Hypomagnesaemia linked to depression: A systematic review and meta-analysis
Abstract
BACKGROUND: The reported risk of depression in patients with hypomagnesaemia is controversial. AIM: The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS: A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inception through October 2014. Studies that reported odds ratios, relative risks or hazard ratios comparing the risk of depression in patients with hypomagnesaemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Six observational studies (three cohort studies, two cross-sectional studies and a case-control study) with a total of 19,137 patients were identified and included in the data analysis. The pooled RR of depression in patients with hypomagnesaemia was 1.34 (95% CI, 1.01-1.79, I(2) = 33%). The association between depression and hypomagnesaemia was marginally insignificant after the sensitivity analysis including only cohort and case-control studies, with a pooled RR of 1.38 (95% CI, 0.92-2.07, I(2) = 24%). CONCLUSION: Our study demonstrates a potential association between hypomagnesaemia and depression. Further studies assessing the benefits of treatment of hypomagnesaemia in patients with depression are needed.
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According to meta-analyses, both insufficient dietary magnesium intakes and low magnesium biological status are associated with a higher risk of depression.
“According to meta-analyses, both insufficient dietary magnesium intakes [182,183] and low magnesium biological status [184] are associated with a higher risk of depression.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [184]
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- Authors
- Cheungpasitporn, W., Thongprayoon, C., Mao, M. A., Srivali, N., Ungprasert, P., Varothai, N., Sanguankeo, A., Kittanamongkolchai, W., & Erickson, S. B.
- Affiliations
- Mayo Clinic (US)
- Tufts Medical Center (US)
- Siriraj Hospital (TH)
- Corresponding author
- Cheungpasitporn, W.
- ORCID
- Venue
- Internal Medicine Journal
- Publisher
- Wiley
- Published
- 2015-04
- Volume
- 45
- Issue
- 4
- Pages
- 436-440
- ISSN
- 1444-0903 (ISSN-L)
- 1445-5994
- OpenAlex
- W1955927122
- Cited by
- 57
- References
- 23
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Internal Medicine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- hypomagnesemia, depression
- MeSH terms
- Cross-Sectional Studies, Depression, Humans, Magnesium Deficiency, Cohort Studies, Case-Control Studies
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