez, G. (2008) · Bioresource Technology · doi:10.1016/j.biortech.2008.02.042 · Cited by 52 · see citing works
Sharma, L., & Mallick, N. (2005) · Biotechnology Letters · doi:10.1007/s10529-004-6586-1 · Cited by 51 · see citing works
Li, Z., Ma, X., Li, A., & Zhang, C. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.04.069 · Cited by 51 · see citing works
Lababpour, A., Hada, K., Shimahara, K., Katsuda, T., & Katoh, S. (2004) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(05)00311-7 · Cited by 51 · see citing works
Cao, H., Zhang, L., & Melis, A. (2001) · Journal of Applied Phycology · doi:10.1023/a:1008131412909 · Cited by 50 · see citing works
Evens, T. J., Niedz, R. P., & Kirkpatrick, G. J. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9277-1 · Cited by 39 · see citing works
Polysaccharide Produced by Anacystis nidulans: Its Ecological Implication
Sangar, V., & Dugan, P. R. (1972) · Applied Microbiology · doi:10.1128/am.24.5.732-734.1972 · Cited by 37 · see citing works
Sixteenth International Seaweed Symposium
Kain, J. M., Brown, M. T., & Lahaye, M. (1999) · Springer eBooks · doi:10.1007/978-94-011-4449-0 · Cited by 36 · see citing works
Biofuels from Microalgae: Towards Meeting Advanced Fuel Standards
Brennan, L., & Owende, P. M. O. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3348-4_24 · Cited by 34 · see citing works
Ben‐Amotz, A. (1999) · Springer eBooks · doi:10.1007/978-94-011-4838-2_31 · Cited by 34 · see citing works
Microalgal Biotechnology and Bioenergy in Dunaliella
Shariati, M., & Reza, M. (2011) · InTech eBooks · doi:10.5772/19046 · Cited by 29 · see citing works
Tran, N.-P., Park, J.-K., & Lee, C. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.07.006 · Cited by 29 · see citing works
Cai, M., Li, Z., & Qi, A. (2009) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-009-9176-1 · Cited by 25 · see citing works
Polysaccharide Produced by Anacystis nidulans: Its Ecological Implication
Sangar, V., & Dugan, P. R. (1972) · Applied Microbiology · doi:10.1128/aem.24.5.732-734.1972 · Cited by 23 · see citing works
Abiotic stress induced production of β-carotene, allophycocyanin and total lipids in Spirulina sp.
Hifney, A. F., Issa, A. A., & Fawzy, M. A. (2013) · Journal of Biology and Earth Sciences · Cited by 20 · see citing works
Marketing Omega-3 Products as Nutraceuticals
Clough, P. (2008) · Nutrition and Health · doi:10.1177/026010600801900313 · Cited by 13 · see citing works
Separation and Purification of Phytochemicals as Co‐Products in Biorefineries
Huang, H., & Ramaswamy, S. (2012) · doi:10.1002/9780470976692.ch3 · Cited by 12 · see citing works
Effect of increasing copper and salinity on glycerol production byDunaliella salina
Lustigman, B. K., McCormick, J. M., Dale, G., & McLaughlin, J. J. A. (1987) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01606687 · Cited by 6 · see citing works
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Knothe, G., & Razón, L. F. (2016) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2016.08.001 · Cited by 757 · see citing works
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 727 · see citing works
Oxidative damage and antioxidative system in algae
Rezayian, M., Niknam, V., & Ebrahimzadeh, H. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.10.001 · Cited by 538 · see citing works
Production, extraction and characterization of microalgal and cyanobacterial exopolysaccharides
Delattre, C., Pierre, G., Laroche, C., & Michaud, P. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.08.001 · Cited by 486 · see citing works
Cuellar‐Bermudez, S. P., Aguilar‐Hernandez, I., Cardenas‐Chavez, D. L., Ornelas‐Soto, N., Romero‐Ogawa, M. A., & Parra‐Saldivar, R. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12167 · Cited by 486 · see citing works
Biologically Active Metabolites Synthesized by Microalgae
