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Cited by 237Cellular Mechanics and InteractionsPhagocytosis and Immune RegulationCellular transport and secretion

Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton

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Rougerie, Pablo, Miskolci, Veronika, Cox, Dianne·2013·Immunological Reviews
DOI 10.1111/imr.12118PMC PMC3806206
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Abstract

Summary: Macrophages are best known for their protective search and destroy functions against invading microorganisms. These processes are commonly known as chemotaxis and phagocytosis. Both of these processes require actin cytoskeletal remodeling to produce distinct F‐actin‐rich membrane structures called lamellipodia and phagocytic cups. This review will focus on the mechanisms by which macrophages regulate actin polymerization through initial receptor signaling and subsequent Arp2/3 activation by nucleation‐promoting factors like the WASP/WAVE family, followed by remodeling of actin networks to produce these very distinct structures.

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Authors
Rougerie, P., Miskolci, V., & Cox, D.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Cox, Dianne
ORCID
Venue
Immunological Reviews
Publisher
Wiley
Published
2013-10-10
Volume
256
Issue
1
Pages
222-239
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
DOI
10.1111/imr.12118
PMC
PMC3806206
OpenAlex
W2138925467
Cited by
237
References
7
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FWCI
1.53
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (GM071828, GM007491, R01GM071828, T32GM007491)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
macrophages, phagocytosis, chemotaxis, actin cytoskeleton, lamellipodia, phagocytic cup, actin polymerization, Arp2/3 complex, nucleation-promoting factors, receptor signaling, membrane structure
MeSH terms
Animals, Cell Membrane, Chemotaxis, Humans, Macrophages, Actin Cytoskeleton, Phagocytosis, Macrophage-1 Antigen, Receptors, IgG

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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