Oligodendrocyte‐microglia cross‐talk in the central nervous system
Open accessAbstract
Communication between the immune system and the central nervous system (CNS) is exemplified by cross-talk between glia and neurons shown to be essential for maintaining homeostasis. While microglia are actively modulated by neurons in the healthy brain, little is known about the cross-talk between oligodendrocytes and microglia. Oligodendrocytes, the myelin-forming cells in the CNS, are essential for the propagation of action potentials along axons, and additionally serve to support neurons by producing neurotrophic factors. In demyelinating diseases such as multiple sclerosis, oligodendrocytes are thought to be the victims. Here, we review evidence that oligodendrocytes also have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the CNS. We also review evidence that during stress events in the brain, oligodendrocytes can trigger a cascade of protective and regenerative responses, in addition to responses that elicit progressive neurodegeneration. Knowledge of the cross-talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration.
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Oligodendrocytes crosstalk with microglia, expressing innate immune receptors and modulating CNS immunity through cytokine signaling.
“Oligodendrocytes are also known to crosstalk with microglia, expressing innate immune receptors and modulating central nervous system (CNS) immunity through cytokine signaling. 62”
From Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses (2026) · cites this paper as [62]
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“62 Like DAM, which appears in 5XFAD at 1 to 2 months of age, DAO is also enriched near A β plaques at 9 to 10 months of age.”
- Authors
- Peferoen, L., Kipp, M., van der Valk, P., van Noort, J. M., & Amor, S.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- RWTH Aachen University (DE)
- Pathology Department VU University Medical Centre Amsterdam the Netherlands
- Delta Crystallon BV Leiden the Netherlands
- Queen Mary University of London (GB)
- Corresponding author
- Amor, Sandra
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2014-02-10
- Volume
- 141
- Issue
- 3
- Pages
- 302-313
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC3930369
- OpenAlex
- W2071493890
- Cited by
- 438
- References
- 11
- Citations by year
- 2026: 29 · 2025: 30 · 2024: 45 · 2023: 56 · 2022: 44 · 2021: 61 · 2020: 57 · 2019: 34 · 2018: 24 · 2017: 15 · 2016: 21 · 2015: 15 · 2014: 5 · 2013: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Multiple Sclerosis Society
- Stichting MS Research
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- oligodendrocytes, microglia, central nervous system immunity, innate immune receptors, chemokines, cytokines, demyelinating disease, multiple sclerosis, neuroinflammation, neurodegeneration, myelination, neurotrophic factors
- MeSH terms
- Animals, Brain, Cell Communication, Demyelinating Diseases, Heat-Shock Proteins, Humans, Myelin Sheath, Oligodendroglia, Stress, Physiological, Signal Transduction, Cytokines, Microglia, Exosomes
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