de Morais, M. G., Vaz, B. D. S., de Morais, E. G., & Costa, J. A. V. (2015) · BioMed Research International · doi:10.1155/2015/835761 · Cited by 471 · see citing works
Siddiki, S. Y. A., Mofijur, M., Kumar, P. S., Ahmed, S. F., Inayat, A., Kusumo, F., Badruddin, I. A., Khan, T. M. Y., Nghiem, L. D., Ong, H. C., et al. (2021) · Fuel · doi:10.1016/j.fuel.2021.121782 · Cited by 465 · see citing works
Minhas, A. K., Hodgson, P., Barrow, C. J., & Adholeya, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00546 · Cited by 451 · see citing works
Astaxanthin as feed supplement in aquatic animals
Lim, K. C., Yusoff, F. M., Shariff, M., & Kamarudin, M. S. (2017) · Reviews in Aquaculture · doi:10.1111/raq.12200 · Cited by 449 · see citing works
Panis, G., & Carreón, J. R. (2016) · Algal Research · doi:10.1016/j.algal.2016.06.007 · Cited by 442 · see citing works
Singh, R., Parihar, P., Singh, M., Bajguz, A., Kumar, J., Singh, S., Singh, V. P., & Prasad, S. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00515 · Cited by 399 · see citing works
Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.170 · Cited by 346 · see citing works
Herrero, M., Sánchez‐Camargo, A. D. P., Cifuentes, A., & Ibáñez, E. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.01.018 · Cited by 344 · see citing works
Phototrophic pigment production with microalgae: biological constraints and opportunities
Mulders, K. J. M., Lamers, P. P., Martens, D. E., & Wijffels, R. H. (2014) · Journal of Phycology · doi:10.1111/jpy.12173 · Cited by 302 · see citing works
Microalgae-based biorefineries for sustainable resource recovery from wastewater
Goswami, R. K., Mehariya, S., Verma, P., Lavecchia, R., & Zuorro, A. (2020) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2020.101747 · Cited by 298 · see citing works
Al-Jabri, H., Das, P., Khan, S., Thaher, M., & AbdulQuadir, M. (2020) · Water · doi:10.3390/w13010027 · Cited by 270 · see citing works
Rammuni, M. N., Ariyadasa, T. U., Nimarshana, P. H. V., & Attalage, R. A. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2018.10.066 · Cited by 269 · see citing works
Overview of Carbon Capture Technology: Microalgal Biorefinery Concept and State-of-the-Art
Singh, J. P., & Dhar, D. W. (2019) · Frontiers in Marine Science · doi:10.3389/fmars.2019.00029 · Cited by 271 · see citing works
Miazek, K., Iwanek, W., Remacle, C., Richel, A., & Goffin, D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161023929 · Cited by 258 · see citing works
Plants as Factories for Human Pharmaceuticals: Applications and Challenges
Yao, J., Weng, Y., Dickey, A., & Wang, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226122 · Cited by 255 · see citing works
Production and extraction of carotenoids produced by microorganisms
Mussagy, C. U., Winterburn, J. B., Santos‐Ebinuma, V. C., & Pereira, J. F. B. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9557-5 · Cited by 254 · see citing works
Recent Developments on Genetic Engineering of Microalgae for Biofuels and Bio‐Based Chemicals
Ng, I., Tan, S., Kao, P., Chang, Y.-K., & Chang, J. (2017) · Biotechnology Journal · doi:10.1002/biot.201600644 · Cited by 253 · see citing works
Zhao, Y., Wang, H., Han, B., & Yu, X. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.12.030 · Cited by 251 · see citing works
Valuable bioproducts obtained from microalgal biomass and their commercial applications: A review
Loganathan, B. G., Orsat, V., & Mark, L. (2018) · Environmental Engineering Research · doi:10.4491/eer.2017.220 · Cited by 253 · see citing works
Light management technologies for increasing algal photobioreactor efficiency
Nwoba, E. G., Parlevliet, D. A., Laird, D. W., Alameh, K., & Moheimani, N. R. (2019) · Algal Research · doi:10.1016/j.algal.2019.101433 · Cited by 248 · see citing works
Applications of microalga <i>Chlorella vulgaris</i> in aquaculture
