Genetics ignite focus on microglial inflammation in Alzheimer’s disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Neuroinflammation in Alzheimer's disease

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The M1 and M2 paradigm of macrophage activation: Time for reassessment

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Inflammation and Alzheimer’s disease

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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<i>TREM2</i> Variants in Alzheimer's Disease

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Replication validity of genetic association studies

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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Untitled work

Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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Ensembl 2015

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

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Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

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Complement activation by beta-amyloid in Alzheimer disease.

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

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CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

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Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus

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Siglecs—the major subfamily of I-type lectins

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Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

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Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study

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Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

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Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

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TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

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APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response

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APOE genotype-specific differences in the innate immune response

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LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide

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Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain

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Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

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LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

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CD33 Alzheimer’s risk-altering polymorphism, CD33 expression, and exon 2 splicing

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APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

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TREM2and Neurodegenerative Disease

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

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Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton

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Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

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Curses—Winner's and Otherwise—in Genetic Epidemiology

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APOE genotype alters glial activation and loss of synaptic markers in mice

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Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

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Complement Receptor 1: Disease associations and therapeutic implications

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ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

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TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis

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Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells

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Deletion ofAbca7Increases Cerebral Amyloid-β Accumulation in the J20 Mouse Model of Alzheimer's Disease

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CNS manifestations of Nasu–Hakola disease

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Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2

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ATP-binding Cassette Transporter A7 (ABCA7) Binds Apolipoprotein A-I and Mediates Cellular Phospholipid but Not Cholesterol Efflux

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APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms

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Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

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Quantifying and correcting for the winner's curse in genetic association studies

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Human ABCA7 Supports Apolipoprotein-mediated Release of Cellular Cholesterol and Phospholipid to Generate High Density Lipoprotein

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Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

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Differential regulation of BACE1 promoter activity by nuclear factor‐κB in neurons and glia upon exposure to β‐amyloid peptides

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The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2

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Systemic Inflammation, Infection, ApoE Alleles, and Alzheimer Disease: A Position Paper

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The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation

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Identification of a Novel Human Sterol-Sensitive ATP-Binding Cassette Transporter (ABCA7)

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<i><scp>APOE</scp></i>‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

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Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

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Specific lipid recognition is a general feature of CD300 and TREM molecules

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Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells

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Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

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TET2 Regulates the Neuroinflammatory Response in Microglia

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TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

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Alzheimer’s Disease: Exploring the Role of Inflammation and Implications for Treatment

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The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

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Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration

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Genetic Determinants Highlight the Existence of Shared Etiopathogenetic Mechanisms Characterizing Age-Related Macular Degeneration and Neurodegenerative Disorders

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APP in the Neuromuscular Junction for the Development of Sarcopenia and Alzheimer’s Disease

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Immune System and Neuroinflammation in Idiopathic Parkinson’s Disease: Association Analysis of Genetic Variants and miRNAs Interactions

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