Mechanisms involved in triggering rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

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2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

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Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

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The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

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Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

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Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors

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Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

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A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

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NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

Khandpur, R., Carmona‐Rivera, C., Vivekanandan‐Giri, A., Gizinski, A. M., Yalavarthi, S., Knight, J. S., Friday, S. C., Li, S., Patel, R. M., Subramanian, V., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005580 · Cited by 1,342 · see citing works

The immune geography of IgA induction and function

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Genetically Distinct Subsets within ANCA-Associated Vasculitis

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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

Raychaudhuri, S., Sandor, C., Stahl, E. A., Freudenberg, J., Lee, H. S., Jia, X., Alfredsson, L. S., Padyukov, L., Klareskog, L., Worthington, J., et al. (2012) · Nature Genetics · doi:10.1038/ng.1076 · Cited by 947 · see citing works

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

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Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.

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Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule

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Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

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Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

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Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

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Periodontitis in systemic rheumatic diseases

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Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis

Scher, J. U., Úbeda, C., Equinda, M. J., Khanin, R., Buischi, Y. D. P., Viale, A. J., Lipuma, L., Attur, M. G., Pillinger, M. H., Weissmann, G., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34539 · Cited by 465 · see citing works

Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

Stoffer, M. A., Schoels, M., Smolen, J. S., Aletaha, D., Breedveld, F. C., Burmester, G. R., Bykerk, V. P., Dougados, M., Emery, P., Haraoui, B. P., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-207526 · Cited by 454 · see citing works

A molecular basis for the association of the <i>HLA-DRB1</i> locus, citrullination, and rheumatoid arthritis

Scally, S. W., Petersen, J., Law, S. C., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20131241 · Cited by 429 · see citing works

Normal Structure, Function, and Histology of Mucosa-Associated Lymphoid Tissue

Cesta, M. F. (2006) · Toxicologic Pathology · doi:10.1080/01926230600865531 · Cited by 386 · see citing works

The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

Mil, A. H. M. V. D. H., Verpoort, K. N., Breedveld, F. C., Huizinga, T. W. J., Toes, R. E. M., & de Vries, R. R. P. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21739 · Cited by 356 · see citing works

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

Krishnamurthy, A., Joshua, V., Hensvold, A. H., Jin, T., Sun, M. Y., Vivar, N., Ytterberg, A. J., Engström, M., Fernandes‐Cerqueira, C., Amara, K., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208093 · Cited by 348 · see citing works

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll‐like receptor 4 and Fcγ receptor

Sokolove, J. B., Zhao, X., Chandra, P. E., & Robinson, W. H. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30081 · Cited by 341 · see citing works

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

Kleyer, A., Finzel, S., Rech, J., Manger, B., Krieter, M., Faustini, F., Araujo, E., Hueber, A. J., Steffen, U., Engelke, K., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202958 · Cited by 328 · see citing works

Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles

Linn-Rasker, S. P., Mil, A. H. M. V. D. H., van Gaalen, F. A., Kloppenburg, M., de Vries, R. R. P., le Cessie, S., Breedveld, F. C., Toes, R. E. M., & Huizinga, T. W. J. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.041079 · Cited by 327 · see citing works

Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment

Rivollier, A., Mazzorana, M., Tebib, J. G., Piperno, M., Aitsiselmi, T., Rabourdin‐Combe, C., Jurdic, P., & Delprat, C. (2004) · Blood · doi:10.1182/blood-2004-01-0041 · Cited by 323 · see citing works

Citrullination is an inflammation-dependent process

Makrygiannakis, D., af Klint, E., Lundberg, I. E., Löfberg, R., Ulfgren, A.-K., Klareskog, L., & Catrina, A. I. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.049403 · Cited by 301 · see citing works

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

Maresz, K., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Kozieł, J., Gawron, K., Mizgalska, D., Marcińska, K., Benedyk‐Machaczka, M., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003627 · Cited by 292 · see citing works

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

Cao, Y., Goods, B. A., Raddassi, K., Nepom, G. T., Kwok, W. W., Love, J. C., & Hafler, D. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa8038 · Cited by 290 · see citing works

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis

Padyukov, L., Seielstad, M. T., Ong, R. T., Ding, B., Rönnelid, J., Seddighzadeh, M., Alfredsson, L. S., & Klareskog, L. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.126821 · Cited by 282 · see citing works

Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

Trouw, L. A., Haisma, E. M., Levarht, E. W. N., van der Woude, D., Ioan‐Facsinay, A., Daha, M. R., Huizinga, T. W. J., & Toes, R. E. M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24622 · Cited by 265 · see citing works

Brief Report: Airways abnormalities and rheumatoid arthritis–related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?