Ahmad, M. T., Shariff, M., Md. Yusoff, F., Goh, Y. M., & Banerjee, S. (2020) · Reviews in Aquaculture · doi:10.1111/raq.12320 · Cited by 244 · see citing works
Functional ingredients from microalgae
Buono, S., Langellotti, A. L., Martello, A., Rinna, F., & Fogliano, V. (2014) · Food & Function · doi:10.1039/c4fo00125g · Cited by 241 · see citing works
Microalgal extracellular polymeric substances and their interactions with metal(loid)s: A review
Naveed, S., Li, C., Lu, X., Chen, S., Yin, B., Zhang, C., & Ge, Y. (2019) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2019.1583052 · Cited by 233 · see citing works
The Essentials of Marine Biotechnology
Rotter, A., Barbier, M., Bertoni, F., Bones, A. M., Cancela, M. L., Carlsson, J., Carvalho, M. F., Cegłowska, M., Martorell, J. C., Dalay, M. C., et al. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.629629 · Cited by 234 · see citing works
Two-stage cultivation of microalgae for production of high-value compounds and biofuels: A review
Liyanaarachchi, V. C., Premaratne, M., Ariyadasa, T. U., Nimarshana, P. H. V., & Malik, A. (2021) · Algal Research · doi:10.1016/j.algal.2021.102353 · Cited by 225 · see citing works
Algal cellulose, production and potential use in plastics: Challenges and opportunities
Zanchetta, E., Damergi, E., Patel, B., Borgmeyer, T., Pick, H. M., Pulgarin, A., & Ludwig, C. D. R. (2021) · Algal Research · doi:10.1016/j.algal.2021.102288 · Cited by 222 · see citing works
Microalgae as source of polyhydroxyalkanoates (PHAs) — A review
Costa, S. S., Miranda, A. L., de Morais, M. G., Costa, J. A. V., & Druzian, J. I. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.099 · Cited by 218 · see citing works
Gonçalves, E., Wilkie, A. C., Kirst, M., & Rathinasabapathi, B. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12523 · Cited by 212 · see citing works
Biomass recovery and lipid extraction processes for microalgae biofuels production: A review
Menegazzo, M. L., & Fonseca, G. G. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.01.064 · Cited by 212 · see citing works
Phaeodactylum tricornutum: A Diatom Cell Factory
Butler, T. O., Kapoore, R. V., & Vaidyanathan, S. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.12.023 · Cited by 212 · see citing works
Potential biotechnological application of microalgae: a critical review
Odjadjare, E. C., Mutanda, T., & Olaniran, A. O. (2015) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2015.1108956 · Cited by 195 · see citing works
Μάρκου, Γ., Wang, L. F., Ye, J., & Unc, A. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.04.003 · Cited by 196 · see citing works
Abreu, A. P., Morais, R. C., Teixeira, J. A., & Nunes, J. (2022) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2022.112247 · Cited by 189 · see citing works
Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms
Torregrosa‐Crespo, J., Montero, Z., Fuentes, J. L., García-Galbis, M. R., Garbayo, I., Vı́lchez, C., & Martínez‐Espinosa, R. M. (2018) · Marine Drugs · doi:10.3390/md16060203 · Cited by 187 · see citing works
Microbial consortia: a critical look at microalgae co-cultures for enhanced biomanufacturing
Padmaperuma, G., Kapoore, R. V., Gilmour, D. J., & Vaidyanathan, S. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1390728 · Cited by 184 · see citing works
Cyanobacterial pigments: Perspectives and biotechnological approaches
Saini, D. K., Pabbi, S., & Shukla, P. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.002 · Cited by 184 · see citing works
Light enhancement strategies improve microalgal biomass productivity
Ramanna, L., Rawat, I., & Bux, F. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.05.202 · Cited by 178 · see citing works
Microalgae as feed sources and feed additives for sustainable aquaculture: Prospects and challenges
Ma, M., & Hu, Q. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12869 · Cited by 177 · see citing works
