Magnesium and depression: a systematic review

Derom, Marie-Laure; Sayón-Orea, Carmen; Martínez-Ortega, José María; Martínez-González, Miguel A.

doi:10.1179/1476830512y.0000000044

Cited by 108Magnesium in Health and DiseaseTreatment of Major DepressionMagnesium Alloys: Properties and Applications

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Magnesium and depression: a systematic review

Derom, Marie-Laure, Sayón-Orea, Carmen, Martínez-Ortega, José María, Martínez-González, Miguel A.·2013·Nutritional Neuroscience

DOI 10.1179/1476830512y.0000000044

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Abstract

INTRODUCTION: The incidence of depression is increasing worldwide. Much is still unknown about the possible role of magnesium in depression prevention and treatment. Magnesium has an effect on biological and transduction pathways implicated in the pathophysiology of depression. The possible role of magnesium in depression prevention and treatment remains unclear. OBJECTIVES: We systematically reviewed the possible links between magnesium and depression in humans. METHODS: Twenty-one cross-sectional studies, three intervention trials, one prospective study, one case only study, and one case series study were included based on specific selection criteria. RESULTS: A higher intake of dietary magnesium seems to be associated with lower depression symptoms though reverse causality cannot be excluded. The results assessing the association between blood and cerebrospinal fluid magnesium and depression are inconclusive. DISCUSSION: Magnesium seems to be effective in the treatment of depression but data are scarce and incongruous. Disturbance in magnesium metabolism might be related to depression. Oral magnesium supplementation may prevent depression and might be used as an adjunctive therapy. However, more interventional and prospective studies are needed in order to further evaluate the benefits of magnesium intake and supplementation for depression.

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According to meta-analyses, both insufficient dietary magnesium intakes and low magnesium biological status are associated with a higher risk of depression.
“According to meta-analyses, both insufficient dietary magnesium intakes [182,183] and low magnesium biological status [184] are associated with a higher risk of depression.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [182]

Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative.
(2007) · PubMed Central · Cited by 2,521
Magnesium
Saris, N.-E. L., Mervaala, E. M. A., Karppanen, H., Khawaja, J. A., & Lewenstam, A. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00258-2 · Cited by 1,365
Magnesium: Nature's physiologic calcium blocker
Iseri, L. T., & French, J. H. (1984) · American Heart Journal · doi:10.1016/0002-8703(84)90572-6 · Cited by 831
Cross-national comparisons of the prevalences and correlates of mental disorders. WHO International Consortium in Psychiatric Epidemiology.
Andrade, L. H., Caraveo-Anduaga, J. J., Berglund, P. A., Bijl, R. C., Kessler, R. C., Demler, O., Walters, E. E., Kylyc, C., Offord, D. R., Üstün, T. B., et al. (2000) · Europe PMC (PubMed Central) · Cited by 711
The Burden of Mental Disorders
Eaton, W. W., Martins, S. S., Nestadt, G., Bienvenu, O. J., Clarke, D. E., & Alexandre, P. K. (2008) · Epidemiologic Reviews · doi:10.1093/epirev/mxn011 · Cited by 481
Fish Consumption and Depressive Symptoms in the General Population in Finland
Tanskanen, A. J., Hibbeln, J. R., Tuomilehto, J., Uutela, A. K., Haukkala, A., Viinamäki, H. T., Lehtonen, J., & Vartiainen, E. (2001) · Psychiatric Services · doi:10.1176/appi.ps.52.4.529 · Cited by 360
Dietary Magnesium Intake in a National Sample of U.S. Adults
Ford, E. S., & Mokdad, A. H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2879 · Cited by 342
Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 2: Practical Issues and Specific Cases
Ellenberg, S. S., & Temple, R. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00015 · Cited by 331
Dietary Magnesium Intake in Relation to Plasma Insulin Levels and Risk of Type 2 Diabetes in Women
Song, Y., Manson, J. E., Buring, J. E., & Liu, S. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.59 · Cited by 302
Magnesium Metabolism: A Review
Ebel, H. F., & Günther, T. (1980) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1980.18.5.257 · Cited by 292
Rapid recovery from major depression using magnesium treatment
Eby, G. A., & Eby, K. L. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.01.047 · Cited by 291
Untitled work
(2001) · PubMed Central · Cited by 289
Dietary Magnesium and C-reactive Protein Levels
King, D. E., Mainous, A. G., Geesey, M. E., & Woolson, R. F. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719461 · Cited by 279
Levels of anxiety and depression as predictors of mortality: the HUNT study
Mykletun, A., Bjerkeset, O., øverland, S., Prince, M., Dewey, M., & Stewart, R. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.054866 · Cited by 279
Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time
Skarupski, K. A., Tangney, C., Li, H., Ouyang, B., Evans, D. A., & Morris, M. C. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29413 · Cited by 228
Cell (patho)physiology of magnesium
Wolf, F. I., & Trapani, V. (2007) · Clinical Science · doi:10.1042/cs20070129 · Cited by 193
Magnesium in clinical medicine
Rhian, M. T. (2004) · Frontiers in bioscience · doi:10.2741/1316 · Cited by 187
Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study
Sánchez‐Villegas, A., Henríquez, P., Figueiras, A., Ortuño, F., Lahortiga‐Ramos, F., & Martínez‐González, M. Á. (2007) · European Journal of Nutrition · doi:10.1007/s00394-007-0671-x · Cited by 187
Magnesium-deficient diet alters depression- and anxiety-related behavior in mice—influence of desipramine and Hypericum perforatum extract
Singewald, N., Sinner, C., Hetzenauer, A., Sartori, S. B., & Murck, H. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.08.010 · Cited by 161
Magnesium and Affective Disorders
Murck, H. (2002) · Nutritional Neuroscience · doi:10.1080/1028415021000039194 · Cited by 157
Dietary Folate and the Risk of Depression in Finnish Middle-Aged Men
Tolmunen, T., Hintikka, J., Ruusunen, A. A., Voutilainen, S., Tanskanen, A. J., Valkonen, V.-P., Viinamäki, H. T., Kaplan, G. A., & Salonen, J. T. (2004) · Psychotherapy and Psychosomatics · doi:10.1159/000080385 · Cited by 147
Association Between Magnesium Intake and Depression and Anxiety in Community-Dwelling Adults: The Hordaland Health Study
Jacka, F. N., Øverland, S. N., Stewart, R. J., Tell, G. S., Bjelland, I., & Mykletun, A. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802534408 · Cited by 146
Mineral and Metal Neurotoxicology
YASUI, M., & Verity, M. A. (1996) · CRC Press eBooks · doi:10.1201/9781439810699 · Cited by 132
Antidepressant- and anxiolytic-like activity of magnesium in mice
Poleszak, E., Szewczyk, B., Kędzierska, E., Właź, P., Pilc, A., & Nowak, G. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.01.006 · Cited by 126
Epidemiology of major depressive episode in a southern European country: Results from the ESEMeD-Spain project
Gabilondo, A., Rojas‐Farreras, S., Vilagut, G., Haro, J. M., Fernández, A., Pinto‐Meza, A., & Alonso, J. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.016 · Cited by 125
Magnesium Supplementation Alleviates Premenstrual Symptoms of Fluid Retention
Walker, A. F., SOUZA, M. C. D., Vickers, M. F., Abeyasekera, S., COLLINS, M. L., & Trinca, L. A. (1998) · Journal of Women s Health · doi:10.1089/jwh.1998.7.1157 · Cited by 123
Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity
Bresink, I., Danysz, W., Parsons, C. G., & Mutschler, E. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00017-z · Cited by 117
Association between folate, vitamin B6 and vitamin B12 intake and depression in the SUN cohort study
Sánchez‐Villegas, A., Doreste‐Alonso, J., Schlatter, J., Pla, J., Bes‐Rastrollo, M., & Martínez‐González, M. Á. (2009) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00931.x · Cited by 114
CSF calcium: clinical correlates in affective illness and schizophrenia.
Dc, J., Post, R. M., Js, C., van Kammen, D. P., Jh, W., Fk, G., & Bunney, W. E. (1979) · PubMed · Cited by 113
Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial.
Barragan-Rodríguez, L., Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2008) · PubMed · Cited by 109
Dietary Magnesium Intake in French Adult Population
Galan, P., Preziosi, P., Durlach, V., Ribas, L., Bouzid, D., Fieux, B., Favier, A. E., & Herçberg, S. (1997) · Springer eBooks · doi:10.1007/978-94-009-0057-8_36 · Cited by 104
One-month prevalence of depression and other DSM-IV disorders among young adults
Aalto-Setälä, T., Marttunen, M., Tuulio-Henriksson, A., Poikolainen, K., & Lönnqvist, J. (2001) · Psychological Medicine · doi:10.1017/s0033291701004081 · Cited by 103
Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms.
Me, M. (1992) · PubMed · Cited by 102
Dietary Magnesium Intake and Risk of Incident Hypertension Among Middle-Aged and Older US Women in a 10-Year Follow-Up Study
Song, Y., Sesso, H. D., Manson, J. E., Cook, N. R., Buring, J. E., & Liu, S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.07.040 · Cited by 102
Dietary Magnesium Intake and Risk of Cardiovascular Disease Among Women
Song, Y., Manson, J. E., Cook, N. R., Albert, C. M., Buring, J. E., & Liu, S. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.045 · Cited by 98
Magnesium in Disease: a Review with Special Emphasis on the Serum Ionized Magnesium
Sanders, G. T., Huijgen, H. J., & Sanders, R. (1999) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1999.151 · Cited by 97
Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium
Cardoso, C. C., Lobato, K. R., Binfaré, R. W., Ferreira, P. K., Rosa, A. O., Santos, A. R. S., & Rodrigues, A. L. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.11.007 · Cited by 92
Essentials of human nutrition
Robinson, F. (2002) · Nutrition Bulletin · doi:10.1046/j.1467-3010.2002.00244.x · Cited by 84
Magnesium as a neuroprotectant in cardiac surgery: A randomized clinical trial
Bhudia, S. K., Cosgrove, D. M., Naugle, R. I., Rajeswaran, J., Lam, B.-K., Walton, E., Petrich, J., Palumbo, R. C., Gillinov, A. M., Apperson-Hansen, C., et al. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.11.018 · Cited by 83
Excitatory Amino Acid Neurotoxicity
Gillessen, T., Budd, S. L., & Lipton, S. A. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0123-7_1 · Cited by 81
Magnesium Attenuates Post-Traumatic Depression/Anxiety Following Diffuse Traumatic Brain Injury in Rats
Fromm, L., Heath, D., Vink, R., & Nimmo, A. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719396 · Cited by 81