Demoruelle, M. K., Weisman, M. H., Simonian, P. L., Lynch, D. A., Sachs, P. B., Pedraza, I. F., Harrington, A., Kolfenbach, J., Striebich, C. C., Pham, Q. N., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.34344 · Cited by 264 · see citing works

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

Steffen, U., Lang, S. C., Pfeifle, R., Rombouts, Y., Frühbeißer, S., Amara, K., Bang, H., Lux, A., Koeleman, C. A. M., Baum, W., et al. (2015) · Nature Communications · doi:10.1038/ncomms7651 · Cited by 264 · see citing works

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti–Citrullinated Protein Antibody–Positive Rheumatoid Arthritis

Reynisdottir, G., Karimi, R., Joshua, V., Olsen, H. H., Hensvold, A. H., Harju, A., Engström, M., Grünewald, J., Nyrén, S., Eklúnd, A., et al. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38201 · Cited by 259 · see citing works

Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response

Ruddle, N. H., & Akirav, E. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804324 · Cited by 259 · see citing works

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

Buckley, C. D., Barone, F., Nayar, S., Bénézech, C., & Caamaño, J. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120252 · Cited by 249 · see citing works

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis

Klareskog, L., Malmström, V., Lundberg, K., Padyukov, L., & Alfredsson, L. S. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.014 · Cited by 245 · see citing works

A novel microbiota stratification system predicts future exacerbations in bronchiectasis

Rogers, G. B., Zain, N. M. M., Bruce, K. D., Burr, L. D., Chen, A. C., Rivett, D. W., McGuckin, M. A., & Serisier, D. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201310-335oc · Cited by 244 · see citing works

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

Spengler, J., Lugonja, B., Ytterberg, A. J., Zubarev, R. A., Creese, A. J., Pearson, M. J., Grant, M. M., Milward, M. R., Lundberg, K., Buckley, C. D., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39313 · Cited by 242 · see citing works

Rheumatoid factor revisited

Dörner, T., Egerer, K., Feist, E., & Burmester, G. R. (2004) · Current Opinion in Rheumatology · doi:10.1097/00002281-200405000-00013 · Cited by 235 · see citing works

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis

Uysal, H., Bockermann, R., Nandakumar, K. S., Sehnert, B., Bajtner, E., Engström, Å., Serre, G., Burkhardt, H., Thunnissen, M. M. G. M., & Holmdahl, R. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081862 · Cited by 234 · see citing works

Loss of Sex and Age Driven Differences in the Gut Microbiome Characterize Arthritis-Susceptible *0401 Mice but Not Arthritis-Resistant *0402 Mice

Gomez, A. M., Luckey, D. H., Yeoman, C. J., Marietta, E. V., Miller, M. E. B., Murray, J. A., White, B. A., & Taneja, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036095 · Cited by 233 · see citing works

Porphyromonas gingivalis and disease‐related autoantibodies in individuals at increased risk of rheumatoid arthritis

Mikuls, T. R., Thiele, G. M., Deane, K. D., Payne, J. B., O’Dell, J. R., Yu, F. H. Z., Sayles, H. R., Weisman, M. H., Gregersen, P. K., Buckner, J. H., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34595 · Cited by 230 · see citing works

Development of the anti–citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

van de Stadt, L. A., Koning, M. H. M. T. D., van de Stadt, R. J., Wolbink, G., Dijkmans, B. A. C., Hamann, D., & van Schaardenburg, D. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30537 · Cited by 226 · see citing works

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

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Sputum Autoantibodies in Patients With Established Rheumatoid Arthritis and Subjects at Risk of Future Clinically Apparent Disease

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Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice

Kang, M., Lee, C. G., Lee, J.-Y., Cruz, C. S. D., Chen, Z. J., Enelow, R. I., & Elias, J. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32709 · Cited by 218 · see citing works

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

Shi, J., van de Stadt, L. A., Levarht, E. W. N., Huizinga, T. W. J., Hamann, D., van Schaardenburg, D., Toes, R. E. M., & Trouw, L. A. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204154 · Cited by 218 · see citing works

Citrulline‐Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

James, E. A., Rieck, M., Pieper, J., Gebe, J. A., Yue, B. B., Tatum, M., Peda, M., Sandin, C., Klareskog, L., Malmström, V., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38637 · Cited by 215 · see citing works

Rheumatoid factors antedating clinical rheumatoid arthritis.

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Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase

van de Sande, M. G. H., de Hair, M. J. H., van der Leij, C., Klarenbeek, P. L., Bos, W. H., Smith, M., Maas, M. M., de Vries, N., van Schaardenburg, D., Dijkmans, B. A. C., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.139527 · Cited by 212 · see citing works

Differential protease, innate immunity, and NF-κB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice

Vlahos, R., Bozinovski, S., Jones, J. E., Powell, J., Gras, J., Lilja, A., Hansen, M. J., Gualano, R. C., Irving, L. B., & Anderson, G. P. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00201.2005 · Cited by 208 · see citing works

Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease

Fischer, A., Solomon, J. J., du Bois, R. M., Deane, K. D., Olson, A. L., Pérez, E. R. F., Huie, T. J., Stevens, A. D., Gill, M. B., Rabinovitch, A. M., et al. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.03.006 · Cited by 205 · see citing works

Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients

Snir, O., Widhe, M., Hermansson, M., von Spee-Mayer, C., Lindberg, J., Hensen, S. M. M., Lundberg, K., Engström, Å., Venables, P. J., Toes, R. E. M., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25036 · Cited by 204 · see citing works

Discriminating gene expression profiles of memory B cell subpopulations

Ehrhardt, G. R. A., Hijikata, A., Kitamura, H., Ohara, O., Wang, J. O., & Cooper, M. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072682 · Cited by 198 · see citing works

Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis

Brink, M., Hansson, M., Mathsson, L., Jakobsson, P., Holmdahl, R., Hallmans, G., Stenlund, H. C., Rönnelid, J., Klareskog, L., & Rantapää‐Dahlqvist, S. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37835 · Cited by 195 · see citing works

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

Yeo, L., Toellner, K., Salmon, M., Filer, A. D., Buckley, C. D., Raza, K., & Scheel‐Toellner, D. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.153312 · Cited by 192 · see citing works

Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

Majka, D. S., Deane, K. D., Parrish, L. A., Lazar, A. A., Barón, A. E., Walker, C., Rubertone, M. V., Gilliland, W. R., Norris, J. M., & Holers, V. M. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.076679 · Cited by 192 · see citing works

Brief Report: Anti–Carbamylated Protein Antibodies Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis

Shi, J., van de Stadt, L. A., Levarht, E. W. N., Huizinga, T. W. J., Toes, R. E. M., Trouw, L. A., & van Schaardenburg, D. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37830 · Cited by 192 · see citing works

Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis

de Hair, M. J. H., van de Sande, M. G. H., Ramwadhdoebé, T. H., Hansson, M., Landewé, R., van der Leij, C., Maas, M. M., Serre, G., van Schaardenburg, D., Klareskog, L., et al. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38273 · Cited by 184 · see citing works

Association of Granulomatosis With Polyangiitis (Wegener's) With HLA–DPB1*04 and SEMA6A Gene Variants: Evidence From Genome‐Wide Analysis

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Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

Seeling, M., Hillenhoff, U., David, J. P., Schett, G. A., Tuckermann, J. P., Lux, A., & Nimmerjahn, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301001110 · Cited by 171 · see citing works

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

Hensvold, A. H., Magnusson, P. K. E., Joshua, V., Hansson, M., Israelsson, L., Ferreira, R., Jakobsson, P., Holmdahl, R., Hammarström, L. L. G., Malmström, V., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203947 · Cited by 170 · see citing works

Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis

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