Ferreira, G. F., Ríos Pinto, L. F., Maciel Filho, R., & Fregolente, L. V. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.04.052 · Cited by 176 · see citing works
Microalgae culture quality indicators: a review
Elisabeth, B., Rayen, F., & Behnam, T. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1854672 · Cited by 175 · see citing works
Bio-based products from microalgae cultivated in digestates
Koutra, E., Economou, C. N., Tsafrakidou, P., & Kornaros, M. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.02.015 · Cited by 168 · see citing works
A review on co-culturing of microalgae: a greener strategy towards sustainable biofuels production
Ray, A., Nayak, M., & Ghosh, A. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149765 · Cited by 168 · see citing works
Heterotrophic cultivation of microalgae: production of metabolites of commercial interest
Morales‐Sánchez, D., Martinez-Rodriguez, O. A., & Martı́nez, A. (2016) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5115 · Cited by 164 · see citing works
Mohan, S. V., & Devi, M. P. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.02.103 · Cited by 165 · see citing works
Živković, S., Veljković, M., Banković‐Ilić, I. B., Krstić, I., Konstantinovic, S. S., Ilić, S. B., Avramović, J. M., Stamenković, O. S., & Veljković, V. B. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.05.048 · Cited by 165 · see citing works
Ren, Y., Deng, J., Huang, J., Wu, Z., Yi, L., Bi, Y., & Chen, F. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125736 · Cited by 155 · see citing works
Exploiting mixotrophy for improving productivities of biomass and co-products of microalgae
Pang, N., Gu, X., Chen, S., Kirchhoff, H., Lei, H., & Roje, S. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.06.001 · Cited by 160 · see citing works
Proteins from Microalgae for the Stabilization of Fluid Interfaces, Emulsions, and Foams
Bertsch, P., Böcker, L., Mathys, A., & Fischer, P. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.12.014 · Cited by 157 · see citing works
Green microalgae biomolecule separations and recovery
Dixon, C. K., & Wilken, L. R. (2018) · Bioresources and Bioprocessing · doi:10.1186/s40643-018-0199-3 · Cited by 150 · see citing works
Neofotis, P. G., Huang, A., Sury, K., Chang, W., Joseph, F., Gabr, A., Twary, S. N., Qiu, W., Holguin, O., & Polle, J. E. W. (2016) · Algal Research · doi:10.1016/j.algal.2016.01.007 · Cited by 146 · see citing works
Using microalgae to produce liquid transportation biodiesel: What is next?
Zhu, L., Nugroho, Y. K., Shakeel, S. R., Li, Z., Martinkauppi, B., & Hiltunen, E. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.04.089 · Cited by 164 · see citing works
Fermentative hydrogen production using algal biomass as feedstock
Xia, A., Cheng, J., Song, W., Su, H., Ding, L., Lin, R., Lu, H., Liu, J., Zhou, J., & Cen, K. (2015) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.05.076 · Cited by 145 · see citing works
Enhancing production of microalgal biopigments through metabolic and genetic engineering
Saini, D. K., Chakdar, H., Pabbi, S., & Shukla, P. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1533518 · Cited by 143 · see citing works
Sun, X., Ren, L., Bi, Z.-Q., Ji, X., Zhao, Q., & Huang, H. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.07.079 · Cited by 141 · see citing works
High-value bioproducts from microalgae: Strategies and progress
Liang, M., Wang, L., Wang, Q., Zhu, J., & Jiang, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1455030 · Cited by 137 · see citing works
Microalgae, a Potential Natural Functional Food Source – a Review
Villarruel‐López, A., Ascencio, F., & Nuño, K. (2017) · Polish Journal of Food and Nutrition Sciences · doi:10.1515/pjfns-2017-0017 · Cited by 138 · see citing works