Plasma Magnesium and Calcium in Depression
Frizel, D. E., Coppen, A. J., & Marks, V. (1969) · The British Journal of Psychiatry · doi:10.1192/bjp.115.529.1375 · Cited by 71
Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts
Bánki, C. M., Vojnik, M., Papp, Z., Balla, K. Z., & Arató, M. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90076-9 · Cited by 66
Serum trace elements in animal models and human depression: Part III. Magnesium. Relationship with copper
Zieba, A., Kata, R., Dudek, D., Schlegel-Zawadzka, M., & Nowak, G. (2000) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.231 · Cited by 61
Anxiety and depression: individual entities or two sides of the same coin?
Nutt, D. (2004) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500410005513 · Cited by 61
Relationship between erythrocyte magnesium, plasma electrolytes and cortisol, and intensity of symptoms in major depressed patients
Widmer, J., Henrotte, J.-G., Raffin, Y., Bovier, P., Hilleret, H., & Gaillard, J.-M. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00018-i · Cited by 59
Calcium and magnesium concentrations in affective disorder: difference between plasma and serum in relation to symptoms
Linder, J., Brismar, K., Beck-Friis, J., Sääf, J., & Wetterberg, L. (1989) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1989.tb03021.x · Cited by 56
High Serum and Cerebrospinal Fluid Ca/Mg Ratio in Recently Hospitalized Acutely Depressed Patients
Levine, J., Stein, D. J., Rapoport, A., & Kurtzman, L. (1999) · Neuropsychobiology · doi:10.1159/000026562 · Cited by 53
Magnesium in major depression
Nechifor, M. (2009) · Magnesium Research · doi:10.1684/mrh.2009.0177 · Cited by 52
Magnesium deficiency diagnosed by an intravenous loading test
Gullestad, L. L., Dolva, L. Ø., Waage, A., Falch, D., Fagerthun, H., & KJEKSHUS, J. K. (1992) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519209088355 · Cited by 50
Magnesium Intake Is Not Related to Depression Risk in Spanish University Graduates
Derom, M.-L., Martínez‐González, M. Á., Sayón-Orea, M. D. C., Bes‐Rastrollo, M., Beunza, J. J., & Sánchez‐Villegas, A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.155572 · Cited by 50
Magnesium, Schizophrenia and Manic-Depressive Disease
Kirov, G., & Tsachev, K. (2008) · Neuropsychobiology · doi:10.1159/000119431 · Cited by 48
Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders
Jung, K. I., Ock, S. M., Chung, J. H., & Song, C. H. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8421-y · Cited by 47
Cerebrospinal Fluid and Serum Cation Levels
Schain, R. J. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460210108012 · Cited by 44
Evolution of Blood Magnesium, Sodium and Potassium in Depressed Patients Followed for Three Months
Widmer, J., Bovier, P., Karege, F., Raffin, Y., Hilleret, H., Gaillard, J.-M., & Tissot, R. (2008) · Neuropsychobiology · doi:10.1159/000118914 · Cited by 43
Does Magnesium Have a Role in the Treatment of Patients with Coronary Artery Disease?
Shechter, M. (2003) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200303040-00001 · Cited by 42
Food for thought
Jacka, F. N., & Berk, M. (2007) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2007.00246.x · Cited by 42
Plasma and erythrocyte electrolytes in affective disorders
Frazer, A., Ramsey, T., Swann, A. C., Bowden, C. L., Brunswick, D. J., Garver, D. L., & Secunda, S. K. (1983) · Journal of Affective Disorders · doi:10.1016/0165-0327(83)90003-4 · Cited by 39
Serum magnesium circadian rhythm in human adults with respect to age, sex and mental status
Touitou, Y., Touitou, C., Bogdan, A., Beck, H., & Reinberg, A. (1978) · Clinica Chimica Acta · doi:10.1016/0009-8981(78)90054-2 · Cited by 38
Plasma magnesium levels and treatment outcome in depressed patients
Camardese, G., Risio, L. D., Pizi, G., Mattioli, B., Buccelletti, F., Serrani, R., Leone, B., Sgambato, A., Bria, P., & Janiri, L. (2012) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000002 · Cited by 37
International differences in major depression prevalence: What do they mean?
Patten, S. B. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00090-8 · Cited by 35
Hypercalcaemia is associated with poor mental health in haemodialysis patients: results from Japan DOPPS
Tanaka, M., Yamazaki, S., Hayashino, Y., Fukuhara, S., Akiba, T., Saitō, A., Asano, Y., Port, F. K., Kurokawa, K., & Akizawa, T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm008 · Cited by 35
Relationships between serum magnesium levels and clinical background factors in patients with mood disorders
Imada, Y., YOSHIOKA, S., Ueda, T., KATAYAMA, S., Kuno, Y., & Kawahara, R. (2002) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2002.01046.x · Cited by 33
The interface between thyroid activity, magnesium, and depression: A pilot study
Hasey, G., D'Alessandro, E., Cooke, R. G., & Warsh, J. J. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90314-4 · Cited by 30
The Ethics of Placebo-Controlled Trials
Reynolds, T. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00103 · Cited by 29
Serum Mg 2+ and Ca 2+ /Mg 2+ Ratio in Major Depressive Disorder
Young, T., Robb, J. C., LEVITT, A. J., Cooke, R. G., & Joffe, R. T. (2008) · Neuropsychobiology · doi:10.1159/000119287 · Cited by 29
Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects
Barragan-Rodríguez, L., Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.03.008 · Cited by 29
Blocker Studies of the Functional Architecture of the NMDA Receptor Channel
Sobolevskiĭ, A. I., & Khodorov, B. I. (2002) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1013927409034 · Cited by 26
CSF magnesium in affective disorder: Lack of correlation with clinical course of treatment
George, M. S., Rosenstein, D. L., Rubinow, D. R., Kling, M. A., & Post, R. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90033-7 · Cited by 24
Electrolytes in erythrocytes of patients with depressive disorders
Kamei, K., Tabata, O., Muneoka, K. T., Muraoka, S., Tomiyoshi, R., & Takigawa, M. (1998) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.1998.00426.x · Cited by 22
Effects of haloperidol on human plasma magnesium
Jabotinsky-Rubin, K., Durst, R., Levitin, L. A., Moscovich, D. G., Silver, H., Lerner, J., van Praag, H. M., & Gardner, E. L. (1993) · Journal of Psychiatric Research · doi:10.1016/0022-3956(93)90003-k · Cited by 22
The thyroid, magnesium and calcium in major depression
Joffe, R. T., LEVITT, A. J., & Young, L. T. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(96)00063-7 · Cited by 20
Dietary intakes of Canadians in the 1990s using population-weighted data derived from the provincial nutrition surveys
Dolega-Cieszkowski, J. H., Bobyn, J. P., & Whiting, S. J. (2006) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h06-096 · Cited by 20
Blood magnesium, potassium, sodium, calcium and cortisol in drug-free depressed patients.
Widmer, J., Stella, N., Raffin, Y., BOVIER, P. A., Gaillard, J. M., Hilleret, H., & Tissot, R. (1993) · PubMed · Cited by 19
Depressive State and Paresthesia Dramatically Improved by Intravenous MgSO4 in Gitelman's Syndrome
Enya, M., Kanoh, Y., Mune, T., Ishizawa, M., Sarui, H., Yamamoto, M., Takeda, N., Yasuda, K., Yasujima, M., Tsutaya, S., et al. (2004) · Internal Medicine · doi:10.2169/internalmedicine.43.410 · Cited by 18
Relationship between blood magnesium and psychomotor retardation in drug-free patients with major depression
Widmer, J., Henrotte, J.-G., Raffin, Y., Mouthon, D., Chollet, D., Stepanian, R., & BOVIER, P. A. (1998) · European Psychiatry · doi:10.1016/s0924-9338(98)80024-2 · Cited by 14
Genetic regulation of blood and tissue magnesium content in mammals.
Jg, H. (1988) · PubMed · Cited by 12
Homeostasis of magnesium in man after oral supplementation: results of a placebo controlled blind study.
Golf, W., Riediger, H., Matthes, S., Kuhn, D., GRAEF, V., Temme, H., Katz, N. R., & Róka, L. (1990) · Magnesium-Bulletin · Cited by 10
Serum magnesium profile in heroin addicts: according to psychiatric comorbidity.
Daini, S., Tonioni, F., Barra, A., Lai, C., Lacerenza, R., Sgambato, A., Bria, P., & Cittadini, A. R. M. (2006) · PubMed · doi:10.1684/mrh.2006.0003 · Cited by 10
Ausgeprägte Störungen des Kalziumstoffwechsels als Ursache psychischer Störungen bei Alterspatienten
Hewer, W., & Stark, H.-W. (2010) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0029-1245146 · Cited by 3