Kuşvuran, Ş. (2021) · Horticultural Plant Journal · doi:10.1016/j.hpj.2021.03.007 · Cited by 136 · see citing works
Algal remediation of CO2 and nutrient discharges: A review
Judd, S. J., van den Broeke, L. J. P., Shurair, M., Kuti, Y. O., & Znad, H. T. (2015) · Water Research · doi:10.1016/j.watres.2015.08.021 · Cited by 135 · see citing works
Behera, S., Priyadarshanee, M., Vandana, V. P., & Das, S. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133723 · Cited by 136 · see citing works
A review on microalgal culture to treat anaerobic digestate food waste effluent
Chuka-ogwude, D., Ogbonna, J. C., & Moheimani, N. R. (2020) · Algal Research · doi:10.1016/j.algal.2020.101841 · Cited by 133 · see citing works
Photobioreactor cultivation strategies for microalgae and cyanobacteria
Johnson, T. J., Katuwal, S., Anderson, G. A., Gu, L., Zhou, R., & Gibbons, W. R. (2018) · Biotechnology Progress · doi:10.1002/btpr.2628 · Cited by 128 · see citing works
Continuous cultivation of photosynthetic microorganisms: Approaches, applications and future trends
Fernandes, B. D., Mota, A., Teixeira, J. A., & Vicente, A. A. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.03.004 · Cited by 129 · see citing works
Bhunia, B., Uday, U. S. P., Oinam, G., Mondal, A., Bandyopadhyay, T. K., & Tiwari, O. N. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.09.091 · Cited by 130 · see citing works
Symbiotic Photosynthetic Oxygenation within 3D-Bioprinted Vascularized Tissues
Maharjan, S., Alva, J., Cámara, C., Rubio, A. G., Hernández, D., Delavaux, C., Corrêa, É., Romo, M. D., Bonilla, D., Santiago, M. L., et al. (2020) · Matter · doi:10.1016/j.matt.2020.10.022 · Cited by 110 · see citing works
Nur, M. M. A., & Buma, A. G. J. (2018) · Waste and Biomass Valorization · doi:10.1007/s12649-018-0256-3 · Cited by 126 · see citing works
Grzesik, M., Romanowska‐Duda, Z., & Kalaji, H. M. (2017) · Photosynthetica · doi:10.1007/s11099-017-0716-1 · Cited by 129 · see citing works
Microalgal industry in China: challenges and prospects
Chen, J., Wang, Y., Benemann, J. R., Zhang, X., Hongjun, H., & Qin, S. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0720-4 · Cited by 124 · see citing works
What Is in Store for EPS Microalgae in the Next Decade?
Pierre, G., Delattre, C., Dubessay, P., Jubeau, S., Vialleix, C., Cadoret, J., Probert, I., & Michaud, P. (2019) · Molecules · doi:10.3390/molecules24234296 · Cited by 124 · see citing works
Biopolymers production from microalgae and cyanobacteria cultivated in wastewater: recent advances
Mastropetros, S. G., Pispas, K., Zagklis, D., Ali, S. S., & Kornaros, M. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.107999 · Cited by 123 · see citing works
Multilateral Approach on Enhancing Economic Viability of Lipid Production from Microalgae: A Review
Shin, Y. S., Choi, H. I., Choi, J. W., Lee, J. S., Sung, Y. J., & Sim, S. J. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.03.002 · Cited by 122 · see citing works
Engineering cyanobacteria as photosynthetic feedstock factories
Hays, S. G., & Ducat, D. C. (2014) · Photosynthesis Research · doi:10.1007/s11120-014-9980-0 · Cited by 122 · see citing works
Vu, C. H. T., Lee, H., Chang, Y. K., & Oh, H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.018 · Cited by 121 · see citing works
Screening of marine microalgae: Investigation of new exopolysaccharide producers
Gaignard, C., Laroche, C., Pierre, G., Dubessay, P., Delattre, C., Gardarin, C., Gourvil, P., Probert, I., Dubuffet, A., & Michaud, P. (2019) · Algal Research · doi:10.1016/j.algal.2019.101711 · Cited by 122 · see citing works
Enhancing microalgal lipid accumulation for biofuel production
Zhu, Z., Sun, J. K., Fa, Y., Liu, X., & Lindblad, P. C. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1024441 · Cited by 120 · see citing works
Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.