Flagged first, then by citations

Research works printed but not linked: 18

Andrade L, 2000, Bull World Health Organ, 78, 413
World Health Organization, 2008, The global burden of disease: 2004 update
Kessler RC, 2007, World Psychiatry, 6, 168
American Psychiatric Association, 2000, Diagnostic and statistical manual of mental disorders: DSM-IV-TR
Food and Nutrition Board IoM.Magnesium. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997. p. 190–249.
Galan P, 1997, Magnesium Res, 10, 321
Widmer J, 1993, Magnesium Res, 6, 33
Barragan-Rodriguez L, 2008, Magnesium Res, 21, 218
10.2169/internalmedicine.43.410 · DOI
10.1016/j.mehy.2006.01.047 · DOI
Jimerson DC, 1979, Biol Psychiatry, 14, 37
Ebel H, 1980, J Clin Chem Clin Biol, 18, 257
Morris ME, 1992, Magnesium Res, 5, 303
Daini S, 2006, Magnesium Res, 19, 162
Mark LP, 2001, Am J Neuroradiol, 22, 1813
Golf SW, 1990, Magnesium-Bulletin, 12, 144
Henrotte JG, 1988, Magnesium, 7, 306
Jekel JF, 2007, Epidemiology, biostatics, and preventive medicine, 197

Sorted by citations

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Boyle, N., Lawton, C., & Dye, L. (2017) · Nutrients · doi:10.3390/nu9050429 · Cited by 162
Role of magnesium supplementation in the treatment of depression: A randomized clinical trial
Tarleton, E. K., Littenberg, B., MacLean, C. D., Kennedy, A. G., & Daley, C. J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180067 · Cited by 154
A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder
Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.83 · Cited by 144
Complementary therapies for clinical depression: an overview of systematic reviews
Haller, H., Anheyer, D., Cramer, H., & Dobos, G. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028527 · Cited by 134
Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study
Islam, M. R., Islam, M. R., Qusar, M. S., Islam, M. S., Kabir, M. H., Rahman, G. K. M. M., Islam, M. S., & Hasnat, A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1685-z · Cited by 117
Anabolic effects of vitamin D and magnesium in aging bone
Erem, A. S., Atfi, A., & Razzaque, M. S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105400 · Cited by 109
Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine
Schwalfenberg, G., & Genuis, S. J. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/318595 · Cited by 97
Recent insights in the impact of emerging technologies on lactic acid bacteria: A review
Peng, K., Koubaa, M., Bals, O., & Vorobiev, E. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109544 · Cited by 90
Healthy and Unhealthy Dietary Patterns Are Related to Depression: A Case-Control Study
Khosravi, M., Sotoudeh, G., Majdzadeh, R., Nejati, S., Darabi, S., Raisi, F., Esmaillzadeh, A., & Sorayani, M. (2015) · Psychiatry Investigation · doi:10.4306/pi.2015.12.4.434 · Cited by 83
The association between dietary patterns derived by reduced rank regression and depressive symptoms over time: the Invecchiare in Chianti (InCHIANTI) study
Vermeulen, E., Stronks, K., Visser, M., Brouwer, I. A., Schene, A. H., Mocking, R. J. T., Colpo, M., Bandinelli, S., Ferrucci, L., & Nicolaou, M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001318 · Cited by 81
Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post‐hoc analysis of a randomised controlled trial
Noah, L., Dye, L., Fer, B. B. D., Mazur, A., Pickering, G. P., & Pouteau, E. B. (2021) · Stress and Health · doi:10.1002/smi.3051 · Cited by 72
Mediterranean Diet, Food Consumption and Risk of Late-Life Depression: The Mugello Study
Pagliai, G., Sofi, F., Vannetti, F., Caiani, S., Pasquini, G., Lova, R. M., Cecchi, F., Sorbi, S., & Macchi, C. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1019-3 · Cited by 66
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial
Milak, M. S., Rashid, R., Dong, Z., Kegeles, L. S., Grunebaum, M. F., Ogden, R. T., Lin, X., Mulhern, S. T., Suckow, R. F., Cooper, T. B., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.13211 · Cited by 63
Pathogenesis and treatment of depression: Role of diet in prevention and therapy
Mrozek, W., Socha, J., Sidorowicz, K., Skrok, A., Syrytczyk, A., Piątkowska‐Chmiel, I., & Herbet, M. (2023) · Nutrition · doi:10.1016/j.nut.2023.112143 · Cited by 65
Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial
Edalati-Fard, F., Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M., Mohammad‐Alizadeh‐Charandabi, S., Farshbaf‐Khalili, A., Javadzadeh, Y., & Asgharian, H. (2016) · Women & Health · doi:10.1080/03630242.2016.1235074 · Cited by 61
Seaweed consumption and prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study
Miyake, Y., Tanaka, K., Okubo, H., Sasaki, S., & Arakawa, M. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-301 · Cited by 60
Association between dietary glycemic index and glycemic load with depression: a systematic review
Rahimlou, M., Morshedzadeh, N., Karimi, S., & Jafarirad, S. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1710-5 · Cited by 59
Hypomagnesaemia linked to depression: A systematic review and meta-analysis
Cheungpasitporn, W., Thongprayoon, C., Mao, M. A., Srivali, N., Ungprasert, P., Varothai, N., Sanguankeo, A., Kittanamongkolchai, W., & Erickson, S. B. (2015) · Internal Medicine Journal · doi:10.1111/imj.12682 · Cited by 57
Malnutrition and inflammation are associated with severity of depressive and cognitive symptoms of old patients affected by chronic kidney disease
Guenzani, D., Buoli, M., Caldiroli, L., Carnevali, G. S., Serati, M., Vezza, C., Armelloni, S., Messa, P., & Vettoretti, S. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109783 · Cited by 53
Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a review
Döme, P., Tombor, L., Lazáry, J., Gonda, X., & Rihmer, Z. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.015 · Cited by 49
Magnesium (Mg2+): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation
Kumar, A., Mehan, S., Tiwari, A., Khan, Z., Gupta, G. D., Narula, A. S., & Samant, R. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128321466240816075041 · Cited by 55
The Association between Serum Magnesium Levels and Depression in an Adult Primary Care Population
Tarleton, E. K., Kennedy, A. G., Rose, G. L., Crocker, A., & Littenberg, B. (2019) · Nutrients · doi:10.3390/nu11071475 · Cited by 45
Complementary Health Practices for Treating Perinatal Depression
Reza, N., Deligiannidis, K. M., Eustis, E. H., & Battle, C. L. (2018) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2018.04.002 · Cited by 46
Magnesium enriched lactic acid bacteria as a carrier for probiotic ice cream production
Góral, M., Kozłowicz, K., Pankiewicz, U., & Góral, D. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.053 · Cited by 45
The Severity of Depressive Symptoms vs. Serum Mg and Zn Levels in Postmenopausal Women
Stanisławska, M., Szkup-Jabłońska, M., Jurczak, A., Wieder-Huszla, S., Samochowiec, A., Jasiewicz, A., Noceń, I., Augustyniuk, K., Brodowska, A., Karakiewicz, B., et al. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9866-6 · Cited by 41
Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Ferriani, L. O., Silva, D. A., Molina, M. D. C. B., Mill, J. G., Brunoni, A. R., da Fonseca, M. D. J. M., Moreno, A. B., Benseñor, I. M., de Aguiar, O. B., Barreto, S. M., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.027 · Cited by 41
Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: The RESMENA project
Perez‐Cornago, A., Lopez‐Legarrea, P., de la Iglesia, R., Lahortiga‐Ramos, F., Martínez, J. A., & Zulet, M. Á. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.11.011 · Cited by 40
Magnesium and mood disorders: systematic review and meta-analysis
Phelan, D., Molero, P., Martínez‐González, M. Á., & Molendijk, M. L. (2018) · BJPsych Open · doi:10.1192/bjo.2018.22 · Cited by 40
Nutritional strategies for dealing with depression
Manosso, L. M., Moretti, M., & Rodrigues, A. L. S. (2013) · Food & Function · doi:10.1039/c3fo60246j · Cited by 39
A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
Zhang, C., Hu, Q., Li, S., Dai, F., Qian, W., Hewlings, S. J., Yan, T., & Wang, Y. (2022) · Nutrients · doi:10.3390/nu14245235 · Cited by 36