Abreu, A. P., Martins, R., & Nunes, J. (2023) · Bioengineering · doi:10.3390/bioengineering10080955 · Cited by 119 · see citing works
Li, X., Li, W., Zhai, J., & Wei, H. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.05.046 · Cited by 119 · see citing works
Zheng, H., Liu, M., Lu, Q., Wu, X., Ma, Y., Cheng, Y., Addy, M., Liu, Y., & Ruan, R. R. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.10.057 · Cited by 118 · see citing works
Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
Saadaoui, I., Rasheed, R., Abdulrahman, N., Bounnit, T., Cherif, M., Jabri, H. M. S. J. A., & Mraiche, F. (2020) · Marine Drugs · doi:10.3390/md18040197 · Cited by 118 · see citing works
Abiotic stress in algae: response, signaling and transgenic approaches
Kaur, M., Saini, K. C., Ojah, H., Sahoo, R., Gupta, K., Kumar, A., & Bast, F. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02746-7 · Cited by 116 · see citing works
Influence of oxygen on the biosynthesis of polyunsaturated fatty acids in microalgae
Sun, X., Geng, L., Ren, L., Ji, X., Hao, N., Chen, K., & Huang, H. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.11.005 · Cited by 115 · see citing works
Forward Osmosis Application in Manufacturing Industries: A Short Review
Haupt, A., & Lerch, A. (2018) · Membranes · doi:10.3390/membranes8030047 · Cited by 115 · see citing works
Agarwal, P., Soni, R., Kaur, P., Madan, A., Mishra, R., Pandey, J., Singh, S., & Singh, G. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.939347 · Cited by 118 · see citing works
Kalra, R., Gaur, S., & Goel, M. (2021) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2020.101794 · Cited by 140 · see citing works
Jun, S., Yang, J., Jeon, H., Kim, H. S., Pack, S. P., Jin, E., & Kim, J. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b05284 · Cited by 113 · see citing works
Kousoulaki, K., Østbye, T.-K. K., Krasnov, A., Torgersen, J. S., Mørkøre, T., & Sweetman, J. W. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.14 · Cited by 113 · see citing works
Blockx, J., Verfaillie, A., Thielemans, W., & Muylaert, K. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b04802 · Cited by 112 · see citing works
Chentir, I., Kchaou, H., Hamdi, M., Jridi, M., Li, S., Doumandji, A., & Nasri, M. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.11.034 · Cited by 112 · see citing works
Couso, I., Evans, B. S., Li, J., Liu, Y., Ma, F., Diamond, S., Allen, D. K., & Umen, J. (2016) · The Plant Cell · doi:10.1105/tpc.16.00351 · Cited by 102 · see citing works
Algae: Study of Edible and Biologically Active Fractions, Their Properties and Applications
Babich, O., Сухих, С. А., Larina, V., Kalashnikova, O. B., Kashirskikh, E., Prosekov, A. Y., Носкова, С., Ivanova, S. A., Fendri, I., Smaoui, S., et al. (2022) · Plants · doi:10.3390/plants11060780 · Cited by 111 · see citing works
Ibrahim, T. N. B. T., Feisal, N. A. S., Kamaludin, N. H., Cheah, W. Y., How, V., Bhatnagar, A., Ma, Z., & Show, P. L. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128661 · Cited by 111 · see citing works
Hamidi, M., Kozani, P. S., Kozani, P. S., Pierre, G., Michaud, P., & Delattre, C. (2019) · Marine Drugs · doi:10.3390/md18010028 · Cited by 107 · see citing works
Microalgal ecotoxicity of nanoparticles: An updated review
Nguyen, M. K., Moon, J., & Lee, Y. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110781 · Cited by 107 · see citing works
Gao, Y., Guo, L., Jin, C., Zhao, Y., Gao, M., She, Z., & Wang, G. (2022) · Water Research · doi:10.1016/j.watres.2022.118256 · Cited by 107 · see citing works
Sreenikethanam, A., Raj, S., Banu, J. R., Gugulothu, P., & Bajhaiya, A. K. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.836056 · Cited by 111 · see citing works
An Overview of Microalgae Lipid Extraction in a Biorefinery Framework
Roux, J.-M., Lamotte, H., & Achard, J. (2017) · Energy Procedia · doi:10.1016/j.egypro.2017.03.1137 · Cited by 106 · see citing works
- Authors
- Markou, G., & Nerantzis, E.
- Affiliations
- Technological Educational Institute of Athens (GR)
- ORCID
- Nerantzis, Elias
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 31
- Issue
- 8
- Pages
- 1532-1542
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W1995250319
- Cited by
- 815
- References
- 173
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 36 · 2023: 66 · 2022: 86 · 2021: 80 · 2020: 85 · 2019: 89 · 2018: 83 · 2017: 73 · 2016: 48 · 2015: 60 · 2014: 15
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Keywords
- microalgae, biofuels, value-added chemicals, secondary metabolites, nutrient deprivation, salt stress, temperature stress, lipid accumulation, carbohydrate accumulation, biorefinery, microalgal biomass
- MeSH terms
- Biotechnology, Stress, Physiological, Cell Culture Techniques, Bioreactors, Biofuels, Microalgae
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