Decreased serum magnesium levels in depression: a systematic review and meta-analysis
You, H. J., Cho, S., Kang, S., Cho, S.-J., & Na, K. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1538388 · Cited by 31
Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
Ryszewska-Pokraśniewicz, B., Mach, A., Skalski, M., Januszko, P., Wawrzyniak, Z. M., Poleszak, E., Nowak, G., Pilc, A., & Radziwoń-Zaleska, M. (2018) · Nutrients · doi:10.3390/nu10081014 · Cited by 30
Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation
Al-Dujaili, A. H., Al‐Hakeim, H. K., Twayej, A. J., & Maes, M. H. J. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00458-5 · Cited by 25
Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis
Pethő, Á. G., Fülöp, T., Orosz, P., & Tapolyai, M. B. (2024) · Clinics and Practice · doi:10.3390/clinpract14020040 · Cited by 29
Effect of Pulsed Electric Fields (PEF) on Accumulation of Magnesium in Lactobacillus rhamnosus B 442 Cells
Góral, M., & Pankiewicz, U. (2017) · The Journal of Membrane Biology · doi:10.1007/s00232-017-9986-6 · Cited by 24
Nutritional Interventions in Clinical Depression
Rechenberg, K. (2015) · Clinical Psychological Science · doi:10.1177/2167702614566815 · Cited by 22
Rapid Dilapidation of Alcohol Using Magnesium Oxide and Magnesium Aspartate based Nanostructures: A Raman Spectroscopic and Molecular Simulation Approach
Durgalakshmi, D., Rakkesh, R. A., Kamil, S., Karthikeyan, S., & Balakumar, S. (2019) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-019-01105-3 · Cited by 25
Assessing the Evidence of Micronutrients on Depression among Children and Adolescents: An Evidence Gap Map
Campisi, S. C., Zasowski, C., Shah, S., Shah, A., Bradley-Ridout, G., Korczak, D. J., & Szatmári, P. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa021 · Cited by 19
Double‐blind, randomized crossover study of intravenous infusion of magnesium sulfate versus 5% dextrose on depressive symptoms in adults with treatment‐resistant depression
Mehdi, S. M. A., Atlas, S. E., Qadir, S., Musselman, D. L., Goldberg, S., Woolger, J. M., Corredor, R. G., Abbas, M. H., Arosemena, L. R., Caccamo, S., et al. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12480 · Cited by 18
Serum Magnesium Status in Patients Subjects with Depression in the City of Yazd in Iran 2013–2014
Rajizadeh, A., Mozaffari–Khosravi, H., Yassini-Ardakani, M., & Dehghani, A. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0542-x · Cited by 18
A randomised controlled trial assessing the effect of a Mediterranean diet on the symptoms of depression in young men (the ‘AMMEND’ study): a study protocol
Bayes, J., Schloss, J. M., & Sibbritt, D. W. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004699 · Cited by 18
The Impact of Malnutrition, Inflammation on Cognitive Impairment in Hemodialysis Patients: A Multicenter Study
Yang, Y., Da, J., Li, Q., Long, Y., Yuan, J., & Zha, Y. (2022) · Kidney & Blood Pressure Research · doi:10.1159/000527453 · Cited by 15
Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
Shammaa, A. A., Al-Thani, A., Al-Kaabi, M. A., Al-Saeed, K., AlAnazi, M. M., & Shi, Z. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s391369 · Cited by 16
Association between mood and diet quality in subjects with metabolic syndrome participating in a behavioural weight-loss programme: A cross-sectional assessment
Perez‐Cornago, A., Zulet, M. Á., & Martínez, J. A. (2014) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000116 · Cited by 17
The serum magnesium concentration as a potential state marker in patients with unipolar affective disorder
Styczeń, K., Siwek, M., Sowa-Kućma, M., Dudek, D., Reczyński, W., Szewczyk, B., Misztak, P., Topór‐Mądry, R., Opoka, W., & Nowak, G. (2015) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/44137 · Cited by 16
The Role of Magnesium in Depression, Migraine, Alzheimer’s Disease, and Cognitive Health: A Comprehensive Review
Varga, P., Lehoczki, A., Fekete, M., Jarecsny, T., Kryczyk‐Poprawa, A., Zábó, V., Major, D., Fazekas‐Pongor, V., Csípő, T., & Varga, J. T. (2025) · Nutrients · doi:10.3390/nu17132216 · Cited by 21
Pulsed electric field treatment for the stimulation of microorganisms: Applications in food production
Kantar, S. E., & Koubaa, M. (2022) · Research in Agricultural Engineering · doi:10.17221/78/2021-rae · Cited by 15
Dietary pattern derived by reduced rank regression and depressive symptoms in a multi-ethnic population: the HELIUS study
Vermeulen, E., Stronks, K., Visser, M., Brouwer, I. A., Snijder, M. B., Mocking, R. J. T., Derks, E. M., Schene, A. H., & Nicolaou, M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.61 · Cited by 15
Magnesium
Costello, R. B., & Rosanoff, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-66162-1.00021-4 · Cited by 15
Is Magnesium Supplementation an Effective Nutritional Method to Reduce Stress in Domestic Pigs? A Systematic Review
Bushby, E. V., Dye, L., & Collins, L. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.596205 · Cited by 14
Investigation into the diets and nutritional knowledge of young men with depression: The MENDDS survey
Bayes, J., Schloss, J. M., & Sibbritt, D. W. (2020) · Nutrition · doi:10.1016/j.nut.2020.110946 · Cited by 13
Dietary Patterns: A New Therapeutic Approach for Depression?
de Jesús, M., Silva, T., Cagigal, C. A. M., Martins, V., & Silva, C. (2018) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201019666180925122116 · Cited by 11
Magnesium Role in Health and Longevity
Barbagallo, M., & Dominguez, L. J. (2018) · Healthy ageing and longevity · doi:10.1007/978-3-030-03742-0_9 · Cited by 10
The Changes of Blood and CSF Ion Levels in Depressed Patients: a Systematic Review and Meta-analysis
Meng, Y., Liu, S., Yu, M., Liang, H., Yu, T., Song, J. S., Shi, J., Wen, C., Wu, Q., Wen, Z., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03891-x · Cited by 10
Integrative Medicine and Mood, Emotions and Mental Health
Shah, A. K., Becicka, R., Talen, M. R., Edberg, D., & Namboodiri, S. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.02.003 · Cited by 9
Association of alkali metals and Alkaline-earth metals with the risk of schizophrenia in a Chinese population: A Case-Control study
Cao, B., Chen, Y., Rosenbalt, J. D., McIntyre, R. S., Wang, D., & Yan, L. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126478 · Cited by 9
Propolis Intake by People Living With HIV: Biochemical Profile, Nutritional Status, and Safety
Tasca, K. I., Conte, F. L., Alves, A. C. M. M., Santiago, K. B., Cardoso, E. O., Sacilotto, L. B., Conti, B. J., Corrente, J. E., Berretta, A. A., de Souza, L. D. R., et al. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100834 · Cited by 7
Comparative Efficacy of Magnesium and Potassium Towards Cholesterol and Quality of Life in Patients With Type 2 Diabetes Mellitus: A Randomised Single‐Blinded Controlled Clinical Trial
Khalid, S., Mehboob, R., Bokhari, S. S., Ali, M. M., Shabbir, A., Mehboob, K., Adnan, H., Karami, M. M., Shalabi, H., & Alshehri, B. J. (2024) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.511 · Cited by 6
Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia
Madireddy, S., & Madireddy, S. (2022) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001070 · Cited by 5
Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study
Chou, M.-H., Yang, Y. K., Wang, J., Lin, C., & Lin, S. (2023) · Nutrients · doi:10.3390/nu15071560 · Cited by 4
Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students
Abdelmoneam, A. H., Khafagy, G. M., Elbeh, K., & Hasan, M. D. A. (2024) · Journal of Primary Care & Community Health · doi:10.1177/21501319241252570 · Cited by 4
Magnesium involvement in social behavior and in the treatment of some psychological disorders. A review
Nechifor, M. (2024) · Journal of Trace Elements and Minerals · doi:10.1016/j.jtemin.2024.100194 · Cited by 4
Acid reflux medication use among adults with depressive symptoms
Meshkat, S., Lin, Q., Tassone, V. K., Janssen‐Aguilar, R., Pang, H. Y. M., Lou, W. Y. W., & Bhat, V. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.085 · Cited by 4
Effects of PMS50 supplementation on psychological symptoms of students with premenstrual syndrome
Sadeghi, F., Javid, A. Z., Nazarinasab, M., & Haghighizadeh, M. H. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13703 · Cited by 4
The Use of Saccharomyces cerevisiae Supplemented with Intracellular Magnesium Ions by Means of Pulsed Electric Field (PEF) in the Process of Bread Production
Pankiewicz, U., Zielińska, E., Sobota, A., & Wirkijowska, A. (2022) · Foods · doi:10.3390/foods11213496 · Cited by 4
Impact of dietary magnesium intake on depression risk in American adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2005–2020
Huang, Y., Ruan, S., Yang, Y., Liang, H. W., Chen, S., & Chang, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1484344 · Cited by 4
Dietary magnesium intake affects the association between dietary vitamin A and depression: a cross-sectional study
Yan, C., Gao, C., Zhan, K., & Li, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1514681 · Cited by 3
Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran
Edalati-Fard, F., Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M., Mohammad‐Alizadeh‐Charandabi, S., & Farshbaf‐Khalili, A. (2016) · Global Journal of Health Science · doi:10.5539/gjhs.v8n11p120 · Cited by 3
Association of Magnesium and Incidence of Depression in Adults
Turkistani, O., Alsadhan, A. O., Alghaith, B. K., Merdad, F., Althawab, B. A., Bossier, A. S. A., Al-Aqeel, S. A., Al-Harbi, A., Alshammari, R., Albalawi, A., et al. (2021) · Journal of Healthcare Sciences · doi:10.52533/johs.2021.2103 · Cited by 3
Progress and trends of research on mineral elements for depression
Gao, B., Li, C., Qu, Y., Cai, M., Zhou, Q., Zhang, Y., Lu, H., Tang, Y., Li, H., & Shen, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35469 · Cited by 4
Role of magnesium in abdominal wall dyskinesia.
Durrani, H. D. (2021) · The Professional Medical Journal · doi:10.29309/tpmj/2021.28.02.5468 · Cited by 3
Nutrition and Psychiatric Disorders: Focus on Schizophrenia
Mansour, H. M. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-5021-6_15 · Cited by 3
Depression Events Associated with Proton-Pump Inhibitors in Postmarketing Drug Surveillance Data
Makunts, T., Joulfayan, H., Ta, K., & Abagyan, R. A. (2023) · Pharmacoepidemiology · doi:10.3390/pharma2030023 · Cited by 2
The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease
Abou-Hashem, R. M., Shaat, M. M., Hamza, S. A., Mahmoud, N. H., & Ali, S. M. (2020) · Electronic Journal of General Medicine · doi:10.29333/ejgm/7887 · Cited by 2
Impaired Magnesium Status and Depression
Veronese, N., & Solmi, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-40007-5_49-1 · Cited by 1
Dietary Networks Identified by Gaussian Graphical Model and Odds of Major Depressive Disorder: A Case‐Control Study
Shahinfar, H., Shab-Bidar, S., Effatpanah, M., Askari, R., & Jazayeri, S. (2024) · International journal of clinical practice · doi:10.1155/2024/8749041 · Cited by 1
Association between dietary patterns and symptoms of depression and anxiety in college students: a cross-sectional study
Cui, L., Zhang, Z., Gao, Y., Ren, L., Wang, Y., Sun, R., Ji, L., & Wang, X. (2025) · Current Psychology · doi:10.1007/s12144-025-07936-3 · Cited by 1
A pilot study on the effect of feed supplementation with magnesium oxide and magnesium aspartate on blood magnesium content and tail lesions in pigs under practical on-farm conditions
Jensen, C., Czycholl, I., Nison, P., Jacquerot, T., Sandøe, P., & Büttner, K. (2026) · Porcine Health Management · doi:10.1186/s40813-026-00526-0 · Cited by 1
Correlation between postpartum depression and omega-3, micronutrients
Mermer, M., & Şanlıer, N. (2017) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20174979 · Cited by 1
Unipolar Depresyon ve Bipolar Duygu Durum Bozukluğunda Serum Magnezyum Düzeylerinin Değerlendirilmesi: Retrospektif Bir Çalışma
Cengiz, G. F. (2021) · OSMANGAZİ JOURNAL OF MEDICINE · doi:10.20515/otd.954075 · Cited by 1
Management of Stress Through Dietary Modifications
Begum, R. A., Chowdhury, E. K., & Shekhar, H. U. (2023) · Springer eBooks · doi:10.1007/978-981-99-7652-2_24 · Cited by 1
Profound Hypomagnesemia Due to Proton Pump Inhibitor Use-Associated Wernicke’s Encephalopathy: A Case Report on Excitotoxicity
Delforge, B., Volon, B., Laurent, Y., & Steinier, C. (2025) · Cureus · doi:10.7759/cureus.94687 · Cited by 1
Impact of magnesium deficiency on the quality of life of women using hormonal contraception
Makatsariya, A. D., & Дикке, Г. Б. (2018) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2018-7-87-96 · Cited by 1
Association Between Magnesium Intake and Depressive Symptoms in People Living With HIV Infection
Currie, J., Perazzo, J. D., Schreiner, N., & Webel, A. R. (2019) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000132 · Cited by 1
Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune ActivationPreprint
Al-Dujaili, A. H., Al‐Hakeim, H. K., Twayej, A. J., & Maes, M. H. J. (2019) · Preprints.org · doi:10.20944/preprints201902.0236.v1
The Relationship Between Nutrient Intake and Social Emotional Functioning in Preschool Children
Daniel, T. L. (2016) · ScholarWorks (Walden University)
Recommendations to Help Prevent Mental Disorders and Limit Stigma
Laupu, W. (2018) · British Journal of Medical and Health Research · doi:10.46624/bjmhr.2018.v5.i09.001
Consciousness Energy Healing Treatment: Physicochemical and Thermal Characterization of Magnesium
Jana, S. (2019) · Aspects in Mining & Mineral Science · doi:10.31031/amms.2019.03.000552
Magnesium Intake and Human Health
Wolf, F. I., & Trapani, V. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-335-5
Predicting Depression using a Biochemistry Profile and Machine Learning for Better Risk Stratification
Mamun, T. I., & Alam, L. (2022) · International Journal of Computer Applications · doi:10.5120/ijca2022921924
Impaired Magnesium Status and Depression
Veronese, N., & Solmi, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-55387-0_49
USO DE SUPLEMENTOS E VITAMINAS NO TRATAMENTO DE DESORDENS PSICOLÓGICAS E SEUS BENEFÍCIOS PARA A SAÚDE MENTAL
Gontijo, A. A., Freire, B. H. D. F., & Araújo, M. P. D. (2022) · Editora Pasteur eBooks · doi:10.29327/562655.4-24

Association of Magnesium and Incidence of Depression in Adults
Turkistani, O., Alsadhan, A. O., Alghaith, B. K., Merdad, F., Althawab, B. A., Bossier, A. S. A., Al-Aqeel, S. A., Al-Harbi, A., Alshammari, R., Albalawi, A., et al. (2021) · Journal of Healthcare Sciences · doi:10.52533/johs.2021.2103 · Cited by 3
Magnesium intake and depression.
Wilson, K., & Brakoulias, V. (2009) · PubMed · Cited by 8
Dietary magnesium intake and the incidence of depression: A 20-year follow-up study
Yary, T., Lehto, S. M., Tolmunen, T., Tuomainen, T., Kauhanen, J., Voutilainen, S., & Ruusunen, A. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.056 · Cited by 64
Dietary magnesium intake and risk of depression
Sun, C., Wang, R., Li, Z., & Zhang, D. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.114 · Cited by 83
Magnesium Intake Is Not Related to Depression Risk in Spanish University Graduates
Derom, M.-L., Martínez‐González, M. Á., Sayón-Orea, M. D. C., Bes‐Rastrollo, M., Beunza, J. J., & Sánchez‐Villegas, A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.155572 · Cited by 50

Authors: Derom, M.-L., Sayón-Orea, C., Martínez-Ortega, J. M., & Martínez-González, M. A.
Affiliations: Universidad de Navarra (ES)
ORCID: Sayón-Orea, Carmen
Venue: Nutritional Neuroscience
Publisher: Informa UK Limited
Published: 2013-09
Volume: 16
Issue: 5
Pages: 191-206
ISSN: 1028-415X (ISSN-L)
1476-8305
DOI: 10.1179/1476830512y.0000000044
OpenAlex: W2015569119
Cited by: 108
References: 80
Citations by year: 2026: 3 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 3
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Locations: Nutritional Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords: magnesium, depression, dietary magnesium, magnesium supplementation, blood magnesium, cerebrospinal fluid magnesium, magnesium metabolism, depression prevention, adjunctive therapy, reverse causality
MeSH terms: Animals, Calcium, Cross-Sectional Studies, Depression, Diet, Humans, Magnesium, Prospective Studies, Neuroprotective Agents, Dietary Supplements

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Magnesium and depression: a systematic review

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